product summary
company name :
MilliporeSigma
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, FLUKA, Sigma-Aldrich, Novabiochem, Guava, Roche Applied Science
product type :
antibody
product name :
Monoclonal Anti-Caspase 11 antibody produced in rat
catalog :
C1354
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
17D9
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 3a
Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, et al. Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis. Oncogene. 2019;38:2658-2674 pubmed publisher
  • western blot knockout validation; human; loading ...; fig 6b
Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed publisher
  • western blot knockout validation; mouse; 1:500; loading ...; fig 1k
Napier B, Brubaker S, Sweeney T, Monette P, Rothmeier G, Gertsvolf N, et al. Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity. J Exp Med. 2016;213:2365-2382 pubmed
  • western blot; mouse; loading ...; fig 3c
Sagulenko V, Vitak N, Vajjhala P, Vince J, Stacey K. Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8. J Mol Biol. 2018;430:238-247 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1g
Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, et al. Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 2016;7:13292 pubmed publisher
  • western blot; mouse; loading ...; fig s1a
Skeldon A, Morizot A, Douglas T, Santoro N, Kursawe R, Kozlitina J, et al. Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance. J Immunol. 2016;196:437-47 pubmed publisher
Moretti J, Jia B, Hutchins Z, Roy S, Yip H, Wu J, et al. Caspase-11 interaction with NLRP3 potentiates the noncanonical activation of the NLRP3 inflammasome. Nat Immunol. 2022;23:705-717 pubmed publisher
Post Y, Puschhof J, Beumer J, Kerkkamp H, de Bakker M, Slagboom J, et al. Snake Venom Gland Organoids. Cell. 2020;180:233-247.e21 pubmed publisher
Caution K, Young N, Robledo Avila F, Krause K, Abu Khweek A, Hamilton K, et al. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019;10:2519 pubmed publisher
Qiu X, Cheng X, Zhang J, Yuan C, Zhao M, Yang X. Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis. Int Immunopharmacol. 2020;78:106016 pubmed publisher
Hara H, Seregin S, Yang D, Fukase K, Chamaillard M, Alnemri E, et al. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018;175:1651-1664.e14 pubmed publisher
Krause K, Caution K, Badr A, Hamilton K, Saleh A, Patel K, et al. CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection. Autophagy. 2018;14:1928-1942 pubmed publisher
Moretti J, Roy S, Bozec D, Martinez J, Chapman J, Ueberheide B, et al. STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell. 2017;171:809-823.e13 pubmed publisher
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli V, Wu H, et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016;535:153-8 pubmed publisher
Dagenais M, Dupaul Chicoine J, Champagne C, Skeldon A, Morizot A, Saleh M. A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways. Mucosal Immunol. 2016;9:146-58 pubmed publisher
Broz P, Ruby T, Belhocine K, Bouley D, Kayagaki N, Dixit V, et al. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature. 2012;490:288-91 pubmed publisher
Mayo L, Jacob Hirsch J, Amariglio N, Rechavi G, Moutin M, Lund F, et al. Dual role of CD38 in microglial activation and activation-induced cell death. J Immunol. 2008;181:92-103 pubmed
Melcher M, Unger B, Schmidt U, Rajantie I, Alitalo K, Ellmeier W. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol. 2008;180:8048-56 pubmed
Wang S, Miura M, Jung Y, Zhu H, Li E, Yuan J. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 1998;92:501-9 pubmed
product information
Product No. :
C1354
Product Name :
Monoclonal Anti-Caspase 11 antibody produced in rat
Host :
rat
Conjugate :
unconjugated
Antibody Type :
monoclonal
Clone Number (if monoclonal) :
17D9
Applications/Description :
Suitable for immunoblotting: 5-10 μg/mL using mouse EL4 cell extracts.; immunoprecipitation (IP); immunohistochemistry (frozen sections)
Species Reactivity :
mouse
Isotype :
IgG2a
Concentration :
~1 mg/mL
Storage :
Store at -20°C
more info or order :
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA