This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p63 (4A4)
catalog :
sc-8431
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 31
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2c
Francis R, Guo H, Streutker C, Ahmed M, Yung T, Dirks P, et al. Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. Sci Adv. 2019;5:eaax8898 pubmed publisher
  • western blot; mouse; loading ...; fig 5d
Chen L, Hayden M, Gilmore E, Alexander Savino C, Oleksyn D, Gillespie K, et al. PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis. Carcinogenesis. 2018;39:418-428 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2e
Kousa Y, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, et al. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017;96:1306-1313 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1a
Giroux V, Lento A, Islam M, Pitarresi J, Kharbanda A, Hamilton K, et al. Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. J Clin Invest. 2017;127:2378-2391 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 5i
Ojeh N, Akgul B, Tomic Canic M, Philpott M, Navsaria H. In vitro skin models to study epithelial regeneration from the hair follicle. PLoS ONE. 2017;12:e0174389 pubmed publisher
  • immunohistochemistry - frozen section; human; fig 1e
Miyashita H, Niwano H, Yoshida S, Hatou S, Inagaki E, Tsubota K, et al. Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model. Sci Rep. 2017;7:43557 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 4a
Mulay A, Akram K, Williams D, Armes H, Russell C, Hood D, et al. An in vitro model of murine middle ear epithelium. Dis Model Mech. 2016;9:1405-1417 pubmed
  • immunoprecipitation; human; loading ...; fig 1d
  • western blot; human; 1:200; loading ...; fig 3e
Han A, Li J, Li Y, Wang Y, Bergholz J, Zhang Y, et al. p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability. Oncotarget. 2016;7:44277-44287 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2b
Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 1
Wang H, Wang L, Jerde T, Chan B, Savran C, Burcham G, et al. Characterization of autoimmune inflammation induced prostate stem cell expansion. Prostate. 2015;75:1620-31 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig s2b
Yang N, Li L, Eguether T, Sundberg J, Pazour G, Chen J. Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development. 2015;142:2194-202 pubmed publisher
Fisher M, Balinth S, Hwangbo Y, Wu C, Ballon C, Wilkinson J, et al. BRD4 Regulates Transcription Factor ΔNp63α to Drive a Cancer Stem Cell Phenotype in Squamous Cell Carcinomas. Cancer Res. 2021;81:6246-6258 pubmed publisher
Islam M, Ichii O, Nakamura T, Irie T, Shinohara A, Masum M, et al. Comparison of Ovarian Morphology and Follicular Disturbances between Two Inbred Strains of Cotton Rats (Sigmodon hispidus). Animals (Basel). 2021;11: pubmed publisher
Leibold J, Ruscetti M, Cao Z, Ho Y, Baslan T, Zou M, et al. Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis. Cancer Discov. 2020;10:1038-1057 pubmed publisher
Sato T, Yoo S, Kong R, Sinha A, Chandramani Shivalingappa P, Patel A, et al. Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma. Cancer Res. 2019;79:6084-6100 pubmed publisher
Ding L, Su Y, Fassl A, Hinohara K, Qiu X, Harper N, et al. Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ. Nat Commun. 2019;10:4182 pubmed publisher
Zubeldia Plazaola A, Recalde Percaz L, Moragas N, Alcaraz M, Chen X, Mancino M, et al. Glucocorticoids promote transition of ductal carcinoma in situ to invasive ductal carcinoma by inducing myoepithelial cell apoptosis. Breast Cancer Res. 2018;20:65 pubmed publisher
Bigas J, Sevilla L, Carceller E, Boix J, Perez P. Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation. Cell Death Dis. 2018;9:588 pubmed publisher
Grun D, Adhikary G, Eckert R. NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival. Oncogene. 2018;37:4711-4722 pubmed publisher
Chua C, Epsi N, Leung E, Xuan S, Lei M, Li B, et al. Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation. elife. 2018;7: pubmed publisher
Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, et al. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol. 2018;217:1097-1112 pubmed publisher
Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017;43:436-448.e6 pubmed publisher
Fisher M, Ciavattone N, Grun D, Adhikary G, Eckert R. Sulforaphane reduces YAP/?Np63? signaling to reduce cancer stem cell survival and tumor formation. Oncotarget. 2017;8:73407-73418 pubmed publisher
Hoelzl M, Heby Henricson K, Gerling M, Dias J, Kuiper R, Trünkle C, et al. Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model. Dev Biol. 2017;429:132-146 pubmed publisher
Carter E, Gopsill J, Gomm J, Jones J, Grose R. A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer. Breast Cancer Res. 2017;19:50 pubmed publisher
Di Giacomo V, Tian T, Mas A, Pecoraro M, Batlle Morera L, Noya L, et al. ΔNp63α promotes adhesion of metastatic prostate cancer cells to the bone through regulation of CD82. Oncogene. 2017;36:4381-4392 pubmed publisher
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed publisher
Yi Y, Chen D, Ao J, Sun S, Wu M, Li X, et al. Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ?Np63? Protein Expression and Inhibits Cancer Cell Viability. J Biol Chem. 2017;292:5253-5261 pubmed publisher
Zheng D, Soh B, Yin L, Hu G, Chen Q, Choi H, et al. Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro. Sci Rep. 2017;7:41661 pubmed publisher
Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, et al. Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma. Sci Rep. 2013;3:1160 pubmed publisher
Ying H, Chang D, Zheng H, McKeon F, Xiao Z. DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol Cell Biol. 2005;25:6154-64 pubmed
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA