This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MilliporeSigma
other brands :
FLUKA, Sigma-Aldrich, Roche Applied Science
product type :
chemical
product name :
Amiloride hydrochloride hydrate
catalog :
A7410
citations: 92
Reference
Enns C, Keith B, Challa N, Harding J, Loewen M. Impairment of electroneutral Na+ transport and associated downregulation of NHE3 contributes to the development of diarrhea following in vivo challenge with Brachyspira spp. Am J Physiol Gastrointest Liver Physiol. 2020;318:G288-G297 pubmed publisher
Garth J, Easter M, Skylar Harris E, Sailland J, Kuenzi L, Chung S, et al. The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance. Front Med (Lausanne). 2019;6:339 pubmed publisher
Laube M, Riedel D, Ackermann B, Haase M, H Thome U. Glucocorticoids Equally Stimulate Epithelial Na+ Transport in Male and Female Fetal Alveolar Cells. Int J Mol Sci. 2019;21: pubmed publisher
Simões F, Quaresma M, Clarke L, Silva I, Pankonien I, Railean V, et al. TMEM16A chloride channel does not drive mucus production. Life Sci Alliance. 2019;2: pubmed publisher
Schultz M, Fawaz M, Azaria R, Hollon T, Liu E, Kunkel T, et al. Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases. BMC Med. 2019;17:200 pubmed publisher
Cuentas Condori A, Mulcahy B, He S, Palumbos S, Zhen M, Miller D. C. elegans neurons have functional dendritic spines. elife. 2019;8: pubmed publisher
Teng B, Wilson C, Tu Y, Joshi N, Kinnamon S, Liman E. Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1. Curr Biol. 2019;29:3647-3656.e5 pubmed publisher
Manickavasagam D, Oyewumi M. Internalization of particulate delivery systems by activated microglia influenced the therapeutic efficacy of simvastatin repurposing for neuroinflammation. Int J Pharm. 2019;570:118690 pubmed publisher
Liu Q, Huang J, Feng Q, Zhang T, Chen X, Li X, et al. Multi-Modal Visualization of Uptake and Distribution of Iron Oxide Nanoparticles in Macrophages, Cancer Cells, and Xenograft Models. J Biomed Nanotechnol. 2019;15:1801-1811 pubmed publisher
Tsujimura T, Ueha R, Yoshihara M, Takei E, Nagoya K, Shiraishi N, et al. Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats. J Physiol. 2019;597:2949-2963 pubmed publisher
Hu Y, Barron A, Gindina S, Kumar S, Chintala S, Nayyar A, et al. Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation. Invest Ophthalmol Vis Sci. 2019;60:1571-1580 pubmed publisher
Musante I, Scudieri P, Venturini A, Guidone D, Caci E, Castellani S, et al. Peripheral localization of the epithelial sodium channel in the apical membrane of bronchial epithelial cells. Exp Physiol. 2019;104:866-875 pubmed publisher
Phua Y, Chen K, Hemker S, Marrone A, Bodnar A, Liu X, et al. Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors. Am J Physiol Renal Physiol. 2019;316:F993-F1005 pubmed publisher
Raheel H, Ghaffari S, Khosraviani N, Mintsopoulos V, Auyeung D, Wang C, et al. CD36 mediates albumin transcytosis by dermal but not lung microvascular endothelial cells: role in fatty acid delivery. Am J Physiol Lung Cell Mol Physiol. 2019;316:L740-L750 pubmed publisher
Hwang S, Kang J, Kim M, Shin D, Hong J. Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5. J Enzyme Inhib Med Chem. 2019;34:179-188 pubmed publisher
Ydegaard R, Andersen H, Oxlund C, Jacobsen I, Hansen P, Jürgensen J, et al. The acute blood pressure-lowering effect of amiloride is independent of endothelial ENaC and eNOS in humans and mice. Acta Physiol (Oxf). 2019;225:e13189 pubmed publisher
Delpiano L, Thomas J, Yates A, Rice S, Gray M, Saint Criq V. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells. Front Pharmacol. 2018;9:1462 pubmed publisher
Emam S, Ando H, Lila A, Shimizu T, Okuhira K, Ishima Y, et al. Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways. Sci Rep. 2018;8:14493 pubmed publisher
Verkest C, Piquet E, Diochot S, Dauvois M, Lanteri Minet M, Lingueglia E, et al. Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine. Br J Pharmacol. 2018;175:4154-4166 pubmed publisher
Walton Z, Patel C, Brooks R, Yu Y, Ibrahim Hashim A, Riddle M, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. 2018;174:72-87.e32 pubmed publisher
Haglind A, Hedeland M, Arvidsson T, Pettersson C. Major signal suppression from metal ion clusters in SFC/ESI-MS - Cause and effects. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1084:96-105 pubmed publisher
Warren B, Matheson T. The Role of the Mechanotransduction Ion Channel Candidate Nanchung-Inactive in Auditory Transduction in an Insect Ear. J Neurosci. 2018;38:3741-3752 pubmed publisher
Imai T, Katoh H, Suyama K, Kuroiwa M, Yanagisawa S, Watanabe M. Amiloride Promotes Oligodendrocyte Survival and Remyelination after Spinal Cord Injury in Rats. J Clin Med. 2018;7: pubmed publisher
Pongrac I, Ahmed L, Mlinarić H, Jurašin D, Pavicic I, Marjanovic Cermak A, et al. Surface coating affects uptake of silver nanoparticles in neural stem cells. J Trace Elem Med Biol. 2018;50:684-692 pubmed publisher
Larabee J, Hauck G, Ballard J. Cell-penetrating peptides derived from Clostridium difficile TcdB2 and a related large clostridial toxin. J Biol Chem. 2018;293:1810-1819 pubmed publisher
Li Y, Wang M, Huang B, Ping Y, You J, Gao J. Transcriptome-wide elucidation of liposomal formulations for anticancer drug delivery. Int J Nanomedicine. 2017;12:8557-8572 pubmed publisher
Stepanova V, Dergilev K, Holman K, Parfyonova Y, Tsokolaeva Z, Teter M, et al. Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumors. J Biol Chem. 2017;292:20528-20543 pubmed publisher
Denk S, Neher M, Messerer D, Wiegner R, Nilsson B, Rittirsch D, et al. Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects. J Immunol. 2017;198:4846-4854 pubmed publisher
Gunduz N, Ceylan H, Guler M, Tekinay A. Intracellular Accumulation of Gold Nanoparticles Leads to Inhibition of Macropinocytosis to Reduce the Endoplasmic Reticulum Stress. Sci Rep. 2017;7:40493 pubmed publisher
Matthewman C, Miller Fleming T, Miller D, Bianchi L. Ca2+ permeability and Na+ conductance in cellular toxicity caused by hyperactive DEG/ENaC channels. Am J Physiol Cell Physiol. 2016;311:C920-C930 pubmed publisher
Antonio L, Jeggle P, MacVinish L, Bartram J, Miller H, Jarvis G, et al. The effect of fluoride on the structure, function, and proteome of a renal epithelial cell monolayer. Environ Toxicol. 2017;32:1455-1467 pubmed publisher
Amith S, Wilkinson J, Fliegel L. KR-33028, a potent inhibitor of the Na+/H+ exchanger NHE1, suppresses metastatic potential of triple-negative breast cancer cells. Biochem Pharmacol. 2016;118:31-39 pubmed publisher
Kesner E, Saada Reich A, Lorberboum Galski H. Characteristics of Mitochondrial Transformation into Human Cells. Sci Rep. 2016;6:26057 pubmed publisher
Tosoni K, Cassidy D, Kerr B, Land S, Mehta A. Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance. PLoS ONE. 2016;11:e0149550 pubmed publisher
Zheng X, Ma X, Li C. Highly efficient nuclear delivery of anti-cancer drugs using a bio-functionalized reduced graphene oxide. J Colloid Interface Sci. 2016;467:35-42 pubmed publisher
Liu Q, Li H, Xia Q, Liu Y, Xiao K. Role of surface charge in determining the biological effects of CdSe/ZnS quantum dots. Int J Nanomedicine. 2015;10:7073-88 pubmed publisher
Kaltofen T, Haase M, Thome U, Laube M. Male Sex is Associated with a Reduced Alveolar Epithelial Sodium Transport. PLoS ONE. 2015;10:e0136178 pubmed publisher
Ismael Badarneh R, Guetta J, Klorin G, Berger G, Abu Saleh N, Abassi Z, et al. The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport. PLoS ONE. 2015;10:e0134175 pubmed publisher
Mueller Tribbensee S, Karna M, Khalil M, Neurath M, Reeh P, Engel M. Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. PLoS ONE. 2015;10:e0128242 pubmed publisher
Laube M, Bossmann M, Thome U. Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life. PLoS ONE. 2015;10:e0124833 pubmed publisher
Han D, Na H, Choi W, Lee J, Kim Y, Won C, et al. Direct cellular delivery of human proteasomes to delay tau aggregation. Nat Commun. 2014;5:5633 pubmed publisher
Yoon S, Park S, Han J, Kang J, Kim J, Lee J, et al. Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns. Cell Death Dis. 2014;5:e1494 pubmed publisher
Pottosin I, Delgado Enciso I, Bonales Alatorre E, Nieto Pescador M, Moreno Galindo E, Dobrovinskaya O. Mechanosensitive Ca²⁺-permeable channels in human leukemic cells: pharmacological and molecular evidence for TRPV2. Biochim Biophys Acta. 2015;1848:51-9 pubmed publisher
El Ayoubi F, Amiral J, Pascaud J, Charrin S, Tassel B, Uzan G, et al. A fibrin antibody binding to fibronectin induces potent inhibition of angiogenesis. Thromb Haemost. 2015;113:143-53 pubmed publisher
Ko S, Kim S, Share A, Lynch V, Park J, Namkung W, et al. Synthetic ion transporters can induce apoptosis by facilitating chloride anion transport into cells. Nat Chem. 2014;6:885-92 pubmed publisher
Lynge M, Fernández Medina M, Postma A, Städler B. Liposomal drug deposits in poly(dopamine) coatings: effect of their composition, cell type, uptake pathway considerations, and shear stress. Macromol Biosci. 2014;14:1677-87 pubmed publisher
Sun X, Jin J, Zhang J, Qi L, Braun F, Zhang X, et al. Expression of acid-sensing ion channels in nucleus pulposus cells of the human intervertebral disk is regulated by non-steroid anti-inflammatory drugs. Acta Biochim Biophys Sin (Shanghai). 2014;46:774-81 pubmed publisher
Li Y, Cheng D, Cheng R, Zhu X, Wan T, Liu J, et al. Mechanisms of U87 astrocytoma cell uptake and trafficking of monomeric versus protofibril Alzheimer's disease amyloid-β proteins. PLoS ONE. 2014;9:e99939 pubmed publisher
Sharifi Sanjani M, Shoushtari A, Quiroz M, Baust J, Sestito S, Mosher M, et al. Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3. J Am Heart Assoc. 2014;3:e000670 pubmed publisher
Kuroiwa M, Watanabe M, Katoh H, Suyama K, Matsuyama D, Imai T, et al. Effect of amiloride on endoplasmic reticulum stress response in the injured spinal cord of rats. Eur J Neurosci. 2014;40:3120-7 pubmed publisher
Mattes C, Laube M, Thome U. Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells. Physiol Rep. 2014;2:e00269 pubmed publisher
Banga A, Flaig S, Lewis S, Winfree S, Blazer Yost B. Epinephrine stimulation of anion secretion in the Calu-3 serous cell model. Am J Physiol Lung Cell Mol Physiol. 2014;306:L937-46 pubmed publisher
Gitrowski C, Al Jubory A, Handy R. Uptake of different crystal structures of TiO₂ nanoparticles by Caco-2 intestinal cells. Toxicol Lett. 2014;226:264-76 pubmed publisher
Tauber P, Penton D, Stindl J, Humberg E, Tegtmeier I, Sterner C, et al. Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas. Endocrinology. 2014;155:1353-62 pubmed publisher
Ingram K, Curtis C, Silasi Mansat R, Lupu F, Griffin C. The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013;9:e1004031 pubmed publisher
Youssef R, Maher H, El Kimary E, Hassan E, Barary M. Validated stability-indicating methods for the simultaneous determination of amiloride hydrochloride, atenolol, and chlorthalidone using HPTLC and HPLC with photodiode array detector. J AOAC Int. 2013;96:313-23 pubmed
Fuchs A, Echeverría C, Pérez Rojo F, Prieto González E, Roldán E. Proline modulates the effect of bisphosphonate on calcium levels and adenosine triphosphate production in cell lines derived from bovine Echinococcus granulosus protoscoleces. J Helminthol. 2014;88:459-67 pubmed publisher
Tugizov S, Herrera R, Palefsky J. Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol. 2013;87:8179-94 pubmed publisher
Bulsiewicz W, Shaheen N, Hansen M, Pruitt A, Orlando R. Effect of amiloride on experimental acid-induced heartburn in non-erosive reflux disease. Dig Dis Sci. 2013;58:1955-9 pubmed publisher
Jared S, Rao J. Effects of Evans Blue and amiloride on anti-diuretic hormone (ADH)-induced sodium transport across frog (Rana hexadactyla) skin. Zoolog Sci. 2013;30:402-7 pubmed publisher
Buck T, Plavchak L, Roy A, Donnelly B, Kashlan O, Kleyman T, et al. The Lhs1/GRP170 chaperones facilitate the endoplasmic reticulum-associated degradation of the epithelial sodium channel. J Biol Chem. 2013;288:18366-80 pubmed publisher
Solymosi E, Kaestle Gembardt S, Vadász I, Wang L, Neye N, Chupin C, et al. Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema. Proc Natl Acad Sci U S A. 2013;110:E2308-16 pubmed publisher
Ren Z, Rhyu M, Phan T, Mummalaneni S, Murthy K, Grider J, et al. TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am J Physiol Gastrointest Liver Physiol. 2013;305:G106-17 pubmed publisher
Liu Y, Swart M, Ke Y, Ly K, McDonald F. Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. Am J Physiol Renal Physiol. 2013;305:F80-9 pubmed publisher
Pavlov T, Levchenko V, O Connor P, Ilatovskaya D, Palygin O, Mori T, et al. Deficiency of renal cortical EGF increases ENaC activity and contributes to salt-sensitive hypertension. J Am Soc Nephrol. 2013;24:1053-62 pubmed publisher
Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, et al. Angiotensin II modulates salty and sweet taste sensitivities. J Neurosci. 2013;33:6267-77 pubmed publisher
Pondugula S, Kampalli S, Wu T, De Lisle R, Raveendran N, Harbidge D, et al. cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium. BMC Physiol. 2013;13:6 pubmed publisher
Pech V, Thumová M, Dikalov S, Hummler E, Rossier B, Harrison D, et al. Nitric oxide reduces Cl? absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism. Am J Physiol Renal Physiol. 2013;304:F1390-7 pubmed publisher
Kakoki M, Pochynyuk O, Hathaway C, Tomita H, Hagaman J, Kim H, et al. Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1. Proc Natl Acad Sci U S A. 2013;110:5600-5 pubmed publisher
Kong X, Tang X, Du W, Tong J, Yan Y, Zheng F, et al. Extracellular acidosis modulates the endocytosis and maturation of macrophages. Cell Immunol. 2013;281:44-50 pubmed publisher
Redelman Sidi G, Iyer G, Solit D, Glickman M. Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells. Cancer Res. 2013;73:1156-67 pubmed publisher
Yuen H, McCrudden C, Huang Y, Tham J, Zhang X, Zeng Q, et al. TAZ expression as a prognostic indicator in colorectal cancer. PLoS ONE. 2013;8:e54211 pubmed publisher
Arun T, Tomassini V, Sbardella E, de Ruiter M, Matthews L, Leite M, et al. Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride. Brain. 2013;136:106-15 pubmed publisher
Walton J, Bourdolle A, Butler S, Soulie M, Delbianco M, McMahon B, et al. Very bright europium complexes that stain cellular mitochondria. Chem Commun (Camb). 2013;49:1600-2 pubmed publisher
Röllecke K, Werner M, Ziemba P, Neuhaus E, Hatt H, Gisselmann G. Amiloride derivatives are effective blockers of insect odorant receptors. Chem Senses. 2013;38:231-6 pubmed publisher
Howard M, Roux J, Iles K, Miyazawa B, Christiaans S, Anjum N, et al. Activation of the heat shock response attenuates the interleukin 1?-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Shock. 2013;39:189-96 pubmed publisher
Lee S, Boron W, Parker M. Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits. Am J Physiol Renal Physiol. 2013;304:F883-99 pubmed publisher
Watts B, George T, Sherwood E, Good D. A two-hit mechanism for sepsis-induced impairment of renal tubule function. Am J Physiol Renal Physiol. 2013;304:F863-74 pubmed publisher
Morishita M, Ariyoshi W, Okinaga T, Usui M, Nakashima K, Nishihara T. A. actinomycetemcomitans LPS enhances foam cell formation induced by LDL. J Dent Res. 2013;92:241-6 pubmed publisher
Zhou R, Tomkovicz V, Butler P, Ochoa L, Peterson Z, Snyder P. Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel. J Biol Chem. 2013;288:5389-97 pubmed publisher
Pask G, Bobkov Y, Corey E, Ache B, Zwiebel L. Blockade of insect odorant receptor currents by amiloride derivatives. Chem Senses. 2013;38:221-9 pubmed publisher
Pasupuleti N, Leon L, Carraway K, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013;344:600-15 pubmed publisher
Aravena C, Beltrán A, Cornejo M, Torres V, Diaz E, Guzman Gutierrez E, et al. Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation. PLoS ONE. 2012;7:e51451 pubmed publisher
Yamazaki M, Wu T, Pondugula S, Harbidge D, Marcus D. Sodium selectivity of semicircular canal duct epithelial cells. BMC Res Notes. 2011;4:355 pubmed publisher
Wiranowska M, Colina L, Johnson J. Clathrin-mediated entry and cellular localization of chlorotoxin in human glioma. Cancer Cell Int. 2011;11:27 pubmed publisher
Sorio C, Buffelli M, Angiari C, Ettorre M, Johansson J, Vezzalini M, et al. Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis. PLoS ONE. 2011;6:e22212 pubmed publisher
Almaca J, Dahimene S, Appel N, Conrad C, Kunzelmann K, Pepperkok R, et al. Functional genomics assays to study CFTR traffic and ENaC function. Methods Mol Biol. 2011;742:249-64 pubmed publisher
Rumsey J, Das M, Bhalkikar A, Stancescu M, Hickman J. Tissue engineering the mechanosensory circuit of the stretch reflex arc: sensory neuron innervation of intrafusal muscle fibers. Biomaterials. 2010;31:8218-27 pubmed publisher
Pondugula S, Raveendran N, Marcus D. Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium. BMC Res Notes. 2010;3:100 pubmed publisher
Dejouvencel T, Doeuvre L, Lacroix R, Plawinski L, Dignat George F, Lijnen H, et al. Fibrinolytic cross-talk: a new mechanism for plasmin formation. Blood. 2010;115:2048-56 pubmed publisher
He Q, Zhu J, Xing Y, Tsang L, Yang N, Rowlands D, et al. Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents. World J Gastroenterol. 2005;11:4173-9 pubmed
Hansson E. Metabotropic glutamate receptor activation induces astroglial swelling. J Biol Chem. 1994;269:21955-61 pubmed
product information
Catalog Number :
A7410
Product Name :
Amiloride hydrochloride hydrate
Product Type :
SMALL MOLECULES
Product Group :
Protein & Pathway Technologies
Product Description :
≥98% (HPLC), powder
company information
MilliporeSigma
PO Box 14508
St. Louis, MO 63178
https://www.sigmaaldrich.com
1-800-325-3010
headquarters: USA