product summary
company name :
Selleck Chemicals
product type :
chemical
product name :
Olaparib (AZD2281)
catalog :
S1060
quantity :
10 g
price :
11,220.00 USD
more info or order :
citations: 11
Reference
Benabdallah N, Williamson I, Illingworth R, Kane L, Boyle S, Sengupta D, et al. Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation. Mol Cell. 2019;76:473-484.e7 pubmed publisher
Mengwasser K, Adeyemi R, Leng Y, Choi M, Clairmont C, D Andrea A, et al. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019;73:885-899.e6 pubmed publisher
Okamoto K, Ohishi T, Kuroiwa M, Iemura S, Natsume T, Seimiya H. MERIT40-dependent recruitment of tankyrase to damaged DNA and its implication for cell sensitivity to DNA-damaging anticancer drugs. Oncotarget. 2018;9:35844-35855 pubmed publisher
Singh R, van Haandel L, Heruth D, Ye S, Leeder J, Becker M, et al. Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATP. J Pharmacol Exp Ther. 2018;365:96-106 pubmed publisher
Vanden Heuvel J, Bullenkamp J. Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells. elife. 2016;5: pubmed publisher
Du Y, Yamaguchi H, Wei Y, Hsu J, Wang H, Hsu Y, et al. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016;22:194-201 pubmed publisher
Howard S, Yanez D, Stark J. DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining. PLoS Genet. 2015;11:e1004943 pubmed publisher
Hill S, Clark A, Silver D, Livingston D. BRCA1 pathway function in basal-like breast cancer cells. Mol Cell Biol. 2014;34:3828-42 pubmed publisher
Heitmann J, Geeleher P, Zuo Z, Weichselbaum R, Vokes E, Fetscher S, et al. Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer. Oral Oncol. 2014;50:825-31 pubmed publisher
Jelinic P, Levine D. New insights into PARP inhibitors' effect on cell cycle and homology-directed DNA damage repair. Mol Cancer Ther. 2014;13:1645-54 pubmed publisher
McMullin R, Wittner B, Yang C, Denton Schneider B, Hicks D, Singavarapu R, et al. A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity. Breast Cancer Res. 2014;16:R25 pubmed publisher
product information
Catalog Number :
S1060
Product Name :
Olaparib (AZD2281)
Synonyms :
KU-0059436, AZD2281
Target :
PARP
CAS Number :
763113-22-0, 894104-70-2, 937799-91-2, 1021843-02-6
Formula :
C24H23FN4O3
Quantity :
10 g
List Price :
11,220.00 USD
Description :
Olaparib(AZD2281, KU0059436) is a selective inhibitor of PARP-1 and PARP-2 enzymes with IC50 of 5 and 1 nM, respectively. Find all the information about Olaparib (AZD2281) for cell signaling research.
Product Type :
Chemical
more info or order :
company information
Selleck Chemicals
2626 South Loop West, Suite 225
Houston, TX 77054
enquiry@selleckchem.com
http://www.selleckchem.com
877 796-6397
headquarters: USA