product summary
company name :
Selleck Chemicals
product type :
chemical
product name :
Y-27632 2HCl
catalog :
S1049
quantity :
10 g
more info or order :
citations: 26
Reference
Reumann D, Krauditsch C, Novatchkova M, Sozzi E, Wong S, Zabolocki M, et al. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids. Nat Methods. 2023;20:2034-2047 pubmed publisher
Liao S, Rudoy D, Frank S, Phan L, Klezovitch O, Kwan J, et al. SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer. Nat Commun. 2023;14:7435 pubmed publisher
Rudraraju R, Gartner M, Neil J, Stout E, Chen J, Needham E, et al. Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment. Stem Cell Reports. 2023;18:1308-1324 pubmed publisher
Saunders J, Sikder K, Phillips E, Ishwar A, Mothy D, Margulies K, et al. Med25 Limits Master Regulators That Govern Adipogenesis. Int J Mol Sci. 2023;24: pubmed publisher
Niu Y, Ferreira Azevedo C, Li X, Kamali E, Haagen Nielsen O, Storgaard S xf8 rensen C, et al. Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select. Nat Genet. 2022;54:1983-1993 pubmed publisher
Sheta R, Teixeira M, Idi W, Pierre M, de Rus Jacquet A, Emond V, et al. Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons. Sci Rep. 2022;12:17176 pubmed publisher
Yang D, Cho H, Tayyebi Z, Shukla A, Luo R, Dixon G, et al. CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction. Nat Cell Biol. 2022;24:1064-1076 pubmed publisher
Saito Y, Nakamura K, Yoshida M, Sugiyama H, Akagi S, Miyoshi T, et al. Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther. 2022;13:141 pubmed publisher
Skylar Scott M, Huang J, Lu A, Ng A, Duenki T, Liu S, et al. Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues. Nat Biomed Eng. 2022;6:449-462 pubmed publisher
Bérard M, Sheta R, Malvaut S, Rodriguez Aller R, Teixeira M, Idi W, et al. A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease. PLoS Biol. 2022;20:e3001578 pubmed publisher
Zywitza V, Rusha E, Shaposhnikov D, Ruiz Orera J, Telugu N, Rishko V, et al. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction. Sci Rep. 2022;12:3100 pubmed publisher
Liu M, Zhao L, Wang Z, Su H, Wang T, Yang G, et al. Generation of Sheep Induced Pluripotent Stem Cells With Defined DOX-Inducible Transcription Factors via piggyBac Transposition. Front Cell Dev Biol. 2021;9:785055 pubmed publisher
Wei T, Choi S, Buehler D, Lee D, Ward Shaw E, Anderson R, et al. Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis. Cancers (Basel). 2021;13: pubmed publisher
Crutcher E, Pal R, Naini F, Zhang P, Laugsch M, Kim J, et al. mTOR and autophagy pathways are dysregulated in murine and human models of Schaaf-Yang syndrome. Sci Rep. 2019;9:15935 pubmed publisher
Vardhana S, Arnold P, Rosen B, Chen Y, Carey B, Huangfu D, et al. Glutamine independence is a selectable feature of pluripotent stem cells. Nat Metab. 2019;1:676-687 pubmed publisher
Li Q, Dixon G, Verma N, Rosen B, Gordillo M, Luo R, et al. Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nat Genet. 2019;: pubmed publisher
Wolff S, Kedziora K, Dumitru R, Dungee C, Zikry T, Beltran A, et al. Inheritance of OCT4 predetermines fate choice in human embryonic stem cells. Mol Syst Biol. 2018;14:e8140 pubmed publisher
Rousseaux M, Tschumperlin T, Lu H, Lackey E, Bondar V, Wan Y, et al. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. 2018;97:1235-1243.e5 pubmed publisher
Verma N, Pan H, Dore L, Shukla A, Li Q, Pelham Webb B, et al. TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet. 2018;50:83-95 pubmed publisher
Spurgeon M, den Boon J, Horswill M, Barthakur S, Forouzan O, Rader J, et al. Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen. Proc Natl Acad Sci U S A. 2017;114:E9076-E9085 pubmed publisher
Shi Z, Lee K, Yang D, Amin S, Verma N, Li Q, et al. Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. 2017;20:675-688.e6 pubmed publisher
Matsui T, Nieto Estévez V, Kyrychenko S, Schneider J, Hsieh J. Retinoblastoma protein controls growth, survival and neuronal migration in human cerebral organoids. Development. 2017;144:1025-1034 pubmed publisher
Wang J, Hu K, Guo J, Cheng F, Lv J, Jiang W, et al. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nat Commun. 2016;7:11363 pubmed publisher
Kearns N, Genga R, Enuameh M, Garber M, Wolfe S, Maehr R. Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells. Development. 2014;141:219-23 pubmed publisher
Joshi A, Dimitropoulou C, Thangjam G, Snead C, Feldman S, Barabutis N, et al. Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling. Am J Respir Cell Mol Biol. 2014;50:170-9 pubmed publisher
Kearns N, Genga R, Ziller M, Kapinas K, Peters H, Brehm M, et al. Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules. Stem Cell Res. 2013;11:1003-12 pubmed publisher
product information
Catalog Number :
S1049
Product Name :
Y-27632 2HCl
Target :
ROCK
CAS Number :
129830-38-2, 146986-50-7
Formula :
C14H21N3O.2HCl
Quantity :
10 g
Description :
Y-27632 2HCl is ROCK inhibitor, as a novel bronchodilator. Y-27632 2HCl is available with IC50 of 3.310.25 uM and 2.810.2 uM in human and rabbit tissues, respectively. Find all the information about Y-27632 2HCl for cell signaling research.
Product Type :
Chemical
more info or order :
company information
Selleck Chemicals
2626 South Loop West, Suite 225
Houston, TX 77054
enquiry@selleckchem.com
http://www.selleckchem.com
877 796-6397
headquarters: USA