product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Cdc27 (AF3.1) Antibody
catalog :
sc-9972
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AF3.1
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 3
Pavlides S, Lecanda J, Daubriac J, Pandya U, Gama P, Blank S, et al. TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth. Cell Cycle. 2016;15:931-47 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • western blot; human; 1:200; fig 1
Qiu L, Wu J, Pan C, Tan X, Lin J, Liu R, et al. Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21Cip1/Waf1. Cell Death Dis. 2016;7:e2074 pubmed publisher
  • western blot; human; 1:1000
Masuda K, Chiyoda T, Sugiyama N, Segura Cabrera A, Kabe Y, Ueki A, et al. LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. PLoS ONE. 2015;10:e0118662 pubmed publisher
  • western blot; human; fig 6c
Meyer H, Rape M. Enhanced protein degradation by branched ubiquitin chains. Cell. 2014;157:910-21 pubmed publisher
Cao X, Shami Shah A, Sanford E, Smolka M, Baskin J. Proximity Labeling Reveals Spatial Regulation of the Anaphase-Promoting Complex/Cyclosome by a Microtubule Adaptor. ACS Chem Biol. 2022;17:2605-2618 pubmed publisher
Yin L, Zeng Y, Zeng R, Chen Y, Wang T, Rodabaugh K, et al. Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer. Oncogene. 2021;40:6772-6785 pubmed publisher
Stauffer S, Zeng Y, Santos M, Zhou J, Chen Y, Dong J. Cyclin-dependent kinase 1-mediated AMPK phosphorylation regulates chromosome alignment and mitotic progression. J Cell Sci. 2019;132: pubmed publisher
Kim D, Han J, Ly P, Ye Q, McMahon M, Myung K, et al. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018;9:4354 pubmed publisher
Bonacci T, Suzuki A, Grant G, Stanley N, Cook J, Brown N, et al. Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates. EMBO J. 2018;37: pubmed publisher
Skowyra A, Allan L, Saurin A, Clarke P. USP9X Limits Mitotic Checkpoint Complex Turnover to Strengthen the Spindle Assembly Checkpoint and Guard against Chromosomal Instability. Cell Rep. 2018;23:852-865 pubmed publisher
Fehr A, Gualberto N, Savaryn J, Terhune S, Yu D. Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog. 2012;8:e1002789 pubmed publisher
Chen M, Gutierrez G, Ronai Z. The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. PLoS ONE. 2012;7:e35520 pubmed publisher
Zeng X, King R. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012;8:383-92 pubmed publisher
Giovinazzi S, Lindsay C, Morozov V, Escobar Cabrera E, Summers M, Han H, et al. Regulation of mitosis and taxane response by Daxx and Rassf1. Oncogene. 2012;31:13-26 pubmed publisher
Ozlu N, Monigatti F, Renard B, Field C, Steen H, Mitchison T, et al. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010;9:336-50 pubmed publisher
Jeganathan K, Malureanu L, van Deursen J. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature. 2005;438:1036-9 pubmed
Nakamura N, Tokumoto T, Ueno S, Iwao Y. The cytoskeleton-dependent localization of cdc2/cyclin B in blastomere cortex during Xenopus embryonic cell cycle. Mol Reprod Dev. 2005;72:336-45 pubmed
product information
Catalog Number :
sc-9972
Product Name :
Cdc27 (AF3.1) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
AF3.1
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Cdc27
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA