product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PML (PG-M3) Antibody
catalog :
sc-966
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
PG-M3
reactivity :
Adenoviridae, African green monkey, human, mouse, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
citations: 119
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:50; loading ...; fig 1a, s1a
Guillon J, Petit C, Moreau M, Toutain B, Henry C, Roche H, et al. Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis. 2019;10:199 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3b
  • western blot; human; loading ...; fig 2a, 3a
Hirano S, Udagawa O, Kobayashi Y, Kato A. Solubility changes of promyelocytic leukemia (PML) and SUMO monomers and dynamics of PML nuclear body proteins in arsenite-treated cells. Toxicol Appl Pharmacol. 2018;360:150-159 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 4b
Forlani G, Tosi G, Turrini F, Poli G, Vicenzi E, Accolla R. Tripartite Motif-Containing Protein 22 Interacts with Class II Transactivator and Orchestrates Its Recruitment in Nuclear Bodies Containing TRIM19/PML and Cyclin T1. Front Immunol. 2017;8:564 pubmed publisher
  • immunocytochemistry; human; loading ...; fig s6i
Li J, Miralles Fusté J, Simavorian T, Bartocci C, Tsai J, Karlseder J, et al. TZAP: A telomere-associated protein involved in telomere length control. Science. 2017;355:638-641 pubmed publisher
  • immunocytochemistry; human; loading ...
Dilley R, Verma P, Cho N, Winters H, Wondisford A, Greenberg R. Break-induced telomere synthesis underlies alternative telomere maintenance. Nature. 2016;539:54-58 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2e
Maroui M, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, et al. Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. PLoS Pathog. 2016;12:e1005834 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 2
Hu Y, Shi G, Zhang L, Li F, Jiang Y, Jiang S, et al. Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX. Sci Rep. 2016;6:32280 pubmed publisher
  • western blot; human; fig 2
Surtees R, Dowall S, Shaw A, Armstrong S, Hewson R, Carroll M, et al. Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle. J Virol. 2016;90:9305-16 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 6
Hahn A, Großkopf A, Jungnickl D, Scholz B, Ensser A. Viral FGARAT Homolog ORF75 of Rhesus Monkey Rhadinovirus Effects Proteasomal Degradation of the ND10 Components SP100 and PML. J Virol. 2016;90:8013-28 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100; fig s10
Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Xu P, Mallon S, Roizman B. PML plays both inimical and beneficial roles in HSV-1 replication. Proc Natl Acad Sci U S A. 2016;113:E3022-8 pubmed publisher
  • immunocytochemistry; human; 1:400; fig s4a
Milutinovic S, Heynen Genel S, Chao E, Dewing A, Solano R, Milan L, et al. Cardiac Glycosides Activate the Tumor Suppressor and Viral Restriction Factor Promyelocytic Leukemia Protein (PML). PLoS ONE. 2016;11:e0152692 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2c
  • immunocytochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 1a
Jo S, Lee Y, Kim S, Lee H, Chung H. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Biochim Biophys Acta. 2016;1863:1499-509 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunocytochemistry; Adenoviridae; fig 1
Komatsu T, Nagata K, Wodrich H. An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies. J Virol. 2016;90:1657-67 pubmed publisher
  • immunoprecipitation; human; 1:100; fig 1
  • western blot; human; 1:250; fig s2
Buczek M, Miles A, Green W, Johnson C, Boocock D, Pockley A, et al. Cytoplasmic PML promotes TGF-β-associated epithelial-mesenchymal transition and invasion in prostate cancer. Oncogene. 2016;35:3465-75 pubmed publisher
  • immunocytochemistry; human; fig 2c
  • immunohistochemistry; human; fig 2d
Zhou W, Cheng L, Shi Y, Ke S, Huang Z, Fang X, et al. Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth. Oncotarget. 2015;6:37300-15 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 5
Vétillard A, Jonchère B, Moreau M, Toutain B, Henry C, Fontanel S, et al. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. 2015;6:43342-62 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig s5a
Pencik J, Schlederer M, Gruber W, Unger C, Walker S, Chalaris A, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 2015;6:7736 pubmed publisher
  • immunocytochemistry; human; fig s4a
Hobbs R, DePianto D, Jacob J, Han M, Chung B, Batazzi A, et al. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015;47:933-8 pubmed publisher
  • immunocytochemistry; African green monkey; fig s4a
Lee Y, Chun S, Kim K. Sumoylation controls CLOCK-BMAL1-mediated clock resetting via CBP recruitment in nuclear transcriptional foci. Biochim Biophys Acta. 2015;1853:2697-708 pubmed publisher
  • western blot; human; fig 4
Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, et al. The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget. 2015;6:23427-44 pubmed
  • immunocytochemistry; human; fig 7
Eid R, Demattei M, Episkopou H, Augé Gouillou C, Decottignies A, Grandin N, et al. Genetic Inactivation of ATRX Leads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells. Mol Cell Biol. 2015;35:2818-30 pubmed publisher
  • immunocytochemistry; human; fig 1
Giovannoni F, Damonte E, García C. Cellular promyelocytic leukemia protein is an important dengue virus restriction factor. PLoS ONE. 2015;10:e0125690 pubmed publisher
  • western blot; human; loading ...; fig 2d
Kim Y, Ahn J. Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus. PLoS Pathog. 2015;11:e1004785 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 4
Warren D, Tajsic T, Porter L, Minaisah R, Cobb A, Jacob A, et al. Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing. Cell Death Differ. 2015;22:1540-50 pubmed publisher
  • immunocytochemistry; human; fig 1
Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, et al. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle. 2015;14:375-87 pubmed publisher
  • immunocytochemistry; human
He W, Hu C, Hou J, Fan L, Xu Y, Liu M, et al. Microtubule-associated protein 1 light chain 3 interacts with and contributes to growth inhibiting effect of PML. PLoS ONE. 2014;9:e113089 pubmed publisher
  • western blot; human; 1:250
Arora R, Lee Y, Wischnewski H, Brun C, Schwarz T, Azzalin C. RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells. Nat Commun. 2014;5:5220 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Pattabiraman C, Hong S, Gunasekharan V, Pranatharthi A, Bajaj J, Srivastava S, et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res. 2014;74:6682-92 pubmed publisher
  • immunocytochemistry; human
Acharya S, Kaul Z, Gocha A, Martinez A, Harris J, Parvin J, et al. Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells. PLoS ONE. 2014;9:e103819 pubmed publisher
  • immunocytochemistry; human
Sun H, Liu Y, Hunter T. Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control. Mol Cell Biol. 2014;34:2981-95 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250
  • western blot; human; 1:250
Mathieu M, Miles A, Ahmad M, Buczek M, Pockley A, Rees R, et al. The helicase HAGE prevents interferon-?-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. Cell Death Dis. 2014;5:e1061 pubmed publisher
  • immunocytochemistry; human; 1:250; fig 2b
O Sullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014;21:167-74 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; fig 1
Tikoo S, Madhavan V, Hussain M, Miller E, Arora P, Zlatanou A, et al. Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination. EMBO J. 2013;32:1778-92 pubmed publisher
  • immunocytochemistry; human
Werwein E, Dzuganova M, Usadel C, Klempnauer K. B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. Cell Death Dis. 2013;4:e511 pubmed publisher
  • western blot; rhesus macaque; fig 4
Boichuk S, Hu L, Hein J, Gjoerup O. Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. J Virol. 2010;84:8007-20 pubmed publisher
  • immunocytochemistry; human; 2 ug/ml
Potts P, Yu H. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. Nat Struct Mol Biol. 2007;14:581-90 pubmed
Pan X, Chen Y, Biju B, Ahmed N, Kong J, Goldenberg M, et al. FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops. Sci Rep. 2019;9:19110 pubmed publisher
Bouchard J, Otero J, Scott D, Szulc E, Martin E, Sabri N, et al. Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments. Mol Cell. 2018;72:19-36.e8 pubmed publisher
Brosnan Cashman J, Yuan M, Graham M, Rizzo A, Myers K, Davis C, et al. ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner. PLoS ONE. 2018;13:e0204159 pubmed publisher
Park R, Miller G. Epstein-Barr Virus-Induced Nodules on Viral Replication Compartments Contain RNA Processing Proteins and a Viral Long Noncoding RNA. J Virol. 2018;92: pubmed publisher
Lassak A, Dean M, Wyczechowska D, Wilk A, Marrero L, Trillo Tinoco J, et al. Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival. Mol Cell Biol. 2018;38: pubmed publisher
Chen M, Wan L, Zhang J, Zhang J, Méndez L, Clohessy J, et al. Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nat Commun. 2018;9:159 pubmed publisher
Rai T, Glass M, Cole J, Rather M, Marsden M, Neilson M, et al. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Res. 2017;45:11673-11683 pubmed publisher
Daniloski Z, Smith S. Loss of Tumor Suppressor STAG2 Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells. Cancer Res. 2017;77:5530-5542 pubmed publisher
Xu P, Roizman B. The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments. Proc Natl Acad Sci U S A. 2017;114:E3823-E3829 pubmed publisher
Lamoliatte F, McManus F, Maarifi G, Chelbi Alix M, Thibault P. Uncovering the SUMOylation and ubiquitylation crosstalk in human cells using sequential peptide immunopurification. Nat Commun. 2017;8:14109 pubmed publisher
Kivipõld P, Võsa L, Ustav M, Kurg R. DAXX modulates human papillomavirus early gene expression and genome replication in U2OS cells. Virol J. 2015;12:104 pubmed publisher
Marchesini M, Matocci R, Tasselli L, Cambiaghi V, Orleth A, Furia L, et al. PML is required for telomere stability in non-neoplastic human cells. Oncogene. 2016;35:1811-21 pubmed publisher
Sharif S, Lee H, Islam M, Seog D, Moon I. N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles. Mol Cells. 2015;38:402-8 pubmed publisher
He X, Riceberg J, Pulukuri S, Grossman S, Shinde V, Shah P, et al. Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation. PLoS ONE. 2015;10:e0123882 pubmed publisher
Tokunaga K, Saitoh N, Goldberg I, Sakamoto C, Yasuda Y, Yoshida Y, et al. Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci Rep. 2014;4:6996 pubmed publisher
Guan D, Lim J, Peng L, Liu Y, Lam M, Seto E, et al. Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death. Cell Death Dis. 2014;5:e1340 pubmed publisher
Sheren J, Kassenbrock C. RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. Biochem Biophys Res Commun. 2013;440:473-8 pubmed publisher
Sasai N, Saitoh N, Saitoh H, Nakao M. The transcriptional cofactor MCAF1/ATF7IP is involved in histone gene expression and cellular senescence. PLoS ONE. 2013;8:e68478 pubmed publisher
Penkert R, Kalejta R. Human embryonic stem cell lines model experimental human cytomegalovirus latency. MBio. 2013;4:e00298-13 pubmed publisher
Foltankova V, Legartova S, Kozubek S, Hofer M, Bartova E. DNA-damage response in chromatin of ribosomal genes and the surrounding genome. Gene. 2013;522:156-67 pubmed publisher
Malloy M, McIntosh D, Walters T, Flores A, Goodwin J, Arinze I. Trafficking of the transcription factor Nrf2 to promyelocytic leukemia-nuclear bodies: implications for degradation of NRF2 in the nucleus. J Biol Chem. 2013;288:14569-83 pubmed publisher
Dutta P, Bui T, Bauckman K, Keyomarsi K, Mills G, Nanjundan M. EVI1 splice variants modulate functional responses in ovarian cancer cells. Mol Oncol. 2013;7:647-68 pubmed publisher
Tamiello C, Kamps M, van den Wijngaard A, Verstraeten V, Baaijens F, Broers J, et al. Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations. Nucleus. 2013;4:61-73 pubmed publisher
Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, et al. PML promotes MHC class II gene expression by stabilizing the class II transactivator. J Cell Biol. 2012;199:49-63 pubmed publisher
Guan D, Factor D, Liu Y, Wang Z, Kao H. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene. 2013;32:3819-28 pubmed publisher
Zhang Y, Cai L, Wei R, Hu H, Jin W, Zhu X. Different expression of alternative lengthening of telomere (ALT)-associated proteins/mRNAs in osteosarcoma cell lines. Oncol Lett. 2011;2:1327-1332 pubmed
Mauvezin C, Sancho A, Ivanova S, Palacin M, Zorzano A. DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus. FEBS Lett. 2012;586:3179-86 pubmed publisher
Hsu J, Lin T, Tsai R. Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1. J Cell Biol. 2012;197:613-24 pubmed publisher
Parikh N, Shuck R, Nguyen T, Herron A, Donehower L. Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses. Mol Cancer Res. 2012;10:845-55 pubmed publisher
Chen S, Evans H, Evans D. FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. PLoS ONE. 2012;7:e32971 pubmed publisher
Dieriks B, Van Oostveldt P. Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription. Int J Mol Med. 2012;29:1031-8 pubmed publisher
Tang Y, Puri A, Ricketts M, Rai T, Hoffmann J, Hoi E, et al. Identification of an ubinuclein 1 region required for stability and function of the human HIRA/UBN1/CABIN1/ASF1a histone H3.3 chaperone complex. Biochemistry. 2012;51:2366-77 pubmed publisher
Rai T, Puri A, McBryan T, Hoffman J, Tang Y, Pchelintsev N, et al. Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol. 2011;31:4107-18 pubmed publisher
Martínez Guinó L, Ballester M, Segales J, Kekarainen T. Expression profile and subcellular localization of Torque teno sus virus proteins. J Gen Virol. 2011;92:2446-57 pubmed publisher
Sides M, Block G, Shan B, Esteves K, Lin Z, Flemington E, et al. Arsenic mediated disruption of promyelocytic leukemia protein nuclear bodies induces ganciclovir susceptibility in Epstein-Barr positive epithelial cells. Virology. 2011;416:86-97 pubmed publisher
Cosme R, Martínez F, Tang Q. Functional interaction of nuclear domain 10 and its components with cytomegalovirus after infections: cross-species host cells versus native cells. PLoS ONE. 2011;6:e19187 pubmed publisher
Jiang M, Entezami P, Gamez M, Stamminger T, Imperiale M. Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection. MBio. 2011;2:e00281-10 pubmed publisher
Yen C, Tsao Y, Chen P, Wu Y, Liu J, Pan C, et al. PML protein as a prognostic molecular marker for patients with esophageal squamous cell carcinomas receiving primary surgery. J Surg Oncol. 2011;103:761-7 pubmed publisher
Park R, Wang ondu R, Heston L, Shedd D, Miller G. Efficient induction of nuclear aggresomes by specific single missense mutations in the DNA-binding domain of a viral AP-1 homolog. J Biol Chem. 2011;286:9748-62 pubmed publisher
Kuny C, Chinchilla K, Culbertson M, Kalejta R. Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases. PLoS Pathog. 2010;6:e1001092 pubmed publisher
Tower C, Fu L, Gill R, Prichard M, Lesort M, Sztul E. Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia. Neurobiol Dis. 2011;41:11-22 pubmed publisher
Kaur S, Modi P, Srivastava V, Mudgal R, Tikoo S, Arora P, et al. Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage. Mol Cancer Res. 2010;8:1234-47 pubmed publisher
Munday D, Emmott E, Surtees R, Lardeau C, Wu W, Duprex W, et al. Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus. Mol Cell Proteomics. 2010;9:2438-59 pubmed publisher
Salmina K, Jankevics E, Huna A, Perminov D, Radovica I, Klymenko T, et al. Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. Exp Cell Res. 2010;316:2099-112 pubmed publisher
Larriba M, Casado Vela J, Pendás Franco N, Peña R, Garcia de Herreros A, Berciano M, et al. Novel snail1 target proteins in human colon cancer identified by proteomic analysis. PLoS ONE. 2010;5:e10221 pubmed publisher
Saffert R, Penkert R, Kalejta R. Cellular and viral control over the initial events of human cytomegalovirus experimental latency in CD34+ cells. J Virol. 2010;84:5594-604 pubmed publisher
Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh E, et al. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem. 2010;285:12906-15 pubmed publisher
Warren D, Tajsic T, Mellad J, Searles R, Zhang Q, Shanahan C. Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. J Biol Chem. 2010;285:1311-20 pubmed publisher
Hancock R, Hadj Sahraoui Y. Isolation of cell nuclei using inert macromolecules to mimic the crowded cytoplasm. PLoS ONE. 2009;4:e7560 pubmed publisher
Temime Smaali N, Guittat L, Sidibe A, Shin ya K, Trentesaux C, Riou J. The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells. PLoS ONE. 2009;4:e6919 pubmed publisher
Moiseeva O, Bourdeau V, Roux A, Deschênes Simard X, Ferbeyre G. Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol. 2009;29:4495-507 pubmed publisher
Haupt S, Di Agostino S, Mizrahi I, Alsheich Bartok O, Voorhoeve M, Damalas A, et al. Promyelocytic leukemia protein is required for gain of function by mutant p53. Cancer Res. 2009;69:4818-26 pubmed publisher
Sobol P, Hummel J, Rodrigues R, Mossman K. PML has a predictive role in tumor cell permissiveness to interferon-sensitive oncolytic viruses. Gene Ther. 2009;16:1077-87 pubmed publisher
Pendino F, Nguyen E, Jonassen I, Dysvik B, Azouz A, Lanotte M, et al. Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis. Blood. 2009;113:3172-81 pubmed publisher
Ecker K, Lorenz A, Wolf F, Ploner C, Böck G, Duncan T, et al. A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein. J Mol Endocrinol. 2009;42:105-17 pubmed publisher
Gu H, Roizman B. The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem. J Virol. 2009;83:181-7 pubmed publisher
Crosetto N, Bienko M, Hibbert R, Perica T, Ambrogio C, Kensche T, et al. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. J Biol Chem. 2008;283:35173-85 pubmed publisher
Zhu J, Zhu S, Guzzo C, Ellis N, Sung K, Choi C, et al. Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification. J Biol Chem. 2008;283:29405-15 pubmed publisher
Gao C, Ho C, Reineke E, Lam M, Cheng X, Stanya K, et al. Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. Mol Cell Biol. 2008;28:5658-67 pubmed publisher
Metzler Guillemain C, Depetris D, Luciani J, Mignon Ravix C, Mitchell M, Mattei M. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res. 2008;16:761-82 pubmed publisher
Gao C, Cheng X, Lam M, Liu Y, Liu Q, Chang K, et al. Signal-dependent regulation of transcription by histone deacetylase 7 involves recruitment to promyelocytic leukemia protein nuclear bodies. Mol Biol Cell. 2008;19:3020-7 pubmed publisher
Temime Smaali N, Guittat L, Wenner T, Bayart E, Douarre C, Gomez D, et al. Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres. EMBO J. 2008;27:1513-24 pubmed publisher
Tan J, Sun Y, Song J, Chen Y, Krontiris T, Durrin L. SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. J Biol Chem. 2008;283:18124-34 pubmed publisher
Konietzko U, Goodger Z, Meyer M, Kohli B, Bosset J, Lahiri D, et al. Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories. Neurobiol Aging. 2010;31:58-73 pubmed publisher
Stagno d Alcontres M, Mendez Bermudez A, Foxon J, Royle N, Salomoni P. Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA. J Cell Biol. 2007;179:855-67 pubmed
Messaoudi L, Yang Y, Kinomura A, Stavreva D, Yan G, Bortolin Cavaillé M, et al. Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress. Nucleic Acids Res. 2007;35:6571-87 pubmed
Coady T, Shababi M, Tullis G, Lorson C. Restoration of SMN function: delivery of a trans-splicing RNA re-directs SMN2 pre-mRNA splicing. Mol Ther. 2007;15:1471-8 pubmed
Tanaka T, Grusby M, Kaisho T. PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol. 2007;8:584-91 pubmed
Mateyak M, Zakian V. Human PIF helicase is cell cycle regulated and associates with telomerase. Cell Cycle. 2006;5:2796-804 pubmed
Mohan R, Rao A, Gagliardi J, Tini M. SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment. Mol Cell Biol. 2007;27:229-43 pubmed
Barcaroli D, Dinsdale D, Neale M, Bongiorno Borbone L, Ranalli M, Munarriz E, et al. FLASH is an essential component of Cajal bodies. Proc Natl Acad Sci U S A. 2006;103:14802-7 pubmed
Joe Y, Jeong J, Yang S, Kang H, Motoyama N, Pandolfi P, et al. ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006;281:28764-71 pubmed
Yang S, Jeong J, Brown A, Lee C, Pandolfi P, Chung J, et al. Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. J Biol Chem. 2006;281:26645-54 pubmed
Son S, Yu E, Ahn Y, Choi E, Lee H, Choi J. Retinoic acid attenuates promyelocytic leukemia protein-induced cell death in breast cancer cells by activation of the ubiquitin-proteasome pathway. Cancer Lett. 2007;247:213-23 pubmed
Tamrakar S, Kapasi A, Spector D. Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7. J Virol. 2005;79:15477-93 pubmed
Fu L, Gao Y, Tousson A, Shah A, Chen T, Vertel B, et al. Nuclear aggresomes form by fusion of PML-associated aggregates. Mol Biol Cell. 2005;16:4905-17 pubmed
Storstein A, Knudsen A, Vedeler C. Proteasome antibodies in paraneoplastic cerebellar degeneration. J Neuroimmunol. 2005;165:172-8 pubmed
Ben Dor A, Steiner M, Gheber L, Danilenko M, Dubi N, Linnewiel K, et al. Carotenoids activate the antioxidant response element transcription system. Mol Cancer Ther. 2005;4:177-86 pubmed
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product information
Product Name :
PML (PG-M3) Antibody
Gene Name :
PML
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-966
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
PML
reactive species  :
human
Application :
WB, IP, IF, IHC(P)
Epitope :
37-51 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA