product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Glucagon antibody produced in mouse
catalog :
G2654
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
K79bB10
reactivity :
black ferret, human, mouse, rat, dogs, pigs , zebrafish
application :
immunohistochemistry, immunocytochemistry, flow cytometry, radioimmunoassay, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 201
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 4f
Viloria K, Nasteska D, Briant L, Heising S, Larner D, Fine N, et al. Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Cell Rep. 2020;31:107761 pubmed publisher
  • immunocytochemistry; mouse; 1:50; loading ...; fig 1a
Zhu K, Lai Y, Cao H, Bai X, Liu C, Yan Q, et al. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun. 2020;11:484 pubmed publisher
  • immunohistochemistry; human; 1:1000; loading ...; fig 1d
Furuyama K, Chera S, van Gurp L, Oropeza D, Ghila L, Damond N, et al. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. Nature. 2019;567:43-48 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 2c
Parilla J, Hull R, Zraika S. Neprilysin Deficiency Is Associated With Expansion of Islet β-Cell Mass in High Fat-Fed Mice. J Histochem Cytochem. 2018;66:523-530 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:100; loading ...; fig s11a
Freudenblum J, Iglesias J, Hermann M, Walsen T, Wilfinger A, Meyer D, et al. In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis. Development. 2018;145: pubmed publisher
  • immunohistochemistry - paraffin section; black ferret; 1:500; loading ...; fig 3a
Rotti P, Xie W, Poudel A, Yi Y, Sun X, Tyler S, et al. Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets. Am J Pathol. 2018;188:876-890 pubmed publisher
  • immunohistochemistry; human; 1:9000; fig 2b
Almgren P, Lindqvist A, Krus U, Hakaste L, Ottosson Laakso E, Asplund O, et al. Genetic determinants of circulating GIP and GLP-1 concentrations. JCI Insight. 2017;2: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 3c
Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, et al. Peripherally derived FGF21 promotes remyelination in the central nervous system. J Clin Invest. 2017;127:3496-3509 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 1c
Spaeth J, Gupte M, Perelis M, Yang Y, CYPHERT H, Guo S, et al. Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning. Diabetes. 2017;66:2830-2839 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 5b
Smith Anttila C, Bensing S, Alimohammadi M, Dalin F, Oscarson M, Zhang M, et al. Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1. Autoimmunity. 2017;50:223-231 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 2h
Krentz N, Van Hoof D, Li Z, Watanabe A, Tang M, Nian C, et al. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell. 2017;41:129-142.e6 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:200; loading ...; fig 6b
Tarifeño Saldivia E, Lavergne A, Bernard A, Padamata K, Bergemann D, Voz M, et al. Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biol. 2017;15:21 pubmed publisher
  • flow cytometry; human; 1:250; fig 5c
  • immunocytochemistry; human; 1:1000; fig 5b
Shi Z, Lee K, Yang D, Amin S, Verma N, Li Q, et al. Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. 2017;20:675-688.e6 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 7d
Zhang Y, Zeng S, Hao Q, Lu H. Monitoring p53 by MDM2 and MDMX is required for endocrine pancreas development and function in a spatio-temporal manner. Dev Biol. 2017;423:34-45 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1
Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, et al. Dopamine D2 Receptor-Mediated Regulation of Pancreatic ? Cell Mass. Stem Cell Reports. 2016;7:95-109 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3a
Omori H, Ogaki S, Sakano D, Sato M, Umeda K, Takeda N, et al. Changes in expression of C2cd4c in pancreatic endocrine cells during pancreatic development. FEBS Lett. 2016;590:2584-93 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Singhal G, Fisher F, Chee M, Tan T, El Ouaamari A, Adams A, et al. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS ONE. 2016;11:e0148252 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 5
Bruin J, Saber N, O Dwyer S, Fox J, Mojibian M, Arora P, et al. Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice. Diabetes. 2016;65:1297-309 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 4
Korytnikov R, Nostro M. Generation of polyhormonal and multipotent pancreatic progenitor lineages from human pluripotent stem cells. Methods. 2016;101:56-64 pubmed publisher
  • immunohistochemistry; mouse; 1:4000; fig 2f
Galloway J, Bethea M, Liu Y, Underwood R, Mobley J, Hunter C. SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes. Mol Endocrinol. 2015;29:1774-86 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 6a
Song I, Patel O, Himpe E, Muller C, Bouwens L. Beta Cell Mass Restoration in Alloxan-Diabetic Mice Treated with EGF and Gastrin. PLoS ONE. 2015;10:e0140148 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Han Y, Ryu S, Park S, Lee K, Lee S, Ho W. Ca(2+) clearance by plasmalemmal NCLX, Li(+)-permeable Na(+)/Ca(2+) exchanger, is required for the sustained exocytosis in rat insulinoma INS-1 cells. Pflugers Arch. 2015;467:2461-72 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; fig 2
Spaeth J, Hunter C, Bonatakis L, Guo M, French C, Slack I, et al. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. 2015;58:1836-44 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000
Tamura K, Minami K, Kudo M, Iemoto K, Takahashi H, Seino S. Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. PLoS ONE. 2015;10:e0126003 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; fig 1&2
Bonner C, Kerr Conte J, Gmyr V, Queniat G, Moerman E, Thévenet J, et al. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med. 2015;21:512-7 pubmed publisher
  • immunohistochemistry; mouse; 1:4000; fig s3
McKenna B, Guo M, Reynolds A, Hara M, Stein R. Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells. Cell Rep. 2015;10:2032-42 pubmed publisher
  • immunohistochemistry; zebrafish ; 1:200
Dalgin G, Prince V. Differential levels of Neurod establish zebrafish endocrine pancreas cell fates. Dev Biol. 2015;402:81-97 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
  • immunohistochemistry; human; 1:1000
Aragón F, Karaca M, Novials A, Maldonado R, Maechler P, Rubí B. Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells. Biochim Biophys Acta. 2015;1850:343-51 pubmed publisher
  • immunohistochemistry; human
Shimoda M, Chen S, Noguchi H, Takita M, Sugimoto K, Itoh T, et al. A new method for generating insulin-secreting cells from human pancreatic epithelial cells after islet isolation transformed by NeuroD1. Hum Gene Ther Methods. 2014;25:206-19 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:2000
  • immunocytochemistry; human; 1:2000
Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout Neveu E, Grenier Godard M, et al. Development of a conditionally immortalized human pancreatic ? cell line. J Clin Invest. 2014;124:2087-98 pubmed publisher
  • immunohistochemistry - paraffin section; pigs ; 1:500
Ellis C, Vulesevic B, Suuronen E, Yeung T, Seeberger K, Korbutt G. Bioengineering a highly vascularized matrix for the ectopic transplantation of islets. Islets. 2013;5:216-25 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Diaz de Durana Y, Lau J, Knee D, Filippi C, Londei M, McNamara P, et al. IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes. PLoS ONE. 2013;8:e78483 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:3000
Chen Z, Morris D, Jiang L, Liu Y, Rui L. SH2B1 in ?-cells regulates glucose metabolism by promoting ?-cell survival and islet expansion. Diabetes. 2014;63:585-95 pubmed publisher
  • immunohistochemistry - paraffin section; human
Bonnavion R, Jaafar R, Kerr Conte J, Assade F, Van Stralen E, Leteurtre E, et al. Both PAX4 and MAFA are expressed in a substantial proportion of normal human pancreatic alpha cells and deregulated in patients with type 2 diabetes. PLoS ONE. 2013;8:e72194 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Qian J, Block G, Colwell C, Matveyenko A. Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes. 2013;62:3469-78 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200
Romero Zerbo S, Rafacho A, Diaz Arteaga A, Suarez J, Quesada I, Imbernon M, et al. A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans. J Endocrinol. 2011;211:177-85 pubmed publisher
Kim H, Kim D, Yoon H, Choi C, Oh Y, Jun H. Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia Kazinoki Siebold Fruit Extract Via the ERK-Nox4 Pathway. Antioxidants (Basel). 2020;9: pubmed publisher
Legøy T, Vethe H, Abadpour S, Strand B, Scholz H, Paulo J, et al. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. Sci Rep. 2020;10:414 pubmed publisher
Ibrahim M, MacFarlane E, Matteo G, Hoyeck M, Rick K, Farokhi S, et al. Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure. Diabetologia. 2020;63:162-178 pubmed publisher
Liu W, Kin T, Ho S, Dorrell C, Campbell S, Luo P, et al. Abnormal regulation of glucagon secretion by human islet alpha cells in the absence of beta cells. EBioMedicine. 2019;50:306-316 pubmed publisher
Hayashi M. Expression of Adenosine Receptors in Rodent Pancreas. Int J Mol Sci. 2019;20: pubmed publisher
Solon Biet S, Cogger V, Pulpitel T, Wahl D, Clark X, Bagley E, et al. Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nat Metab. 2019;1:532-545 pubmed publisher
Zammit N, Walters S, Seeberger K, O Connell P, Korbutt G, Grey S. A20 as an immune tolerance factor can determine islet transplant outcomes. JCI Insight. 2019;4: pubmed publisher
Bensellam M, Chan J, Lee K, Joglekar M, Hardikar A, Loudovaris T, et al. Phlda3 regulates beta cell survival during stress. Sci Rep. 2019;9:12827 pubmed publisher
Dirice E, Kahraman S, De Jesus D, El Ouaamari A, Basile G, Baker R, et al. Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019;1:509-518 pubmed publisher
Tudurí E, Glavas M, Asadi A, Baker R, Ellis C, Soukhatcheva G, et al. AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells. Sci Rep. 2019;9:10829 pubmed publisher
Shik Mun K, Arora K, Huang Y, Yang F, Yarlagadda S, Ramananda Y, et al. Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders. Nat Commun. 2019;10:3124 pubmed publisher
Koltes J, Arora I, Gupta R, Nguyen D, Schaid M, Kim J, et al. A gene expression network analysis of the pancreatic islets from lean and obese mice identifies complement 1q like-3 secreted protein as a regulator of β-cell function. Sci Rep. 2019;9:10119 pubmed publisher
Li L, Martin Levilain J, Jiménez Sánchez C, Karaca M, Foti M, Martinou J, et al. In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way. J Biol Chem. 2019;294:12581-12598 pubmed publisher
van Krieken P, Voznesenskaya A, Dicker A, Xiong Y, Park J, Lee J, et al. Translational assessment of a genetic engineering methodology to improve islet function for transplantation. EBioMedicine. 2019;: pubmed publisher
Wei R, Gu L, Yang J, Yang K, Liu J, Le Y, et al. Antagonistic Glucagon Receptor Antibody Promotes α-Cell Proliferation and Increases β-Cell Mass in Diabetic Mice. iScience. 2019;16:326-339 pubmed publisher
Proshchina A, Krivova Y, Barabanov V, Saveliev S. Pancreatic endocrine cell arrangement during human ontogeny. Acta Histochem. 2019;121:638-645 pubmed publisher
Vethe H, Ghila L, Berle M, Hoareau L, Haaland Ø, Scholz H, et al. The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation. Front Endocrinol (Lausanne). 2019;10:293 pubmed publisher
Liu J, Luo G, Sun J, Men L, Ye H, He C, et al. METTL14 is essential for β-cell survival and insulin secretion. Biochim Biophys Acta Mol Basis Dis. 2019;: pubmed publisher
Yuan F, Wang D, Ma L, Qin X, Gong J, Hu M, et al. Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic β Cell Identity in db/db Mice. Evid Based Complement Alternat Med. 2019;2019:1232913 pubmed publisher
Wang C, Chi J, Che K, Ma X, Qiu M, Wang Z, et al. The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy. Exp Ther Med. 2019;17:3555-3563 pubmed publisher
Lee K, Kim H, Lee J, Oh C, Song H, Kim H, et al. Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3. Diabetes Metab J. 2019;43:649-658 pubmed publisher
Wang X, Sterr M, Ansarullah -, Burtscher I, Böttcher A, Beckenbauer J, et al. Point mutations in the PDX1 transactivation domain impair human β-cell development and function. Mol Metab. 2019;24:80-97 pubmed publisher
Gurlo T, Kim S, Butler A, Liu C, Pei L, Rosenberger M, et al. Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes. Diabetologia. 2019;62:1000-1010 pubmed publisher
Toselli C, Wilkinson B, Paterson J, Kieffer T. Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation. Sci Rep. 2019;9:3594 pubmed publisher
Duin S, Schütz K, Ahlfeld T, Lehmann S, Lode A, Ludwig B, et al. 3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend. Adv Healthc Mater. 2019;8:e1801631 pubmed publisher
Giannios I, Serafimidis I, Anastasiou V, Pezzolla D, Lesche M, Andree C, et al. Protein Methyltransferase Inhibition Decreases Endocrine Specification Through the Upregulation of Aldh1b1 Expression. Stem Cells. 2019;37:640-651 pubmed publisher
Bethea M, Liu Y, Wade A, Mullen R, Gupta R, Gelfanov V, et al. The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis. Am J Physiol Endocrinol Metab. 2019;316:E397-E409 pubmed publisher
