product summary
company name :
Selleck Chemicals
product type :
chemical
product name :
MK-2206 2HCl
catalog :
S1078
quantity :
10 g
more info or order :
citations: 21
Reference
Miskin R, Warren J, Ndoye A, Wu L, Lamar J, DiPersio C. Integrin α3β1 Promotes Invasive and Metastatic Properties of Breast Cancer Cells through Induction of the Brn-2 Transcription Factor. Cancers (Basel). 2021;13: pubmed publisher
Glorieux C, Xia X, He Y, Hu Y, Cremer K, Robert A, et al. Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling. Redox Biol. 2021;38:101780 pubmed publisher
Collins M, Stransky L, Forgac M. AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells. J Biol Chem. 2020;295:9433-9444 pubmed publisher
Zhou H, Zeng H, Yuan D, Ren J, Cheng S, Yu H, et al. NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma. Cell Commun Signal. 2019;17:168 pubmed publisher
Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, et al. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Mol Cell. 2019;76:516-527.e7 pubmed publisher
Han R, Hu S, Qin W, Shi J, Hou Q, Wang X, et al. C3a and suPAR drive versican V1 expression in tubular cells of focal segmental glomerulosclerosis. JCI Insight. 2019;4: pubmed publisher
He J, Deng L, Liu H, Chen T, Chen S, Xia S, et al. BCL2L10/BECN1 modulates hepatoma cells autophagy by regulating PI3K/AKT signaling pathway. Aging (Albany NY). 2019;11:350-370 pubmed publisher
Du L, Roberts J. Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling. Am J Physiol Lung Cell Mol Physiol. 2019;316:L20-L34 pubmed publisher
Bernard S, Myers M, Fang W, Zinda B, Smart C, Lambert D, et al. CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms. J Mammary Gland Biol Neoplasia. 2018;23:249-267 pubmed publisher
Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett E. Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches. Mol Biol Cell. 2018;: pubmed publisher
Brolih S, Parks S, Vial V, Durivault J, Mostosi L, Pouyssegur J, et al. AKT1 restricts the invasive capacity of head and neck carcinoma cells harboring a constitutively active PI3 kinase activity. BMC Cancer. 2018;18:249 pubmed publisher
Prasasya R, Mayo K. Notch Signaling Regulates Differentiation and Steroidogenesis in Female Mouse Ovarian Granulosa Cells. Endocrinology. 2018;159:184-198 pubmed publisher
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
Zhang H, Chen F, He Y, Yi L, Ge C, Shi X, et al. Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway. Biosci Rep. 2017;37: pubmed publisher
Lyu L, Wang B, Xiong C, Zhang X, Zhang X, Zhang J. Selective export of autotaxin from the endoplasmic reticulum. J Biol Chem. 2017;292:7011-7022 pubmed publisher
Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S. NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Mol Cell. 2017;65:801-817.e4 pubmed publisher
Lee M, Jeong M, Lee H, Han H, Ko A, Hewitt S, et al. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 2015;6:7769 pubmed publisher
Wan N, Liu X, Zhang X, Zhao Y, Hu G, Wan F, et al. Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis. Br J Pharmacol. 2015;172:3383-96 pubmed publisher
Vignarajan S, Xie C, Yao M, Sun Y, Simanainen U, Sved P, et al. Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A?? via AKT in prostate cancer cells. Oncotarget. 2014;5:6289-99 pubmed publisher
Bae G, Choi S, Lee J, Jo J, Lee J, Kim J, et al. Loss of E-cadherin activates EGFR-MEK/ERK signaling, which promotes invasion via the ZEB1/MMP2 axis in non-small cell lung cancer. Oncotarget. 2013;4:2512-22 pubmed
Cheshenko N, Trepanier J, Stefanidou M, Buckley N, Gonzalez P, Jacobs W, et al. HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression. FASEB J. 2013;27:2584-99 pubmed publisher
product information
Catalog Number :
S1078
Product Name :
MK-2206 2HCl
Synonyms :
MK2206 2HCl
Target :
Akt
CAS Number :
1032350-13-2, 1032349-93-1 (free base), 1032349-77-1 (HCl)
Formula :
C25H21N5O.2HCl
Quantity :
10 g
Description :
MK-2206 is a highly selective inhibitor of Akt1, Akt2 and Akt3 with IC50 of 8, 12 and 65 nM, respectively. Find all the information about MK-2206 dihydrochloride for cell signaling research.
Product Type :
Chemical
more info or order :
company information
Selleck Chemicals
2626 South Loop West, Suite 225
Houston, TX 77054
enquiry@selleckchem.com
http://www.selleckchem.com
877 796-6397
headquarters: USA