Patrinostro X, O Rourke A, Chamberlain C, Moriarity B, Perrin B, Ervasti J. Relative importance of ?cyto- and ?cyto-actin in primary mouse embryonic fibroblasts. Mol Biol Cell. 2017;28:771-782 pubmed publisher

Tondeleir D, Lambrechts A, Muller M, Jonckheere V, Doll T, Vandamme D, et al. Cells lacking ?-actin are genetically reprogrammed and maintain conditional migratory capacity. Mol Cell Proteomics. 2012;11:255-71 pubmed publisher

Bajpai R, Sharma A, Achreja A, Edgar C, Wei C, Siddiqa A, et al. Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Nat Commun. 2020;11:1228 pubmed publisher

Bunnell T, Burbach B, Shimizu Y, Ervasti J. ?-Actin specifically controls cell growth, migration, and the G-actin pool. Mol Biol Cell. 2011;22:4047-58 pubmed publisher

Watanabe D, Nakagawa S, Morofuji Y, Tóth A, Vastag M, Aruga J, et al. Characterization of a Primate Blood-Brain Barrier Co-Culture Model Prepared from Primary Brain Endothelial Cells, Pericytes and Astrocytes. Pharmaceutics. 2021;13: pubmed publisher

Ma S, Mangala L, Hu W, Bayaktar E, Yokoi A, Hu W, et al. CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance. Cell Rep. 2021;36:109549 pubmed publisher

Ito S, Nomura T, Ueda T, Inui S, Morioka Y, Honjo H, et al. Gene expression profiles during tissue remodeling following bladder outlet obstruction. Sci Rep. 2021;11:13171 pubmed publisher

Wang J, Zhang Y, Xiao Y, Yuan X, Li P, Wang X, et al. Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Am J Cancer Res. 2021;11:2005-2024 pubmed

Koeniger A, Brichkina A, Nee I, Dempwolff L, Hupfer A, Galperin I, et al. Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers (Basel). 2021;13: pubmed publisher

Fang W, Sofia Acevedo D, Smart C, Zinda B, Alissa N, Warren K, et al. Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression. Sci Rep. 2021;11:8708 pubmed publisher

Sharma V, Sood R, Lou D, Hung T, Levesque M, Han Y, et al. 4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher

Baquero J, Benitez Buelga C, Rajagopal V, Zhenjun Z, Torres Ruiz R, Muller S, et al. Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects. Sci Rep. 2021;11:3490 pubmed publisher

Iwata S, Morikawa M, Takei Y, Hirokawa N. An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility. Sci Adv. 2020;6: pubmed publisher

Torretta S, Scagliola A, Ricci L, Mainini F, Di Marco S, Cuccovillo I, et al. D-mannose suppresses macrophage IL-1β production. Nat Commun. 2020;11:6343 pubmed publisher

Pavlova N, King B, Josselsohn R, Violante S, Macera V, Vardhana S, et al. Translation in amino-acid-poor environments is limited by tRNAGln charging. elife. 2020;9: pubmed publisher

Riou R, Ladli M, Gerbal Chaloin S, Bossard P, Gougelet A, Godard C, et al. ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription. elife. 2020;9: pubmed publisher

Boucher J, Balandre A, Debant M, Vix J, Harnois T, Bourmeyster N, et al. Cx43 Present at the Leading Edge Membrane Governs Promigratory Effects of Osteoblast-Conditioned Medium on Human Prostate Cancer Cells in the Context of Bone Metastasis. Cancers (Basel). 2020;12: pubmed publisher

Huang Y, Liang C, Ritz D, Coelho R, Septiadi D, Estermann M, et al. Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. elife. 2020;9: pubmed publisher

Blazquez C, Ruiz Calvo A, Bajo Grañeras R, Baufreton J, Resel E, Varilh M, et al. Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination. elife. 2020;9: pubmed publisher

Huang H, Liu R, Huang Y, Feng Y, Fu Y, Chen L, et al. Acetylation-mediated degradation of HSD17B4 regulates the progression of prostate cancer. Aging (Albany NY). 2020;12:14699-14717 pubmed publisher

Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisher

Golenberg N, Squirrell J, Bennin D, Rindy J, Pistono P, Eliceiri K, et al. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020;219: pubmed publisher

Zhang R, Liakath Ali K, Sudhof T. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum. elife. 2020;9: pubmed publisher

De Luna N, Turon Sans J, Cortés Vicente E, Carrasco Rozas A, Illán Gala I, Dols Icardo O, et al. Downregulation of miR-335-5P in Amyotrophic Lateral Sclerosis Can Contribute to Neuronal Mitochondrial Dysfunction and Apoptosis. Sci Rep. 2020;10:4308 pubmed publisher

Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, Komori M, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Eneuro. 2020;7: pubmed publisher

Yang F, Huang X, Zang R, Chen J, Fidalgo M, Sanchez Priego C, et al. DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State. Cell Stem Cell. 2020;26:234-250.e7 pubmed publisher

Majewski L, Maciąg F, Boguszewski P, Kuznicki J. Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration. Int J Mol Sci. 2020;21: pubmed publisher

Chen F, Liu X, Chen Y, Liu J, Lu H, Wang W, et al. Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells. EBioMedicine. 2020;52:102618 pubmed publisher

Hsu H, Liu C, Lin J, Hsu T, Hsu J, Li A, et al. Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells. J Biomed Sci. 2020;27:5 pubmed publisher

Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher

Lehmann M, Lukonin I, Noe F, Schmoranzer J, Clementi C, Loerke D, et al. Nanoscale coupling of endocytic pit growth and stability. Sci Adv. 2019;5:eaax5775 pubmed publisher

Zhang Y, Thery F, Wu N, Luhmann E, Dussurget O, Foecke M, et al. The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Nat Commun. 2019;10:5383 pubmed publisher

Padmanaban V, Krol I, Suhail Y, Szczerba B, Aceto N, Bader J, et al. E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 2019;573:439-444 pubmed publisher

Sanghvi V, Leibold J, Mina M, Mohan P, Berishaj M, Li Z, et al. The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase. Cell. 2019;178:807-819.e21 pubmed publisher

Yang M, Chen P, Liu J, Zhu S, Kroemer G, Klionsky D, et al. Clockophagy is a novel selective autophagy process favoring ferroptosis. Sci Adv. 2019;5:eaaw2238 pubmed publisher

Ortega F, Roefs M, De Miguel Pérez D, Kooijmans S, de Jong O, Sluijter J, et al. Interfering with endolysosomal trafficking enhances release of bioactive exosomes. Nanomedicine. 2019;:102014 pubmed publisher

Bayer S, Grither W, Brenot A, Hwang P, Barcus C, Ernst M, et al. DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs. elife. 2019;8: pubmed publisher

Mikuličić S, Finke J, Boukhallouk F, Wüstenhagen E, Sons D, Homsi Y, et al. ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly. elife. 2019;8: pubmed publisher

Kong X, Chen J, Xie W, Brown S, Cai Y, Wu K, et al. Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties. Cancer Cell. 2019;35:633-648.e7 pubmed publisher

Zhang X, Wang L, Ireland S, Ahat E, Li J, Bekier Ii M, et al. GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. Autophagy. 2019;:1-14 pubmed publisher

Wobser M, Weber A, Glunz A, Tauch S, Seitz K, Butelmann T, et al. Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells. J Hematol Oncol. 2019;12:30 pubmed publisher

Diamond E, Durham B, Ulaner G, Drill E, Buthorn J, Ki M, et al. Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019;567:521-524 pubmed publisher

Hlavac N, VandeVord P. Astrocyte Mechano-Activation by High-Rate Overpressure Involves Alterations in Structural and Junctional Proteins. Front Neurol. 2019;10:99 pubmed publisher

Carballo Carbajal I, Laguna A, Romero Gimenez J, Cuadros T, Bove J, Martinez Vicente M, et al. Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis. Nat Commun. 2019;10:973 pubmed publisher

Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher

Horos R, Büscher M, Kleinendorst R, Alleaume A, Tarafder A, Schwarzl T, et al. The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy. Cell. 2019;176:1054-1067.e12 pubmed publisher

Vrijens P, Noppen S, Boogaerts T, Vanstreels E, Ronca R, Chiodelli P, et al. Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway. J Gen Virol. 2019;100:583-601 pubmed publisher

Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk S, Fulda S. Cell cycle arrest in mitosis promotes interferon-induced necroptosis. Cell Death Differ. 2019;: pubmed publisher

Gronke K, Hernandez P, Zimmermann J, Klose C, Kofoed Branzk M, Guendel F, et al. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature. 2019;566:249-253 pubmed publisher

Beug S, Cheung H, Sanda T, St Jean M, Beauregard C, Mamady H, et al. The transcription factor SP3 drives TNF-α expression in response to Smac mimetics. Sci Signal. 2019;12: pubmed publisher

Oliveira H, Roma Rodrigues C, Santos A, Veigas B, Brás N, Faria A, et al. GLUT1 and GLUT3 involvement in anthocyanin gastric transport- Nanobased targeted approach. Sci Rep. 2019;9:789 pubmed publisher

Sayas C, Medina M, Cuadros R, Ollá I, Garcia E, Perez M, et al. Role of tau N-terminal motif in the secretion of human tau by End Binding proteins. PLoS ONE. 2019;14:e0210864 pubmed publisher

Poulopoulos A, Murphy A, Ozkan A, Davis P, Hatch J, Kirchner R, et al. Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex. Nature. 2019;565:356-360 pubmed publisher

Martins R, Malbert Colas L, Lista M, Daskalogianni C, Apcher S, Pla M, et al. Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides. Nucleic Acids Res. 2019;47:3086-3100 pubmed publisher

Urtishak K, Wang L, Culjkovic Kraljacic B, Davenport J, Porazzi P, Vincent T, et al. Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia. Oncogene. 2019;38:2241-2262 pubmed publisher

Rai S, Arasteh M, Jefferson M, Pearson T, Wang Y, Zhang W, et al. The ATG5-binding and coiled coil domains of ATG16L1 maintain autophagy and tissue homeostasis in mice independently of the WD domain required for LC3-associated phagocytosis. Autophagy. 2019;15:599-612 pubmed publisher

Xu P, Chen A, Ganaie S, Cheng F, Shen W, Wang X, et al. The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs. J Virol. 2019;93: pubmed publisher

Ruscetti M, Leibold J, Bott M, Fennell M, Kulick A, Salgado N, et al. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018;362:1416-1422 pubmed publisher

Wang M, Tang C, Xing R, Liu X, Han X, Liu Y, et al. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Mol Psychiatry. 2018;: pubmed publisher

Sarracino A, Gharu L, Kula A, Pasternak A, Avettand Fenoel V, Rouzioux C, et al. Posttranscriptional Regulation of HIV-1 Gene Expression during Replication and Reactivation from Latency by Nuclear Matrix Protein MATR3. MBio. 2018;9: pubmed publisher

Persi E, Duran Frigola M, Damaghi M, Roush W, Aloy P, Cleveland J, et al. Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat Commun. 2018;9:2997 pubmed publisher

Liu H, Lorenzini P, Zhang F, Xu S, Wong M, Zheng J, et al. Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator. Nucleic Acids Res. 2018;46:6069-6086 pubmed publisher

Fujimoto M, Takii R, Katiyar A, Srivastava P, Nakai A. Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA. Mol Cell Biol. 2018;38: pubmed publisher

Soncin F, Khater M, To C, Pizzo D, Farah O, Wakeland A, et al. Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development. Development. 2018;145: pubmed publisher

Teater M, Domínguez P, Redmond D, Chen Z, Ennishi D, Scott D, et al. AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis. Nat Commun. 2018;9:222 pubmed publisher

Sala M, Chen C, Zhang Q, Do Umehara H, Wu W, Misharin A, et al. JNK2 up-regulates hypoxia-inducible factors and contributes to hypoxia-induced erythropoiesis and pulmonary hypertension. J Biol Chem. 2018;293:271-284 pubmed publisher

Kumar S, Nakashizuka H, Jones A, Lambert A, Zhao X, Shen M, et al. Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. Am J Pathol. 2017;187:2841-2857 pubmed publisher

Simond A, Rao T, Zuo D, Zhao J, Muller W. ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor. Oncogene. 2017;36:6059-6066 pubmed publisher

Read M, Fong J, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson R, et al. Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene. 2017;36:5296-5308 pubmed publisher

Rippe C, Zhu B, Krawczyk K, Bavel E, Albinsson S, Sjölund J, et al. Hypertension reduces soluble guanylyl cyclase expression in the mouse aorta via the Notch signaling pathway. Sci Rep. 2017;7:1334 pubmed publisher

Cho H, Kim J, Jang H, Lee T, Jung M, Kim T, et al. Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice. Sci Rep. 2017;7:46065 pubmed publisher

Busnelli M, Manzini S, Hilvo M, Parolini C, Ganzetti G, Dellera F, et al. Liver-specific deletion of the Plpp3 gene alters plasma lipid composition and worsens atherosclerosis in apoE-/- mice. Sci Rep. 2017;7:44503 pubmed publisher

Pi H, Li M, Tian L, Yang Z, Yu Z, Zhou Z. Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity. Sci Rep. 2017;7:43466 pubmed publisher

Sun A, Wei J, Childress C, Shaw J, Peng K, Shao G, et al. The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy. Autophagy. 2017;13:522-537 pubmed publisher

Natarajan S, Muthukrishnan E, Khalimonchuk O, Mott J, Becker D. Evidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress. J Cell Biochem. 2017;118:1678-1688 pubmed publisher

Wizeman J, Nicholas A, Ishigami A, Mohan R. Citrullination of glial intermediate filaments is an early response in retinal injury. Mol Vis. 2016;22:1137-1155 pubmed

Cizmecioglu O, Ni J, Xie S, Zhao J, Roberts T. Rac1-mediated membrane raft localization of PI3K/p110? is required for its activation by GPCRs or PTEN loss. elife. 2016;5: pubmed publisher

Hesler R, Huang J, Starr M, Treboschi V, Bernanke A, Nixon A, et al. TGF-?-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3. Carcinogenesis. 2016;37:1041-1051 pubmed publisher

García Carpizo V, Sarmentero J, Han B, Grana O, Ruiz Llorente S, Pisano D, et al. NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation. Sci Rep. 2016;6:32952 pubmed publisher

Kim J, Kim C, Sohn E, Kim J. Cytoplasmic translocation of high-mobility group box-1 protein is induced by diabetes and high glucose in retinal pericytes. Mol Med Rep. 2016;14:3655-61 pubmed publisher

Lee M, Tsai K, Hsu J, Shin S, Wu J, Yeh J. Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways. Sci Rep. 2016;6:31788 pubmed publisher

Krawczyk K, Ekman M, Rippe C, Grossi M, Nilsson B, Albinsson S, et al. Assessing the contribution of thrombospondin-4 induction and ATF6? activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep. 2016;6:32449 pubmed publisher

Yamada H, Takeda T, Michiue H, Abe T, Takei K. Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells. Int J Oncol. 2016;49:877-86 pubmed publisher

Wilkie A, Lawler J, Coen D. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. MBio. 2016;7: pubmed publisher

Sakai Y, Miyake A, Doi N, Sasada H, Miyazaki Y, Adachi A, et al. Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage. Front Microbiol. 2016;7:1211 pubmed publisher

Gusscott S, Jenkins C, Lam S, Giambra V, Pollak M, Weng A. IGF1R Derived PI3K/AKT Signaling Maintains Growth in a Subset of Human T-Cell Acute Lymphoblastic Leukemias. PLoS ONE. 2016;11:e0161158 pubmed publisher

Sun L, Fan G, Shan P, Qiu X, Dong S, Liao L, et al. Regulation of energy homeostasis by the ubiquitin-independent REG? proteasome. Nat Commun. 2016;7:12497 pubmed publisher

Meliopoulos V, Van De Velde L, Van De Velde N, Karlsson E, Neale G, Vogel P, et al. An Epithelial Integrin Regulates the Amplitude of Protective Lung Interferon Responses against Multiple Respiratory Pathogens. PLoS Pathog. 2016;12:e1005804 pubmed publisher

Wong M, Chen S. Human Choline Kinase-? Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex Formation. J Virol. 2016;90:9075-95 pubmed publisher

Zhang M, Qi Y, Li H, Cui J, Dai L, Frank J, et al. AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 ? and IL-18. Oncoimmunology. 2016;5:e1160182 pubmed publisher

Cabral W, Ishikawa M, Garten M, Makareeva E, Sargent B, Weis M, et al. Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta. PLoS Genet. 2016;12:e1006156 pubmed publisher

Penney J, Tsurudome K, Liao E, Kauwe G, Gray L, Yanagiya A, et al. LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nat Commun. 2016;7:12188 pubmed publisher

Li S, Qu Z, Haas M, Ngo L, Heo Y, Kang H, et al. The HSA21 gene EURL/C21ORF91 controls neurogenesis within the cerebral cortex and is implicated in the pathogenesis of Down Syndrome. Sci Rep. 2016;6:29514 pubmed publisher

Kawano S, Grassian A, Tsuda M, Knutson S, Warholic N, Kuznetsov G, et al. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS ONE. 2016;11:e0158888 pubmed publisher

Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, et al. Wars2 is a determinant of angiogenesis. Nat Commun. 2016;7:12061 pubmed publisher

Bayne R, Donnachie D, Kinnell H, Childs A, Anderson R. BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2. Mol Hum Reprod. 2016;22:622-33 pubmed publisher

Davis M, Delaney J, Patel C, Storgard R, Stupack D. Nelfinavir is effective against human cervical cancer cells in vivo: a potential treatment modality in resource-limited settings. Drug Des Devel Ther. 2016;10:1837-46 pubmed publisher

Herring A, Münster Y, Akkaya T, Moghaddam S, Deinsberger K, Meyer J, et al. Kallikrein-8 inhibition attenuates Alzheimer's disease pathology in mice. Alzheimers Dement. 2016;12:1273-1287 pubmed publisher

Helmke C, Raab M, Rodel F, Matthess Y, Oellerich T, Mandal R, et al. Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8. Cell Res. 2016;26:914-34 pubmed publisher

Kovacevic S, Nestorov J, Matić G, Elaković I. Fructose and stress induce opposite effects on lipid metabolism in the visceral adipose tissue of adult female rats through glucocorticoid action. Eur J Nutr. 2017;56:2115-2128 pubmed publisher

Kathania M, Khare P, Zeng M, Cantarel B, Zhang H, Ueno H, et al. Itch inhibits IL-17-mediated colon inflammation and tumorigenesis by ROR-?t ubiquitination. Nat Immunol. 2016;17:997-1004 pubmed publisher

Muñoz Félix J, Pérez Roque L, Núñez Gómez E, Oujo B, Arevalo M, Ruiz Remolina L, et al. Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction. Biochim Biophys Acta. 2016;1862:1801-14 pubmed publisher

Mohammed H, Pickard M, Mourtada Maarabouni M. The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cell Signal. 2016;28:1389-400 pubmed publisher

Toneff M, Sreekumar A, Tinnirello A, Hollander P, Habib S, Li S, et al. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016;14:47 pubmed publisher

Herring A, Münster Y, Metzdorf J, Bolczek B, Krüssel S, Krieter D, et al. Late running is not too late against Alzheimer's pathology. Neurobiol Dis. 2016;94:44-54 pubmed publisher

Kanemori Y, Koga Y, Sudo M, Kang W, Kashiwabara S, Ikawa M, et al. Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. Proc Natl Acad Sci U S A. 2016;113:E3696-705 pubmed publisher

Muroyama A, Seldin L, Lechler T. Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. J Cell Biol. 2016;213:679-92 pubmed publisher

Kim H, Lee J, Park K, Kim W, Roh G. A mitochondrial division inhibitor, Mdivi-1, inhibits mitochondrial fragmentation and attenuates kainic acid-induced hippocampal cell death. BMC Neurosci. 2016;17:33 pubmed publisher

Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher

Andersen A, Flinck M, Oernbo E, Pedersen N, Viuff B, Pedersen S. Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment. Mol Cancer. 2016;15:45 pubmed publisher

Wang X, Mazurkiewicz M, Hillert E, Olofsson M, Pierrou S, Hillertz P, et al. The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep. 2016;6:26979 pubmed publisher

Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed publisher

Garcia Fuster M, Garcia Sevilla J. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology (Berl). 2016;233:2955-71 pubmed publisher

Krachulec J, Sedlmeier G, Thiele W, Sleeman J. Footprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology. Biochem Cell Biol. 2016;94:289-96 pubmed publisher

Tzani I, Ivanov I, Andreev D, Dmitriev R, Dean K, Baranov P, et al. Systematic analysis of the PTEN 5' leader identifies a major AUU initiated proteoform. Open Biol. 2016;6: pubmed publisher

Guo Q, Li X, Han H, Li C, Liu S, Gao W, et al. Histone Lysine Methylation in TGF-?1 Mediated p21 Gene Expression in Rat Mesangial Cells. Biomed Res Int. 2016;2016:6927234 pubmed publisher

van Ree J, Nam H, Jeganathan K, Kanakkanthara A, van Deursen J. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016;18:814-21 pubmed publisher

Lee S, Kim H, Kim K, Lee H, Lee S, Lee D. Arhgap17, a RhoGTPase activating protein, regulates mucosal and epithelial barrier function in the mouse colon. Sci Rep. 2016;6:26923 pubmed publisher

Schütz I, López Hernández T, Gao Q, Puchkov D, Jabs S, Nordmeyer D, et al. Lysosomal Dysfunction Caused by Cellular Accumulation of Silica Nanoparticles. J Biol Chem. 2016;291:14170-84 pubmed publisher

Hudish L, Galati D, Ravanelli A, Pearson C, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016;143:2292-304 pubmed publisher

Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y. Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm. Mol Med Rep. 2016;14:655-60 pubmed publisher

Rodríguez Jiménez F, Alastrue A, Stojkovic M, Erceg S, Moreno Manzano V. Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells. Cell Tissue Res. 2016;365:295-307 pubmed publisher

Wang J, Hu K, Guo J, Cheng F, Lv J, Jiang W, et al. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nat Commun. 2016;7:11363 pubmed publisher

Ranjan A, Srivastava S. Penfluridol suppresses pancreatic tumor growth by autophagy-mediated apoptosis. Sci Rep. 2016;6:26165 pubmed publisher

Lin S, Wang B, Lin C, Chien P, Wu Y, Ko J, et al. Chidamide alleviates TGF-?-induced epithelial-mesenchymal transition in lung cancer cell lines. Mol Biol Rep. 2016;43:687-95 pubmed publisher

Ferrán B, Martí Pàmies I, Alonso J, Rodríguez Calvo R, Aguiló S, Vidal F, et al. The nuclear receptor NOR-1 regulates the small muscle protein, X-linked (SMPX) and myotube differentiation. Sci Rep. 2016;6:25944 pubmed publisher

Tsai L, Chang Y, Lee M, Chang Y, Hwang P, Huang Y, et al. Biphasic and Stage-Associated Expression of CPEB4 in Hepatocellular Carcinoma. PLoS ONE. 2016;11:e0155025 pubmed publisher

Kant R, Yen C, Lu C, Lin Y, Li J, Chen Y. Identification of 1,2,3,4,6-Penta-O-galloyl-?-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. Int J Mol Sci. 2016;17: pubmed publisher

Vorvis C, Hatziapostolou M, Mahurkar Joshi S, Koutsioumpa M, Williams J, Donahue T, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2016;310:G1124-37 pubmed publisher

O Santos A, Parrini M, Camonis J. RalGPS2 Is Essential for Survival and Cell Cycle Progression of Lung Cancer Cells Independently of Its Established Substrates Ral GTPases. PLoS ONE. 2016;11:e0154840 pubmed publisher

Taniguchi T, Iizumi Y, Watanabe M, Masuda M, Morita M, Aono Y, et al. Resveratrol directly targets DDX5 resulting in suppression of the mTORC1 pathway in prostate cancer. Cell Death Dis. 2016;7:e2211 pubmed publisher

Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed publisher

Shearn C, Orlicky D, McCullough R, Jiang H, Maclean K, Mercer K, et al. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS ONE. 2016;11:e0154152 pubmed publisher

Zhu H, Bai W, Liu J, Zheng Z, Guan H, Zhou Q, et al. Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells. Sci Rep. 2016;6:25272 pubmed publisher

Beard J, Tenga A, Hills J, Hoyer J, Cherian M, Wang Y, et al. The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Sci Rep. 2016;6:25108 pubmed publisher

Choudhury S, Fitzpatrick Z, Harris A, Maitland S, Ferreira J, Zhang Y, et al. In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Mol Ther. 2016;24:1247-57 pubmed publisher

De Boeck M, Cui C, Mulder A, Jost C, Ikeno S, Ten Dijke P. Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model. Sci Rep. 2016;6:24968 pubmed publisher

Rios A, Fu N, Jamieson P, Pal B, Whitehead L, Nicholas K, et al. Essential role for a novel population of binucleated mammary epithelial cells in lactation. Nat Commun. 2016;7:11400 pubmed publisher

Rebolleda N, Losada Fernandez I, Perez Chacon G, Castejon R, Rosado S, Morado M, et al. Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS ONE. 2016;11:e0154159 pubmed publisher

van Loon E, Little R, Prehar S, Bindels R, Cartwright E, Hoenderop J. Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?. PLoS ONE. 2016;11:e0153483 pubmed publisher

Tasdemir N, Banito A, Roe J, Alonso Curbelo D, Camiolo M, Tschaharganeh D, et al. BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance. Cancer Discov. 2016;6:612-29 pubmed publisher

Li Z, Hodgkinson T, Gothard E, Boroumand S, Lamb R, Cummins I, et al. Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun. 2016;7:11394 pubmed publisher

Kwenda L, Collins C, Dattoli A, Dunleavy E. Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis. Development. 2016;143:1400-12 pubmed publisher

Cao Y, Liang H, Zhang F, Luan Z, Zhao S, Wang X, et al. Prohibitin overexpression predicts poor prognosis and promotes cell proliferation and invasion through ERK pathway activation in gallbladder cancer. J Exp Clin Cancer Res. 2016;35:68 pubmed publisher

Lauterborn J, Kramar E, Rice J, Babayan A, Cox C, Karsten C, et al. Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus. Cereb Cortex. 2017;27:2640-2651 pubmed publisher

Zattas D, Berk J, Kreft S, Hochstrasser M. A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation. J Biol Chem. 2016;291:12105-18 pubmed publisher

Hobbs R, Batazzi A, Han M, Coulombe P. Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo. Oncogene. 2016;35:5653-5662 pubmed publisher

Bueno C, Tabares Seisdedos R, Moraleda J, Martinez S. Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands. PLoS ONE. 2016;11:e0153262 pubmed publisher

Caviness J, Lue L, Hentz J, Schmitz C, Adler C, Shill H, et al. Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease. Mov Disord. 2016;31:1012-9 pubmed publisher

Martínez M, Ubeda A, Moreno J, Trillo M. Power Frequency Magnetic Fields Affect the p38 MAPK-Mediated Regulation of NB69 Cell Proliferation Implication of Free Radicals. Int J Mol Sci. 2016;17:510 pubmed publisher

Xing M, Wang X, Chi Y, Zhou D. Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab. Oncotarget. 2016;7:28262-72 pubmed publisher

Brown P, Gascoyne D, Lyne L, Spearman H, Felce S, McFadden N, et al. N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells. Haematologica. 2016;101:861-71 pubmed publisher

O Neill K, Huang K, Zhang J, Chen Y, Luo X. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane. Genes Dev. 2016;30:973-88 pubmed publisher

Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher

Canton J, Schlam D, Breuer C, Gutschow M, Glogauer M, Grinstein S. Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages. Nat Commun. 2016;7:11284 pubmed publisher

Yosef R, Pilpel N, Tokarsky Amiel R, Biran A, Ovadya Y, Cohen S, et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun. 2016;7:11190 pubmed publisher

Foot N, Gembus K, MacKenzie K, Kumar S. Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver. Sci Rep. 2016;6:24045 pubmed publisher

Aizawa S, Fujiwara Y, Contu V, Hase K, Takahashi M, Kikuchi H, et al. Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes. Autophagy. 2016;12:565-78 pubmed publisher

Lee Y, Lee S, Lee C, Kim S, Song Y, Yoon M, et al. Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies. Sci Rep. 2016;6:24013 pubmed publisher

Rhee M, Lee S, Kim J, Ham D, Park H, Yang H, et al. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Sci Rep. 2016;6:23960 pubmed publisher

Hernández Bule M, Martinez Botas J, Trillo M, Paíno C, Ubeda A. Antiadipogenic effects of subthermal electric stimulation at 448 kHz on differentiating human mesenchymal stem cells. Mol Med Rep. 2016;13:3895-903 pubmed publisher

Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, et al. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways. Nat Commun. 2016;7:11123 pubmed publisher

Riggle K, Riehle K, Kenerson H, Turnham R, Homma M, Kazami M, et al. Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma. Pediatr Res. 2016;80:110-8 pubmed publisher

Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-? regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher

Woodfield S, Guo R, Liu Y, Major A, Hollingsworth E, Indiviglio S, et al. Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. Genes Cancer. 2016;7:13-26 pubmed

Ziegler C, Eisenhauer P, Bruce E, Weir M, King B, Klaus J, et al. The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. PLoS Pathog. 2016;12:e1005501 pubmed publisher

Viringipurampeer I, Metcalfe A, Bashar A, Sivak O, Yanai A, Mohammadi Z, et al. NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration. Hum Mol Genet. 2016;25:1501-16 pubmed publisher

Chan Y, Gack M. A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity. Nat Immunol. 2016;17:523-30 pubmed publisher

Galán M, Varona S, Orriols M, Rodríguez J, Aguiló S, Dilmé J, et al. Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors. Dis Model Mech. 2016;9:541-52 pubmed publisher

German P, Bai S, Liu X, Sun M, Zhou L, Kalra S, et al. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016;35:4973-80 pubmed publisher

Nishida Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, et al. Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A). J Biol Chem. 2016;291:10490-500 pubmed publisher

Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher

Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed publisher

Pavlides S, Lecanda J, Daubriac J, Pandya U, Gama P, Blank S, et al. TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth. Cell Cycle. 2016;15:931-47 pubmed publisher

Mitxelena J, Apraiz A, Vallejo Rodríguez J, Malumbres M, Zubiaga A. E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation. Nucleic Acids Res. 2016;: pubmed

Hirth S, Bühler A, Bührdel J, Rudeck S, Dahme T, Rottbauer W, et al. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE. 2016;11:e0150323 pubmed publisher

Shukla P, Chaudhry K, Mir H, Gangwar R, Yadav N, Manda B, et al. Chronic ethanol feeding promotes azoxymethane and dextran sulfate sodium-induced colonic tumorigenesis potentially by enhancing mucosal inflammation. BMC Cancer. 2016;16:189 pubmed publisher

Gdynia G, Sauer S, Kopitz J, Fuchs D, Duglova K, Ruppert T, et al. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun. 2016;7:10764 pubmed publisher

Nagase M, Kurihara H, Aiba A, Young M, Sakai T. Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. PLoS ONE. 2016;11:e0150886 pubmed publisher

Tao Y, Hu K, Tan F, Zhang S, Zhou M, Luo J, et al. SH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathway. Oncotarget. 2016;7:18356-70 pubmed publisher

Chen R, Du Y, Han P, Wang H, Liang F, Feng G, et al. ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma. Oncotarget. 2016;7:16910-22 pubmed publisher

Köhler C, Koalick D, Fabricius A, Parplys A, Borgmann K, Pospiech H, et al. Cdc45 is limiting for replication initiation in humans. Cell Cycle. 2016;15:974-85 pubmed publisher

Fong S, Lin H, Wu M, Chen C, Huang Y. CPEB3 Deficiency Elevates TRPV1 Expression in Dorsal Root Ganglia Neurons to Potentiate Thermosensation. PLoS ONE. 2016;11:e0148491 pubmed publisher

Bistulfi G, Affronti H, Foster B, Karasik E, Gillard B, Morrison C, et al. The essential role of methylthioadenosine phosphorylase in prostate cancer. Oncotarget. 2016;7:14380-93 pubmed publisher

Swetzig W, Wang J, Das G. Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget. 2016;7:16049-69 pubmed publisher

Wilson N, Titus D, Oliva A, Furones C, Atkins C. Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus. Front Syst Neurosci. 2016;10:5 pubmed publisher

Williams A, Maman Y, Alinikula J, Schatz D. Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells. PLoS ONE. 2016;11:e0149146 pubmed publisher

Burgy O, Wettstein G, Bellaye P, Decologne N, Racoeur C, Goirand F, et al. Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity. Sci Transl Med. 2016;8:326ra20 pubmed publisher

Rubattu S, Di Castro S, Schulz H, Geurts A, Cotugno M, Bianchi F, et al. Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. J Am Heart Assoc. 2016;5: pubmed publisher

Hatori Y, Yan Y, Schmidt K, Furukawa E, Hasan N, Yang N, et al. Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun. 2016;7:10640 pubmed publisher

Wang J, Goetsch L, Tucker L, Zhang Q, Gonzalez A, Vaidya K, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016;16:105 pubmed publisher

Nyhan M, O Donovan T, Boersma A, Wiemer E, McKenna S. MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells. BMC Cancer. 2016;16:101 pubmed publisher

Lehmann W, Mossmann D, Kleemann J, Mock K, Meisinger C, Brummer T, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun. 2016;7:10498 pubmed publisher

Lei Y, Kansy B, Li J, Cong L, Liu Y, Trivedi S, et al. EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex. Oncogene. 2016;35:4698-707 pubmed publisher

Kim D, Helfman D. Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. Oncogene. 2016;35:4495-508 pubmed publisher

Currie S, Gwyer Findlay E, McFarlane A, Fitch P, Böttcher B, Colegrave N, et al. Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans. J Immunol. 2016;196:2699-710 pubmed publisher

Merdzo I, Rutkai I, Tokés T, Sure V, Katakam P, Busija D. The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats. Am J Physiol Heart Circ Physiol. 2016;310:H830-8 pubmed publisher

Estruch S, Graham S, Deriziotis P, Fisher S. The language-related transcription factor FOXP2 is post-translationally modified with small ubiquitin-like modifiers. Sci Rep. 2016;6:20911 pubmed publisher

Wadosky K, Berthiaume J, Tang W, Zungu M, Portman M, Gerdes A, et al. MuRF1 mono-ubiquitinates TRα to inhibit T3-induced cardiac hypertrophy in vivo. J Mol Endocrinol. 2016;56:273-90 pubmed publisher

Su R, Strug M, Jeong J, Miele L, Fazleabas A. Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility. Proc Natl Acad Sci U S A. 2016;113:2300-5 pubmed publisher

Liu Y, Takahashi Y, Desai N, Zhang J, Serfass J, Shi Y, et al. Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance. Sci Rep. 2016;6:20453 pubmed publisher

Nawaz M, Giarda E, Bedogni F, La Montanara P, Ricciardi S, Ciceri D, et al. CDKL5 and Shootin1 Interact and Concur in Regulating Neuronal Polarization. PLoS ONE. 2016;11:e0148634 pubmed publisher

De Toni E, Ziesch A, Rizzani A, Török H, Hocke S, Lü S, et al. Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptor-mediated apoptosis. Oncotarget. 2016;7:9477-90 pubmed publisher

Regina C, Compagnone M, Peschiaroli A, Lena A, Annicchiarico Petruzzelli M, Piro M, et al. Setdb1, a novel interactor of ΔNp63, is involved in breast tumorigenesis. Oncotarget. 2016;7:28836-48 pubmed publisher

Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci. 2016;17: pubmed publisher

Fujiwara S, Ohashi K, Mashiko T, Kondo H, Mizuno K. Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement. Mol Biol Cell. 2016;27:954-66 pubmed publisher

Madonna R, Giovannelli G, Confalone P, Renna F, Geng Y, De Caterina R. High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy. Cardiovasc Diabetol. 2016;15:18 pubmed publisher

Lin L, Jiang P, Park J, Wang J, Lu Z, Lam M, et al. The contribution of Alu exons to the human proteome. Genome Biol. 2016;17:15 pubmed publisher

Kishi N, MacDonald J, Ye J, Molyneaux B, Azim E, Macklis J. Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice. Nat Commun. 2016;7:10520 pubmed publisher

Díaz Barreiro A, Bernal Quirós M, Georg I, Marañón C, Alarcón Riquelme M, Castillejo López C. The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function. Genes Immun. 2016;17:128-38 pubmed publisher

Long C, Guo W, Zhou H, Wang J, Wang H, Sun X. Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi's sarcoma-associated and herpesvirus-related primary effusion lymphoma cells. Int J Oncol. 2016;48:1519-30 pubmed publisher

Bothur E, Raifer H, Haftmann C, Stittrich A, Brüstle A, Brenner D, et al. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015;6:8576 pubmed publisher

Bindesbøll C, Tan S, Bott D, Cho T, Tamblyn L, MacPherson L, et al. TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. Biochem J. 2016;473:899-910 pubmed publisher

Zhang G, Chan B, Samarina N, Abere B, Weidner Glunde M, Buch A, et al. Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci U S A. 2016;113:E1034-43 pubmed publisher

Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher

Santhanam A, Torricelli A, Wu J, Marino G, Wilson S. Differential expression of epithelial basement membrane components nidogens and perlecan in corneal stromal cells in vitro. Mol Vis. 2015;21:1318-27 pubmed

Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher

Tien S, Lee H, Yang Y, Lin M, Chen Y, Chang Z. The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42. Nat Commun. 2016;7:10420 pubmed publisher

Schirmer M, Trentin L, Queudeville M, Seyfried F, Demir S, Tausch E, et al. Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death Dis. 2016;7:e2052 pubmed publisher

Dieckmann N, Hackmann Y, Aricò M, Griffiths G. Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes. Traffic. 2015;16:1330-41 pubmed publisher

Wang S, Ni H, Dorko K, Kumer S, Schmitt T, Nawabi A, et al. Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury. Oncotarget. 2016;7:17681-98 pubmed publisher

Ketel K, Krauss M, Nicot A, Puchkov D, Wieffer M, Müller R, et al. A phosphoinositide conversion mechanism for exit from endosomes. Nature. 2016;529:408-12 pubmed publisher

Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, et al. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. elife. 2016;5:e10727 pubmed publisher

Liu H, Shi H, Huang F, Peterson K, Wu H, Lan Y, et al. Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway. Sci Rep. 2016;6:19137 pubmed publisher

Li N, Dhar S, Chen T, Kan P, Wei Y, Kim J, et al. JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. Cancer Res. 2016;76:831-43 pubmed publisher

Hérate C, Ramdani G, Grant N, Marion S, Gasman S, Niedergang F, et al. Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages. PLoS ONE. 2016;11:e0145617 pubmed publisher

Vacca V, Marinelli S, Pieroni L, Urbani A, Luvisetto S, Pavone F. 17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice. Sci Rep. 2016;6:18980 pubmed publisher

Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher

Piggin C, Roden D, Gallego Ortega D, Lee H, Oakes S, Ormandy C. ELF5 isoform expression is tissue-specific and significantly altered in cancer. Breast Cancer Res. 2016;18:4 pubmed publisher

Liberante F, Pouryahya T, McMullin M, Zhang S, Mills K. Identification and validation of the dopamine agonist bromocriptine as a novel therapy for high-risk myelodysplastic syndromes and secondary acute myeloid leukemia. Oncotarget. 2016;7:6609-19 pubmed publisher

Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed publisher

Rassoolzadeh H, Coucoravas C, Farnebo M. The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1. Nucleus. 2015;6:417-24 pubmed publisher

Zayas M, Long G, Madan V, Bartenschlager R. Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A. PLoS Pathog. 2016;12:e1005376 pubmed publisher

Han M, Lee D, Woo S, Seo B, Min K, Kim S, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep. 2016;6:18642 pubmed publisher

Clark D, Mei Y, Sun S, Zhang H, Yang A, Mao L. Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells. Theranostics. 2016;6:65-77 pubmed publisher

Wang Q, Wang D, Yan G, Sun L, Tang C. TRPC6 is required for hypoxia-induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells. Mol Med Rep. 2016;13:1577-85 pubmed publisher

Gallego Ortega D, Ledger A, Roden D, Law A, Magenau A, Kikhtyak Z, et al. ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells. PLoS Biol. 2015;13:e1002330 pubmed publisher

Xu Y, Wu D, Zheng W, Yu F, Yang F, Yao Y, et al. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. 2016;7:6146-58 pubmed publisher

Noh H, Hah Y, Ha J, Kang M, Zada S, Rha S, et al. Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity. Oncotarget. 2016;7:4632-46 pubmed publisher

Li R, Liao G, Nirujogi R, Pinto S, Shaw P, Huang T, et al. Phosphoproteomic Profiling Reveals Epstein-Barr Virus Protein Kinase Integration of DNA Damage Response and Mitotic Signaling. PLoS Pathog. 2015;11:e1005346 pubmed publisher

Choudhury S, Harris A, Cabral D, Keeler A, Sapp E, Ferreira J, et al. Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector. Mol Ther. 2016;24:726-35 pubmed publisher

Bartosch C, Monteiro Reis S, Almeida Rios D, Vieira R, Castro A, Moutinho M, et al. Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium. Oncotarget. 2016;7:1144-54 pubmed publisher

Khoutorsky A, Bonin R, Sorge R, Gkogkas C, Pawlowski S, Jafarnejad S, et al. Translational control of nociception via 4E-binding protein 1. elife. 2015;4: pubmed publisher

Kamitani T, Sakaguchi H, Tamura A, Miyashita T, Yamazaki Y, Tokumasu R, et al. Deletion of Tricellulin Causes Progressive Hearing Loss Associated with Degeneration of Cochlear Hair Cells. Sci Rep. 2015;5:18402 pubmed publisher

Gong X, Tan M, Gao Y, Chen K, Guo G. CRMP‑5 interacts with actin to regulate neurite outgrowth. Mol Med Rep. 2016;13:1179-85 pubmed publisher

Wille C, Nawandar D, Henning A, Ma S, Oetting K, Lee D, et al. 5-hydroxymethylation of the EBV genome regulates the latent to lytic switch. Proc Natl Acad Sci U S A. 2015;112:E7257-65 pubmed publisher

Arévalo Turrubiarte M, Perruchot M, Finot L, Mayeur F, Dessauge F. Phenotypic and functional characterization of two bovine mammary epithelial cell lines in 2D and 3D models. Am J Physiol Cell Physiol. 2016;310:C348-56 pubmed publisher

Yu F, Shen X, Fan L, Yu Z. Analysis of histone modifications at human ribosomal DNA in liver cancer cell. Sci Rep. 2015;5:18100 pubmed publisher

Ageta Ishihara N, Yamazaki M, Konno K, Nakayama H, Abe M, Hashimoto K, et al. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nat Commun. 2015;6:10090 pubmed publisher

Bowser J, Blackburn M, Shipley G, Molina J, Dunner K, Broaddus R. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest. 2016;126:220-38 pubmed publisher

Aimi F, Georgiopoulou S, Kalus I, Lehner F, Hegglin A, Limani P, et al. Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult. Sci Rep. 2015;5:17705 pubmed publisher

Seidensaal K, Nollert A, Feige A, Muller M, Fleming T, Gunkel N, et al. Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma. Mol Cancer. 2015;14:204 pubmed publisher

Jimenez Mateos E, Arribas Blázquez M, Sanz Rodriguez A, Concannon C, Olivos Ore L, Reschke C, et al. microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Sci Rep. 2015;5:17486 pubmed publisher

Lommel M, Trairatphisan P, Gäbler K, Laurini C, Muller A, Kaoma T, et al. L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. FASEB J. 2016;30:1218-33 pubmed publisher

Biziota E, Briasoulis E, Mavroeidis L, Marselos M, Harris A, Pappas P. Cellular and molecular effects of metronomic vinorelbine and 4-O-deacetylvinorelbine on human umbilical vein endothelial cells. Anticancer Drugs. 2016;27:216-24 pubmed publisher

Mehraein Ghomi F, Church D, Schreiber C, Weichmann A, Basu H, Wilding G. Inhibitor of p52 NF-κB subunit and androgen receptor (AR) interaction reduces growth of human prostate cancer cells by abrogating nuclear translocation of p52 and phosphorylated AR(ser81). Genes Cancer. 2015;6:428-44 pubmed

Pankow S, Bamberger C, Calzolari D, Martínez Bartolomé S, Lavallée Adam M, Balch W, et al. ∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature. 2015;528:510-6 pubmed publisher

de Jong O, van Balkom B, Gremmels H, Verhaar M. Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2. J Cell Mol Med. 2016;20:342-50 pubmed publisher

Fang M, Yuan Y, Rangarajan P, Lu J, Wu Y, Wang H, et al. Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. BMC Neurosci. 2015;16:84 pubmed publisher

Ni Y, Nagashimada M, Zhuge F, Zhan L, Nagata N, Tsutsui A, et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E. Sci Rep. 2015;5:17192 pubmed publisher

Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher

Ferri F, Parcelier A, Petit V, Gallouet A, Lewandowski D, Dalloz M, et al. TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation. Nat Commun. 2015;6:8900 pubmed publisher

Lyu L, Whitcomb E, Jiang S, Chang M, Gu Y, Duncan M, et al. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract. FASEB J. 2016;30:1087-95 pubmed publisher

Isernhagen A, Schilling D, Monecke S, Shah P, Elsner L, Walter L, et al. The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA. Immunogenetics. 2016;68:109-23 pubmed publisher

van Jaarsveld M, van Kuijk P, Boersma A, Helleman J, Van Ijcken W, Mathijssen R, et al. miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway. Mol Cancer. 2015;14:196 pubmed publisher

Nanba K, Chen A, Turcu A, Rainey W. H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness. J Mol Endocrinol. 2016;56:69-76 pubmed publisher

Lamana A, López Santalla M, Castillo González R, Ortiz A, Martín J, García Vicuña R, et al. The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression. PLoS ONE. 2015;10:e0142683 pubmed publisher

Fridriksdottir A, Kim J, Villadsen R, Klitgaard M, Hopkinson B, Petersen O, et al. Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun. 2015;6:8786 pubmed publisher

Ninkina N, Connor Robson N, Ustyugov A, Tarasova T, Shelkovnikova T, Buchman V. A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression. Sci Rep. 2015;5:16615 pubmed publisher

He X, Wang L, Yan J, Yuan C, Witze E, Hua X. Menin localization in cell membrane compartment. Cancer Biol Ther. 2016;17:114-22 pubmed publisher

Funauchi Y, Tanikawa C, Yi Lo P, Mori J, Daigo Y, Takano A, et al. Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep. 2015;5:16497 pubmed publisher

Scherer M, Otto V, Stump J, Klingl S, Müller R, Reuter N, et al. Characterization of Recombinant Human Cytomegaloviruses Encoding IE1 Mutants L174P and 1-382 Reveals that Viral Targeting of PML Bodies Perturbs both Intrinsic and Innate Immune Responses. J Virol. 2016;90:1190-205 pubmed publisher

Seidel C, Schnekenburger M, Mazumder A, Teiten M, Kirsch G, Dicato M, et al. 4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer. Biochem Pharmacol. 2016;99:31-52 pubmed publisher

Buczek M, Miles A, Green W, Johnson C, Boocock D, Pockley A, et al. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 2016;35:3465-75 pubmed publisher

Hatanaka Y, Watase K, Wada K, Nagai Y. Abnormalities in synaptic dynamics during development in a mouse model of spinocerebellar ataxia type 1. Sci Rep. 2015;5:16102 pubmed publisher

Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, et al. Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget. 2015;6:40655-66 pubmed publisher

Yu D, Makkar G, Dong T, Strickland D, Sarkar R, Monahan T. MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27kip1- Dependent Mechanism. PLoS ONE. 2015;10:e0141397 pubmed publisher

Zhao E, Maj T, Kryczek I, Li W, Wu K, Zhao L, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol. 2016;17:95-103 pubmed publisher

Hunter J, Butterworth J, Zhao B, Sellier H, Campbell K, Thomas H, et al. The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene. 2016;35:3476-84 pubmed publisher

Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, et al. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016;310:H92-103 pubmed publisher

Fernández Santiago R, Carballo Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez Danés A, et al. Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients. EMBO Mol Med. 2015;7:1529-46 pubmed publisher

Hadzic E, Catillon M, Halavatyi A, Medves S, Van Troys M, Moes M, et al. Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption. PLoS ONE. 2015;10:e0140511 pubmed publisher

Eiseler T, Wille C, Koehler C, Illing A, Seufferlein T. Protein Kinase D2 Assembles a Multiprotein Complex at the Trans-Golgi Network to Regulate Matrix Metalloproteinase Secretion. J Biol Chem. 2016;291:462-77 pubmed publisher

Knoll M, Macher Goeppinger S, Kopitz J, Duensing S, Pahernik S, Hohenfellner M, et al. The ribosomal protein S6 in renal cell carcinoma: functional relevance and potential as biomarker. Oncotarget. 2016;7:418-32 pubmed publisher

Chidlow G, Wood J, Knoops B, Casson R. Expression and distribution of peroxiredoxins in the retina and optic nerve. Brain Struct Funct. 2016;221:3903-3925 pubmed

Brown P, Wong K, Felce S, Lyne L, Spearman H, Soilleux E, et al. FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas. Leukemia. 2016;30:605-16 pubmed publisher

Slemmons K, Crose L, Rudzinski E, Bentley R, Linardic C. Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. PLoS ONE. 2015;10:e0140781 pubmed publisher

Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher

Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher

Du J, Ge X, Liu Y, Jiang P, Wang Z, Zhang R, et al. Targeting Swine Leukocyte Antigen Class I Molecules for Proteasomal Degradation by the nsp1α Replicase Protein of the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06. J Virol. 2016;90:682-93 pubmed publisher

Slaats G, Isabella C, Kroes H, Dempsey J, Gremmels H, Monroe G, et al. MKS1 regulates ciliary INPP5E levels in Joubert syndrome. J Med Genet. 2016;53:62-72 pubmed publisher

Graindorge D, Martineau S, Machon C, Arnoux P, Guitton J, Francesconi S, et al. Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication. PLoS ONE. 2015;10:e0140645 pubmed publisher

Hochrainer K, Pejanovic N, Olaseun V, Zhang S, Iadecola C, Anrather J. The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res. 2015;43:9889-904 pubmed publisher

Liu Z, Hu J, Liang J, Zhou A, Li M, Yan S, et al. Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression. Cell Death Dis. 2015;6:e1920 pubmed publisher

Montes M, Coiras M, Becerra S, Moreno Castro C, Mateos E, Majuelos J, et al. Functional Consequences for Apoptosis by Transcription Elongation Regulator 1 (TCERG1)-Mediated Bcl-x and Fas/CD95 Alternative Splicing. PLoS ONE. 2015;10:e0139812 pubmed publisher

Bae E, Yang N, Lee C, Kim S, Lee H, Lee S. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates. Cell Death Dis. 2015;6:e1901 pubmed publisher

Phinney D, Di Giuseppe M, Njah J, Sala E, Shiva S, St Croix C, et al. Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs. Nat Commun. 2015;6:8472 pubmed publisher

Meng Z, Moroishi T, Mottier Pavie V, Plouffe S, Hansen C, Hong A, et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015;6:8357 pubmed publisher

Fink S, Myeroff L, Kariv R, Platzer P, Xin B, Mikkola D, et al. Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival. Oncotarget. 2015;6:30500-15 pubmed publisher

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584-93 pubmed publisher

Felli N, Errico M, Pedini F, Petrini M, Puglisi R, Bellenghi M, et al. AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression. Oncogene. 2016;35:3016-26 pubmed publisher

Patruno A, Pesce M, Grilli A, Speranza L, Franceschelli S, De Lutiis M, et al. mTOR Activation by PI3K/Akt and ERK Signaling in Short ELF-EMF Exposed Human Keratinocytes. PLoS ONE. 2015;10:e0139644 pubmed publisher

Nawandar D, Wang A, Makielski K, Lee D, Ma S, Barlow E, et al. Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells. PLoS Pathog. 2015;11:e1005195 pubmed publisher

Schmidt J, Klingler F, Proschak E, Steinhilber D, Schubert Zsilavecz M, Merk D. NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor. Sci Rep. 2015;5:14782 pubmed publisher

Hu D, Gur M, Zhou Z, Gamper A, Hung M, Fujita N, et al. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015;6:8419 pubmed publisher

Kharaziha P, Chioureas D, Baltatzis G, Fonseca P, Rodriguez P, Gogvadze V, et al. Sorafenib-induced defective autophagy promotes cell death by necroptosis. Oncotarget. 2015;6:37066-82 pubmed publisher

Moody P, Sayers E, Magnusson J, Alexander C, Borri P, Watson P, et al. Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes. Mol Ther. 2015;23:1888-98 pubmed publisher

Zulliger R, Conley S, Mwoyosvi M, Stuck M, Azadi S, Naash M. SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS ONE. 2015;10:e0138508 pubmed publisher

Xiong R, Zhou W, Siegel D, Kitson R, Freed C, Moody C, et al. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity. Mol Pharmacol. 2015;88:1045-54 pubmed publisher

Cecchetti S, Bortolomai I, Ferri R, Mercurio L, Canevari S, Podo F, et al. Inhibition of Phosphatidylcholine-Specific Phospholipase C Interferes with Proliferation and Survival of Tumor Initiating Cells in Squamous Cell Carcinoma. PLoS ONE. 2015;10:e0136120 pubmed publisher

Polettini J, Behnia F, Taylor B, Saade G, Taylor R, Menon R. Telomere Fragment Induced Amnion Cell Senescence: A Contributor to Parturition?. PLoS ONE. 2015;10:e0137188 pubmed publisher

Wu L, Guo L, Liang Y, Liu X, Jiang L, Wang L. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncol Rep. 2015;34:3311-7 pubmed publisher

Haim Y, Bluher M, Slutsky N, Goldstein N, Kloting N, Harman Boehm I, et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015;11:2074-2088 pubmed publisher

Grootaert M, da Costa Martins P, Bitsch N, Pintelon I, De Meyer G, Martinet W, et al. Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. Autophagy. 2015;11:2014-2032 pubmed publisher

Granato M, Santarelli R, Filardi M, Gonnella R, Farina A, Torrisi M, et al. The activation of KSHV lytic cycle blocks autophagy in PEL cells. Autophagy. 2015;11:1978-1986 pubmed publisher

Yao H, Ferdaus M, Zahid H, Ohara H, Nakahara T, Nabika T. Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases. PLoS ONE. 2015;10:e0138551 pubmed publisher

Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed publisher

Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen P, Viero G, et al. eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. Nat Commun. 2015;6:8261 pubmed publisher

Iriondo O, Rábano M, Domenici G, Carlevaris O, López Ruiz J, Zabalza I, et al. Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions. Oncotarget. 2015;6:31721-39 pubmed publisher

Ashford A, Dunkley T, Cockerill M, Rowlinson R, Baak L, Gallo R, et al. Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome. Cell Mol Life Sci. 2016;73:883-900 pubmed publisher

King C, Li X, Barbachano Guerrero A, Bhaduri McIntosh S. STAT3 Regulates Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2015;89:11347-55 pubmed publisher

Reuther C, Heinzle V, Spampatti M, Vlotides G, de Toni E, Spöttl G, et al. Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition. Neuroendocrinology. 2016;103:383-401 pubmed publisher

Sharma B, Kolhe R, Black S, Keller J, Mivechi N, Satyanarayana A. Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J. 2016;30:262-75 pubmed publisher

Yao X, Tang Z, Fu X, Yin J, Liang Y, Li C, et al. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015;34:2885-902 pubmed publisher

Chun Y, Oh H, Park M, Kim T, Chung S. Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C. J Neurodegener Dis. 2013;2013:407903 pubmed publisher

Chojnowski A, Ong P, Wong E, Lim J, Mutalif R, Navasankari R, et al. Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria. elife. 2015;4: pubmed publisher

Barão S, Gärtner A, Leyva Díaz E, Demyanenko G, Munck S, Vanhoutvin T, et al. Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse. Cell Rep. 2015;12:1367-76 pubmed publisher

Gramolelli S, Weidner Glunde M, Abere B, Viejo Borbolla A, Bala K, Rückert J, et al. Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells. PLoS Pathog. 2015;11:e1005105 pubmed publisher

Lee Y, Liu C, Liao M, Sukhova G, Shirakawa J, Abdennour M, et al. Deficiency of FcϵR1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015;156:4047-58 pubmed publisher

Fritz H, Gustafsson A, Ljungberg B, Ceder Y, Axelson H, Dahlbäck B. The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels. PLoS ONE. 2015;10:e0135991 pubmed publisher

Galicia Vázquez G, Chu J, Pelletier J. eIF4AII is dispensable for miRNA-mediated gene silencing. RNA. 2015;21:1826-33 pubmed publisher

Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, et al. Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival. Oncogene. 2016;35:2441-52 pubmed publisher

Lim T, Lee I, Kim J, Kang W. Synergistic Effect of Simvastatin Plus Radiation in Gastric Cancer and Colorectal Cancer: Implications of BIRC5 and Connective Tissue Growth Factor. Int J Radiat Oncol Biol Phys. 2015;93:316-25 pubmed publisher

Uchiyama T, Kawabata H, Miura Y, Yoshioka S, Iwasa M, Yao H, et al. The role of growth differentiation factor 15 in the pathogenesis of primary myelofibrosis. Cancer Med. 2015;4:1558-72 pubmed publisher

Steingruber M, Socher E, Hutterer C, Webel R, Bergbrede T, Lenac T, et al. The Interaction between Cyclin B1 and Cytomegalovirus Protein Kinase pUL97 is Determined by an Active Kinase Domain. Viruses. 2015;7:4582-601 pubmed publisher

Meraviglia V, Azzimato V, Colussi C, Florio M, Binda A, Panariti A, et al. Acetylation mediates Cx43 reduction caused by electrical stimulation. J Mol Cell Cardiol. 2015;87:54-64 pubmed publisher

Radoshevich L, Impens F, Ribet D, Quereda J, Nam Tham T, Nahori M, et al. ISG15 counteracts Listeria monocytogenes infection. elife. 2015;4: pubmed publisher

Zhen Y, Li W. Impairment of autophagosome-lysosome fusion in the buff mutant mice with the VPS33A(D251E) mutation. Autophagy. 2015;11:1608-22 pubmed publisher

Genin M, Clement F, Fattaccioli A, Raes M, Michiels C. M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide. BMC Cancer. 2015;15:577 pubmed publisher

Ju X, Yan Y, Liu Q, Li N, Sheng M, Zhang L, et al. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. J Virol. 2015;89:10347-58 pubmed publisher

Lutzenberger M, Burwinkel M, Riemer C, Bode V, Baier M. Ablation of CCAAT/Enhancer-Binding Protein Delta (C/EBPD): Increased Plaque Burden in a Murine Alzheimer's Disease Model. PLoS ONE. 2015;10:e0134228 pubmed publisher

Verrier E, Colpitts C, Bach C, Heydmann L, Weiss A, Renaud M, et al. A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses. Hepatology. 2016;63:35-48 pubmed publisher

Chen C, Tian F, Lu L, Wang Y, Xiao Z, Yu C, et al. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. J Cell Sci. 2015;128:3290-303 pubmed publisher

Roncero A, López Nieva P, Cobos Fernández M, Villa Morales M, González Sánchez L, López Lorenzo J, et al. Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development. Leukemia. 2016;30:94-103 pubmed publisher

Prasad S, Sajja R, Park J, Naik P, Kaisar M, Cucullo L. Impact of cigarette smoke extract and hyperglycemic conditions on blood-brain barrier endothelial cells. Fluids Barriers CNS. 2015;12:18 pubmed publisher

He D, Chen H, Muramatsu H, Lasek A. Ethanol activates midkine and anaplastic lymphoma kinase signaling in neuroblastoma cells and in the brain. J Neurochem. 2015;135:508-21 pubmed publisher

Gingras S, Earls L, Howell S, Smeyne R, Zakharenko S, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015;35:10510-22 pubmed publisher

Kreit M, Vertommen D, Gillet L, Michiels T. The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS ONE. 2015;10:e0133190 pubmed publisher

Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, et al. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. 2015;43:8325-39 pubmed publisher

Chiou S, Winters I, Wang J, Naranjo S, Dudgeon C, Tamburini F, et al. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. Genes Dev. 2015;29:1576-85 pubmed publisher

Malik I, Stange I, Martius G, Cameron S, Rave Fränk M, Hess C, et al. Role of PECAM-1 in radiation-induced liver inflammation. J Cell Mol Med. 2015;19:2441-52 pubmed publisher

Zhang F, Patel D, Colavita K, Rodionova I, Buckley B, Scott D, et al. Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase. Nat Commun. 2015;6:7517 pubmed publisher

Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed publisher

Wu H, Barik A, Lu Y, Shen C, Bowman A, Li L, et al. Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. elife. 2015;4: pubmed publisher

Maggiorani D, Dissard R, Belloy M, Saulnier Blache J, Casemayou A, Ducassé L, et al. Shear Stress-Induced Alteration of Epithelial Organization in Human Renal Tubular Cells. PLoS ONE. 2015;10:e0131416 pubmed publisher

Yang F, Silber S, Leu N, Oates R, Marszalek J, Skaletsky H, et al. TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. EMBO Mol Med. 2015;7:1198-210 pubmed publisher

Sadaie M, Dillon C, Narita M, Young A, Cairney C, Godwin L, et al. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell. 2015;26:2971-85 pubmed publisher

Thatcher S, Zhang X, Woody S, Wang Y, Alsiraj Y, Charnigo R, et al. Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice. Biol Sex Differ. 2015;6:12 pubmed publisher

Sive J, Basilico S, Hannah R, Kinston S, Calero Nieto F, Göttgens B. Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia. Leukemia. 2016;30:14-23 pubmed publisher

Huygens C, Liénart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie P, et al. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells. J Biol Chem. 2015;290:20105-16 pubmed publisher

Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2016;35:1926-42 pubmed publisher

Goichon A, Bertrand J, Chan P, Lecleire S, Coquard A, Cailleux A, et al. Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa. Am J Clin Nutr. 2015;102:359-67 pubmed publisher

Zhang J, Li L, Baldwin A, Friedman A, Paz Priel I. Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells. PLoS ONE. 2015;10:e0130441 pubmed publisher

Pishas K, Adwal A, Neuhaus S, Clayer M, Farshid G, Staudacher A, et al. XI-006 induces potent p53-independent apoptosis in Ewing sarcoma. Sci Rep. 2015;5:11465 pubmed publisher

Loveless T, Topacio B, Vashisht A, Galaang S, Ulrich K, Young B, et al. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. PLoS Genet. 2015;11:e1005292 pubmed publisher

Lu H, Xue Y, Xue Y, Yu G, Arias C, Lin J, et al. Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. elife. 2015;4:e06535 pubmed publisher

Liu G, Wang Z, Wang Z, Yang D, Liu Z, Wang L. Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead. Arch Toxicol. 2016;90:1193-209 pubmed publisher

Whalley H, Porter A, Diamantopoulou Z, White G, Castañeda Saucedo E, Malliri A. Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation. Nat Commun. 2015;6:7437 pubmed publisher

Specks J, Lecona E, Lopez Contreras A, Fernandez Capetillo O. A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development. Mol Cell Biol. 2015;35:2910-7 pubmed publisher

Preca B, Bajdak K, Mock K, Sundararajan V, Pfannstiel J, Maurer J, et al. A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells. Int J Cancer. 2015;137:2566-77 pubmed publisher

Stermann A, Huebener N, Seidel D, Fest S, Eschenburg G, Stauder M, et al. Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice. Cancer Immunol Immunother. 2015;64:1215-27 pubmed publisher

Schell C, Kretz O, Bregenzer A, Rogg M, Helmstädter M, Lisewski U, et al. Podocyte-Specific Deletion of Murine CXADR Does Not Impair Podocyte Development, Function or Stress Response. PLoS ONE. 2015;10:e0129424 pubmed publisher

Su Y, Chang Y, Lin W, Liang C, Lee J. An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/β-catenin-elicited promotion of the cancer stem cell phenotype. Oncogenesis. 2015;4:e157 pubmed publisher

Bijata M, Wlodarczyk J, Figiel I. Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci. 2015;9:199 pubmed publisher

Shen Y, Zeng L, Novosyadlyy R, Forest A, Zhu A, Korytko A, et al. A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation. MAbs. 2015;7:931-45 pubmed publisher

Cerella C, Muller F, Gaigneaux A, Radogna F, Viry E, Chateauvieux S, et al. Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis. 2015;6:e1782 pubmed publisher

Wagenknecht N, Reuter N, Scherer M, Reichel A, Müller R, Stamminger T. Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1. Viruses. 2015;7:2884-907 pubmed publisher

Dille S, Kleinschnitz E, Kontchou C, Nölke T, Häcker G. In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport. Infect Immun. 2015;83:3268-80 pubmed publisher

von Einem B, Wahler A, Schips T, Serrano Pozo A, Proepper C, Boeckers T, et al. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). PLoS ONE. 2015;10:e0129047 pubmed publisher

Holtzhausen A, Zhao F, Evans K, Tsutsui M, Orabona C, Tyler D, et al. Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. Cancer Immunol Res. 2015;3:1082-95 pubmed publisher

Subathra M, Korrapati M, Howell L, Arthur J, Shayman J, Schnellmann R, et al. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells. Am J Physiol Renal Physiol. 2015;309:F204-15 pubmed publisher

Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, et al. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS ONE. 2015;10:e0128094 pubmed publisher

Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, et al. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. Biochim Biophys Acta. 2015;1853:2392-403 pubmed publisher

Vinue A, Andrés Blasco I, Herrero Cervera A, Piqueras L, Andres V, Burks D, et al. Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling. Biochim Biophys Acta. 2015;1852:1729-42 pubmed publisher

Hayashi T, Wills S, Bussey K, Takimoto T. Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low Temperatures. J Virol. 2015;89:8042-9 pubmed publisher

Yen C, Chiang W, Liu S, Lin C, Liao K, Lin C, et al. Impacts of autophagy-inducing ingredient of areca nut on tumor cells. PLoS ONE. 2015;10:e0128011 pubmed publisher

Mulholland C, Smets M, Schmidtmann E, Leidescher S, Markaki Y, Hofweber M, et al. A modular open platform for systematic functional studies under physiological conditions. Nucleic Acids Res. 2015;43:e112 pubmed publisher

Reigada D, Nieto Díaz M, Navarro Ruiz R, Caballero López M, Del Águila A, Muñoz Galdeano T, et al. Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury. Neuroscience. 2015;300:404-17 pubmed publisher

Suárez Causado A, Caballero Díaz D, Bertrán E, Roncero C, Addante A, García Álvaro M, et al. HGF/c-Met signaling promotes liver progenitor cell migration and invasion by an epithelial-mesenchymal transition-independent, phosphatidyl inositol-3 kinase-dependent pathway in an in vitro model. Biochim Biophys Acta. 2015;1853:2453-63 pubmed publisher

Peng B, Wang J, Hu Y, Zhao H, Hou W, Zhao H, et al. Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage. Nucleic Acids Res. 2015;43:5936-47 pubmed publisher

Fischer S, Paul A, Wagner A, Mathias S, Geiss M, Schandock F, et al. miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality. Biotechnol Bioeng. 2015;112:2142-53 pubmed publisher

Moon J, Eo S, Lee J, Park S. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375-81 pubmed publisher

Yufune S, Satoh Y, Takamatsu I, Ohta H, Kobayashi Y, Takaenoki Y, et al. Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice. Sci Rep. 2015;5:10252 pubmed publisher

Robinson H, Deykin A, Bronovitsky E, Ovchinnikov R, Ustyugov A, Shelkovnikova T, et al. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:402-9 pubmed publisher

Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher

Wang Z, Ma B, Ji X, Deng Y, Zhang T, Zhang X, et al. MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF. Cancer Cell Int. 2015;15:40 pubmed publisher

Noss E, Watts G, Zocco D, Keller T, Whitman M, Blobel C, et al. Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Res Ther. 2015;17:126 pubmed publisher

Wang C, Nie Z, Zhou Z, Zhang H, Liu R, Wu J, et al. The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1. Oncotarget. 2015;6:17685-97 pubmed

Adhikary G, Grun D, Balasubramanian S, Kerr C, Huang J, Eckert R. Survival of skin cancer stem cells requires the Ezh2 polycomb group protein. Carcinogenesis. 2015;36:800-10 pubmed publisher

Bergeron D, Pal G, Beaulieu Y, Chabot B, Bachand F. Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 Autoregulation. Mol Cell Biol. 2015;35:2503-17 pubmed publisher

Tanas M, Ma S, Jadaan F, Ng C, Weigelt B, Reis Filho J, et al. Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein. Oncogene. 2016;35:929-38 pubmed publisher

Pang B, de Jong J, Qiao X, Wessels L, Neefjes J. Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat Chem Biol. 2015;11:472-80 pubmed publisher

Fujikawa Y, Tominaga K, Tanaka F, Tanigawa T, Watanabe T, Fujiwara Y, et al. Enteric glial cells are associated with stress-induced colonic hyper-contraction in maternally separated rats. Neurogastroenterol Motil. 2015;27:1010-23 pubmed publisher

Son Y, Heo K, Bae M, Lee C, Cho W, Kim S, et al. Injury to the blood-testis barrier after low-dose-rate chronic radiation exposure in mice. Radiat Prot Dosimetry. 2015;167:316-20 pubmed publisher

Barrett K, Fang H, Cukovic D, Dombkowski A, Kocarek T, Runge Morris M. Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation. Drug Metab Dispos. 2015;43:1061-70 pubmed publisher

Shi Y, Tan S, Ng S, Zhou J, Yang N, Koo G, et al. Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy. Autophagy. 2015;11:769-84 pubmed publisher

Milenkovic A, Brandl C, Milenkovic V, Jendryke T, Sirianant L, Wanitchakool P, et al. Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells. Proc Natl Acad Sci U S A. 2015;112:E2630-9 pubmed publisher

Fisher M, Keillor J, Xu W, Eckert R, Kerr C. Transglutaminase Is Required for Epidermal Squamous Cell Carcinoma Stem Cell Survival. Mol Cancer Res. 2015;13:1083-94 pubmed publisher

Isogai T, van der Kammen R, Innocenti M. SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep. 2015;5:9802 pubmed publisher

Cardoso F, Herz J, Fernandes A, Rocha J, Sepodes B, Brito M, et al. Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects. J Neuroinflammation. 2015;12:82 pubmed publisher

Hsu P, Liu X, Zhang J, Wang H, Ye J, Shi Y. Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy. Autophagy. 2015;11:643-52 pubmed publisher

Bhushan S, Tchatalbachev S, Lu Y, Fröhlich S, Fijak M, Vijayan V, et al. Differential activation of inflammatory pathways in testicular macrophages provides a rationale for their subdued inflammatory capacity. J Immunol. 2015;194:5455-64 pubmed publisher

Watanabe M, Takahashi H, Saeki Y, Ozaki T, Itoh S, Suzuki M, et al. The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ. elife. 2015;4:e05615 pubmed publisher

Ezzati P, Komher K, Severini G, Coombs K. Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells. Front Cell Infect Microbiol. 2015;5:30 pubmed publisher

Willy J, Young S, Stevens J, Masuoka H, Wek R. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell. 2015;26:2190-204 pubmed publisher

Huang S, Sung C, Chen W, Chen C, Feng C, Yang S, et al. Involvement of phosphatase and tensin homolog deleted from chromosome 10 in rodent model of neuropathic pain. J Neuroinflammation. 2015;12:59 pubmed publisher

Zhao H, Agazie Y. Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment. BMC Cancer. 2015;15:109 pubmed publisher

Mues M, Cheshenko N, Wilson D, Gunther Cummins L, Herold B. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015;89:6673-84 pubmed publisher

Meidhof S, Brabletz S, Lehmann W, Preca B, Mock K, Ruh M, et al. ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat. EMBO Mol Med. 2015;7:831-47 pubmed publisher

Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, et al. Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation. Chem Biol. 2015;22:472-482 pubmed publisher

Jørgensen M, Bæk R, Varming K. Potentials and capabilities of the Extracellular Vesicle (EV) Array. J Extracell Vesicles. 2015;4:26048 pubmed publisher

Lund K, Dembinski J, Solberg N, Urbanucci A, Mills I, Krauss S. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment. PLoS ONE. 2015;10:e0123684 pubmed publisher

Wang X, D Arcy P, Caulfield T, Paulus A, Chitta K, Mohanty C, et al. Synthesis and evaluation of derivatives of the proteasome deubiquitinase inhibitor b-AP15. Chem Biol Drug Des. 2015;86:1036-48 pubmed publisher

Ecker J, Oehme I, Mazitschek R, Korshunov A, Kool M, Hielscher T, et al. Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma. Acta Neuropathol Commun. 2015;3:22 pubmed publisher

Saha K, Eckert R. Methylosome Protein 50 and PKC?/p38? Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression. J Biol Chem. 2015;290:13521-30 pubmed publisher

Kim T, Lawson M. GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology. 2015;156:2185-99 pubmed publisher

Li Y, Drabsch Y, Pujuguet P, Ren J, van Laar T, Zhang L, et al. Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models. Breast Cancer Res. 2015;17:28 pubmed publisher

Majumder A, Syed K, Joseph S, Scambler P, Dutta D. Histone Chaperone HIRA in Regulation of Transcription Factor RUNX1. J Biol Chem. 2015;290:13053-63 pubmed publisher

Fausther M, Goree J, Lavoie Ã, Graham A, Sévigny J, Dranoff J. Establishment and characterization of rat portal myofibroblast cell lines. PLoS ONE. 2015;10:e0121161 pubmed publisher

Bol G, Vesuna F, Xie M, Zeng J, Aziz K, Gandhi N, et al. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med. 2015;7:648-69 pubmed publisher

Ngo J, Matsuyama M, Kim C, Poventud Fuentes I, Bates A, Siedlak S, et al. Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases. Cell Death Dis. 2015;6:e1706 pubmed publisher

Sajja R, Green K, Cucullo L. Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro. PLoS ONE. 2015;10:e0122358 pubmed publisher

Yan J, Zapata J, PAUZA C, Salvato M. Modulation of SIV and HIV DNA vaccine immunity by Fas-FasL signaling. Viruses. 2015;7:1429-53 pubmed publisher

Kirschner K, Samarajiwa S, Cairns J, Menon S, Perez Mancera P, Tomimatsu K, et al. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genet. 2015;11:e1005053 pubmed publisher

Kuo R, Lin Y, Wang R, Hsu C, Chiu Y, Huang H, et al. Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication. J Proteome Res. 2015;14:1818-30 pubmed publisher

CURTIS J, Luo Y, Zenner H, Cuchet Lourenço D, Wu C, Lo K, et al. Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet. 2015;47:523-527 pubmed publisher

Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher

Hodgson A, Wier E, Fu K, Sun X, Yu H, Zheng W, et al. Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction. PLoS Pathog. 2015;11:e1004705 pubmed publisher

Howlin J, Cirenajwis H, Lettiero B, Staaf J, Lauss M, Saal L, et al. Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours. Peerj. 2015;3:e788 pubmed publisher

Münzberg C, Höhn K, Krndija D, Maaß U, Bartsch D, Slater E, et al. IGF-1 drives chromogranin A secretion via activation of Arf1 in human neuroendocrine tumour cells. J Cell Mol Med. 2015;19:948-59 pubmed publisher

Pone E, Lam T, Lou Z, Wang R, Chen Y, Liu D, et al. B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015;194:3065-78 pubmed publisher

Rogler A, Kendziorra E, Giedl J, Stoehr C, Taubert H, Goebell P, et al. Functional analyses and prognostic significance of SFRP1 expression in bladder cancer. J Cancer Res Clin Oncol. 2015;141:1779-90 pubmed publisher

Medina D, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, et al. Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB. Nat Cell Biol. 2015;17:288-99 pubmed

Cruse G, Beaven M, Music S, Bradding P, Gilfillan A, Metcalfe D. The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling. Mol Biol Cell. 2015;26:1711-27 pubmed publisher

Koganti S, Clark C, Zhi J, Li X, Chen E, Chakrabortty S, et al. Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes. J Virol. 2015;89:5002-11 pubmed publisher

Susanto J, Colvin E, Pinese M, Chang D, Pajic M, Mawson A, et al. The epigenetic agents suberoylanilide hydroxamic acid and 5‑AZA‑2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo. Int J Oncol. 2015;46:2223-30 pubmed publisher

Nakagawa Y, Sedukhina A, Okamoto N, Nagasawa S, Suzuki N, Ohta T, et al. NF-κB signaling mediates acquired resistance after PARP inhibition. Oncotarget. 2015;6:3825-39 pubmed

Bitler B, Aird K, Garipov A, Li H, Amatangelo M, Kossenkov A, et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015;21:231-8 pubmed publisher

Nagasawa S, Sedukhina A, Nakagawa Y, Maeda I, Kubota M, Ohnuma S, et al. LSD1 overexpression is associated with poor prognosis in basal-like breast cancer, and sensitivity to PARP inhibition. PLoS ONE. 2015;10:e0118002 pubmed publisher

Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, et al. Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. J Biol Chem. 2015;290:10368-81 pubmed publisher

Gotink K, Rovithi M, de Haas R, Honeywell R, Dekker H, Poel D, et al. Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib. Cell Oncol (Dordr). 2015;38:119-29 pubmed publisher

Porquet D, Andrés Benito P, Griñán Ferré C, Camins A, Ferrer I, Canudas A, et al. Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8). Age (Dordr). 2015;37:9747 pubmed publisher

Suganya R, Chakraborty A, Miriyala S, Hazra T, Izumi T. Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA Repair (Amst). 2015;27:40-8 pubmed publisher

Kathania M, Zeng M, Yadav V, Moghaddam S, Yang B, Venuprasad K. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015;194:2160-7 pubmed publisher

Niu Z, Liu H, Zhou M, Wang H, Liu Y, Li X, et al. Knockdown of c-Myc inhibits cell proliferation by negatively regulating the Cdk/Rb/E2F pathway in nasopharyngeal carcinoma cells. Acta Biochim Biophys Sin (Shanghai). 2015;47:183-91 pubmed publisher

Hole S, Pedersen A, Hansen S, Lundqvist J, Yde C, Lykkesfeldt A. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. Int J Oncol. 2015;46:1481-90 pubmed publisher

Cai K, Wang Y, Smith E, Smedberg J, Yang D, Yang W, et al. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia. 2015;17:89-100 pubmed publisher

Warnier M, Roudbaraki M, Derouiche S, Delcourt P, Bokhobza A, Prevarskaya N, et al. CACNA2D2 promotes tumorigenesis by stimulating cell proliferation and angiogenesis. Oncogene. 2015;34:5383-94 pubmed publisher

Han M, Woo S, Min K, Kim S, Park J, Kim D, et al. 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression. Chem Biol Interact. 2015;228:69-78 pubmed publisher

Sadegh M, Ekman M, Krawczyk K, Svensson D, Göransson O, Dahan D, et al. Detrusor induction of miR-132/212 following bladder outlet obstruction: association with MeCP2 repression and cell viability. PLoS ONE. 2015;10:e0116784 pubmed publisher

Olsen R, Mary Sinclair M, Yin Z, Freeman K. Antagonizing Bcl-2 family members sensitizes neuroblastoma and Ewing's sarcoma to an inhibitor of glutamine metabolism. PLoS ONE. 2015;10:e0116998 pubmed publisher

Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed publisher

Yuan Y, Rangarajan P, Kan E, Wu Y, Wu C, Ling E. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. J Neuroinflammation. 2015;12:11 pubmed publisher

Keembiyehetty C, Love D, Harwood K, Gavrilova O, Comly M, Hanover J. Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis. J Biol Chem. 2015;290:7097-113 pubmed publisher

Tanaka T, Kajiwara T, Torigoe T, Okamoto Y, Sato N, Tamura Y. Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding. J Immunol. 2015;194:2004-10 pubmed publisher

Stolz A, Ertych N, Bastians H. A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation. Cell Cycle. 2015;14:827-37 pubmed publisher

Maurya S, Mishra J, Abbas S, Bandyopadhyay S. Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators. Mol Neurobiol. 2016;53:968-82 pubmed publisher

Chang K, Nayak R, Roy S, Perumbeti A, Wellendorf A, Bezold K, et al. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial ATâ‚‚R and cytoskeletal dysregulation. Nat Commun. 2015;6:5914 pubmed publisher

Besschetnova T, Ichimura T, Katebi N, St Croix B, Bonventre J, Olsen B. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015;42:56-73 pubmed publisher

Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher

Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat Immunol. 2015;16:178-87 pubmed publisher

Harr J, Luperchio T, Wong X, Cohen E, Wheelan S, Reddy K. Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins. J Cell Biol. 2015;208:33-52 pubmed publisher

Mendoza E, Tokarev K, Düring D, Retamosa E, Weiss M, Arpenik N, et al. Differential coexpression of FoxP1, FoxP2, and FoxP4 in the Zebra Finch (Taeniopygia guttata) song system. J Comp Neurol. 2015;523:1318-40 pubmed publisher

Krysiak K, Tibbitts J, Shao J, Liu T, Ndonwi M, Walter M. Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells. Exp Hematol. 2015;43:319-30.e10 pubmed publisher

Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, et al. CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway. J Immunol. 2015;194:960-72 pubmed publisher

Ni H, Bhakta A, Wang S, Li Z, Manley S, Huang H, et al. Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice. PLoS ONE. 2014;9:e115849 pubmed publisher

Yang Y, Otte A, Hass R. Human mesenchymal stroma/stem cells exchange membrane proteins and alter functionality during interaction with different tumor cell lines. Stem Cells Dev. 2015;24:1205-22 pubmed publisher

Tsai M, Chu C, Wei T, Chiu M, Chang C, Wei I, et al. CD200 in growing rat lungs: developmental expression and control by dexamethasone. Cell Tissue Res. 2015;359:729-42 pubmed publisher

Shao C, Ahmad N, Hodges K, Kuang S, Ratliff T, Liu X. Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer. J Biol Chem. 2015;290:2024-33 pubmed publisher

Qiao X, Roth I, Féraille E, Hasler U. Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Cell Cycle. 2014;13:3059-75 pubmed publisher

Jirawatnotai S, Sharma S, Michowski W, Suktitipat B, Geng Y, Quackenbush J, et al. The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis. Cell Cycle. 2014;13:2889-900 pubmed publisher

Selmi A, de Saint Jean M, Jallas A, Garin E, Hogarty M, Bénard J, et al. TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma. Cancer Lett. 2015;357:412-8 pubmed publisher

Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR. J Cell Sci. 2015;128:397-407 pubmed publisher

Yang D, Sun Y, Bhaumik S, Li Y, Baumann J, Lin X, et al. Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns. J Neurosci. 2014;34:16467-81 pubmed publisher

Oksala N, Ekmekçi F, Ozsoy E, Kirankaya S, Kokkola T, Emecen G, et al. Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress. Redox Biol. 2014;3:25-8 pubmed publisher

Kuo P, Huang C, Lee C, Chang H, Hsieh S, Chung Y, et al. BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability. Br J Cancer. 2015;112:391-402 pubmed publisher

Ågren M, Schnabel R, Christensen L, Mirastschijski U. Tumor necrosis factor-α-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo. Eur J Cell Biol. 2015;94:12-21 pubmed publisher

Yokoi F, Dang M, Liu J, Gandre J, Kwon K, Yuen R, et al. Decreased dopamine receptor 1 activity and impaired motor-skill transfer in Dyt1 ΔGAG heterozygous knock-in mice. Behav Brain Res. 2015;279:202-10 pubmed publisher

Zhao S, Ge X, Wang X, Liu A, Guo X, Zhou L, et al. The DEAD-box RNA helicase 5 positively regulates the replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp9 in vitro. Virus Res. 2015;195:217-24 pubmed publisher

Kim H, Jung G. Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. FEBS Lett. 2014;588:4413-21 pubmed publisher

Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 2015;17:95-103 pubmed publisher

Zanotti K, Maul R, Castiblanco D, Yang W, Choi Y, Fox J, et al. ATAD5 deficiency decreases B cell division and Igh recombination. J Immunol. 2015;194:35-42 pubmed publisher

Krawczyk P, Twarog E, Kurowska E, Klopotowska D, Matuszyk J. Establishment of a cellular model to study TrkC-dependent neuritogenesis. In Vitro Cell Dev Biol Anim. 2015;51:241-8 pubmed publisher

Choi C, Kim J, Wee S, Lee J, Nam D, Kim C, et al. Expression of nuclear factor erythroid 2 protein in malignant cutaneous tumors. Arch Plast Surg. 2014;41:654-60 pubmed publisher

Chruscicka B, Burnat G, Branski P, Chorobik P, Lenda T, Marciniak M, et al. Tetracycline-based system for controlled inducible expression of group III metabotropic glutamate receptors. J Biomol Screen. 2015;20:350-8 pubmed publisher

Shimamoto A, Kagawa H, Zensho K, Sera Y, Kazuki Y, Osaki M, et al. Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture. PLoS ONE. 2014;9:e112900 pubmed publisher

Martínez Vega R, Garrido F, Partearroyo T, Cediel R, Zeisel S, Martínez Álvarez C, et al. Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. FASEB J. 2015;29:418-32 pubmed publisher

Dejos C, Voisin P, Bernard M, Régnacq M, Bergès T. Canthin-6-one displays antiproliferative activity and causes accumulation of cancer cells in the G2/M phase. J Nat Prod. 2014;77:2481-7 pubmed publisher

Pérez Alvarez M, Mateos L, Alonso A, Wandosell F. Estradiol and Progesterone Administration After pMCAO Stimulates the Neurological Recovery and Reduces the Detrimental Effect of Ischemia Mainly in Hippocampus. Mol Neurobiol. 2015;52:1690-1703 pubmed publisher

Qin J, Rajaratnam R, Feng L, Salami J, Barber Rotenberg J, Domsic J, et al. Development of organometallic S6K1 inhibitors. J Med Chem. 2015;58:305-14 pubmed publisher

Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher

Srinivasan S, Romagnoli M, Bohm A, Sonenshein G. N-glycosylation regulates ADAM8 processing and activation. J Biol Chem. 2014;289:33676-88 pubmed publisher

Lambert J, Whitson R, Iczkowski K, La Rosa F, Smith M, Wilson R, et al. Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate. Prostate. 2015;75:255-65 pubmed publisher

Bowton E, Saunders C, Reddy I, Campbell N, Hamilton P, Henry L, et al. SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry. 2014;4:e464 pubmed publisher

Goren I, Pfeilschifter J, Frank S. Uptake of neutrophil-derived Ym1 protein distinguishes wound macrophages in the absence of interleukin-4 signaling in murine wound healing. Am J Pathol. 2014;184:3249-61 pubmed publisher

Yang N, Tan S, Ng S, Shi Y, Zhou J, Tan K, et al. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 2014;289:33425-41 pubmed publisher

Laporta J, Keil K, Vezina C, Hernandez L. Peripheral serotonin regulates maternal calcium trafficking in mammary epithelial cells during lactation in mice. PLoS ONE. 2014;9:e110190 pubmed publisher

Ashok A, Rai N, Tripathi S, Bandyopadhyay S. Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. Toxicol Sci. 2015;143:64-80 pubmed publisher

Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher

Saloura V, Cho H, Kiyotani K, Alachkar H, Zuo Z, Nakakido M, et al. WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck. Mol Cancer Res. 2015;13:293-304 pubmed publisher

Schmidt J, Dalby A, Cech T. Identification of human TERT elements necessary for telomerase recruitment to telomeres. elife. 2014;3: pubmed publisher

Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, et al. An important role of endothelial hairy-related transcription factors in mouse vascular development. Genesis. 2014;52:897-906 pubmed publisher

Lupino E, Ramondetti C, Buccinnà B, Piccinini M. Exposure of neuroblastoma cell lines to imatinib results in the upregulation of the CDK inhibitor p27(KIP1) as a consequence of c-Abl inhibition. Biochem Pharmacol. 2014;92:235-50 pubmed publisher

Ahn J, Ruiz P, Barber G. Intrinsic self-DNA triggers inflammatory disease dependent on STING. J Immunol. 2014;193:4634-42 pubmed publisher

Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed publisher

Ishii J, Sato H, Yazawa T, Shishido Hara Y, Hiramatsu C, Nakatani Y, et al. Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation. Pathol Int. 2014;64:415-22 pubmed publisher

Chang Y, Huang Y. Arsenite-activated JNK signaling enhances CPEB4-Vinexin interaction to facilitate stress granule assembly and cell survival. PLoS ONE. 2014;9:e107961 pubmed publisher

Perreten Lambert H, Zenger M, Azarias G, Chatton J, Magistretti P, Lengacher S. Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival. J Biol Chem. 2014;289:31014-28 pubmed publisher

Bertin S, Lozano Ruiz B, Bachiller V, García Martínez I, Herdman S, Zapater P, et al. Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol. 2015;8:505-15 pubmed publisher

Jebelli J, Hooper C, Pocock J. Microglial p53 activation is detrimental to neuronal synapses during activation-induced inflammation: Implications for neurodegeneration. Neurosci Lett. 2014;583:92-7 pubmed publisher

Kelsey L, Katoch P, Ray A, Mitra S, Chakraborty S, Lin M, et al. Vitamin D3 regulates the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells. PLoS ONE. 2014;9:e106437 pubmed publisher

Yamasaki T, Suzuki A, Hasebe R, Horiuchi M. Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells. PLoS ONE. 2014;9:e106516 pubmed publisher

Gruol D, Vo K, Bray J. Increased astrocyte expression of IL-6 or CCL2 in transgenic mice alters levels of hippocampal and cerebellar proteins. Front Cell Neurosci. 2014;8:234 pubmed publisher

Wang H, Yuan Y, Zhang Z, Yan H, Feng Y, Li W. Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus. J Biol Chem. 2014;289:29060-72 pubmed publisher

Peng M, Emmadi R, Wang Z, Wiley E, Gann P, Khan S, et al. PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors. Oncotarget. 2014;5:6038-48 pubmed

Xiong R, Siegel D, Ross D. Quinone-induced protein handling changes: implications for major protein handling systems in quinone-mediated toxicity. Toxicol Appl Pharmacol. 2014;280:285-95 pubmed publisher

Yang L, Kan E, Lu J, Wu C, Ling E. Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and its roles in activated microglia in vivo and in vitro. J Neuroinflammation. 2014;11:148 pubmed publisher

Ito S, Ueda T, Ueno A, Nakagawa H, Taniguchi H, Hongo F, et al. Paired box 2 upregulates androgen receptor gene expression in androgen-independent prostate cancer. FEBS J. 2014;281:4506-18 pubmed publisher

Chau M, Deveau T, Song M, Gu X, Chen D, Wei L. iPSC Transplantation increases regeneration and functional recovery after ischemic stroke in neonatal rats. Stem Cells. 2014;32:3075-87 pubmed publisher

Wu A, Yang M, Dalvi P, Turinsky A, Wang W, Butcher D, et al. Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland. Am J Physiol Endocrinol Metab. 2014;307:E596-610 pubmed publisher

Bae J, Lee S, Park C, Lee Y, Chun T. Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling. J Immunol. 2014;193:3101-12 pubmed publisher

Baek J, Kim J, Cheon Y, Park S, Ahn S, Yoon K, et al. Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone. Molecules. 2014;19:11628-44 pubmed publisher

Matsuda M, Suzuki R, Kataoka C, Watashi K, Aizaki H, Kato N, et al. Alternative endocytosis pathway for productive entry of hepatitis C virus. J Gen Virol. 2014;95:2658-67 pubmed publisher

Viceconte N, McKenna T, Eriksson M. Low levels of the reverse transactivator fail to induce target transgene expression in vascular smooth muscle cells. PLoS ONE. 2014;9:e104098 pubmed publisher

Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed publisher

Bartuzi P, Wijshake T, Dekker D, Fedoseienko A, Kloosterhuis N, Youssef S, et al. A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta. 2014;1842:2257-65 pubmed publisher

Rutkai I, Katakam P, Dutta S, Busija D. Sustained mitochondrial functioning in cerebral arteries after transient ischemic stress in the rat: a potential target for therapies. Am J Physiol Heart Circ Physiol. 2014;307:H958-66 pubmed publisher

Dalmases M, Torres M, Márquez Kisinousky L, Almendros I, Planas A, Embid C, et al. Brain tissue hypoxia and oxidative stress induced by obstructive apneas is different in young and aged rats. Sleep. 2014;37:1249-56 pubmed publisher

Requejo Aguilar R, Lopez Fabuel I, Fernandez E, Martins L, Almeida A, Bolanos J. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nat Commun. 2014;5:4514 pubmed publisher

Shibeeb O, Wood J, Casson R, Chidlow G. Effects of a conventional photocoagulator and a 3-ns pulse laser on preconditioning responses and retinal ganglion cell survival after optic nerve crush. Exp Eye Res. 2014;127:77-90 pubmed publisher

Tan G, Chan E, Molnar A, Sarkar R, Alexieva D, Isa I, et al. 5' isomiR variation is of functional and evolutionary importance. Nucleic Acids Res. 2014;42:9424-35 pubmed publisher

Banoujaafar H, Van Hoecke J, Mossiat C, Marie C. Brain BDNF levels elevation induced by physical training is reduced after unilateral common carotid artery occlusion in rats. J Cereb Blood Flow Metab. 2014;34:1681-7 pubmed publisher

Boros J, Arnoult N, Stroobant V, Collet J, Decottignies A. Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1? at chromatin. Mol Cell Biol. 2014;34:3662-74 pubmed publisher

Ciavardelli D, Rossi C, Barcaroli D, Volpe S, Consalvo A, Zucchelli M, et al. Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment. Cell Death Dis. 2014;5:e1336 pubmed publisher

Lo Sasso G, Ryu D, Mouchiroud L, Fernando S, Anderson C, Katsyuba E, et al. Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PLoS ONE. 2014;9:e102495 pubmed publisher

Kłossowicz M, Marek Bukowiec K, Arbulo Echevarria M, Scirka B, Majkowski M, Sikorski A, et al. Identification of functional, short-lived isoform of linker for activation of T cells (LAT). Genes Immun. 2014;15:449-56 pubmed publisher

Osterman M, Kathawa D, Liu D, Guo H, Zhang C, Li M, et al. Elevated DNA damage response in pancreatic cancer. Histochem Cell Biol. 2014;142:713-20 pubmed publisher

Gonzalez Rodriguez A, Reibert B, Amann T, Constien R, Rondinone C, Valverde A. In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice. Dis Model Mech. 2014;7:1093-100 pubmed publisher

Sadleir K, Eimer W, Kaufman R, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS ONE. 2014;9:e101643 pubmed publisher

Wei X, Li J, Xie H, Wang H, Wang J, Zhang X, et al. Chloride intracellular channel 1 participates in migration and invasion of hepatocellular carcinoma by targeting maspin. J Gastroenterol Hepatol. 2015;30:208-16 pubmed publisher

Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, et al. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049 pubmed publisher

Samartzis E, Gutsche K, Dedes K, Fink D, Stucki M, Imesch P. Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition. Oncotarget. 2014;5:5295-303 pubmed

von Roemeling C, Radisky D, Marlow L, Cooper S, Grebe S, ANASTASIADIS P, et al. Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4. Cancer Res. 2014;74:4796-810 pubmed publisher

Fernandes J, Vieira M, Carreto L, Santos M, Duarte C, Carvalho A, et al. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons. PLoS ONE. 2014;9:e99958 pubmed publisher

Zhao Z, Wu L, Xiong R, Wang L, Zhang B, Wang C, et al. MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease. Neuroscience. 2014;275:232-7 pubmed publisher

Tanaka T, Iino M. Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. Cell Signal. 2014;26:2071-85 pubmed publisher

Herrera A, Saade M, Menendez A, Marti E, Pons S. Sustained Wnt/?-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole. Nat Commun. 2014;5:4168 pubmed publisher

Cheshenko N, Trepanier J, González P, Eugenin E, Jacobs W, Herold B. Herpes simplex virus type 2 glycoprotein H interacts with integrin ?v?3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells. J Virol. 2014;88:10026-38 pubmed publisher

Price D, Ackland M, Burks W, Knight M, Suphioglu C. Peanut allergens alter intestinal barrier permeability and tight junction localisation in Caco-2 cell cultures. Cell Physiol Biochem. 2014;33:1758-77 pubmed publisher

Kaneko Y, Ota A, Nakashima A, Nagasaki H, Kodani Y, Mori K, et al. Lipopolysaccharide treatment arrests the cell cycle of BV-2 microglial cells in G? phase and protects them from UV light-induced apoptosis. J Neural Transm (Vienna). 2015;122:187-99 pubmed publisher

Etnyre D, Stone A, Fong J, Jacobs R, Uppada S, Botting G, et al. Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. Cancer Biol Ther. 2014;15:1129-41 pubmed publisher

van Doremalen N, Miazgowicz K, Milne Price S, Bushmaker T, Robertson S, Scott D, et al. Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4. J Virol. 2014;88:9220-32 pubmed publisher

Devi L, Ohno M. PERK mediates eIF2? phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiol Aging. 2014;35:2272-81 pubmed publisher

Fausther M, Lavoie E, Goree J, Baldini G, Dranoff J. NT5E mutations that cause human disease are associated with intracellular mistrafficking of NT5E protein. PLoS ONE. 2014;9:e98568 pubmed publisher

Kodama T, Tsukaguchi T, Yoshida M, Kondoh O, Sakamoto H. Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance. Cancer Lett. 2014;351:215-21 pubmed publisher

Cho M, Kwon S, Kim C, Lee Y, Nam H, Lee S. Overexpression of KAI1 Protein in Diabetic Skin Tissues. Arch Plast Surg. 2014;41:248-52 pubmed publisher

Kadota S, Nagata K. Silencing of IFN-stimulated gene transcription is regulated by histone H1 and its chaperone TAF-I. Nucleic Acids Res. 2014;42:7642-53 pubmed publisher

Zeng L, Holly J, Perks C. Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells. Front Endocrinol (Lausanne). 2014;5:61 pubmed publisher

Maas N, Singh N, Diehl J. Generation and characterization of an analog-sensitive PERK allele. Cancer Biol Ther. 2014;15:1106-11 pubmed publisher

Israelow B, Narbus C, Sourisseau M, Evans M. HepG2 cells mount an effective antiviral interferon-lambda based innate immune response to hepatitis C virus infection. Hepatology. 2014;60:1170-9 pubmed publisher

Li S, Zhou T, Li C, Dai Z, Che D, Yao Y, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS ONE. 2014;9:e97330 pubmed publisher

Kitagawa K, Shibata K, Matsumoto A, Matsumoto M, Ohhata T, Nakayama K, et al. Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Mol Cell Biol. 2014;34:2732-44 pubmed

Li C, Egloff A, Sen M, Grandis J, Johnson D. Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth. Mol Oncol. 2014;8:1220-30 pubmed publisher

Sreedharan R, Chen S, Miller M, Haribhai D, Williams C, Van Why S. Mice with an absent stress response are protected against ischemic renal injury. Kidney Int. 2014;86:515-24 pubmed publisher

Senkiv Y, Riabtseva A, Heffeter P, Boiko N, Kowol C, Jungwith U, et al. Enhanced anticancer activity and circumvention of resistance mechanisms by novel polymeric/ phospholipidic nanocarriers of doxorubicin. J Biomed Nanotechnol. 2014;10:1369-81 pubmed

Brandl C, Zimmermann S, Milenkovic V, Rosendahl S, Grassmann F, Milenkovic A, et al. In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC). Neuromolecular Med. 2014;16:551-64 pubmed publisher

Jacob A, Singh R, Mohammad F, Bebee T, Chandler D. The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA. J Biol Chem. 2014;289:17350-64 pubmed publisher

Gruol D, Vo K, Bray J, Roberts A. CCL2-ethanol interactions and hippocampal synaptic protein expression in a transgenic mouse model. Front Integr Neurosci. 2014;8:29 pubmed publisher

Klaus C, Kaemmerer E, Reinartz A, Schneider U, Plum P, Jeon M, et al. TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas. Cell Tissue Res. 2014;357:267-78 pubmed publisher

Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A, van der Vos K, Burgering B, et al. The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway. Biochem J. 2014;460:25-34 pubmed publisher

Sahlberg S, Spiegelberg D, Glimelius B, Stenerlow B, Nestor M. Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS ONE. 2014;9:e94621 pubmed publisher

Shi W, Ogbomo S, Wagh N, Zhou Z, Jia Y, Brusnahan S, et al. The influence of linker length on the properties of cathepsin S cleavable (177)Lu-labeled HPMA copolymers for pancreatic cancer imaging. Biomaterials. 2014;35:5760-70 pubmed publisher

O Sullivan D, Henry M, Joyce H, Walsh N, Mc Auley E, Dowling P, et al. 7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells. Tumour Biol. 2014;35:6983-97 pubmed publisher

Gonzalez Rodriguez A, Mayoral R, Agra N, Valdecantos M, Pardo V, Miquilena Colina M, et al. Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD. Cell Death Dis. 2014;5:e1179 pubmed publisher

Juan W, Roca X, Ong S. Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing. PLoS ONE. 2014;9:e95210 pubmed publisher

Calabrese B, Saffin J, Halpain S. Activity-dependent dendritic spine shrinkage and growth involve downregulation of cofilin via distinct mechanisms. PLoS ONE. 2014;9:e94787 pubmed publisher

Veronese A, Pepe F, Chiacchia J, Pagotto S, Lanuti P, Veschi S, et al. Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. Leukemia. 2015;29:86-95 pubmed publisher

Tobin G, Zhang J, Goodwin D, Stewart S, Xu L, Knapton A, et al. The role of eNOS phosphorylation in causing drug-induced vascular injury. Toxicol Pathol. 2014;42:709-24 pubmed publisher

Han X, Cheng D, Song F, Zeng T, An L, Xie K. Decelerated transport and its mechanism of 2,5-hexanedione on middle-molecular-weight neurofilament in rat dorsal root ganglia cells. Neuroscience. 2014;269:192-8 pubmed publisher

Rodier M, Prigent Tessier A, B jot Y, Jacquin A, Mossiat C, Marie C, et al. Exogenous t-PA administration increases hippocampal mature BDNF levels. plasmin- or NMDA-dependent mechanism?. PLoS ONE. 2014;9:e92416 pubmed publisher

Scharfmann R, Pechberty S, Hazhouz Y, von Bülow M, Bricout Neveu E, Grenier Godard M, et al. Development of a conditionally immortalized human pancreatic ? cell line. J Clin Invest. 2014;124:2087-98 pubmed publisher

Balk Møller E, Kim J, Hopkinson B, Timmermans Wielenga V, Petersen O, Villadsen R. A marker of endocrine receptor-positive cells, CEACAM6, is shared by two major classes of breast cancer: luminal and HER2-enriched. Am J Pathol. 2014;184:1198-208 pubmed publisher

Morrison J, Pike L, Sams S, Sharma V, Zhou Q, Severson J, et al. Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer. Mol Cancer. 2014;13:62 pubmed publisher

Boudoukha S, Rivera Vargas T, Dang I, Kropp J, Cuvellier S, Gautreau A, et al. MiRNA let-7g regulates skeletal myoblast motility via Pinch-2. FEBS Lett. 2014;588:1623-9 pubmed publisher

Ahmed N, Iu J, Brown C, Taylor D, Kandel R. Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction. Tissue Eng Part A. 2014;20:2224-33 pubmed publisher

Jha P, Knopf A, Koefeler H, Mueller M, Lackner C, Hoefler G, et al. Role of adipose tissue in methionine-choline-deficient model of non-alcoholic steatohepatitis (NASH). Biochim Biophys Acta. 2014;1842:959-70 pubmed publisher

Ekman M, Uvelius B, Albinsson S, Swärd K. HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Lab Invest. 2014;94:557-68 pubmed publisher

Fernandez Estevez M, Casarejos M, Lopez Sendon J, Garcia Caldentey J, Ruiz C, Gomez A, et al. Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition. PLoS ONE. 2014;9:e90202 pubmed publisher

Herve D, Philippi A, Belbouab R, Zerah M, Chabrier S, Collardeau Frachon S, et al. Loss of ?1?1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia. Am J Hum Genet. 2014;94:385-94 pubmed publisher

López Farré A, Modrego J, Azcona L, Guerra R, Segura A, Rodriguez P, et al. Nitric oxide from mononuclear cells may be involved in platelet responsiveness to aspirin. Eur J Clin Invest. 2014;44:463-9 pubmed publisher

Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher

Hwang W, Jiang J, Yang S, Huang T, Lan H, Teng H, et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-80 pubmed publisher

Qi Y, Zhang M, Li H, Frank J, Dai L, Liu H, et al. MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1/RAX/PKR cascade. J Biol Chem. 2014;289:10201-10 pubmed publisher

Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, et al. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 2014;34:1576-93 pubmed publisher

Akiyama M, Izumi H, Wang K, Yamaguchi T, Kuma A, Kitamura N, et al. Hypersensitivity to aurora kinase inhibitors in cells resistant against platinum- containing anticancer agents. Anticancer Agents Med Chem. 2014;14:1042-50 pubmed

Muenyi C, Trivedi A, Helm C, States J. Cisplatin plus sodium arsenite and hyperthermia induces pseudo-G1 associated apoptotic cell death in ovarian cancer cells. Toxicol Sci. 2014;139:74-82 pubmed publisher

Kilander M, Petersen J, Andressen K, Ganji R, Levy F, Schuster J, et al. Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6. FASEB J. 2014;28:2293-305 pubmed publisher

Anastasía A, Deinhardt K, Wang S, Martin L, Nichol D, Irmady K, et al. Trkb signaling in pericytes is required for cardiac microvessel stabilization. PLoS ONE. 2014;9:e87406 pubmed publisher

Matthess Y, Raab M, Knecht R, Becker S, Strebhardt K. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. Mol Oncol. 2014;8:596-608 pubmed publisher

Dhar S, Alam H, Li N, Wagner K, Chung J, Ahn Y, et al. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014;289:7483-96 pubmed publisher

Tuttle T, Hugo E, Tong W, Ben Jonathan N. Placental lactogen is expressed but is not translated into protein in breast cancer. PLoS ONE. 2014;9:e87325 pubmed publisher

Prensner J, Chen W, Iyer M, Cao Q, Ma T, Han S, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 2014;74:1651-60 pubmed publisher

Galicia Vázquez G, Di Marco S, Lian X, Ma J, Gallouzi I, Pelletier J. Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation. PLoS ONE. 2014;9:e87237 pubmed publisher

Jordan N, Dutkowski C, Barrow D, Mottram H, Hutcheson I, Nicholson R, et al. Impact of dual mTORC1/2 mTOR kinase inhibitor AZD8055 on acquired endocrine resistance in breast cancer in vitro. Breast Cancer Res. 2014;16:R12 pubmed publisher

Kempf A, Tews B, Arzt M, Weinmann O, Obermair F, Pernet V, et al. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol. 2014;12:e1001763 pubmed publisher

Massimino M, Consoli M, Mesuraca M, Stagno F, Tirrò E, Stella S, et al. IRF5 is a target of BCR-ABL kinase activity and reduces CML cell proliferation. Carcinogenesis. 2014;35:1132-43 pubmed publisher

Salvi M, Raiborg C, Hanson P, Campsteijn C, Stenmark H, Pinna L. CK2 involvement in ESCRT-III complex phosphorylation. Arch Biochem Biophys. 2014;545:83-91 pubmed publisher

Wadosky K, Rodriguez J, Hite R, Min J, Walton B, Willis M. Muscle RING finger-1 attenuates IGF-I-dependent cardiomyocyte hypertrophy by inhibiting JNK signaling. Am J Physiol Endocrinol Metab. 2014;306:E723-39 pubmed publisher

Denissov S, Hofemeister H, Marks H, Kranz A, Ciotta G, Singh S, et al. Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant. Development. 2014;141:526-37 pubmed publisher

Syedain Z, Meier L, Lahti M, Johnson S, Tranquillo R. Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery. Tissue Eng Part A. 2014;20:1726-34 pubmed publisher

Rouhigharabaei L, Finalet Ferreiro J, Tousseyn T, van der Krogt J, Put N, Haralambieva E, et al. Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1. PLoS ONE. 2014;9:e85851 pubmed publisher

Moore R, Tao W, Meng Y, Smith E, Xu X. Cell adhesion and sorting in embryoid bodies derived from N- or E-cadherin deficient murine embryonic stem cells. Biol Open. 2014;3:121-8 pubmed publisher

Heyne K, Förster J, Schüle R, Roemer K. Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2. Nucleic Acids Res. 2014;42:3565-79 pubmed publisher

Stahlschmidt W, Robertson M, Robinson P, McCluskey A, Haucke V. Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors. J Biol Chem. 2014;289:4906-18 pubmed publisher

Doherty B, Lawlor D, Gillet J, Gottesman M, O Leary J, Stordal B. Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells. Anticancer Res. 2014;34:503-7 pubmed

Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher

Ahn J, Jang J, Choi J, Lee J, Oh S, Lee J, et al. GSK3?, but not GSK3?, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of rapamycin complex1. Stem Cells Dev. 2014;23:1121-33 pubmed publisher

Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno S, et al. Loss of aPKC? in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. PLoS ONE. 2013;8:e84036 pubmed publisher

Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges Labouesse E, Menko A. ?6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2014;289:3842-55 pubmed publisher

Borghgraef P, Menuet C, Theunis C, Louis J, Devijver H, Maurin H, et al. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS ONE. 2013;8:e84442 pubmed publisher

Adhikary G, Grun D, Kerr C, Balasubramanian S, Rorke E, Vemuri M, et al. Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. PLoS ONE. 2013;8:e84324 pubmed publisher

Sahlberg S, Gustafsson A, Pendekanti P, Glimelius B, Stenerlow B. The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. Tumour Biol. 2014;35:3525-34 pubmed publisher

Sharma Walia N, Chandran K, Patel K, Veettil M, Marginean A. The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. J Virol. 2014;88:2131-56 pubmed publisher

Xavier J, Morgado A, Sola S, Rodrigues C. Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress. Antioxid Redox Signal. 2014;21:1009-24 pubmed publisher

Feng Y, Wu H, Xu Y, Zhang Z, Liu T, Lin X, et al. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-? signaling. J Biol Chem. 2014;289:2072-83 pubmed publisher

Wu C, Ko J, Chen S, Lin Y, Han C, Yang T, et al. Clinical implications of aldo-keto reductase family 1 member C3 and its relationship with lipocalin 2 in cancer of the uterine cervix. Gynecol Oncol. 2014;132:474-82 pubmed publisher

Holtzhausen A, Golzio C, How T, Lee Y, Schiemann W, Katsanis N, et al. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014;28:1248-67 pubmed publisher

Wagner M, Koslowski M, Paret C, Schmidt M, Tureci O, Sahin U. NCOA3 is a selective co-activator of estrogen receptor ?-mediated transactivation of PLAC1 in MCF-7 breast cancer cells. BMC Cancer. 2013;13:570 pubmed publisher

Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher

Sandow J, Dorstyn L, O Reilly L, Tailler M, Kumar S, Strasser A, et al. ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis. Cell Death Differ. 2014;21:475-80 pubmed publisher

Nakajima T, Yanagihara M, Nishii H. Temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia. J Neurol Sci. 2014;337:25-37 pubmed publisher

Lam T, Thomas L, White C, Li G, Pone E, Xu Z, et al. Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS ONE. 2013;8:e80414 pubmed publisher

Rubio N, Verrax J, Dewaele M, Verfaillie T, Johansen T, Piette J, et al. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radic Biol Med. 2014;67:292-303 pubmed publisher

Han J, Rho S, Lee J, Bae J, Park S, Lee S, et al. Human cytomegalovirus (HCMV) US2 protein interacts with human CD1d (hCD1d) and down-regulates invariant NKT (iNKT) cell activity. Mol Cells. 2013;36:455-64 pubmed publisher

Singh A, Zapata M, Choi Y, Yoon S. GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation. Cell Cycle. 2014;13:157-66 pubmed publisher

Wu H, Balsbaugh J, Chandler H, Georgilis A, Zullow H, Shabanowitz J, et al. Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. J Biol Chem. 2013;288:36398-408 pubmed publisher

Formosa A, Markert E, Lena A, Italiano D, Finazzi Agrò E, Levine A, et al. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. Oncogene. 2014;33:5173-82 pubmed publisher

Bana E, Sibille E, Valente S, Cerella C, Chaimbault P, Kirsch G, et al. A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. Mol Carcinog. 2015;54:229-41 pubmed publisher

Gastaldello S, Chen X, Callegari S, Masucci M. Caspase-1 promotes Epstein-Barr virus replication by targeting the large tegument protein deneddylase to the nucleus of productively infected cells. PLoS Pathog. 2013;9:e1003664 pubmed publisher

Ni H, Du K, You M, Ding W. Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol. 2013;183:1815-1825 pubmed publisher

Bray K, Gillette M, Young J, Loughran E, Hwang M, Sears J, et al. Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration. Breast Cancer Res. 2013;15:R91 pubmed

Soler A, Serra H, Pearce W, Angulo A, Guillermet Guibert J, Friedman L, et al. Inhibition of the p110? isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis. J Exp Med. 2013;210:1937-45 pubmed publisher

Fatemi S, Folsom T, Rooney R, Thuras P. Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. Transl Psychiatry. 2013;3:e303 pubmed publisher

Yi X, Pashaj A, Xia M, Moreau R. Reversal of obesity-induced hypertriglyceridemia by (R)-?-lipoic acid in ZDF (fa/fa) rats. Biochem Biophys Res Commun. 2013;439:390-5 pubmed publisher

Subramanian V, Moorleghen J, Balakrishnan A, Howatt D, Chishti A, Uchida H. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS ONE. 2013;8:e72214 pubmed publisher

O Brien M, Carbin S, Morrison J, Smith T. Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy. Reprod Biol Endocrinol. 2013;11:79 pubmed publisher

Garcia Jove Navarro M, Basset C, Arcondeguy T, Touriol C, Perez G, Prats H, et al. Api5 contributes to E2F1 control of the G1/S cell cycle phase transition. PLoS ONE. 2013;8:e71443 pubmed publisher

Gurung B, Feng Z, Hua X. Menin directly represses Gli1 expression independent of canonical Hedgehog signaling. Mol Cancer Res. 2013;11:1215-22 pubmed publisher

Bucur O, Pennarun B, Stancu A, Nadler M, Muraru M, Bertomeu T, et al. Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP. Apoptosis. 2013;18:1154-62 pubmed publisher

Wong K, Gascoyne D, Brown P, Soilleux E, Snell C, Chen H, et al. Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients. Leukemia. 2014;28:362-72 pubmed publisher

Devi L, Ohno M. Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease. Transl Psychiatry. 2013;3:e284 pubmed publisher

Gurkar A, Chu K, Raj L, Bouley R, Lee S, Kim Y, et al. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun. 2013;4:2189 pubmed publisher

Montiel V, León Gómez E, Bouzin C, Esfahani H, Romero Pérez M, Lobysheva I, et al. Genetic deletion of aquaporin-1 results in microcardia and low blood pressure in mouse with intact nitric oxide-dependent relaxation, but enhanced prostanoids-dependent relaxation. Pflugers Arch. 2014;466:237-51 pubmed publisher

Roux C, Lesueur C, Aligny C, Brasse Lagnel C, Genty D, Marret S, et al. 3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis. Cell Transplant. 2014;23:1425-50 pubmed publisher

Hafko R, Villapol S, Nostramo R, Symes A, Sabban E, Inagami T, et al. Commercially available angiotensin II At? receptor antibodies are nonspecific. PLoS ONE. 2013;8:e69234 pubmed publisher

Puglisi F, Vanni V, Ponterio G, Tassone A, Sciamanna G, Bonsi P, et al. Torsin A Localization in the Mouse Cerebellar Synaptic Circuitry. PLoS ONE. 2013;8:e68063 pubmed publisher

Hou P, Chuang C, Kao C, Chou S, Stone L, Ho H, et al. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res. 2013;41:7753-70 pubmed publisher

Luijten M, Basten S, Claessens T, Vernooij M, Scott C, Janssen R, et al. Birt-Hogg-Dube syndrome is a novel ciliopathy. Hum Mol Genet. 2013;22:4383-97 pubmed publisher

Fatemi S, Folsom T, Rooney R, Thuras P. mRNA and protein expression for novel GABAA receptors ? and ?2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway. Transl Psychiatry. 2013;3:e271 pubmed publisher

Rajendran P, Kidane A, Yu T, Dashwood W, Bisson W, LOHR C, et al. HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics. 2013;8:612-23 pubmed publisher

Shibata K, Nakahara S, Shimizu E, Yamashita T, Matsuki N, Koyama R. Repulsive guidance molecule a regulates hippocampal mossy fiber branching in vitro. Neuroreport. 2013;24:609-15 pubmed publisher

Zhang X, Hernandez I, Rei D, Mair W, Laha J, Cornwell M, et al. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem. 2013;288:22042-56 pubmed publisher

Gillette M, Bray K, Blumenthaler A, Vargo Gogola T. P190B RhoGAP overexpression in the developing mammary epithelium induces TGF?-dependent fibroblast activation. PLoS ONE. 2013;8:e65105 pubmed publisher

Takasugi M, Hayakawa K, Arai D, Shiota K. Age- and sex-dependent DNA hypomethylation controlled by growth hormone in mouse liver. Mech Ageing Dev. 2013;134:331-7 pubmed publisher

Huang B, Ray P, Iwasaki K, Tsuji Y. Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J. 2013;27:3763-74 pubmed publisher

Mobasher M, Gonzalez Rodriguez A, Santamaria B, Ramos S, Martin M, Goya L, et al. Protein tyrosine phosphatase 1B modulates GSK3?/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death Dis. 2013;4:e626 pubmed publisher

Sharma A, Diecke S, Zhang W, Lan F, He C, Mordwinkin N, et al. The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J Biol Chem. 2013;288:18439-47 pubmed publisher

Nguyen H, Hübener J, Weber J, Grueninger S, Riess O, Weiss A. Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice. PLoS ONE. 2013;8:e62043 pubmed publisher

Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed publisher

Moreno A, Soleto I, García Sanz P, Moreno Bueno G, Palmero I. ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth. Oncogene. 2014;33:1945-53 pubmed publisher

Rodriguez Martin T, Cuchillo Ibanez I, Noble W, Nyenya F, Anderton B, Hanger D. Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging. 2013;34:2146-57 pubmed publisher

Mandemakers W, Abuhatzira L, Xu H, Caromile L, Hébert S, Snellinx A, et al. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 ?: identification of miR-153 target genes with functions related to IA-2? in pancreas and brain. Diabetologia. 2013;56:1547-56 pubmed publisher

Ipenberg I, Guttmann Raviv N, Khoury H, Kupershmit I, Ayoub N. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem. 2013;288:14681-7 pubmed publisher

Vanoirbeek E, Eelen G, Verlinden L, Carmeliet G, Mathieu C, Bouillon R, et al. PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D. Oncogene. 2014;33:1904-11 pubmed publisher

Gurung B, Feng Z, Iwamoto D, Thiel A, Jin G, Fan C, et al. Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome. Cancer Res. 2013;73:2650-8 pubmed publisher

Avena P, Anselmo W, Whitaker Menezes D, Wang C, Pestell R, Lamb R, et al. Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle. 2013;12:1360-70 pubmed publisher

Ward J, Rider V, Abdou N, Kimler B. Estradiol differentially regulates calreticulin: a potential link with abnormal T cell function in systemic lupus erythematosus?. Lupus. 2013;22:583-96 pubmed publisher

Mitterberger M, Zwerschke W. Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes. J Gerontol A Biol Sci Med Sci. 2013;68:1356-76 pubmed publisher

Fu H, Sohail A, Valiathan R, Wasinski B, Kumarasiri M, Mahasenan K, et al. Shedding of discoidin domain receptor 1 by membrane-type matrix metalloproteinases. J Biol Chem. 2013;288:12114-29 pubmed publisher

Dellago H, Preschitz Kammerhofer B, Terlecki Zaniewicz L, Schreiner C, Fortschegger K, Chang M, et al. High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan. Aging Cell. 2013;12:446-58 pubmed publisher

Yamada H, Abe T, Satoh A, Okazaki N, Tago S, Kobayashi K, et al. Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia. J Neurosci. 2013;33:4514-26 pubmed publisher

Werwein E, Dzuganova M, Usadel C, Klempnauer K. B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. Cell Death Dis. 2013;4:e511 pubmed publisher

Caldon C, Sergio C, Burgess A, Deans A, Sutherland R, Musgrove E. Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1. Cell Cycle. 2013;12:606-17 pubmed publisher

Petrie C, Smithson L, Crotty A, Michalski B, Fahnestock M, Kawaja M. Overexpression of nerve growth factor by murine smooth muscle cells: role of the p75 neurotrophin receptor on sympathetic and sensory sprouting. J Comp Neurol. 2013;521:2621-43 pubmed publisher

Balaburski G, Leu J, Beeharry N, Hayik S, Andrake M, Zhang G, et al. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res. 2013;11:219-29 pubmed publisher

Maute R, Schneider C, Sumazin P, Holmes A, Califano A, Basso K, et al. tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma. Proc Natl Acad Sci U S A. 2013;110:1404-9 pubmed publisher

Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS ONE. 2012;7:e52810 pubmed publisher

Nagakura A, Shitaka Y, Yarimizu J, Matsuoka N. Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine. Eur J Pharmacol. 2013;703:53-61 pubmed publisher

Sánchez Alvarez R, Martinez Outschoorn U, Lin Z, Lamb R, Hulit J, Howell A, et al. Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention. Cell Cycle. 2013;12:289-301 pubmed publisher

Sánchez Alvarez R, Martinez Outschoorn U, Lamb R, Hulit J, Howell A, Gandara R, et al. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle. 2013;12:172-82 pubmed publisher

Landry W, Woolley J, Cotter T. Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox. Leuk Res. 2013;37:183-9 pubmed publisher

Ballarino M, Jobert L, Dembele D, de la Grange P, Auboeuf D, Tora L. TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs. Oncogene. 2013;32:4646-55 pubmed publisher

Godinho B, Ogier J, Darcy R, O Driscoll C, Cryan J. Self-assembling modified ?-cyclodextrin nanoparticles as neuronal siRNA delivery vectors: focus on Huntington's disease. Mol Pharm. 2013;10:640-9 pubmed publisher

Einheber S, MENG X, Rubin M, Lam I, Mohandas N, An X, et al. The 4.1B cytoskeletal protein regulates the domain organization and sheath thickness of myelinated axons. Glia. 2013;61:240-53 pubmed publisher

Gallo M, Ho J, Coutinho F, Vanner R, Lee L, Head R, et al. A tumorigenic MLL-homeobox network in human glioblastoma stem cells. Cancer Res. 2013;73:417-27 pubmed publisher

Oliva A, Kang Y, Furones C, Alonso O, Bruno O, Dietrich W, et al. Phosphodiesterase isoform-specific expression induced by traumatic brain injury. J Neurochem. 2012;123:1019-29 pubmed publisher

Wu S, Shin J, Sepich D, Solnica Krezel L. Chemokine GPCR signaling inhibits β-catenin during zebrafish axis formation. PLoS Biol. 2012;10:e1001403 pubmed publisher

Salem A, Howell A, Sartini M, Sotgia F, Lisanti M. Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1?, autophagy and ketone body production. Cell Cycle. 2012;11:4167-73 pubmed publisher

Marchetti P, Lupi R, Bugliani M, Kirkpatrick C, Sebastiani G, Grieco F, et al. A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. Diabetologia. 2012;55:3262-72 pubmed publisher

Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, et al. Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes. Cell Stress Chaperones. 2012;17:757-63 pubmed publisher

Deschacht M, Van Assche T, Hendrickx S, Bult H, Maes L, Cos P. Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection. Parasitology. 2012;139:1429-37 pubmed publisher

Chao H, Lai Y, Lu Y, Lin C, Mai W, Huang Y. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Nucleic Acids Res. 2012;40:8484-98 pubmed

Osterloh J, Yang J, Rooney T, Fox A, Adalbert R, Powell E, et al. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012;337:481-4 pubmed publisher

Shimada I, LeComte M, Granger J, Quinlan N, Spees J. Self-renewal and differentiation of reactive astrocyte-derived neural stem/progenitor cells isolated from the cortical peri-infarct area after stroke. J Neurosci. 2012;32:7926-40 pubmed publisher

Wu C, Tang S, Wang P, Lee H, Ko J. Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem. 2012;287:25292-302 pubmed publisher

Zhou F, Zhang X, van Dam H, Ten Dijke P, Huang H, Zhang L. Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation. J Biol Chem. 2012;287:11002-10 pubmed publisher

Badeaux A, Yang Y, Cardenas K, Vemulapalli V, Chen K, Kusewitt D, et al. Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem. 2012;287:429-37 pubmed publisher

Balsas P, Galán Malo P, Marzo I, Naval J. Bortezomib resistance in a myeloma cell line is associated to PSM?5 overexpression and polyploidy. Leuk Res. 2012;36:212-8 pubmed publisher

Wang W, Wu S, Lee A, Chiang C. Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription. J Biol Chem. 2011;286:40974-86 pubmed publisher

Wang Z, Zhang Y, Zhang S, Guo Q, Tan Y, Wang X, et al. DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. Mol Neurodegener. 2011;6:38 pubmed publisher

Ariumi Y, Kuroki M, Kushima Y, Osugi K, Hijikata M, Maki M, et al. Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol. 2011;85:6882-92 pubmed publisher

Mouton Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, et al. PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-? activation in mouse models of Down syndrome. J Comp Neurol. 2011;519:2779-802 pubmed publisher

Kawaja M, Smithson L, Elliott J, Trinh G, Crotty A, Michalski B, et al. Nerve growth factor promoter activity revealed in mice expressing enhanced green fluorescent protein. J Comp Neurol. 2011;519:2522-45 pubmed publisher

Karius T, Schnekenburger M, Ghelfi J, Walter J, Dicato M, Diederich M. Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. Biochem Pharmacol. 2011;81:1329-42 pubmed publisher

Wan F, Weaver A, Gao X, Bern M, Hardwidge P, Lenardo M. IKK? phosphorylation regulates RPS3 nuclear translocation and NF-?B function during infection with Escherichia coli strain O157:H7. Nat Immunol. 2011;12:335-43 pubmed publisher

Kapoor A, Goldberg M, Cumberland L, Ratnakumar K, Segura M, Emanuel P, et al. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature. 2010;468:1105-9 pubmed publisher

Day T, Palle K, Barkley L, Kakusho N, Zou Y, Tateishi S, et al. Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication. J Cell Biol. 2010;191:953-66 pubmed publisher

Modi H, Li L, Chu S, Rossi J, Yee J, Bhatia R. Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. Leukemia. 2011;25:305-12 pubmed publisher

Schwartz C, Cheng A, Mughal M, Mattson M, Yao P. Clathrin assembly proteins AP180 and CALM in the embryonic rat brain. J Comp Neurol. 2010;518:3803-18 pubmed publisher

Kurz A, Double K, Lastres Becker I, Tozzi A, Tantucci M, Bockhart V, et al. A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice. PLoS ONE. 2010;5:e11464 pubmed publisher

Magnus N, Garnier D, Rak J. Oncogenic epidermal growth factor receptor up-regulates multiple elements of the tissue factor signaling pathway in human glioma cells. Blood. 2010;116:815-8 pubmed publisher

Wang W, Schwemmers S, Hexner E, Pahl H. AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Blood. 2010;116:254-66 pubmed publisher

Koschny R, Holland H, Sykora J, Erdal H, Krupp W, Bauer M, et al. Bortezomib sensitizes primary human esthesioneuroblastoma cells to TRAIL-induced apoptosis. J Neurooncol. 2010;97:171-85 pubmed publisher

Furmanski O, Gajavelli S, Lee J, Collado M, Jergova S, Sagen J. Combined extrinsic and intrinsic manipulations exert complementary neuronal enrichment in embryonic rat neural precursor cultures: an in vitro and in vivo analysis. J Comp Neurol. 2009;515:56-71 pubmed publisher

Nichols G, Schaack J, Ornelles D. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. J Virol. 2009;83:5987-98 pubmed publisher

Zhang J, Kundu M, Ney P. Mitophagy in mammalian cells: the reticulocyte model. Methods Enzymol. 2009;452:227-45 pubmed publisher

Tuomela S, Rautajoki K, Moulder R, Nyman T, Lahesmaa R. Identification of novel Stat6 regulated proteins in IL-4-treated mouse lymphocytes. Proteomics. 2009;9:1087-98 pubmed publisher

Ito K, Inoue K, Bae S, Ito Y. Runx3 expression in gastrointestinal tract epithelium: resolving the controversy. Oncogene. 2009;28:1379-84 pubmed publisher

Papadeas S, Halloran C, McCown T, Breese G, Blake B. Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. J Comp Neurol. 2008;511:271-85 pubmed publisher

Sejersen H, Rattan S. Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts. Biogerontology. 2009;10:203-11 pubmed publisher

Sui J, Zhang J, Tan T, Ching C, Chen W. Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS. Mol Cell Proteomics. 2008;7:1007-18 pubmed publisher

Strauss G, Westhoff M, Fischer Posovszky P, Fulda S, Schanbacher M, Eckhoff S, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008;15:332-43 pubmed

Daniele L, Adams R, Durante D, Pugh E, Philp N. Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epithelium. J Comp Neurol. 2007;505:166-76 pubmed

Koschny R, Ganten T, Sykora J, Haas T, Sprick M, Kolb A, et al. TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology. 2007;45:649-58 pubmed

Spada F, Haemmer A, Kuch D, Rothbauer U, Schermelleh L, Kremmer E, et al. DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol. 2007;176:565-71 pubmed

Tanno B, Vitali R, De Arcangelis D, Mancini C, Eleuteri P, Dominici C, et al. Bim-dependent apoptosis follows IGFBP-5 down-regulation in neuroblastoma cells. Biochem Biophys Res Commun. 2006;351:547-52 pubmed

Han H, Karabiyikoglu M, Kelly S, Sobel R, Yenari M. Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke. J Cereb Blood Flow Metab. 2003;23:589-98 pubmed

Shinoura N, Sakurai S, Shibasaki F, Asai A, Kirino T, Hamada H. Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas. Br J Cancer. 2002;86:587-95 pubmed

Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Over-expression of APAF-1 and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells. Int J Cancer. 2001;93:252-61 pubmed

Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H. Co-transduction of Apaf-1 and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells. Jpn J Cancer Res. 2001;92:467-74 pubmed

Chen Y, Chen C, Chien C, Su Y, Luo S, Li S. Overexpression of UTX promotes tumor progression in Oral tongue squamous cell carcinoma patients receiving surgical resection: a case control study. BMC Cancer. 2021;21:979 pubmed publisher

Tobacyk J, Kc G, Macmillan Crow L. Overexpression of MnSOD Protects against Cold Storage-Induced Mitochondrial Injury but Not against OMA1-Dependent OPA1 Proteolytic Processing in Rat Renal Proximal Tubular Cells. Antioxidants (Basel). 2021;10: pubmed publisher

Samson J, Derlipanska M, Zaheed O, Dean K. Molecular and cellular characterization of two patient-derived ductal carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC-010. BMC Cancer. 2021;21:790 pubmed publisher

Saura Esteller J, Sánchez Vera I, Núñez Vázquez S, Cosialls A, Gama Pérez P, Bhosale G, et al. Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines. Int J Mol Sci. 2021;22: pubmed publisher

Xu S, Wu X, Wang P, Cao S, Peng B, Xu X. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience. 2021;24:102534 pubmed publisher

Anderson M, Zhang Q, Rodriguez L, Hecquet C, Donawho C, Ansell P, et al. ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition. BMC Cancer. 2021;21:681 pubmed publisher

Baik S, Selvaraji S, Fann D, Poh L, Jo D, Herr D, et al. Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging. Aging (Albany NY). 2021;13:14651-14674 pubmed publisher

Potteti H, Venkareddy L, Noone P, Ankireddy A, Tamatam C, Mehta D, et al. Nrf2 Regulates Anti-Inflammatory A20 Deubiquitinase Induction by LPS in Macrophages in Contextual Manner. Antioxidants (Basel). 2021;10: pubmed publisher

Cai C, Gu S, Yu Y, Zhu Y, Zhang H, Yuan B, et al. PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7. Adv Sci (Weinh). 2021;8:2003047 pubmed publisher

Du F, Yu Q, Yan S, Zhang Z, Vangavaragu J, Chen D, et al. Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer's disease. Aging Cell. 2021;20:e13368 pubmed publisher

Cartaya A, Lutz H, Maiocchi S, Nalesnik M, Bahnson E. Delivery of Cinnamic Aldehyde Antioxidant Response Activating nanoParticles (ARAPas) for Vascular Applications. Antioxidants (Basel). 2021;10: pubmed publisher

García Escudero V, Ruiz Gabarre D, Gargini R, Perez M, Garcia E, Cuadros R, et al. A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease. Acta Neuropathol. 2021;142:159-177 pubmed publisher

Pinto Bravo P, Rebordão M, Amaral A, Fernandes C, Galvão A, Silva E, et al. Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct. Animals (Basel). 2021;11: pubmed publisher

Sánchez Infantes D, Nus M, Navas Madroñal M, Fite J, Perez B, Barros Membrilla A, et al. Oxidative Stress and Inflammatory Markers in Abdominal Aortic Aneurysm. Antioxidants (Basel). 2021;10: pubmed publisher

Wang W, Han R, He H, Li J, Chen S, Gu Y, et al. Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson's disease models. Aging (Albany NY). 2021;13:11738-11751 pubmed publisher

Varona S, Puertas L, Galán M, Orriols M, Cañes L, Aguiló S, et al. Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants (Basel). 2021;10: pubmed publisher

Actis C, Muzio G, Autelli R. Autophagy Triggers Tamoxifen Resistance in Human Breast Cancer Cells by Preventing Drug-Induced Lysosomal Damage. Cancers (Basel). 2021;13: pubmed publisher

Li D, Tang L, Liu B, Xu S, Jin M, Bo W. RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma. Aging (Albany NY). 2021;13:10450-10467 pubmed publisher

Bosa L, Batura V, Colavito D, Fiedler K, Gaio P, Guo C, et al. Novel CARMIL2 loss-of-function variants are associated with pediatric inflammatory bowel disease. Sci Rep. 2021;11:5945 pubmed publisher

Arcones A, Vila Bedmar R, Mirasierra M, Cruces Sande M, Vallejo M, Jones B, et al. GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo. BMC Biol. 2021;19:40 pubmed publisher

Ferreira N, Gonçalves N, Jan A, Jensen N, van der Laan A, Mohseni S, et al. Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. Acta Neuropathol Commun. 2021;9:31 pubmed publisher

Spits M, Heesterbeek I, Voortman L, Akkermans J, Wijdeven R, Cabukusta B, et al. Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture. EMBO Rep. 2021;:e50815 pubmed publisher

Kushwaha R, Sinha A, Makarava N, Molesworth K, Baskakov I. Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases. Acta Neuropathol Commun. 2021;9:22 pubmed publisher

Cheah P, Prabhakar S, Yellen D, Beauchamp R, Zhang X, Kasamatsu S, et al. Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin. Sci Adv. 2021;7: pubmed publisher

Birkisdóttir M, Jaarsma D, Brandt R, Barnhoorn S, van Vliet N, Imholz S, et al. Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice. Aging Cell. 2021;20:e13302 pubmed publisher

Truman J, Ruiz C, Trayssac M, Mao C, Hannun Y, Obeid L. Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. FASEB J. 2021;35:e21284 pubmed publisher

Rey F, Ottolenghi S, Giallongo T, Balsari A, Martinelli C, Rey R, et al. Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson's Disease. Antioxidants (Basel). 2021;10: pubmed publisher

Feng Y, Liu S, Zha R, Sun X, Li K, ROBLING A, et al. Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms. Cancers (Basel). 2021;13: pubmed publisher

Shin H, Jeong E, Lee J, An H, Jang H, Ahn Y, et al. Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death. Antioxidants (Basel). 2021;10: pubmed publisher

Webb L, Fra Bido S, Innocentin S, Matheson L, Attaf N, Bignon A, et al. Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ. Aging Cell. 2021;20:e13295 pubmed publisher

Agrawal P, Blinka S, Pulakanti K, Reimer M, Stelloh C, Meyer A, et al. Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment. J Biol Chem. 2021;296:100189 pubmed publisher

Vara D, Mailer R, Tarafdar A, Wolska N, Heestermans M, Konrath S, et al. NADPH Oxidases Are Required for Full Platelet Activation In Vitro and Thrombosis In Vivo but Dispensable for Plasma Coagulation and Hemostasis. Arterioscler Thromb Vasc Biol. 2021;41:683-697 pubmed publisher

Wang J, Lin Z, Li L, Zhang S, Li W, Liu W, et al. SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1. J Biol Chem. 2021;296:100032 pubmed publisher

Wei F, Jing H, Wei M, Liu L, Wu J, Wang M, et al. Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1. Aging (Albany NY). 2020;12:26199-26220 pubmed publisher

Yuan X, Piao L, Wang L, Han X, Tong L, Shao S, et al. Erythrocyte membrane protein band 4.1-like 3 inhibits osteosarcoma cell invasion through regulation of Snai1-induced epithelial-to-mesenchymal transition. Aging (Albany NY). 2020;13:1947-1961 pubmed publisher

Wasson C, Ross R, Wells R, Corinaldesi C, Georgiou I, Riobo Del Galdo N, et al. Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts. Arthritis Res Ther. 2020;22:286 pubmed publisher

Yu J, Ju J, Musacchio N, Mathias T, Vitolo M. Long Noncoding RNA DANCR Activates Wnt/β-Catenin Signaling through MiR-216a Inhibition in Non-Small Cell Lung Cancer. Biomolecules. 2020;10: pubmed publisher

Vallese F, Catoni C, Cieri D, Barazzuol L, Ramírez O, Calore V, et al. An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo. Nat Commun. 2020;11:6069 pubmed publisher

Zhou L, Huntington K, Zhang S, Carlsen L, So E, Parker C, et al. MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection. Oncotarget. 2020;11:4201-4223 pubmed publisher

Nakajima K, Miranda A, Craig D, Shekhtman T, Kmoch S, Bleyer A, et al. Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice. Transl Psychiatry. 2020;10:407 pubmed publisher

Gutiérrez Miranda B, Gallardo I, Melliou E, Cabero I, Alvarez Y, Magiatis P, et al. Oleacein Attenuates the Pathogenesis of Experimental Autoimmune Encephalomyelitis through Both Antioxidant and Anti-Inflammatory Effects. Antioxidants (Basel). 2020;9: pubmed publisher

BORRAS T, Cowley D, Asokan P, Pandya K. Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye. Sci Rep. 2020;10:18583 pubmed publisher

Ruiz Rodado V, Lita A, Dowdy T, Celiku O, Saldana A, Wang H, et al. Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition. Cancer Metab. 2020;8:23 pubmed publisher

Schuster S, Heuten E, Velic A, Admard J, Synofzik M, Ossowski S, et al. CHIP mutations affect the heat shock response differently in human fibroblasts and iPSC-derived neurons. Dis Model Mech. 2020;13: pubmed publisher

Mandl M, Ritthammer H, Ejaz A, Wagner S, Hatzmann F, Baumgarten S, et al. CRISPR/Cas9-mediated gene knockout in human adipose stem/progenitor cells. Adipocyte. 2020;9:626-635 pubmed publisher

Ide S, Imai R, Ochi H, Maeshima K. Transcriptional suppression of ribosomal DNA with phase separation. Sci Adv. 2020;6: pubmed publisher

Hollinshead K, Parker S, Eapen V, Encarnación Rosado J, Sohn A, Oncu T, et al. Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer. Cell Rep. 2020;33:108231 pubmed publisher

Blankenbach K, Claas R, Aster N, Spohner A, Trautmann S, Ferreirós N, et al. Dissecting Gq/11-Mediated Plasma Membrane Translocation of Sphingosine Kinase-1. Cells. 2020;9: pubmed publisher

Muniraj N, Siddharth S, Shriver M, Nagalingam A, Parida S, Woo J, et al. Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon honokiol treatment. Cell Death Discov. 2020;6:81 pubmed publisher

Talwar D, Messens J, Dick T. A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex. Nat Commun. 2020;11:4512 pubmed publisher

Kooij R, Liu S, Sapmaz A, Xin B, Janssen G, van Veelen P, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020;142:16825-16841 pubmed publisher

He B, Moreau R. R-α-Lipoic Acid and 4-Phenylbutyric Acid Have Distinct Hypolipidemic Mechanisms in Hepatic Cells. Biomedicines. 2020;8: pubmed publisher

Fan J, You L, Wang W, Huang W, Chu C, Chi Y, et al. Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis. EMBO Rep. 2020;21:e49680 pubmed publisher

Yi J, Kim T, Pak J, Chung J. Protective Effects of Glucose-Related Protein 78 and 94 on Cisplatin-Mediated Ototoxicity. Antioxidants (Basel). 2020;9: pubmed publisher

Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, et al. BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy. Acta Neuropathol Commun. 2020;8:120 pubmed publisher

Bayraktar G, Yuanxiang P, Confettura A, Gomes G, Raza S, Stork O, et al. Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus. Neuropsychopharmacology. 2020;45:2120-2130 pubmed publisher

Guo Y, Gu D, Huang T, Cao L, Zhu X, Zhou Y, et al. Essential role of Salmonella Enteritidis DNA adenine methylase in modulating inflammasome activation. BMC Microbiol. 2020;20:226 pubmed publisher

Trümper V, Wittig I, Heidler J, Richter F, Brüne B, von Knethen A. Redox Regulation of PPARγ in Polarized Macrophages. PPAR Res. 2020;2020:8253831 pubmed publisher

Feldker N, Ferrazzi F, Schuhwerk H, Widholz S, Guenther K, Frisch I, et al. Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer. EMBO J. 2020;:e103209 pubmed publisher

Qi Y, Liu J, Chao J, Greer P, Li S. PTEN dephosphorylates Abi1 to promote epithelial morphogenesis. J Cell Biol. 2020;219: pubmed publisher

Guarino Almeida E, Renaudin X, Venkitaraman A. A kinase-independent function for AURORA-A in replisome assembly during DNA replication initiation. Nucleic Acids Res. 2020;: pubmed publisher

Park H, Gholam Zadeh M, Suh J, Choi H. Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts. Antioxidants (Basel). 2020;9: pubmed publisher

Seo G, Han H, Vargas R, Yang B, Li X, Wang W. MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation. Cell Rep. 2020;32:107860 pubmed publisher

Aravani D, Foote K, Figg N, Finigan A, Uryga A, Clarke M, et al. Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells. Apoptosis. 2020;25:648-662 pubmed publisher

Kim Y, Won Y, Lim B, Min T, Kim Y, Lee I. Neuroprotective effects of magnesium L-threonate in a hypoxic zebrafish model. BMC Neurosci. 2020;21:29 pubmed publisher

Geng X, Yanagida K, Akwii R, Choi D, Chen L, Ho Y, et al. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020;5: pubmed publisher

Ando K, Ndjim M, Turbant S, Fontaine G, Pregoni G, Dauphinot L, et al. The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease. Acta Neuropathol Commun. 2020;8:79 pubmed publisher

Martello A, Lauriola A, Mellis D, Parish E, Dawson J, Imrie L, et al. Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. EMBO Rep. 2020;21:e48192 pubmed publisher

Albers E, Avram A, Sbroggiò M, Fernandez Capetillo O, López Contreras A. Supraphysiological protection from replication stress does not extend mammalian lifespan. Aging (Albany NY). 2020;12:5612-5624 pubmed publisher

Palrasu M, Zaika E, El Rifai W, Garcia Buitrago M, Piazuelo M, Wilson K, et al. Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells. J Clin Invest. 2020;130:2422-2434 pubmed publisher

Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, et al. Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Cell Death Dis. 2020;11:214 pubmed publisher

Liu Y, Lu Y, Li A, Celiku O, Han S, Qian M, et al. mTORC2/Rac1 Pathway Predisposes Cancer Aggressiveness in IDH1-Mutated Glioma. Cancers (Basel). 2020;12: pubmed publisher

Costa A, Sousa S, Pinto Costa R, Mateus J, Lopes C, Costa A, et al. The membrane periodic skeleton is an actomyosin network that regulates axonal diameter and conduction. elife. 2020;9: pubmed publisher

Tsai M, Huang C, Wei Y, Liu T, Lin M, Yi L, et al. Combined Chibby and β-Catenin Predicts Clinical Outcomes in Patients with Hepatocellular Carcinoma. Int J Mol Sci. 2020;21: pubmed publisher

Dubois M, Meller A, Samandi S, Brunelle M, Frion J, Brunet M, et al. UBB pseudogene 4 encodes functional ubiquitin variants. Nat Commun. 2020;11:1306 pubmed publisher

Nachtigal A, Milenkovic A, Brandl C, Schulz H, Duerr L, Lang G, et al. Mutation-Dependent Pathomechanisms Determine the Phenotype in the Bestrophinopathies. Int J Mol Sci. 2020;21: pubmed publisher

van Gastel N, Stegen S, Eelen G, Schoors S, Carlier A, Daniëls V, et al. Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature. 2020;579:111-117 pubmed publisher

Kosuge Y, Kaneko E, Nango H, Miyagishi H, Ishige K, Ito Y. Bidens pilosa Extract Administered after Symptom Onset Attenuates Glial Activation, Improves Motor Performance, and Prolongs Survival in a Mouse Model of Amyotrophic Lateral Sclerosis. Oxid Med Cell Longev. 2020;2020:1020673 pubmed publisher

Chojnowski A, Ong P, Foo M, Liebl D, Hor L, Stewart C, et al. Heterochromatin loss as a determinant of progerin-induced DNA damage in Hutchinson-Gilford Progeria. Aging Cell. 2020;19:e13108 pubmed publisher

Odintsova E, Mohammed F, Trieber C, Rodriguez Zamora P, Al Jassar C, Huang T, et al. Binding of the periplakin linker requires vimentin acidic residues D176 and E187. Commun Biol. 2020;3:83 pubmed publisher

Luciani A, Schumann A, Berquez M, Chen Z, Nieri D, Failli M, et al. Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency. Nat Commun. 2020;11:970 pubmed publisher

Marycz K, Sobierajska P, Roecken M, Kornicka Garbowska K, Kepska M, Idczak R, et al. Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action. J Nanobiotechnology. 2020;18:33 pubmed publisher

Zhang Y, Yang K, Yang J, Lao Y, Deng L, Deng G, et al. SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes. Cell Rep. 2020;30:1951-1963.e4 pubmed publisher

Sethi N, Kikuchi O, Duronio G, Stachler M, McFarland J, Ferrer Luna R, et al. Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nat Genet. 2020;52:219-230 pubmed publisher

Shu J, Cui D, Ma Y, Xiong X, Sun Y, Zhao Y. SCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II. Oncogenesis. 2020;9:8 pubmed publisher

Bera R, Chiu M, Huang Y, Huang G, Lee Y, Shih L. DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells. Oncogenesis. 2020;9:7 pubmed publisher

Laperle A, Sances S, Yucer N, Dardov V, García V, Ho R, et al. iPSC modeling of young-onset Parkinson's disease reveals a molecular signature of disease and novel therapeutic candidates. Nat Med. 2020;26:289-299 pubmed publisher

McGinn O, Ward A, Fettig L, Riley D, Ivie J, Paul K, et al. Cytokeratin 5 alters β-catenin dynamics in breast cancer cells. Oncogene. 2020;39:2478-2492 pubmed publisher

Li C, He X, Huang Z, Han L, Wu X, Li L, et al. Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway. Aging (Albany NY). 2020;12:1610-1623 pubmed publisher

Wu J, Tsai H, Hsiao Y, Wu J, Wu C, Tai M. Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition. Int J Mol Sci. 2020;21: pubmed publisher

Wright W, Chenge J, Wang J, Girvan H, Yang L, Chai S, et al. Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem. 2020;63:1415-1433 pubmed publisher

Cotzomi Ortega I, Rosas Cruz A, Ramírez Ramírez D, Reyes Leyva J, Rodriguez Sosa M, Aguilar Alonso P, et al. Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer. Biology (Basel). 2020;9: pubmed publisher

Klee K, Storti F, Maggi J, Todorova V, Karademir D, Berger W, et al. The Expression of Decidual Protein Induced by Progesterone (DEPP) is Controlled by Three Distal Consensus Hypoxia Responsive Element (HRE) in Hypoxic Retinal Epithelial Cells. Genes (Basel). 2020;11: pubmed publisher

Kang Y, Hsu W, Ou C, Tai H, Hsu H, Yeh K, et al. Metformin Mitigates Nickel-Elicited Angiopoietin-Like Protein 4 Expression via HIF-1α for Lung Tumorigenesis. Int J Mol Sci. 2020;21: pubmed publisher

He L, Liu Y, Lai W, Tian H, Chen L, Xie L, et al. DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease. J Cancer. 2020;11:893-905 pubmed publisher

Poddar I, Callahan P, Hernandez C, Pillai A, Yang X, Bartlett M, et al. Chronic oral treatment with risperidone impairs recognition memory and alters brain-derived neurotrophic factor and related signaling molecules in rats. Pharmacol Biochem Behav. 2020;189:172853 pubmed publisher

Goya M, Xue F, Sampedro Torres Quevedo C, Arnaouteli S, Riquelme Dominguez L, Romanowski A, et al. Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans. Cell Rep. 2020;30:367-380.e7 pubmed publisher

Miyajima C, Kawarada Y, Inoue Y, Suzuki C, Mitamura K, Morishita D, et al. Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. Cells. 2020;9: pubmed publisher

Riis S, Murray J, O Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway. Cells. 2020;9: pubmed publisher

Vogt D, Zaver S, Ranjan A, DiMaio T, Gounder A, Smith J, et al. STING is dispensable during KSHV infection of primary endothelial cells. Virology. 2020;540:150-159 pubmed publisher

Prieto I, Alarcón C, Garcia Gomez R, Berdun R, Urgel T, Portero M, et al. Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential. Redox Biol. 2020;29:101396 pubmed publisher

Benny M, Hernández D, Sharma M, Yousefi K, Kulandavelu S, Batlahally S, et al. Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats. Physiol Rep. 2020;8:e14334 pubmed publisher

Chen W, Li Y, Hsu C, Niu C, Pen W, Cheng K, et al. Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation. Mol Med Rep. 2020;21:1390-1398 pubmed publisher

Pirozzi C, Lama A, Annunziata C, Cavaliere G, De Caro C, Citraro R, et al. Butyrate prevents valproate-induced liver injury: In vitro and in vivo evidence. FASEB J. 2020;34:676-690 pubmed publisher

Matsuhisa K, Saito A, Cai L, Kaneko M, Okamoto T, Sakaue F, et al. Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis. FASEB J. 2020;34:865-880 pubmed publisher

Wu D, Dasgupta A, Chen K, Neuber Hess M, Patel J, Hurst T, et al. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020;34:1447-1464 pubmed publisher

Tibaldi E, Brocca A, Sticca A, Gola E, Pizzi M, Bordin L, et al. Fam20C-mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis. FASEB J. 2020;34:1122-1135 pubmed publisher

Kasahara T, Kubota Sakashita M, Nagatsuka Y, Hirabayashi Y, Hanasaka T, Tohyama K, et al. Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. FASEB J. 2020;34:1465-1480 pubmed publisher

Affronti H, Rowsam A, Pellerite A, Rosario S, Long M, Jacobi J, et al. Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy. Nat Commun. 2020;11:52 pubmed publisher

Zhao E, Shen Y, Amir M, Farris A, Czaja M. Stathmin 1 Induces Murine Hepatocyte Proliferation and Increased Liver Mass. Hepatol Commun. 2020;4:38-49 pubmed publisher

Komarynets O, Chassot A, Bernabeu E, Czogalla J, Roth I, Liaudet N, et al. Aldosterone controls primary cilium length and cell size in renal collecting duct principal cells. FASEB J. 2020;34:2625-2640 pubmed publisher

Piers T, Cosker K, Mallach A, Johnson G, Guerreiro R, Hardy J, et al. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB J. 2020;34:2436-2450 pubmed publisher

Ferrari A, Longo R, Peri C, Coppi L, Caruso D, Mai A, et al. Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865:158594 pubmed publisher

Bibbo S, Lamolinara A, Capone E, Purgato S, Tsakaneli A, Panella V, et al. Repurposing a psychoactive drug for children with cancer: p27Kip1-dependent inhibition of metastatic neuroblastomas by Prozac. Oncogenesis. 2020;9:3 pubmed publisher

Ollauri Ibáñez C, Núñez Gómez E, Egido Turrión C, Silva Sousa L, Diaz Rodriguez E, Rodriguez Barbero A, et al. Continuous endoglin (CD105) overexpression disrupts angiogenesis and facilitates tumor cell metastasis. Angiogenesis. 2020;23:231-247 pubmed publisher

Zhang X, Liu P, Shang Y, Kerndl H, Kumstel S, Gong P, et al. Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1. J Cancer. 2020;11:479-487 pubmed publisher

Suwanmanee G, Yosudjai J, Phimsen S, Wongkham S, Jirawatnotai S, Kaewkong W. Upregulation of AGR2vH facilitates cholangiocarcinoma cell survival under endoplasmic reticulum stress via the activation of the unfolded protein response pathway. Int J Mol Med. 2020;45:669-677 pubmed publisher

Chen Y, Lu H, Lo C, Hsiao C, Li S. NOX4 overexpression is a poor prognostic factor in patients undergoing curative esophagectomy for esophageal squamous cell carcinoma. Surgery. 2020;167:620-627 pubmed publisher

Kline K, Lian H, Zhong X, Luo X, Winston J, Cong Y, et al. Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood. J Immunol. 2020;204:980-989 pubmed publisher

Hu T, Zhang N, Ruan Y, Tan Q, Wang J. Hydrogen sulfide modulates high glucose-induced NLRP3 inflammasome activation in 3T3-L1 adipocytes. Exp Ther Med. 2020;19:771-776 pubmed publisher

Lin W, Bwayi M, Wu J, Li Y, Chai S, Huber A, et al. CITCO Directly Binds to and Activates Human Pregnane X Receptor. Mol Pharmacol. 2020;97:180-190 pubmed publisher

Cabrera Cruz H, Oróstica L, Plaza Parrochia F, Torres Pinto I, Romero C, Vega M. The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment. Am J Physiol Endocrinol Metab. 2020;318:E237-E248 pubmed publisher

Hong J, Moon J, Park S. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020;119:105680 pubmed publisher

Matsubara T, Yaginuma T, Addison W, Fujita Y, Watanabe K, Yoshioka I, et al. Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2. Bone. 2020;132:115209 pubmed publisher

Seo B, Jeon K, Moon S, Lee K, Kim W, Jeong H, et al. Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice. Cell Host Microbe. 2020;27:25-40.e6 pubmed publisher

Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto R, Wada H, et al. The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation. Lab Invest. 2020;100:311-323 pubmed publisher

Zhao L, Zhao J, Gao R, Tian Y, Zhang Y, Tang W, et al. Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis. Biomed Pharmacother. 2020;123:109783 pubmed publisher

Kubra K, Uddin M, Akhter M, Barabutis N. Hsp90 inhibitors induce the unfolded protein response in bovine and mice lung cells. Cell Signal. 2020;67:109500 pubmed publisher

Wang W, Wang J, Lin W, Kao C, Hung M, Teng Y, et al. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020;19:e13090 pubmed publisher

Qu C, Yan C, Cao W, Li F, Qu Y, Guan K, et al. miR-128-3p contributes to mitochondrial dysfunction and induces apoptosis in glioma cells via targeting pyruvate dehydrogenase kinase 1. IUBMB Life. 2020;72:465-475 pubmed publisher

Fan Q, He W, Gayen M, Benoit M, Luo X, Hu X, et al. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2020;40:1133-1144 pubmed publisher

Zhang J, Jazii F, Haghighi M, Alvares D, Liu L, Khosraviani N, et al. miR-130b is a potent stimulator of hepatic very-low-density lipoprotein assembly and secretion via marked induction of microsomal triglyceride transfer protein. Am J Physiol Endocrinol Metab. 2020;318:E262-E275 pubmed publisher

Ross N, Lohmann F, Carbonneau S, Fazal A, Weihofen W, Gleim S, et al. CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. Nat Chem Biol. 2020;16:50-59 pubmed publisher

Kondrikov D, Elmansi A, Bragg R, Mobley T, Barrett T, Eisa N, et al. Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway. Exp Gerontol. 2020;130:110805 pubmed publisher

Hoffmann D, Dvorakova T, Stroobant V, Bouzin C, Daumerie A, Solvay M, et al. Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers. Cancer Immunol Res. 2020;8:19-31 pubmed publisher

Sah J, Hao N, Han X, Tran T, McCarthy S, Oh Y, et al. Ectonucleotide pyrophosphatase 2 (ENPP2) plays a crucial role in myogenic differentiation through the regulation by WNT/β-Catenin signaling. Int J Biochem Cell Biol. 2020;118:105661 pubmed publisher

Mahajan S, Mellins E, Faccio R. Diacylglycerol Kinase ζ Regulates Macrophage Responses in Juvenile Arthritis and Cytokine Storm Syndrome Mouse Models. J Immunol. 2020;204:137-146 pubmed publisher

Ylitalo E, Thysell E, Thellenberg Karlsson C, Lundholm M, Widmark A, Bergh A, et al. Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens. Prostate. 2020;80:214-224 pubmed publisher

Oshima M, Pechberty S, Bellini L, Gopel S, Campana M, Rouch C, et al. Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity. Diabetologia. 2020;63:395-409 pubmed publisher

Yang C, McDermot D, Pasricha S, Brown A, Bedoui S, Lenz L, et al. IFNγ receptor down-regulation facilitates Legionella survival in alveolar macrophages. J Leukoc Biol. 2020;107:273-284 pubmed publisher

Cho H, Yadav A, Do Y, Heo M, Bishop Bailey D, Lee J, et al. Anti‑survival and pro‑apoptotic effects of meridianin C derivatives on MV4‑11 human acute myeloid leukemia cells. Int J Oncol. 2020;56:368-378 pubmed publisher

Głombik K, Detka J, Goralska J, Kurek A, Solnica B, Budziszewska B. Brain Metabolic Alterations in Rats Showing Depression-Like and Obesity Phenotypes. Neurotox Res. 2020;37:406-424 pubmed publisher

Long C, Lai Y, Li T, Nyunoya T, Zou C. Cigarette smoke extract modulates Pseudomonas aeruginosa bacterial load via USP25/HDAC11 axis in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2020;318:L252-L263 pubmed publisher

Alsabban A, Morikawa M, Tanaka Y, Takei Y, Hirokawa N. Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice. EMBO J. 2020;39:e101090 pubmed publisher

Gao N, Li J, Qin Y, Wang Y, Kang Q, Pei C. SNAI1 interacts with HDAC1 to control TGF‑β2‑induced epithelial‑mesenchymal transition in human lens epithelial cells. Int J Mol Med. 2020;45:265-273 pubmed publisher

Zhang K, Lv D, Li R. Protein inhibitor of activated STAT1 (PIAS1) inhibits IRF8 activation of Epstein-Barr virus lytic gene expression. Virology. 2020;540:75-87 pubmed publisher

He D, Lasek A. Anaplastic Lymphoma Kinase Regulates Internalization of the Dopamine D2 Receptor. Mol Pharmacol. 2020;97:123-131 pubmed publisher

Cheng X, Huang Z, Long D, Jin W. BET inhibitor bromosporine enhances 5-FU effect in colorectal cancer cells. Biochem Biophys Res Commun. 2020;521:840-845 pubmed publisher

Das N, Miyata H, Hara H, Chida J, Uchiyama K, Masujin K, et al. The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region. Mol Neurobiol. 2020;57:1203-1216 pubmed publisher

Culbreth M, Rand M. Methylmercury modifies temporally expressed myogenic regulatory factors to inhibit myoblast differentiation. Toxicol In Vitro. 2020;63:104717 pubmed publisher

Ramlan H, Damanhuri H. Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. Exp Gerontol. 2020;129:110779 pubmed publisher