GSK1120212 (Trametinib) | Selleck Chemicals S2673 product information

product summary

company name :

Selleck Chemicals

product type :

chemical

product name :

GSK1120212 (Trametinib)

catalog :

S2673

quantity :

5 mg

price :

120.00 USD

more info or order :

Selleck Chemicals product webpage

citations: 6

Reference
Strub T, Ghiraldini F, Carcamo S, Li M, Wroblewska A, Singh R, et al. SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. Nat Commun. 2018;9:3440 pubmed publisher
Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
Kemper K, Krijgsman O, Kong X, Cornelissen Steijger P, Shahrabi A, Weeber F, et al. BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts. Cell Rep. 2016;16:263-277 pubmed publisher
Myers A, Lin L, Nancarrow D, Wang Z, Ferrer Torres D, Thomas D, et al. IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma. Oncotarget. 2015;6:25897-916 pubmed publisher
Kemper K, Krijgsman O, Cornelissen Steijger P, Shahrabi A, Weeber F, Song J, et al. Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts. EMBO Mol Med. 2015;7:1104-18 pubmed publisher
Zinn R, Gardner E, Marchionni L, Murphy S, Dobromilskaya I, Hann C, et al. ERK phosphorylation is predictive of resistance to IGF-1R inhibition in small cell lung cancer. Mol Cancer Ther. 2013;12:1131-9 pubmed publisher

product information

Catalog Number :

S2673

Product Name :

GSK1120212 (Trametinib)

Synonyms :

GSK212, Trametinib

Target :

MEK

CAS Number :

871700-17-3, 871702-06-6 (sodium salt)

Formula :

C26H23FIN5O4

Quantity :

5 mg

List Price :

120.00 USD

Description :

GSK1120212 (Trametinib) is a reversible, selective, allosteric MEK1/MEK2 kinase activity inhibitor with IC50 of 0.7 and 0.9 nM for MEK1 and MEK2. Find all the information about GSK1120212 (Trametinib) for cell signaling research.

Product Type :

Chemical

more info or order :

Selleck Chemicals product webpage