product summary
company name :
Selleck Chemicals
product type :
chemical
product name :
AZD6244 (Selumetinib)
catalog :
S1008
quantity :
10 g
price :
4,020.00 USD
more info or order :
citations: 13
Reference
Cebulla C, Kim B, George V, Heisler Taylor T, Hamadmad S, Reese A, et al. Oral Selumetinib Does Not Negatively Impact Photoreceptor Survival in Murine Experimental Retinal Detachment. Invest Ophthalmol Vis Sci. 2019;60:349-357 pubmed publisher
Du L, Roberts J. Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling. Am J Physiol Lung Cell Mol Physiol. 2019;316:L20-L34 pubmed publisher
Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
Liu R, Zhang T, Zhu G, Xing M. Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer. Nat Commun. 2018;9:579 pubmed publisher
Sharma V, Young L, Cavadas M, Owen K. Registered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. elife. 2016;5: pubmed publisher
Myers A, Lin L, Nancarrow D, Wang Z, Ferrer Torres D, Thomas D, et al. IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma. Oncotarget. 2015;6:25897-916 pubmed publisher
Lee M, Jeong M, Lee H, Han H, Ko A, Hewitt S, et al. PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 2015;6:7769 pubmed publisher
Kemper K, Krijgsman O, Cornelissen Steijger P, Shahrabi A, Weeber F, Song J, et al. Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts. EMBO Mol Med. 2015;7:1104-18 pubmed publisher
Wang M, Kern A, Hülskötter M, Greninger P, Singh A, Pan Y, et al. EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res. 2014;74:2825-34 pubmed publisher
Zinn R, Gardner E, Marchionni L, Murphy S, Dobromilskaya I, Hann C, et al. ERK phosphorylation is predictive of resistance to IGF-1R inhibition in small cell lung cancer. Mol Cancer Ther. 2013;12:1131-9 pubmed publisher
Maira S, Pecchi S, Huang A, Burger M, Knapp M, Sterker D, et al. Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. Mol Cancer Ther. 2012;11:317-28 pubmed publisher
Prickett T, Wei X, Cardenas Navia I, Teer J, Lin J, Walia V, et al. Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. Nat Genet. 2011;43:1119-26 pubmed publisher
Burkhard K, Shapiro P. Use of inhibitors in the study of MAP kinases. Methods Mol Biol. 2010;661:107-22 pubmed publisher
product information
Catalog Number :
S1008
Product Name :
AZD6244 (Selumetinib)
Synonyms :
ARRY-142888,Selumetinib
Target :
MEK
CAS Number :
606143-52-6, 942275-12-9 (4-methylbenzenesulfonate)
Formula :
C17H15BrClFN4O3
Quantity :
10 g
List Price :
4,020.00 USD
Description :
AZD6244 (Selumetinib, ARRY-142886) is highly potent to inhibit MEK1 with IC50 of 14 nM. Find all the information about AZD6244 (Selumetinib) for cell signaling research.
Product Type :
Chemical
more info or order :
company information
Selleck Chemicals
2626 South Loop West, Suite 225
Houston, TX 77054
enquiry@selleckchem.com
http://www.selleckchem.com
877 796-6397
headquarters: USA