product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p53 (Pab 1801) Antibody
catalog :
sc-98
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
Pab 1801
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 55
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 1b
Sivakumar S, Qi S, Cheng N, Sathe A, Kanchwala M, Kumar A, et al. TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling. Cell Rep. 2022;38:110395 pubmed publisher
  • western blot; rat; 1:200; loading ...; fig 3c
Cai H, Han B, Hu Y, Zhao X, He Z, Chen X, et al. Metformin attenuates the D‑galactose‑induced aging process via the UPR through the AMPK/ERK1/2 signaling pathways. Int J Mol Med. 2020;45:715-730 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig s5b
Goodman D, Pretto C, Krepostman T, Carnahan K, Spindler K. Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR). MBio. 2019;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7a
Li R, Sahu S, Schachner M. Phenelzine, a small organic compound mimicking the functions of cell adhesion molecule L1, promotes functional recovery after mouse spinal cord injury. Restor Neurol Neurosci. 2018;36:469-483 pubmed publisher
  • western blot; human; 1:3000; loading ...; fig 1d
Liu W, Huang K, Lu M, Huang H, Chen C, Cheng Y, et al. TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability. Oncogene. 2017;36:2715-2723 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2g
  • western blot; human; loading ...; fig 4a
Luo H, Cowen L, Yu G, Jiang W, Tang Y. SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov. 2016;2:15042 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 6
Kobayashi K, Tsugami Y, Matsunaga K, Oyama S, Kuki C, Kumura H. Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells. Biochim Biophys Acta. 2016;1863:2006-16 pubmed publisher
  • western blot; human; fig 2
Katoh I, Fukunishi N, Fujimuro M, Kasai H, Moriishi K, Hata R, et al. Repression of Wnt/β-catenin response elements by p63 (TP63). Cell Cycle. 2016;15:699-710 pubmed publisher
  • western blot; human; fig 1a
Du C, Wu H, Leng R. UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget. 2016;7:2823-36 pubmed publisher
  • western blot; human; 1:500; fig 6
Vétillard A, Jonchère B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
  • western blot; mouse; fig 3
  • western blot; human; fig 3
Crivellaro S, Panuzzo C, Carrà G, Volpengo A, Crasto F, Gottardi E, et al. Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion. Oncotarget. 2015;6:25217-25 pubmed publisher
  • immunocytochemistry; human
Bishop R, Valle Oseguera C, Spencer J. Human Cytomegalovirus interleukin-10 promotes proliferation and migration of MCF-7 breast cancer cells. Cancer Cell Microenviron. 2015;2: pubmed
  • western blot; human; 1:500; fig 3
Mahale S, Bharate S, Manda S, Joshi P, Jenkins P, Vishwakarma R, et al. Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization. Cell Death Dis. 2015;6:e1743 pubmed publisher
  • chromatin immunoprecipitation; human; fig 3b
  • western blot; human; fig 1f
Wang X, Docanto M, Sasano H, Lo C, Simpson E, Brown K. Prostaglandin E2 inhibits p53 in human breast adipose stromal cells: a novel mechanism for the regulation of aromatase in obesity and breast cancer. Cancer Res. 2015;75:645-55 pubmed publisher
  • western blot; human
Weilbacher A, Gutekunst M, Oren M, Aulitzky W, van der Kuip H. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell Death Dis. 2014;5:e1318 pubmed publisher
Mukherjee S, Maddalena M, Lu Y, Martinez S, Nataraj N, Noronha A, et al. Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins. Proc Natl Acad Sci U S A. 2022;119:e2119644119 pubmed publisher
Miller J, Dakic A, Spurgeon M, Saenz F, Kallakury B, Zhao B, et al. AIB1 is a novel target of the high-risk HPV E6 protein and a biomarker of cervical cancer progression. J Med Virol. 2022;94:3962-3977 pubmed publisher
Chang C, Kuo C, Ito T, Su Y, Jiang S, Chiu M, et al. CK1? ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation. Proc Natl Acad Sci U S A. 2017;114:E8035-E8044 pubmed publisher
Wiechmann S, Gärtner A, Kniss A, Stengl A, Behrends C, Rogov V, et al. Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation. J Biol Chem. 2017;292:15340-15351 pubmed publisher
Min J, Wright W, Shay J. Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Mol Cell Biol. 2017;37: pubmed publisher
Min M, Chen X, Wang P, Landeck L, Chen J, Li W, et al. Role of keratin 24 in human epidermal keratinocytes. PLoS ONE. 2017;12:e0174626 pubmed publisher
Yao C, Chow J, Lin P, Hu T, Kuo H, Huang J, et al. Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evid Based Complement Alternat Med. 2016;2016:5989681 pubmed publisher
Vaughan C, Pearsall I, Singh S, Windle B, Deb S, Grossman S, et al. Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter. Oncotarget. 2016;7:12426-46 pubmed publisher
Chand H, Montaño G, Huang X, Randell S, Mebratu Y, Petersen H, et al. A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression. Nat Commun. 2014;5:5567 pubmed publisher
Huang Y, Bulavin D. Oncogene-mediated regulation of p53 ISGylation and functions. Oncotarget. 2014;5:5808-18 pubmed
Bassères D, Ebbs A, Cogswell P, Baldwin A. IKK is a therapeutic target in KRAS-Induced lung cancer with disrupted p53 activity. Genes Cancer. 2014;5:41-55 pubmed
Loughery J, Cox M, Smith L, Meek D. Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters. Nucleic Acids Res. 2014;42:7666-80 pubmed publisher
Tengku Ahmad T, Jaafar F, Jubri Z, Abdul Rahim K, Rajab N, Makpol S. Gelam honey attenuated radiation-induced cell death in human diploid fibroblasts by promoting cell cycle progression and inhibiting apoptosis. BMC Complement Altern Med. 2014;14:108 pubmed publisher
Contreras A, Mebratu Y, Delgado M, Montaño G, Hu C, Ryter S, et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol. 2013;201:427-37 pubmed publisher
Cai B, Hsu P, Hsin I, Chao C, Lu M, Lin H, et al. p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation. PLoS ONE. 2012;7:e41742 pubmed publisher
Thomas M, Luchelli L, Pascual M, Gottifredi V, Boccaccio G. A monoclonal antibody against p53 cross-reacts with processing bodies. PLoS ONE. 2012;7:e36447 pubmed publisher
Rahman M, Zhang Z, Mody A, Su D, Das H. Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis. Brain Res. 2012;1448:117-28 pubmed publisher
Bansal N, Kadamb R, Mittal S, Vig L, Sharma R, Dwarakanath B, et al. Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress. PLoS ONE. 2011;6:e26156 pubmed publisher
Lenos K, de Lange J, Teunisse A, Lodder K, Verlaan de Vries M, Wiercinska E, et al. Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts. Mol Cancer. 2011;10:111 pubmed publisher
Goñi Oliver P, Avila J, Hernandez F. Calpain regulates N-terminal interaction of GSK-3? with 14-3-3?, p53 and PKB but not with axin. Neurochem Int. 2011;59:97-100 pubmed publisher
Wang X, Wang J, Jiang X. MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem. 2011;286:23725-34 pubmed publisher
Meissner J, FREUND R, Krone D, Umeda P, Chang K, Gros G, et al. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of p300 enhances myosin heavy chain I/beta gene expression via acetylation of nuclear factor of activated T cells c1. Nucleic Acids Res. 2011;39:5907-25 pubmed publisher
Midde K, Batchinsky A, Cancio L, Shetty S, Komissarov A, Florova G, et al. Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells. Shock. 2011;36:128-37 pubmed publisher
Renault V, Thekkat P, Hoang K, White J, Brady C, Kenzelmann Broz D, et al. The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene. 2011;30:3207-21 pubmed publisher
Liu X, Yang J, Zhang S, Liu X, Liu D. Induction of cell cycle arrest at G1 and S phases and cAMP-dependent differentiation in C6 glioma by low concentration of cycloheximide. BMC Cancer. 2010;10:684 pubmed publisher
Smoak K, Aloor J, Madenspacher J, Merrick B, Collins J, Zhu X, et al. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metab. 2010;11:493-502 pubmed publisher
Eby K, Rosenbluth J, Mays D, Marshall C, Barton C, Sinha S, et al. ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. Mol Cancer. 2010;9:95 pubmed publisher
Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, et al. Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. Oncogene. 2009;28:4469-79 pubmed publisher
Kim C, Jung S, Naqvi A, Hoffman T, Dericco J, Yamamori T, et al. p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc. Circ Res. 2008;103:1441-50 pubmed publisher
Gochhait S, Dar S, Pal R, Gupta P, Bamezai R. Expression of DNA damage response genes indicate progressive breast tumors. Cancer Lett. 2009;273:305-11 pubmed publisher
Maimets T, Neganova I, Armstrong L, Lako M. Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. Oncogene. 2008;27:5277-87 pubmed publisher
Reamon Buettner S, Ciribilli Y, Inga A, Borlak J. A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Hum Mol Genet. 2008;17:1397-405 pubmed publisher
Saito T, Hama S, Izumi H, Yamasaki F, Kajiwara Y, Matsuura S, et al. Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells. Br J Cancer. 2008;98:345-55 pubmed publisher
Yosifov D, Dineva I, Zaharieva M, Konstantinov S, Berger M. The expression level of the tumor suppressor retinoblastoma protein (Rb) influences the antileukemic efficacy of erucylphospho-N,N,N-trimethylpropylammonium (ErPC3). Cancer Biol Ther. 2007;6:930-5 pubmed
Kennedy R, Chen C, Stuckert P, Archila E, De la Vega M, Moreau L, et al. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. 2007;117:1440-9 pubmed
Jackson R, Cho Y, Stein S, Liang P. CYFIP2, a direct p53 target, is leptomycin-B sensitive. Cell Cycle. 2007;6:95-103 pubmed
Alves da Costa C, Sunyach C, Pardossi Piquard R, Sevalle J, Vincent B, Boyer N, et al. Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease. J Neurosci. 2006;26:6377-85 pubmed
Fu X, Ravindranath L, Tran N, Petrovics G, Srivastava S. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol. 2006;25:135-41 pubmed
Le H, Minn A, Massague J. Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. J Biol Chem. 2005;280:32018-25 pubmed
Fan X, Liu Y, Chen J. Down-regulation of p21 contributes to apoptosis induced by HPV E6 in human mammary epithelial cells. Apoptosis. 2005;10:63-73 pubmed
product information
Catalog Number :
sc-98
Product Name :
p53 (Pab 1801) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
Pab 1801
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
p53
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), FCM
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA