product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
HDAC2 (C-8) Antibody
catalog :
sc-9959
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C-8
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 27
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:50; loading ...; fig 4b, e6a
Gordon A, Yoon S, Tran S, Makinson C, Park J, Andersen J, et al. Long-term maturation of human cortical organoids matches key early postnatal transitions. Nat Neurosci. 2021;24:331-342 pubmed publisher
  • western blot; human; loading ...; fig 3b
Santos M, Morais S, Pereira C, Sequeiros J, Alonso I. Parkin truncating variants result in a loss-of-function phenotype. Sci Rep. 2019;9:16150 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Singh A, Khare P, Obaid A, Conlon K, Basrur V, Depinho R, et al. SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018;9:4515 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 7b
Kurkewich J, Hansen J, Klopfenstein N, Zhang H, Wood C, Boucher A, et al. The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis. PLoS Genet. 2017;13:e1006887 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Patrick N, Griggs C, Icenogle A, Gilpatrick M, Kadiyala V, Jaime Frias R, et al. Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1. J Steroid Biochem Mol Biol. 2017;167:1-13 pubmed publisher
  • western blot; human; fig 1
Liu J, Gu J, Feng Z, Yang Y, Zhu N, Lu W, et al. Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med. 2016;14:7 pubmed publisher
  • western blot; human; 1:250; fig 3
Damiani E, Puebla Osorio N, Gorbea E, Ullrich S. Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. J Invest Dermatol. 2015;135:3034-3040 pubmed publisher
  • western blot; human; fig 1
Huang J, Cardamone M, JOHNSON H, Neault M, Chan M, Floyd Z, et al. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015;290:19044-54 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 4b
Kim H, Park J, Won H, Lee J, Kong G. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/β-catenin pathway. FASEB J. 2015;29:300-13 pubmed publisher
  • western blot; human
Xia B, Ren X, Zhuang Z, Yang L, Huang H, Pang L, et al. Effect of hexavalent chromium on histone biotinylation in human bronchial epithelial cells. Toxicol Lett. 2014;228:241-7 pubmed publisher
  • western blot; human
Isaacs J, Antony L, Dalrymple S, Brennen W, Gerber S, Hammers H, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013;73:1386-99 pubmed publisher
Park D, Kim S, Koo D, Kang M. Histone deacetylases inhibitor and RAD51 recombinase increase transcription activator-like effector nucleases-mediated homologous recombination on the bovine β-casein gene locus. Asian-Australas J Anim Sci. 2020;33:1023-1033 pubmed publisher
Fellows R, Denizot J, Stellato C, Cuomo A, Jain P, Stoyanova E, et al. Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases. Nat Commun. 2018;9:105 pubmed publisher
Qu Y, Yang Y, Ma D, He L, Xiao W. Expression level of histone deacetylase 2 correlates with occurring of chronic obstructive pulmonary diseases. Mol Biol Rep. 2013;40:3995-4000 pubmed publisher
Oh J, Choi E, Carp R, Kim Y. Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells. Autophagy. 2012;8:1448-61 pubmed publisher
Pakala S, Singh K, Reddy S, Ohshiro K, Li D, Mishra L, et al. TGF-?1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells. Oncogene. 2011;30:2230-41 pubmed publisher
Kim D, Hwang C, Wagley Y, Law P, Wei L, Loh H. p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide. J Neurochem. 2011;116:1077-87 pubmed publisher
Ellison Zelski S, Alarid E. Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor. Mol Cancer. 2010;9:263 pubmed publisher
Ellison Zelski S, Solodin N, Alarid E. Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter. Mol Cell Biol. 2009;29:4949-58 pubmed publisher
Tsutsui T, Umemura H, Tanaka A, Mizuki F, Hirose Y, Ohkuma Y. Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation. Genes Cells. 2008;13:817-26 pubmed publisher
Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung S, et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol. 2008;10:731-9 pubmed publisher
Laudes M, Bilkovski R, Oberhauser F, Droste A, Gomolka M, Leeser U, et al. Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4. J Mol Med (Berl). 2008;86:597-608 pubmed publisher
Kramer O, Müller S, Buchwald M, Reichardt S, Heinzel T. Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha. FASEB J. 2008;22:1369-79 pubmed
Kuppuswamy M, Vijayalingam S, Zhao L, Zhou Y, Subramanian T, Ryerse J, et al. Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex. Mol Cell Biol. 2008;28:269-81 pubmed
Pluemsampant S, Safronova O, Nakahama K, Morita I. Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors. Int J Cancer. 2008;122:333-41 pubmed
Zhao L, Subramanian T, Chinnadurai G. Changes in C-terminal binding protein 2 (CtBP2) corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2. J Biol Chem. 2006;281:36613-23 pubmed
Kaiser C, James S. Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation. BMC Biol. 2004;2:23 pubmed
product information
Catalog Number :
sc-9959
Product Name :
HDAC2 (C-8) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
C-8
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
HDAC2
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA