product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Brn-3a (14A6) Antibody
catalog :
sc-8429
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
14A6
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig s2g
Portillo J, Lopez Corcino Y, Miao Y, Tang J, Sheibani N, Kern T, et al. CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. Diabetes. 2017;66:483-493 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig 6
Jain V, Srivastava I, Palchaudhuri S, Goel M, Sinha Mahapatra S, Dhingra N. Classical Photoreceptors Are Primarily Responsible for the Pupillary Light Reflex in Mouse. PLoS ONE. 2016;11:e0157226 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 5
Sluch V, Davis C, Ranganathan V, Kerr J, Krick K, Martin R, et al. Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep. 2015;5:16595 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Wende C, Zoubaa S, Blak A, Echevarria D, Martinez S, Guillemot F, et al. Hairy/Enhancer-of-Split MEGANE and Proneural MASH1 Factors Cooperate Synergistically in Midbrain GABAergic Neurogenesis. PLoS ONE. 2015;10:e0127681 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Munguba G, Galeb S, Liu Y, Landy D, Lam D, Camp A, et al. Nerve fiber layer thinning lags retinal ganglion cell density following crush axonopathy. Invest Ophthalmol Vis Sci. 2014;55:6505-13 pubmed publisher
  • immunocytochemistry; rat; 1:200
  • immunohistochemistry; rat; 1:200
Omodaka K, Kurimoto T, Nakamura O, Sato K, Yasuda M, Tanaka Y, et al. Artemin augments survival and axon regeneration in axotomized retinal ganglion cells. J Neurosci Res. 2014;92:1637-46 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200
Mesman S, von Oerthel L, Smidt M. Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling. PLoS ONE. 2014;9:e97926 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 2, 3
Di Giovannantonio L, Di Salvio M, Omodei D, Prakash N, Wurst W, Pierani A, et al. Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity. Development. 2014;141:377-88 pubmed publisher
  • immunohistochemistry; mouse; 1:250
Jain V, Ravindran E, Dhingra N. Differential expression of Brn3 transcription factors in intrinsically photosensitive retinal ganglion cells in mouse. J Comp Neurol. 2012;520:742-55 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:200
Díaz E, Bravo D, Rojas X, Concha M. Morphologic and immunohistochemical organization of the human habenular complex. J Comp Neurol. 2011;519:3727-47 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
Nasonkin I, Lazo K, Hambright D, Brooks M, Fariss R, Swaroop A. Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina. J Comp Neurol. 2011;519:1914-30 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50
Kawano J, Tanizawa Y, Shinoda K. Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system. J Comp Neurol. 2008;510:1-23 pubmed publisher
  • immunohistochemistry; mouse; 1:500
Elshatory Y, Deng M, Xie X, Gan L. Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol. 2007;503:182-97 pubmed
Korecki A, Hickmott J, Lam S, Dreolini L, Mathelier A, Baker O, et al. Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele. Genetics. 2019;211:1155-1177 pubmed publisher
Assi S, Imperato M, Coleman D, Pickin A, Potluri S, Ptasinska A, et al. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nat Genet. 2019;51:151-162 pubmed publisher
Lin Y, Kuo K, Chen S, Huang H. RBFOX3/NeuN is dispensable for visual function. PLoS ONE. 2018;13:e0192355 pubmed publisher
Riazifar H, Sun G, Wang X, Rupp A, Vemaraju S, Ross Cisneros F, et al. Phenotypic and functional characterization of Bst+/- mouse retina. Dis Model Mech. 2015;8:969-76 pubmed publisher
Deng M, Yang H, Xie X, Liang G, Gan L. Comparative expression analysis of POU4F1, POU4F2 and ISL1 in developing mouse cochleovestibular ganglion neurons. Gene Expr Patterns. 2014;15:31-7 pubmed publisher
Francius C, Harris A, Rucchin V, Hendricks T, Stam F, Barber M, et al. Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord. PLoS ONE. 2013;8:e70325 pubmed publisher
Nadal Nicolás F, Jiménez López M, Salinas Navarro M, Sobrado Calvo P, Alburquerque Béjar J, Vidal Sanz M, et al. Whole number, distribution and co-expression of brn3 transcription factors in retinal ganglion cells of adult albino and pigmented rats. PLoS ONE. 2012;7:e49830 pubmed publisher
Asahina H, Masuba A, Hirano S, Yuri K. Distribution of protocadherin 9 protein in the developing mouse nervous system. Neuroscience. 2012;225:88-104 pubmed publisher
Achim K, Peltopuro P, Lahti L, Li J, Salminen M, Partanen J. Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region. Development. 2012;139:2360-70 pubmed publisher
Espana A, Clotman F. Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Mol Cell Neurosci. 2012;50:93-102 pubmed publisher
Greber B, Coulon P, Zhang M, Moritz S, Frank S, Müller Molina A, et al. FGF signalling inhibits neural induction in human embryonic stem cells. EMBO J. 2011;30:4874-84 pubmed publisher
Camp A, Ruggeri M, Munguba G, Tapia M, John S, Bhattacharya S, et al. Structural correlation between the nerve fiber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene. Invest Ophthalmol Vis Sci. 2011;52:5226-32 pubmed publisher
Peltopuro P, Kala K, Partanen J. Distinct requirements for Ascl1 in subpopulations of midbrain GABAergic neurons. Dev Biol. 2010;343:63-70 pubmed publisher
Lin W, Metzakopian E, Mavromatakis Y, Gao N, Balaskas N, Sasaki H, et al. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Dev Biol. 2009;333:386-96 pubmed publisher
Li H, Costantini C, Scrable H, Weindruch R, Puglielli L. Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R. Neurobiol Aging. 2009;30:2010-20 pubmed publisher
Elshatory Y, Everhart D, Deng M, Xie X, Barlow R, Gan L. Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci. 2007;27:12707-20 pubmed
Ferri A, Lin W, Mavromatakis Y, Wang J, Sasaki H, Whitsett J, et al. Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007;134:2761-9 pubmed
Weishaupt J, Klocker N, Bahr M. Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. J Mol Neurosci. 2005;26:17-25 pubmed
Vernay B, Koch M, Vaccarino F, Briscoe J, Simeone A, Kageyama R, et al. Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci. 2005;25:4856-67 pubmed
Wagner N, Wagner K, Hammes A, Kirschner K, Vidal V, Schedl A, et al. A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development. 2005;132:1327-36 pubmed
product information
Product Name :
Brn-3a (14A6) Antibody
Gene Name :
POU4F1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8429
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Brn-3a
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1-109 (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA