product summary
company name :
Selleck Chemicals
product type :
chemical
product name :
Vemurafenib (PLX4032)
catalog :
S1267
quantity :
10 g
price :
20,700.00 USD
more info or order :
citations: 8
Reference
Wu S, Naar A. SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. Sci Rep. 2019;9:10369 pubmed publisher
Phung B, Ciesla M, Sanna A, Guzzi N, Beneventi G, Cao Thi Ngoc P, et al. The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma. Cell Rep. 2019;27:3573-3586.e7 pubmed publisher
Strub T, Ghiraldini F, Carcamo S, Li M, Wroblewska A, Singh R, et al. SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. Nat Commun. 2018;9:3440 pubmed publisher
Liu R, Zhang T, Zhu G, Xing M. Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer. Nat Commun. 2018;9:579 pubmed publisher
Yue J, Lai F, Beckedorff F, Zhang A, Pastori C, Shiekhattar R. Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs. Genes Dev. 2017;31:1809-1820 pubmed publisher
Kemper K, Krijgsman O, Cornelissen Steijger P, Shahrabi A, Weeber F, Song J, et al. Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts. EMBO Mol Med. 2015;7:1104-18 pubmed publisher
Goodall M, Wang T, Martin K, Kortus M, Kauffman A, Trent J, et al. Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib. Autophagy. 2014;10:1120-36 pubmed publisher
Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature. 2012;483:100-3 pubmed publisher
product information
Catalog Number :
S1267
Product Name :
Vemurafenib (PLX4032)
Synonyms :
RG7204, PLX4032
Target :
Raf
CAS Number :
918504-65-1
Formula :
C23H18ClF2N3O3S
Quantity :
10 g
List Price :
20,700.00 USD
Description :
Vemurafenib (PLX4032) also known as RG7204, R7204 & RO5185426. PLX4032A is a B-raf inhibitor with an IC50 of 44 nM. Find all the information about Vemurafenib (PLX4032) for cell signaling research.
Product Type :
Chemical
more info or order :
company information
Selleck Chemicals
2626 South Loop West, Suite 225
Houston, TX 77054
enquiry@selleckchem.com
http://www.selleckchem.com
877 796-6397
headquarters: USA