Knudsen J, Hamilton A, Ramracheya R, Tarasov A, Brereton M, Haythorne E, et al. Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production. Cell Metab. 2019;29:430-442.e4 pubmed publisher
Araújo T, da Silva J, Vettorazzi J, Freitas I, Lubaczeuski C, Magalhães E, et al. Glucose intolerance in monosodium glutamate obesity is linked to hyperglucagonemia and insulin resistance in α cells. J Cell Physiol. 2019;234:7019-7031 pubmed publisher
Li X, Jia L, Chen X, Dong Y, Ren X, Dong Y, et al. Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice. Theranostics. 2018;8:5960-5971 pubmed publisher
Yang J, Lu J, Yuan S, Asan -, Cao X, Qiu H, et al. From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Cell Rep. 2018;25:3800-3810.e6 pubmed publisher
Jahan M, Johnström P, Selvaraju R, Svedberg M, Winzell M, Bernström J, et al. The development of a GPR44 targeting radioligand [11C]AZ12204657 for in vivo assessment of beta cell mass. EJNMMI Res. 2018;8:113 pubmed publisher
Balboa D, Saarimäki Vire J, Borshagovski D, Survila M, Lindholm P, Galli E, et al. Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes. elife. 2018;7: pubmed publisher
Thomsen S, Raimondo A, Hastoy B, Sengupta S, Dai X, Bautista A, et al. Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nat Genet. 2018;50:1122-1131 pubmed publisher
Ramond C, Beydag Tasöz B, Azad A, van de Bunt M, Petersen M, Beer N, et al. Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling. Development. 2018;145: pubmed publisher
Sun J, Mao L, Yang H, Ren D. Critical role for the Tsc1-mTORC1 pathway in ?-cell mass in Pdx1-deficient mice. J Endocrinol. 2018;238:151-163 pubmed publisher
Millership S, Da Silva Xavier G, Choudhury A, Bertazzo S, Chabosseau P, Pedroni S, et al. Neuronatin regulates pancreatic β cell insulin content and secretion. J Clin Invest. 2018;128:3369-3381 pubmed publisher
Hansson S, Zhou A, Vachet P, Eriksson J, Pereira M, Skrtic S, et al. Secretagogin is increased in plasma from type 2 diabetes patients and potentially reflects stress and islet dysfunction. PLoS ONE. 2018;13:e0196601 pubmed publisher
Aslamy A, Oh E, Olson E, Zhang J, Ahn M, Moin A, et al. Doc2b Protects β-Cells Against Inflammatory Damage and Enhances Function. Diabetes. 2018;67:1332-1344 pubmed publisher
Robert T, De Mesmaeker I, Stangé G, Suenens K, Ling Z, Kroon E, et al. Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control. Stem Cell Reports. 2018;10:739-750 pubmed publisher
Rakshit K, Qian J, Gaonkar K, Dhawan S, Colwell C, Matveyenko A. Postnatal Ontogenesis of the Islet Circadian Clock Plays a Contributory Role in β-Cell Maturation Process. Diabetes. 2018;67:911-922 pubmed publisher
Mitok K, Freiberger E, Schueler K, Rabaglia M, Stapleton D, Kwiecien N, et al. Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion. J Biol Chem. 2018;293:5860-5877 pubmed publisher
Burchfield J, Kebede M, Meoli C, Stöckli J, Whitworth P, Wright A, et al. High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. J Biol Chem. 2018;293:5731-5745 pubmed publisher
Xiao X, Guo P, Shiota C, Zhang T, Coudriet G, Fischbach S, et al. Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. Cell Stem Cell. 2018;22:78-90.e4 pubmed publisher
Villamayor L, Rodríguez Seguel E, Araujo R, Carrasco M, Bru Tari E, Mellado Gil J, et al. GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells. Diabetes. 2018;67:448-460 pubmed publisher
Medina A, Parween S, Ullsten S, Vishnu N, Siu Y, Quach M, et al. Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats. Diabetologia. 2018;61:896-905 pubmed publisher
Nagy N, de la Zerda A, Kaber G, Johnson P, Hu K, Kratochvil M, et al. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018;293:567-578 pubmed publisher
Mita Y, Nakayama K, Inari S, Nishito Y, Yoshioka Y, Sakai N, et al. Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Nat Commun. 2017;8:1658 pubmed publisher
Fan J, Wang Y, Liu L, Zhang H, Zhang F, Shi L, et al. cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice. J Cell Biol. 2017;216:4153-4164 pubmed publisher
Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, et al. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. 2017;114:11745-11750 pubmed publisher
Burnett L, Hubner G, LeDuc C, Morabito M, Carli J, Leibel R. Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes. Hum Mol Genet. 2017;26:4606-4616 pubmed publisher
Enge M, Arda H, Mignardi M, Beausang J, Bottino R, Kim S, et al. Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns. Cell. 2017;171:321-330.e14 pubmed publisher
Levet S, Medina J, Joanou J, Demolder A, Queruel N, Réant K, et al. An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes. JCI Insight. 2017;2: pubmed publisher
Liu H, Javaheri A, Godar R, Murphy J, Ma X, Rohatgi N, et al. Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway. Autophagy. 2017;:1-17 pubmed publisher
Duan H, Li Y, Arora D, Xu D, Lim H, Wang W. Discovery of a Benzamide Derivative That Protects Pancreatic β-Cells against Endoplasmic Reticulum Stress. J Med Chem. 2017;60:6191-6204 pubmed publisher
Kim J, Okamoto H, Huang Z, Anguiano G, Chen S, Liu Q, et al. Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice. Cell Metab. 2017;25:1348-1361.e8 pubmed publisher
D souza A, Kieffer T. Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia. Mol Metab. 2017;6:585-593 pubmed publisher
Kondo Y, Toyoda T, Ito R, Funato M, Hosokawa Y, Matsui S, et al. Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 2017;60:1454-1466 pubmed publisher
Ishida E, Kim Muller J, Accili D. Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice. Diabetes. 2017;66:2092-2101 pubmed publisher
Xu E, Sasaki S, Speckmann T, Nian C, Lynn F. SOX4 Allows Facultative β-Cell Proliferation Through Repression of Cdkn1a. Diabetes. 2017;66:2213-2219 pubmed publisher
Zeng C, Mulas F, Sui Y, Guan T, Miller N, Tan Y, et al. Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal β Cell Proliferation. Cell Metab. 2017;25:1160-1175.e11 pubmed publisher
Hafizur R, Momin S, Fatima N. Prevention of advanced glycation end-products formation in diabetic rats through beta-cell modulation by Aegle marmelos. BMC Complement Altern Med. 2017;17:227 pubmed publisher
Kemter E, Cohrs C, Schafer M, Schuster M, Steinmeyer K, Wolf van Buerck L, et al. INS-eGFP transgenic pigs: a novel reporter system for studying maturation, growth and vascularisation of neonatal islet-like cell clusters. Diabetologia. 2017;60:1152-1156 pubmed publisher
Pham Hua D, Padgett L, Xue B, Anderson B, Zeiger M, Barra J, et al. Islet encapsulation with polyphenol coatings decreases pro-inflammatory chemokine synthesis and T cell trafficking. Biomaterials. 2017;128:19-32 pubmed publisher
Qu X, Nyeng P, Xiao F, Dorantes J, Jensen J. Growth Factor Independence-1 (Gfi1) Is Required for Pancreatic Acinar Unit Formation and Centroacinar Cell Differentiation. Cell Mol Gastroenterol Hepatol. 2015;1:233-247.e1 pubmed publisher
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
Cheng X, Yamauchi J, Lee S, Zhang T, Gong Z, Muzumdar R, et al. APOC3 Protein Is Not a Predisposing Factor for Fat-induced Nonalcoholic Fatty Liver Disease in Mice. J Biol Chem. 2017;292:3692-3705 pubmed publisher
Mastrolia V, Flucher S, Obermair G, Drach M, Hofer H, Renstrom E, et al. Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes. Diabetes. 2017;66:897-907 pubmed publisher
Salama A, Mosser M, Lévêque X, Perota A, Judor J, Danna C, et al. Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs. Diabetes. 2017;66:987-993 pubmed publisher
Kume S, Kondo M, Maeda S, Nishio Y, Yanagimachi T, Fujita Y, et al. Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic ? Cells during Fasting and in Type 2 Diabetes. EBioMedicine. 2016;13:168-180 pubmed publisher
Hill J, Franzosa E, Huttenhower C, Guillemin K. A conserved bacterial protein induces pancreatic beta cell expansion during zebrafish development. elife. 2016;5: pubmed publisher
Cao L, Xia C, Shi Z, Wang N, Gu Z, Yu L, et al. Na+/HCO3- cotransporter is expressed on ? and ? cells during rat pancreatic development. World J Gastroenterol. 2016;22:9525-9533 pubmed
Ben Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, et al. Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis. Cell. 2017;168:73-85.e11 pubmed publisher
Hibsher D, Epshtein A, Oren N, Landsman L. Pancreatic Mesenchyme Regulates Islet Cellular Composition in a Patched/Hedgehog-Dependent Manner. Sci Rep. 2016;6:38008 pubmed publisher
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product information
Product No. :
G2654
Product Name :
Monoclonal Anti-Glucagon antibody produced in mouse
Host :
mouse
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
K79bB10
Applications/Description :
Suitable for dot blot; radioimmunoassay; immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:2,000 using human or animal pancreas
Species Reactivity :
rat, pig, guinea pig, feline, mouse, canine, human, rabbit
Isotype :
IgG1
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA