product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
SHIP-1 (P1C1) Antibody
catalog :
sc-8425
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P1C1
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; fig 4
Jing W, Zhang X, Sun W, Hou X, Yao Z, Zhu Y. CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells. Biomed Res Int. 2015;2015:326042 pubmed publisher
  • western blot; human
Chen Z, Shojaee S, Buchner M, Geng H, Lee J, Klemm L, et al. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015;521:357-61 pubmed publisher
  • western blot; human; fig 2
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher
  • western blot; human
Albrecht V, Hofer T, Foxwell B, Frankenberger M, Ziegler Heitbrock L. Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. BMC Immunol. 2008;9:69 pubmed publisher
Nunes de Miranda S, Wilhelm T, Huber M, Zorn C. Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype. Cell Commun Signal. 2016;14:12 pubmed publisher
Freedman T, Tan Y, Skrzypczynska K, Manz B, Sjaastad F, Goodridge H, et al. LynA regulates an inflammation-sensitive signaling checkpoint in macrophages. elife. 2015;4: pubmed publisher
Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne J, Brennan K, et al. Btk regulates macrophage polarization in response to lipopolysaccharide. PLoS ONE. 2014;9:e85834 pubmed publisher
Li Y, Zhang P, Wang C, Han C, Meng J, Liu X, et al. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J Biol Chem. 2013;288:16225-34 pubmed publisher
Brauer H, Strauss J, Wegner W, Muller Tidow C, Horstmann M, Jücker M. Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling. Cell Signal. 2012;24:2095-101 pubmed publisher
Vartanian K, Stevens S, Marsh B, Williams Karnesky R, Lessov N, Stenzel Poore M. LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury. J Neuroinflammation. 2011;8:140 pubmed publisher
Nalaskowski M, Metzner A, Brehm M, Labiadh S, Brauer H, Grabinski N, et al. The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei. Cell Signal. 2012;24:621-8 pubmed publisher
Hou S, Pauls S, Liu P, Marshall A. The PH domain adaptor protein Bam32/DAPP1 functions in mast cells to restrain Fc?RI-induced calcium flux and granule release. Mol Immunol. 2010;48:89-97 pubmed publisher
Zhang J, Ravichandran K, Garrison J. A key role for the phosphorylation of Ser440 by the cyclic AMP-dependent protein kinase in regulating the activity of the Src homology 2 domain-containing Inositol 5'-phosphatase (SHIP1). J Biol Chem. 2010;285:34839-49 pubmed publisher
Levin V, Panchabhai S, Shen L, Kornblau S, Qiu Y, Baggerly K. Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. J Proteome Res. 2010;9:179-91 pubmed publisher
Mihrshahi R, Barclay A, Brown M. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. J Immunol. 2009;183:4879-86 pubmed publisher
Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, et al. Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. J Periodontal Res. 2009;44:21-7 pubmed publisher
Lo T, Barnhill L, Kim Y, Nakae E, Yu A, Diccianni M. Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing. Leuk Res. 2009;33:1562-6 pubmed publisher
Marois L, Vaillancourt M, Marois S, Proulx S, Pare G, Rollet Labelle E, et al. The ubiquitin ligase c-Cbl down-regulates FcgammaRIIa activation in human neutrophils. J Immunol. 2009;182:2374-84 pubmed publisher
Sly L, Hamilton M, Kuroda E, Ho V, Antignano F, Omeis S, et al. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood. 2009;113:2945-54 pubmed publisher
Bishop J, Sly L, Krystal G, Finlay B. The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo. Infect Immun. 2008;76:2913-22 pubmed publisher
Tessmer M, Fugere C, Stevenaert F, Naidenko O, Chong H, Leclercq G, et al. KLRG1 binds cadherins and preferentially associates with SHIP-1. Int Immunol. 2007;19:391-400 pubmed
Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, et al. T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2. J Exp Med. 2006;203:2509-18 pubmed
Vaillancourt M, Levasseur S, Tremblay M, Marois L, Rollet Labelle E, Naccache P. The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils. Cell Signal. 2006;18:2022-32 pubmed
Yogo K, Mizutamari M, Mishima K, Takenouchi H, Ishida Kitagawa N, Sasaki T, et al. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Endocrinology. 2006;147:3307-17 pubmed
Wain C, Westwick J, Ward S. Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes. Cell Signal. 2005;17:1194-202 pubmed
Vanderwinden J, Wang D, Paternotte N, Mignon S, Isozaki K, Erneux C. Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor tyrosine kinase KIT. Cell Signal. 2006;18:661-9 pubmed
Nakamura K, Kouro T, Kincade P, Malykhin A, Maeda K, Coggeshall K. Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow. J Exp Med. 2004;199:243-54 pubmed
product information
Product Name :
SHIP-1 (P1C1) Antibody
Gene Name :
INPP5D
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8425
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
SHIP-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
866-1020 (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA