Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; fig 5d
| Gotovac J, Kader T, Milne J, Fujihara K, Lara Gonzalez L, Gorringe K, et al. Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett's Esophagus. Cell Mol Gastroenterol Hepatol. 2021;12:689-713 pubmed publisher
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- western blot; human; 1:500; loading ...; fig 4b
| Lei T, Zhang P, Zhang X, Xiao X, Zhang J, Qiu T, et al. Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation. Nat Commun. 2018;9:1876 pubmed publisher
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- western blot; human; 1:20,000; loading ...; fig s2e
| Matson J, Dumitru R, Coryell P, Baxley R, Chen W, Twaroski K, et al. Rapid DNA replication origin licensing protects stem cell pluripotency. elife. 2017;6: pubmed publisher
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- western blot; human; 1:1500; fig 1
| Huang Y, Amin A, Qin Y, Wang Z, Jiang H, Liang L, et al. A Role of hIPI3 in DNA Replication Licensing in Human Cells. PLoS ONE. 2016;11:e0151803 pubmed publisher
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- western blot; human; 1:1000; fig s7
| Passerini V, Ozeri Galai E, de Pagter M, Donnelly N, Schmalbrock S, Kloosterman W, et al. The presence of extra chromosomes leads to genomic instability. Nat Commun. 2016;7:10754 pubmed publisher
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- western blot; human; loading ...; fig 1b
| Preet R, Siddharth S, Satapathy S, Das S, Nayak A, Das D, et al. Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade. Biochem Pharmacol. 2016;105:23-33 pubmed publisher
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- western blot; human; fig 8
| Yao M, Xie C, Kiang M, Teng Y, Harman D, Tiffen J, et al. Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells. Oncotarget. 2015;6:34458-74 pubmed publisher
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- western blot; mouse; 1:200; fig 2
| Cardona M, López J, SerafÃn A, Rongvaux A, Inserte J, GarcÃa Dorado D, et al. Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. PLoS ONE. 2015;10:e0131411 pubmed publisher
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- western blot; human; fig 2a
| Wu M, Lu W, Santos R, Frattini M, Kelly T. Geminin inhibits a late step in the formation of human pre-replicative complexes. J Biol Chem. 2014;289:30810-21 pubmed publisher
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- western blot; human; 1:500; fig 1
| Fernandez Vidal A, Guitton Sert L, Cadoret J, Drac M, Schwob E, Baldacci G, et al. A role for DNA polymerase ? in the timing of DNA replication. Nat Commun. 2014;5:4285 pubmed publisher
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- western blot; human; fig 2e
| Wang J, Xu X, Alontaga A, Chen Y, Liu Y. Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. Cell Rep. 2014;7:848-58 pubmed publisher
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- western blot; human; 1:1000; fig 2
| Clijsters L, Wolthuis R. PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase. J Cell Sci. 2014;127:1336-45 pubmed publisher
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| Wei Q, Li J, Liu T, Tong X, Ye X. Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation. J Biol Chem. 2013;288:19715-25 pubmed publisher
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- western blot; human; 1:1000
| Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011;39:5356-68 pubmed publisher
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| Barua D, Sultana A, Islam M, Cox F, Gupta A, Gupta S. RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity. BMC Cancer. 2023;23:288 pubmed publisher
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| Kumar R, Rao G. Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization. Arterioscler Thromb Vasc Biol. 2022;42:407-427 pubmed publisher
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| Enrico T, Stallaert W, Wick E, Ngoi P, Wang X, Rubin S, et al. Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2. elife. 2021;10: pubmed publisher
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| van Schie J, Faramarz A, Balk J, Stewart G, Cantelli E, Oostra A, et al. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. Nat Commun. 2020;11:4287 pubmed publisher
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| Matson J, House A, Grant G, Wu H, Perez J, Cook J. Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence. J Cell Biol. 2019;: pubmed publisher
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| Lemmens B, Hegarat N, Akopyan K, Sala Gaston J, Bartek J, Hochegger H, et al. DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation. Mol Cell. 2018;71:117-128.e3 pubmed publisher
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| Patel P, Suram A, Mirani N, Bischof O, Herbig U. Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc Natl Acad Sci U S A. 2016;113:E5024-33 pubmed publisher
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| Kliszczak M, Sedlackova H, Pitchai G, Streicher W, Krejci L, Hickson I. Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells. Oncotarget. 2015;6:40464-79 pubmed publisher
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| Kalfalah F, Berg E, Christensen M, Linka R, Dirks W, Boege F, et al. Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis. Cell Cycle. 2015;14:1704-15 pubmed publisher
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| Clijsters L, Ogink J, Wolthuis R. The spindle checkpoint, APC/C(Cdc20), and APC/C(Cdh1) play distinct roles in connecting mitosis to S phase. J Cell Biol. 2013;201:1013-26 pubmed publisher
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| Booher K, Lin D, Borrego S, Kaiser P. Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells. Cell Cycle. 2012;11:4414-23 pubmed publisher
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| Moriyama K, Yoshizawa Sugata N, Obuse C, Tsurimoto T, Masai H. Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: stimulation by Cdc6 through its direct interaction with EBNA1. J Biol Chem. 2012;287:23977-94 pubmed publisher
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| Varma D, Chandrasekaran S, Sundin L, Reidy K, Wan X, Chasse D, et al. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat Cell Biol. 2012;14:593-603 pubmed publisher
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| Isaacs J, D Antonio J, Chen S, Antony L, Dalrymple S, Ndikuyeze G, et al. Adaptive auto-regulation of androgen receptor provides a paradigm shifting rationale for bipolar androgen therapy (BAT) for castrate resistant human prostate cancer. Prostate. 2012;72:1491-505 pubmed publisher
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| Yao M, Xie C, Constantine M, Hua S, Hambly B, Jardine G, et al. How can food extracts consumed in the Mediterranean and East Asia suppress prostate cancer proliferation?. Br J Nutr. 2012;108:424-30 pubmed publisher
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| Chandrasekaran S, Tan T, Hall J, Cook J. Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor. Mol Cell Biol. 2011;31:4405-16 pubmed publisher
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| Li C, Nyman J, Braithwaite A, Eccles M. PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene. 2011;30:4824-34 pubmed publisher
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| Munkley J, Copeland N, Moignard V, Knight J, Greaves E, Ramsbottom S, et al. Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells. Nucleic Acids Res. 2011;39:2671-7 pubmed publisher
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| Zhang J, Yu L, Wu X, Zou L, Sou K, Wei Z, et al. The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells. Cell Cycle. 2010;9:4848-57 pubmed
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| Ladstein R, Bachmann I, Straume O, Akslen L. Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma. BMC Cancer. 2010;10:140 pubmed publisher
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| Eliades A, Papadantonakis N, Ravid K. New roles for cyclin E in megakaryocytic polyploidization. J Biol Chem. 2010;285:18909-17 pubmed publisher
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| Di Paola D, Rampakakis E, Chan M, Arvanitis D, Zannis Hadjopoulos M. Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. Nucleic Acids Res. 2010;38:2314-31 pubmed publisher
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| Lu X, Liu J, Legerski R. Cyclin E is stabilized in response to replication fork barriers leading to prolonged S phase arrest. J Biol Chem. 2009;284:35325-37 pubmed publisher
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| Gan F, Chua Y, Scarmagnani S, Palaniappan P, Franks M, Poobalasingam T, et al. Structure-activity analysis of 2'-modified cinnamaldehyde analogues as potential anticancer agents. Biochem Biophys Res Commun. 2009;387:741-7 pubmed publisher
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| Agherbi H, Gaussmann Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M. Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence. PLoS ONE. 2009;4:e5622 pubmed publisher
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| Nevis K, Cordeiro Stone M, Cook J. Origin licensing and p53 status regulate Cdk2 activity during G(1). Cell Cycle. 2009;8:1952-63 pubmed
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| Salabat M, Melstrom L, Strouch M, Ding X, Milam B, Ujiki M, et al. Geminin is overexpressed in human pancreatic cancer and downregulated by the bioflavanoid apigenin in pancreatic cancer cell lines. Mol Carcinog. 2008;47:835-44 pubmed publisher
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| Barkley L, Hong H, Kingsbury S, James M, Stoeber K, Williams G. Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation. Exp Cell Res. 2007;313:3789-99 pubmed
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| Chew E, Poobalasingam T, Hawkey C, Hagen T. Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerization. Cell Signal. 2007;19:1071-80 pubmed
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| Vassilev L, Tovar C, Chen S, Knezevic D, Zhao X, Sun H, et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A. 2006;103:10660-5 pubmed
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| Fujii Yamamoto H, Kim J, Arai K, Masai H. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. J Biol Chem. 2005;280:12976-87 pubmed
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| Anger M, Stein P, Schultz R. CDC6 requirement for spindle formation during maturation of mouse oocytes. Biol Reprod. 2005;72:188-94 pubmed
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| Martins S, Eikvar S, Furukawa K, Collas P. HA95 and LAP2 beta mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. J Cell Biol. 2003;160:177-88 pubmed
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