product summary
company name :
Selleck Chemicals
product type :
chemical
product name :
ABT-737
catalog :
S1002
quantity :
10 g
price :
27,000.00 USD
more info or order :
citations: 7
Reference
Yosef R, Pilpel N, Tokarsky Amiel R, Biran A, Ovadya Y, Cohen S, et al. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL. Nat Commun. 2016;7:11190 pubmed publisher
Pedro J, Wei Y, Sica V, Maiuri M, Zou Z, Kroemer G, et al. BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. Autophagy. 2015;11:452-9 pubmed publisher
Deng Y, Xu J, Zhang X, Yang J, Zhang D, Huang J, et al. Berberine attenuates autophagy in adipocytes by targeting BECN1. Autophagy. 2014;10:1776-86 pubmed publisher
Garimella S, Gehlhaus K, Dine J, Pitt J, Grandin M, Chakka S, et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. Breast Cancer Res. 2014;16:R41 pubmed publisher
Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher
Song T, Xue Z, Zhang Z, Shen X, Li X. Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak. Basic Clin Pharmacol Toxicol. 2013;113:145-51 pubmed publisher
Song T, Chang X, Zhang Z, Liu Y, Shen X. S1, a novel pan-BH3 mimetic, induces apoptosis in Mcl-1-overexpressing cells through Bak. J Pharmacol Sci. 2012;119:330-40 pubmed
product information
Catalog Number :
S1002
Product Name :
ABT-737
Synonyms :
ABT737, ABT 737
Target :
Bcl-2
CAS Number :
852808-04-9
Formula :
C42H45ClN6O5S2
Quantity :
10 g
List Price :
27,000.00 USD
Description :
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 uM (Nalm-6, K562 and HL-60). Find all the information about ABT-737 for cell signaling research.
Product Type :
Chemical
more info or order :
company information
Selleck Chemicals
2626 South Loop West, Suite 225
Houston, TX 77054
enquiry@selleckchem.com
http://www.selleckchem.com
877 796-6397
headquarters: USA