product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
E-cadherin (G-10) Antibody
catalog :
sc-8426
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G-10
reactivity :
human, mouse, rat, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 81
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5c
Gao S, Gao L, Wang S, Shi X, Yue C, Wei S, et al. ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021;9:618987 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 4b
Wijshake T, Zou Z, Chen B, Zhong L, Xiao G, Xie Y, et al. Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2a
Li Y, He J, Wang F, Wang X, Yang F, Zhao C, et al. Role of MMP-9 in epithelial-mesenchymal transition of thyroid cancer. World J Surg Oncol. 2020;18:181 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 5a
Wang Z, Li Y, Zhan S, Zhang L, Zhang S, Tang Q, et al. SMAD4 Y353C promotes the progression of PDAC. BMC Cancer. 2019;19:1037 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4e
Xu P, Tao X, Zhao C, Huang Q, Chang H, Ban N, et al. DTX3L is upregulated in glioma and is associated with glioma progression. Int J Mol Med. 2017;40:491-498 pubmed publisher
  • immunocytochemistry; human; 2 ug/ml; loading ...; fig s1
Samson E, Tsao D, Zimak J, McLaughlin R, Trenton N, Mace E, et al. The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks. Biol Open. 2017;6:785-799 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6a
Fu H, Ma Y, Yang M, Zhang C, Huang H, Xia Y, et al. Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation. Sci Rep. 2016;6:29762 pubmed publisher
  • western blot; human; 1:1000; fig 3B
Lin X, Yang Z, Zhang P, Liu Y, Shao G. miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2. Oncol Lett. 2016;12:301-306 pubmed
  • western blot; human; 1:1000; fig 4
Kokado M, Okada Y, Miyamoto T, Yamanaka O, Saika S. Effects of epiplakin-knockdown in cultured corneal epithelial cells. BMC Res Notes. 2016;9:278 pubmed publisher
  • western blot; human; fig 4
  • western blot; mouse; fig 8
Shukla S, Sinha S, Khan S, Kumar S, Singh K, Mitra K, et al. Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis. Sci Rep. 2016;6:21860 pubmed publisher
  • western blot; human; fig 3
Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, et al. ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. PLoS ONE. 2016;11:e0147344 pubmed publisher
  • western blot; human; 1:500; fig 2a
Martínez Revollar G, Garay E, Martín Tapia D, Nava P, Huerta M, Lopez Bayghen E, et al. Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways. Exp Cell Res. 2015;339:67-80 pubmed publisher
  • western blot; human; fig 5
Yan M, Yao C, Chow J, Chang C, Hwang P, Chuang S, et al. Fucoidan Elevates MicroRNA-29b to Regulate DNMT3B-MTSS1 Axis and Inhibit EMT in Human Hepatocellular Carcinoma Cells. Mar Drugs. 2015;13:6099-116 pubmed publisher
  • western blot; mouse
Wang J, Bao L, Yu B, Liu Z, Han W, Deng C, et al. Interleukin-1β Promotes Epithelial-Derived Alveolar Elastogenesis via αvβ6 Integrin-Dependent TGF-β Activation. Cell Physiol Biochem. 2015;36:2198-216 pubmed publisher
  • western blot; human
Faura Tellez G, Vandepoele K, Brouwer U, Koning H, Elderman R, Hackett T, et al. Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription. Am J Physiol Lung Cell Mol Physiol. 2015;309:L725-35 pubmed publisher
  • immunocytochemistry; rat; fig 5
  • western blot; rat; fig 2
He D, Lu Y, Hu H, Zhang J, Qin B, Wang Y, et al. The Wnt11 Signaling Pathway in Potential Cellular EMT and Osteochondral Differentiation Progression in Nephrolithiasis Formation. Int J Mol Sci. 2015;16:16313-29 pubmed publisher
  • western blot; human; fig s2a
Cho J, Lee S, Oh A, Yoon M, Woo T, Park B. NF2 blocks Snail-mediated p53 suppression in mesothelioma. Oncotarget. 2015;6:10073-85 pubmed
  • western blot; human; fig 6
Li S, Wu X, Dong C, Xie X, Wu J, Zhang X. The differential expression of OCT4 isoforms in cervical carcinoma. PLoS ONE. 2015;10:e0118033 pubmed publisher
  • western blot; human; 1:1000; fig 3
Chen C, Zhao Z, Liu Y, Mu D. microRNA-99a is downregulated and promotes proliferation, migration and invasion in non-small cell lung cancer A549 and H1299 cells. Oncol Lett. 2015;9:1128-1134 pubmed
  • immunohistochemistry - paraffin section; mouse; fig 6
  • immunohistochemistry - paraffin section; human; fig 6
Bele A, Mirza S, Zhang Y, Ahmad Mir R, Lin S, Kim J, et al. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Cell Cycle. 2015;14:990-1000 pubmed publisher
  • immunocytochemistry; domestic rabbit; 5 ug/ml
Powell J, Hess B, Hutchison J, Straub T. Construction of an in vitro primary lung co-culture platform derived from New Zealand white rabbits. In Vitro Cell Dev Biol Anim. 2015;51:433-40 pubmed publisher
  • western blot; human; fig 2
Shukla S, Sharma H, Abbas A, MacLennan G, Fu P, Danielpour D, et al. Upregulation of SATB1 is associated with prostate cancer aggressiveness and disease progression. PLoS ONE. 2013;8:e53527 pubmed publisher
Fu D, Ren Y, Wang C, Yu L, Yu R. LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway. BMC Cancer. 2021;21:782 pubmed publisher
Chen Y, Lear T, EVANKOVICH J, Larsen M, Lin B, Alfaras I, et al. A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry. Nat Commun. 2021;12:3907 pubmed publisher
Gori M, Altomare A, Cocca S, Solida E, Ribolsi M, Carotti S, et al. Palmitic Acid Affects Intestinal Epithelial Barrier Integrity and Permeability In Vitro. Antioxidants (Basel). 2020;9: pubmed publisher
Jalaleddine N, El Hajjar L, Dakik H, Shaito A, Saliba J, Safi R, et al. Pannexin1 Is Associated with Enhanced Epithelial-To-Mesenchymal Transition in Human Patient Breast Cancer Tissues and in Breast Cancer Cell Lines. Cancers (Basel). 2019;11: pubmed publisher
Huang J, Lo U, Wu S, Wang B, Pong R, Lai C, et al. The roles and mechanism of IFIT5 in bladder cancer epithelial-mesenchymal transition and progression. Cell Death Dis. 2019;10:437 pubmed publisher
McNair K, Forrest C, Vincenten M, Darlington L, Stone T. Serine protease modulation of Dependence Receptors and EMT protein expression. Cancer Biol Ther. 2018;:1-19 pubmed publisher
Schaal C, Bora Singhal N, Kumar D, Chellappan S. Regulation of Sox2 and stemness by nicotine and electronic-cigarettes in non-small cell lung cancer. Mol Cancer. 2018;17:149 pubmed publisher
Huang L, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, et al. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun. 2018;9:3569 pubmed publisher
Gunasekaran M, Sharma M, Hachem R, Bremner R, Smith M, Mohanakumar T. Circulating Exosomes with Distinct Properties during Chronic Lung Allograft Rejection. J Immunol. 2018;200:2535-2541 pubmed publisher
Zhang J, Cao H, Xie J, Fan C, Xie Y, He X, et al. The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation. Cell Death Dis. 2018;9:224 pubmed publisher
Mendes G, Haag T, Trott G, Rech C, Ferreira N, Oliveira M, et al. Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly. Braz J Med Biol Res. 2017;51:e6808 pubmed publisher
Sathyanarayanan A, Chandrasekaran K, Karunagaran D. microRNA-145 downregulates SIP1-expression but differentially regulates proliferation, migration, invasion and Wnt signaling in SW480 and SW620 cells. J Cell Biochem. 2018;119:2022-2035 pubmed publisher
Duan F, Jia D, Zhao J, Wu W, Min L, Song S, et al. Loss of GFAT1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer. Oncotarget. 2016;7:38427-39 pubmed publisher
Verma N, Keinan O, Selitrennik M, Karn T, Filipits M, Lev S. PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition. Nat Commun. 2015;6:6064 pubmed publisher
Yao D, Peng S, Dai C. The role of hepatocyte nuclear factor 4alpha in metastatic tumor formation of hepatocellular carcinoma and its close relationship with the mesenchymal-epithelial transition markers. BMC Cancer. 2013;13:432 pubmed publisher
Su H, Weng C, Hsiao P, Chen L, Kuo T, Chen Y, et al. Stem cell marker nestin is critical for TGF-?1-mediated tumor progression in pancreatic cancer. Mol Cancer Res. 2013;11:768-79 pubmed publisher
König K, Meder L, Kröger C, Diehl L, Florin A, Rommerscheidt Fuss U, et al. Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS ONE. 2013;8:e57996 pubmed publisher
Rouabhia M, Semlali A, Audoy J, Chmielewski W. Antagonistic effect of Candida albicans and IFN? on E-cadherin expression and production by human primary gingival epithelial cells. Cell Immunol. 2012;280:61-7 pubmed publisher
Liu S, Miao Y, Fan C, Liu Y, Yu J, Zhang Y, et al. Clinicopathologic correlations of liver kinase B1, E-cadherin, and N-cadherin expression in non-small cell lung cancer. Appl Immunohistochem Mol Morphol. 2013;21:334-40 pubmed publisher
Chen S, Nieh S, Jao S, Liu C, Wu C, Chang Y, et al. Quercetin suppresses drug-resistant spheres via the p38 MAPK-Hsp27 apoptotic pathway in oral cancer cells. PLoS ONE. 2012;7:e49275 pubmed publisher
Yao X, Wang X, Wang Z, Dai L, Zhang G, Yan Q, et al. Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma. Onco Targets Ther. 2012;5:255-61 pubmed publisher
Miao Y, Li A, Wang L, Fan C, Zhang X, Xu H, et al. Overexpression of NEDD9 is associated with altered expression of E-Cadherin, β-Catenin and N-Cadherin and predictive of poor prognosis in non-small cell lung cancer. Pathol Oncol Res. 2013;19:281-6 pubmed publisher
Song H, Song C, Wang H, Li C, Yang F, Lu S, et al. Suppression of hepatocarcinoma model in vitro and in vivo by ECRG2 delivery using adenoviral vector. Cancer Gene Ther. 2012;19:875-9 pubmed publisher
Mozzetti S, Martinelli E, Raspaglio G, Prislei S, De Donato M, Filippetti F, et al. Gli family transcription factors are drivers of patupilone resistance in ovarian cancer. Biochem Pharmacol. 2012;84:1409-18 pubmed publisher
Leung C, Shaheen F, Bernatchez P, Hackett T. Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression. PLoS ONE. 2012;7:e40478 pubmed publisher
Cheng B, Jiang Y, Li D, Fan J, Ma M. Up-regulation of thy-1 promotes invasion and metastasis of hepatocarcinomas. Asian Pac J Cancer Prev. 2012;13:1349-53 pubmed
Liu W, Ji S, Sun J, Zhang Y, Liu Z, Liang A, et al. CD146 expression correlates with epithelial-mesenchymal transition markers and a poor prognosis in gastric cancer. Int J Mol Sci. 2012;13:6399-406 pubmed publisher
Zhan L, Zhang H, Zhang Q, Woods C, Chen Y, Xue P, et al. Regulatory role of KEAP1 and NRF2 in PPAR? expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012;53:758-68 pubmed publisher
Yu J, Miao Y, Xu H, Liu Y, Jiang G, Stoecker M, et al. N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. PLoS ONE. 2012;7:e37008 pubmed publisher
Li Q, Gao H, Xu H, Wang X, Pan Y, Hao F, et al. Expression of ezrin correlates with malignant phenotype of lung cancer, and in vitro knockdown of ezrin reverses the aggressive biological behavior of lung cancer cells. Tumour Biol. 2012;33:1493-504 pubmed publisher
Chen S, Chang Y, Nieh S, Liu C, Yang C, Lin Y. Nonadhesive culture system as a model of rapid sphere formation with cancer stem cell properties. PLoS ONE. 2012;7:e31864 pubmed publisher
Acuña Sanhueza G, Faller L, George B, Koffler J, Misetic V, Flechtenmacher C, et al. Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells. BMC Cancer. 2012;12:72 pubmed publisher
Lee M, Kim H, Kim T, Lee J. Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition. Biochim Biophys Acta. 2012;1823:514-23 pubmed publisher
Fan C, Zhao Y, Liu D, Zhang X, Wang E. Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance. Tumour Biol. 2011;32:873-80 pubmed publisher
Doratiotto S, Krause P, Serra M, Marongiu F, Sini M, Koenig S, et al. The growth pattern of transplanted normal and nodular hepatocytes. Histochem Cell Biol. 2011;135:581-91 pubmed publisher
Huang K, Sui L. The relevance and role of vascular endothelial growth factor C, matrix metalloproteinase-2 and E-cadherin in epithelial ovarian cancer. Med Oncol. 2012;29:318-23 pubmed publisher
Li Q, Chen Z, Cao X, Xu J, Xu J, Chen Y, et al. Involvement of NF-?B/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ. 2011;18:16-25 pubmed publisher
Ren X, Zhang J, Gong X, Niu X, Zhang X, Chen P, et al. Differentiation of murine embryonic stem cells toward renal lineages by conditioned medium from ureteric bud cells in vitro. Acta Biochim Biophys Sin (Shanghai). 2010;42:464-71 pubmed publisher
Shi Y, Tu Z, Bao J, Sun H, Wang W, Luo G, et al. Urinary connective tissue growth factor increases far earlier than histopathological damage and functional deterioration in early chronic renal allograft injury. Scand J Urol Nephrol. 2009;43:390-9 pubmed publisher
Prasad C, Rath G, Mathur S, Bhatnagar D, Parshad R, Ralhan R. Expression analysis of E-cadherin, Slug and GSK3beta in invasive ductal carcinoma of breast. BMC Cancer. 2009;9:325 pubmed publisher
Guo W, Dong Z, Guo Y, Kuang G, Yang Z, Chen Z. Detection of promoter hypermethylation of the CpG island of E-cadherin in gastric cardiac adenocarcinoma. Eur J Med Res. 2009;14:453-8 pubmed
Rieber M, Strasberg Rieber M. DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin. Int J Cancer. 2009;125:1604-12 pubmed publisher
Isohata N, Aoyagi K, Mabuchi T, Daiko H, Fukaya M, Ohta H, et al. Hedgehog and epithelial-mesenchymal transition signaling in normal and malignant epithelial cells of the esophagus. Int J Cancer. 2009;125:1212-21 pubmed publisher
Nikolova D, Asangani I, Nelson L, Hughes D, Siwak D, Mills G, et al. Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity. Cancer Res. 2009;69:2461-70 pubmed publisher
Prudkin L, Liu D, Ozburn N, Sun M, Behrens C, Tang X, et al. Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung. Mod Pathol. 2009;22:668-78 pubmed publisher
Zhou W, Ye X, Sun Z, Ji X, Chen H, Xie D. Overexpression of degenerative spermatocyte homolog 1 up-regulates the expression of cyclin D1 and enhances metastatic efficiency in esophageal carcinoma Eca109 cells. Mol Carcinog. 2009;48:886-94 pubmed publisher
Cokakli M, Erdal E, Nart D, Yilmaz F, Sagol O, Kilic M, et al. Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasion. BMC Cancer. 2009;9:65 pubmed publisher
Arican R, Sahin Z, Ustunel I, Sarikcioglu L, Ozdem S, Oguz N. Effects of formaldehyde inhalation on the junctional proteins of nasal respiratory mucosa of rats. Exp Toxicol Pathol. 2009;61:297-305 pubmed publisher
Bataille F, Rohrmeier C, Bates R, Weber A, Rieder F, Brenmoehl J, et al. Evidence for a role of epithelial mesenchymal transition during pathogenesis of fistulae in Crohn's disease. Inflamm Bowel Dis. 2008;14:1514-27 pubmed publisher
Bao J, Tu Z, Sun H, Luo G, Yang L, Song J, et al. R2: identification of renal potential progenitor/stem cells that participate in the renal regeneration processes of kidney allograft fibrosis. Nephrology (Carlton). 2008;13:500-7 pubmed publisher
Atsumi T, Kato K, Uno K, Iijima K, Koike T, Imatani A, et al. Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer. Pathol Int. 2007;57:635-44 pubmed
Jung J, Hwang S, Hwang J, Oh E, Park S, Han I. Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells. Eur J Cancer. 2007;43:1214-24 pubmed
Kim H, Litzenburger B, Cui X, Delgado D, Grabiner B, Lin X, et al. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol Cell Biol. 2007;27:3165-75 pubmed
Kleiner S, Faisal A, Nagamine Y. Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling. FEBS J. 2007;274:227-40 pubmed
Yuecheng Y, Hongmei L, Xiaoyan X. Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer. Clin Exp Metastasis. 2006;23:65-74 pubmed
Hernandez Quintero M, Kuri Harcuch W, González Robles A, Castro Muñozledo F. Interleukin-6 promotes human epidermal keratinocyte proliferation and keratin cytoskeleton reorganization in culture. Cell Tissue Res. 2006;325:77-90 pubmed
Kramer J, Steinhoff J, Klinger M, Fricke L, Rohwedel J. Cells differentiated from mouse embryonic stem cells via embryoid bodies express renal marker molecules. Differentiation. 2006;74:91-104 pubmed
Su P, Hu Y, Ho I, Cheng Y, Lee T. Distinct gene expression profiles in immortalized human urothelial cells exposed to inorganic arsenite and its methylated trivalent metabolites. Environ Health Perspect. 2006;114:394-403 pubmed
Shih J, Tsai M, Chang T, Chang Y, Yuan A, Yu C, et al. Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res. 2005;11:8070-8 pubmed
product information
Product Name :
E-cadherin (G-10) Antibody
Gene Name :
CDH1
Size :
200 µg/ml
Catalog Number :
sc-8426
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
E-cadherin
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
600-707 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA