product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
DAPT
catalog :
D5942
more info or order :
citations: 30
Reference
Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019;18:156 pubmed publisher
De Santis R, Alfano V, de Turris V, Colantoni A, Santini L, Garone M, et al. Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis. Cell Rep. 2019;27:3818-3831.e5 pubmed publisher
McDermott L, Weir G, Themistocleous A, Segerdahl A, Blesneac I, Baskozos G, et al. Defining the Functional Role of NaV1.7 in Human Nociception. Neuron. 2019;101:905-919.e8 pubmed publisher
Wimmer R, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505-510 pubmed publisher
Lee C, Lin J, Hwang W, Kuo Y, Chen H, Tai S, et al. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun. 2018;9:3763 pubmed publisher
Zong D, Li J, Cai S, He S, Liu Q, Jiang J, et al. Notch1 regulates endothelial apoptosis via the ERK pathway in chronic obstructive pulmonary disease. Am J Physiol Cell Physiol. 2018;315:C330-C340 pubmed publisher
Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti Bugaeva O, Paatero I, et al. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. elife. 2018;7: pubmed publisher
Johnson J, Watson J, Nikolić M, Rawlins E. Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium. Biol Open. 2018;7: pubmed publisher
Sonnen K, Lauschke V, Uraji J, Falk H, Petersen Y, Funk M, et al. Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation. Cell. 2018;172:1079-1090.e12 pubmed publisher
He L, Si G, Huang J, Samuel A, Perrimon N. Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel. Nature. 2018;555:103-106 pubmed publisher
Asfahani R, Tahoun M, Miller Hodges E, Bellerby J, Virasami A, Sampson R, et al. Activation of podocyte Notch mediates early Wt1 glomerulopathy. Kidney Int. 2018;93:903-920 pubmed publisher
Nandagopal N, Santat L, Lebon L, Sprinzak D, Bronner M, Elowitz M. Dynamic Ligand Discrimination in the Notch Signaling Pathway. Cell. 2018;172:869-880.e19 pubmed publisher
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle N, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017;32:824-839.e8 pubmed publisher
Pera M, Larrea D, Guardia Laguarta C, Montesinos J, Velasco K, Agrawal R, et al. Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. EMBO J. 2017;36:3356-3371 pubmed publisher
Dvoriantchikova G, Tao W, Pappas S, Gaidosh G, Tse D, Ivanov D, et al. Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis. Invest Ophthalmol Vis Sci. 2017;58:1098-1109 pubmed publisher
Shimshek D, Jacobson L, Kolly C, Zamurovic N, Balavenkatraman K, Morawiec L, et al. Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice. Sci Rep. 2016;6:21917 pubmed publisher
Tognon E, Kobia F, Busi I, Fumagalli A, De Masi F, Vaccari T. Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Autophagy. 2016;12:499-514 pubmed publisher
Kim B, Stephen S, Hanby A, Horgan K, Perry S, Richardson J, et al. Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy. BMC Cancer. 2015;15:634 pubmed publisher
Reinardy H, Emerson C, Manley J, Bodnar A. Tissue regeneration and biomineralization in sea urchins: role of Notch signaling and presence of stem cell markers. PLoS ONE. 2015;10:e0133860 pubmed publisher
Lizama C, Hawkins J, Schmitt C, Bos F, Zape J, Cautivo K, et al. Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun. 2015;6:7739 pubmed publisher
Aspalter I, Gordon E, Dubrac A, Ragab A, Narloch J, Vizan P, et al. Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun. 2015;6:7264 pubmed publisher
Ding R, Jiang X, Ha Y, Wang Z, Guo J, Jiang H, et al. Activation of Notch1 signalling promotes multi-lineage differentiation of c-Kit(POS)/NKX2.5(POS) bone marrow stem cells: implication in stem cell translational medicine. Stem Cell Res Ther. 2015;6:91 pubmed publisher
Murta D, Batista M, Trindade A, Silva E, Henrique D, Duarte A, et al. In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse. PLoS ONE. 2014;9:e113365 pubmed publisher
Laos M, Anttonen T, Kirjavainen A, af Hällström T, Laiho M, Pirvola U. DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells. Aging (Albany NY). 2014;6:496-510 pubmed
Dubuc T, Traylor Knowles N, Martindale M. Initiating a regenerative response; cellular and molecular features of wound healing in the cnidarian Nematostella vectensis. BMC Biol. 2014;12:24 pubmed publisher
Yao L, Kan E, Kaur C, Dheen S, Hao A, Lu J, et al. Notch-1 signaling regulates microglia activation via NF-?B pathway after hypoxic exposure in vivo and in vitro. PLoS ONE. 2013;8:e78439 pubmed publisher
Pascoal S, Esteves de Lima J, Leslie J, Hughes S, Saude L. Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish. PLoS ONE. 2013;8:e68021 pubmed publisher
Qiao L, Xie L, Shi K, Zhou T, Hua Y, Liu H. Notch signaling change in pulmonary vascular remodeling in rats with pulmonary hypertension and its implication for therapeutic intervention. PLoS ONE. 2012;7:e51514 pubmed publisher
Area Gomez E, Del Carmen Lara Castillo M, Tambini M, Guardia Laguarta C, de Groof A, Madra M, et al. Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J. 2012;31:4106-23 pubmed publisher
Acharya A, Hans C, Koenig S, Nichols H, Galindo C, Garner H, et al. Inhibitory role of Notch1 in calcific aortic valve disease. PLoS ONE. 2011;6:e27743 pubmed publisher
product information
Catalog Number :
D5942
Product Name :
DAPT
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), solid
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA