product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Fibronectin (EP5) Antibody
catalog :
sc-8422
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
EP5
reactivity :
human, mouse, rat, swine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 42
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 1d
  • western blot; human; loading ...; fig 1e
Varadaraj A, JENKINS L, Singh P, Chanda A, Snider J, Lee N, et al. TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism. Mol Biol Cell. 2017;28:1195-1207 pubmed publisher
  • western blot; human; loading ...; fig 2a
Dismuke W, Klingeborn M, Stamer W. Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. PLoS ONE. 2016;11:e0165326 pubmed publisher
  • western blot; human; loading ...
Richter E, Harms M, Ventz K, Nölker R, Fraunholz M, Mostertz J, et al. Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus. J Proteome Res. 2016;15:4369-4386 pubmed
  • immunohistochemistry - paraffin section; rat; 1:300; fig 1
Zhang M, Huang W, Bai J, Nie X, Wang W. Chymase inhibition protects diabetic rats from renal lesions. Mol Med Rep. 2016;14:121-8 pubmed publisher
  • immunohistochemistry - paraffin section; swine; fig 7
O Connor Mooney R, Davis N, Hoey D, Hogan L, McGloughlin T, Walsh M. On the Automatic Decellularisation of Porcine Aortae: A Repeatability Study Using a Non-Enzymatic Approach. Cells Tissues Organs. 2016;201:299-318 pubmed publisher
  • western blot; mouse; fig 12
Lee E, Oh J, Selvaraj S, Park S, Choi M, Spanel R, et al. Immunogenomics reveal molecular circuits of diclofenac induced liver injury in mice. Oncotarget. 2016;7:14983-5017 pubmed publisher
  • western blot; human; fig 3
Wang G, Yu Y, Sun C, Liu T, Liang T, Zhan L, et al. STAT3 selectively interacts with Smad3 to antagonize TGF-β signalling. Oncogene. 2016;35:4388-98 pubmed publisher
  • western blot; human; loading ...; fig 6D
Asanoma K, Liu G, Yamane T, Miyanari Y, Takao T, Yagi H, et al. Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells. Mol Cell Biol. 2015;35:4096-109 pubmed publisher
  • western blot; rat; fig 1
Liu H, Dolkas J, Hoang K, Angert M, Chernov A, Remacle A, et al. The alternatively spliced fibronectin CS1 isoform regulates IL-17A levels and mechanical allodynia after peripheral nerve injury. J Neuroinflammation. 2015;12:158 pubmed publisher
  • immunocytochemistry; mouse
Suhaeri M, Subbiah R, Van S, Du P, Kim I, Lee K, et al. Cardiomyoblast (h9c2) differentiation on tunable extracellular matrix microenvironment. Tissue Eng Part A. 2015;21:1940-51 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 3
  • western blot; human; 1:1000; fig 3
Kim S, Wen W, Prowse P, Hamilton D. Regulation of matrix remodelling phenotype in gingival fibroblasts by substratum topography. J Cell Mol Med. 2015;19:1183-96 pubmed publisher
  • western blot; human
Jung S, Ohk J, Jeong D, Li C, Lee S, Duan J, et al. Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells. Int J Oncol. 2014;45:189-96 pubmed publisher
  • immunocytochemistry; human
Pei M, Li J, Zhang Y, Liu G, Wei L, Zhang Y. Expansion on a matrix deposited by nonchondrogenic urine stem cells strengthens the chondrogenic capacity of repeated-passage bone marrow stromal cells. Cell Tissue Res. 2014;356:391-403 pubmed publisher
  • western blot; human; fig 2
Fang F, Liu G, Kim C, Yassa R, Zhou J, Scholey J. Adiponectin attenuates angiotensin II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways. Am J Physiol Renal Physiol. 2013;304:F1366-74 pubmed publisher
Sarker M, Lee J, Lee D, Chun K, Jun H. Attenuation of diabetic kidney injury in DPP4-deficient rats; role of GLP-1 on the suppression of AGE formation by inducing glyoxalase 1. Aging (Albany NY). 2020;12:593-610 pubmed publisher
Gurrapu S, Franzolin G, Fard D, Accardo M, Medico E, Sarotto I, et al. Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells. Sci Signal. 2019;12: pubmed publisher
Cibi D, Mia M, Guna Shekeran S, Yun L, Sandireddy R, Gupta P, et al. Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate. elife. 2019;8: pubmed publisher
He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, et al. Sumoylation of RORγt regulates TH17 differentiation and thymocyte development. Nat Commun. 2018;9:4870 pubmed publisher
Yoshimura A, Sawada K, Nakamura K, Kinose Y, Nakatsuka E, Kobayashi M, et al. Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells. BMC Cancer. 2018;18:1065 pubmed publisher
Ma X, Chen J, Xu B, Long X, Qin H, Zhao R, et al. Keloid-derived keratinocytes acquire a fibroblast-like appearance and an enhanced invasive capacity in a hypoxic microenvironment in vitro. Int J Mol Med. 2015;35:1246-56 pubmed publisher
Prakoura N, Politis P, Ihara Y, Michalak M, Charonis A. Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development. Am J Pathol. 2013;183:1474-1487 pubmed publisher
Lee J, Lin J, Fong J, Ryder M, Ho S. The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model. Biomed Res Int. 2013;2013:876316 pubmed publisher
Ding S, Yang Y, Li X, Michelli Rivera A, Han S, Wang L, et al. Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells. Toxicol Appl Pharmacol. 2013;269:61-71 pubmed publisher
Lin S, Lee Y, Wang J, Miller S, Chiou S, Hung M, et al. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS ONE. 2012;7:e49605 pubmed publisher
Cha M, Do S, Park G, Du P, Han K, Han D, et al. Induction of re-differentiation of passaged rat chondrocytes using a naturally obtained extracellular matrix microenvironment. Tissue Eng Part A. 2013;19:978-88 pubmed publisher
Chaves K, Turaça L, Pesquero J, Mennecier G, Dagli M, Chammas R, et al. Fibronectin expression is decreased in metastatic renal cell carcinoma following endostatin gene therapy. Biomed Pharmacother. 2012;66:464-8 pubmed publisher
Li Z, Choo Wing R, Sun H, Sureshbabu A, Sakurai R, Rehan V, et al. A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-?1-mediated injury in the developing murine lung. BMC Cell Biol. 2011;12:54 pubmed publisher
Soetikno V, Watanabe K, Sari F, Harima M, Thandavarayan R, Veeraveedu P, et al. Curcumin attenuates diabetic nephropathy by inhibiting PKC-? and PKC-?1 activity in streptozotocin-induced type I diabetic rats. Mol Nutr Food Res. 2011;55:1655-65 pubmed publisher
Wang R, Xie H, Huang Z, Ma J, Fang X, Ding Y, et al. T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway. J Immunol. 2011;187:5964-73 pubmed publisher
Cummins T, Mendenhall M, Lowry M, Korte E, Barati M, Khundmiri S, et al. Elongin C is a mediator of Notch4 activity in human renal tubule cells. Biochim Biophys Acta. 2011;1814:1748-57 pubmed publisher
Santana A, Soares da Costa C, Armada L, de Paula Lopes Gonzalez G, Dos Santos Ribeiro M, de Sousa Dos Santos A, et al. Fat tissue morphology of long-term sex steroid deficiency and estrogen treatment in female rats. Fertil Steril. 2011;95:1478-81 pubmed publisher
Uramoto H, Iwata T, Onitsuka T, Shimokawa H, Hanagiri T, Oyama T. Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma. Anticancer Res. 2010;30:2513-7 pubmed
Kim J, Kim D, Park M, Cho H, Zervos A, Bonventre J, et al. Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2010;298:F1332-40 pubmed publisher
Akino K, Akita S, Yakabe A, Mineda T, Hayashi T, Hirano A. Human mesenchymal stem cells may be involved in keloid pathogenesis. Int J Dermatol. 2008;47:1112-7 pubmed publisher
Yuan H, Lanting L, Xu Z, Li S, Swiderski P, Putta S, et al. Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes. Am J Physiol Renal Physiol. 2008;295:F605-17 pubmed publisher
Sasaki S, Tohda C, Kim M, Yokozawa T. Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats. Biol Pharm Bull. 2007;30:687-91 pubmed
Yasuda M, Miyachi Y, Ishikawa O, Takahashi K. Spatial expressions of fibronectin and integrins by human and rodent dermal fibroblasts. Br J Dermatol. 2006;155:522-31 pubmed
Akino K, Mineda T, Mori N, Hirano A, Imaizumi T, Akita S. Attenuation of cysteinyl leukotrienes induces human mesenchymal stem cell differentiation. Wound Repair Regen. 2006;14:343-9 pubmed
Xie H, Huang Z, Sadim M, Sun Z. Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL. J Immunol. 2005;175:7981-8 pubmed
Quan G, Choi J, Lee D, Lee S. TGF-beta1 up-regulates transglutaminase two and fibronectin in dermal fibroblasts: a possible mechanism for the stabilization of tissue inflammation. Arch Dermatol Res. 2005;297:84-90 pubmed
Akino K, Mineda T, Akita S. Early cellular changes of human mesenchymal stem cells and their interaction with other cells. Wound Repair Regen. 2005;13:434-40 pubmed
Serandour A, Loyer P, Garnier D, Courselaud B, Theret N, Glaise D, et al. TNFalpha-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes. Hepatology. 2005;41:478-86 pubmed
product information
Product Name :
Fibronectin (EP5) Antibody
Gene Name :
FN1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8422
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Fibronectin
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA