product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
eIF4E (P-2) Antibody
catalog :
sc-9976
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P-2
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 7c
Méndez Solís O, Bendjennat M, Naipauer J, Theodoridis P, Ho J, Verdun R, et al. Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis. Cell Rep. 2021;37:110144 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Ruan H, Li X, Xu X, Leibowitz B, Tong J, Chen L, et al. eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:100; loading ...; fig s1c
Xu Z, Kim G, Tan J, Riso A, Sun Y, Xu E, et al. Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations. Nat Commun. 2020;11:1797 pubmed publisher
  • western blot; mouse; fig 5c
Alvarez Dominguez J, Zhang X, Hu W. Widespread and dynamic translational control of red blood cell development. Blood. 2017;129:619-629 pubmed publisher
  • western blot; human; loading ...; fig 1b
Lyons S, Achorn C, Kedersha N, Anderson P, Ivanov P. YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression. Nucleic Acids Res. 2016;44:6949-60 pubmed publisher
  • immunocytochemistry; human; 10 ug/ml; fig 1d
Arimoto Matsuzaki K, Saito H, Takekawa M. TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis. Nat Commun. 2016;7:10252 pubmed publisher
  • western blot; human; fig 2
Zucal C, D Agostino V, Casini A, Mantelli B, Thongon N, Soncini D, et al. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. BMC Cancer. 2015;15:855 pubmed publisher
  • western blot; human; 1:1000; fig s8
Pasini L, Re A, Tebaldi T, Ricci G, Boi S, Adami V, et al. TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines. BMC Cancer. 2015;15:777 pubmed publisher
  • western blot; mouse; fig 4
Lee S, Kim J, Hong S, Lee A, Park E, Seo H, et al. High Inorganic Phosphate Intake Promotes Tumorigenesis at Early Stages in a Mouse Model of Lung Cancer. PLoS ONE. 2015;10:e0135582 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 4
Riz I, Hawley T, Hawley R. KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Oncotarget. 2015;6:14814-31 pubmed
  • western blot; human; 1:200
Panas M, Kedersha N, McInerney G. Methods for the characterization of stress granules in virus infected cells. Methods. 2015;90:57-64 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; fig 1a
Li Y, Li B, Xu B, Han B, Xia H, Chen Q, et al. Expression of p53, p21(CIP1/WAF1) and eIF4E in the adjacent tissues of oral squamous cell carcinoma: establishing the molecular boundary and a cancer progression model. Int J Oral Sci. 2015;7:161-8 pubmed publisher
  • western blot; human
Modelska A, Turro E, Russell R, Beaton J, Sbarrato T, Spriggs K, et al. The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape. Cell Death Dis. 2015;6:e1603 pubmed publisher
  • western blot; mouse; 1:2000
Smith H, Matthews K, Oldham J, Jeanplong F, Falconer S, Bass J, et al. Translational signalling, atrogenic and myogenic gene expression during unloading and reloading of skeletal muscle in myostatin-deficient mice. PLoS ONE. 2014;9:e94356 pubmed publisher
  • western blot; mouse
Galicia Vázquez G, Di Marco S, Lian X, Ma J, Gallouzi I, Pelletier J. Regulation of eukaryotic initiation factor 4AII by MyoD during murine myogenic cell differentiation. PLoS ONE. 2014;9:e87237 pubmed publisher
Palma M, Leroy C, Salomé Desnoulez S, Werkmeister E, Kong R, Mongy M, et al. A role for AKT1 in nonsense-mediated mRNA decay. Nucleic Acids Res. 2021;49:11022-11037 pubmed publisher
Chen H, Yu H, Yang M, Tarn W. DDX3 Activates CBC-eIF3-Mediated Translation of uORF-Containing Oncogenic mRNAs to Promote Metastasis in HNSCC. Cancer Res. 2018;78:4512-4523 pubmed publisher
Behrens G, Winzen R, Rehage N, Dörrie A, Barsch M, Hoffmann A, et al. A translational silencing function of MCPIP1/Regnase-1 specified by the target site context. Nucleic Acids Res. 2018;46:4256-4270 pubmed publisher
Riz I, Hawley T, Marsal J, Hawley R. Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming. Oncotarget. 2016;7:66360-66385 pubmed publisher
Millican Slater R, Sayers C, Hanby A, Hughes T. Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer. Br J Cancer. 2016;115:339-45 pubmed publisher
Landon A, Muniandy P, Shetty A, Lehrmann E, Volpon L, Houng S, et al. MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Nat Commun. 2014;5:5413 pubmed publisher
Zahreddine H, Culjkovic Kraljacic B, Assouline S, Gendron P, Romeo A, Morris S, et al. The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation. Nature. 2014;511:90-3 pubmed publisher
Lin C, Nasr Z, Premsrirut P, Porco J, Hippo Y, Lowe S, et al. Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis. Cell Rep. 2012;1:325-33 pubmed
Sharma A, Yilmaz A, Marsh K, Cochrane A, Boris Lawrie K. Thriving under stress: selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eIF4E translation activity. PLoS Pathog. 2012;8:e1002612 pubmed publisher
Satheesha S, Cookson V, Coleman L, Ingram N, Madhok B, Hanby A, et al. Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer. Mol Cancer. 2011;10:19 pubmed publisher
Yang C, Albin D, Wang Z, Stoll B, Lackeyram D, Swanson K, et al. Apical Na+-D-glucose cotransporter 1 (SGLT1) activity and protein abundance are expressed along the jejunal crypt-villus axis in the neonatal pig. Am J Physiol Gastrointest Liver Physiol. 2011;300:G60-70 pubmed publisher
Smith L, Brannan R, Hanby A, Shaaban A, Verghese E, Peter M, et al. Differential regulation of oestrogen receptor ? isoforms by 5' untranslated regions in cancer. J Cell Mol Med. 2010;14:2172-84 pubmed publisher
Choi C, Lee J, Kim S, Lee Y, Kim C, Lee J, et al. Direct inhibition of eIF4E reduced cell growth in endometrial adenocarcinoma. J Cancer Res Clin Oncol. 2011;137:463-9 pubmed publisher
Mishra R, Miyamoto M, Yoshioka T, Ishikawa K, Matsumura Y, Shoji Y, et al. Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo. Int J Oncol. 2009;34:1231-40 pubmed
Sanz M, Castello A, Ventoso I, Berlanga J, Carrasco L. Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells. PLoS ONE. 2009;4:e4772 pubmed publisher
Iresjö B, Körner U, Hyltander A, Ljungman D, Lundholm K. Initiation factors for translation of proteins in the rectus abdominis muscle from patients on overnight standard parenteral nutrition before surgery. Clin Sci (Lond). 2008;114:603-10 pubmed
Yagoda N, von Rechenberg M, Zaganjor E, Bauer A, Yang W, Fridman D, et al. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007;447:864-8 pubmed
Lee J, Choi J, Lee K, Choi C, Kim T, Lee J, et al. eIF-4E expression is associated with histopathologic grades in cervical neoplasia. Hum Pathol. 2005;36:1197-203 pubmed
Rigby W, Roy K, Collins J, Rigby S, Connolly J, Bloch D, et al. Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP function. J Immunol. 2005;174:7883-93 pubmed
product information
Catalog Number :
sc-9976
Product Name :
eIF4E (P-2) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
P-2
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
eIF4E
Specificity :
mouse, rat, human, porcine
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA