Olivares O, Mayers J, Gouirand V, Torrence M, Gicquel T, Borge L, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun. 2017;8:16031 pubmed publisher

ElHady A, Abdel Halim M, Abadi A, Engel M. Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins. J Med Chem. 2017;60:5377-5391 pubmed publisher

Aukrust I, Rosenberg L, Ankerud M, Bertelsen V, Hollås H, Saraste J, et al. Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes. FEBS Open Bio. 2017;7:160-173 pubmed publisher

Roversi F, Pericole F, Machado Neto J, da Silva Santos Duarte A, Longhini A, Corrocher F, et al. Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway. Biochim Biophys Acta Mol Basis Dis. 2017;1863:450-461 pubmed publisher

Li R, Xu J, Fu C, Zhang J, Zheng Y, Jia H, et al. Regulation of mTORC1 by lysosomal calcium and calmodulin. elife. 2016;5: pubmed publisher

Pichon X, Bastide A, Safieddine A, Chouaib R, Samacoits A, Basyuk E, et al. Visualization of single endogenous polysomes reveals the dynamics of translation in live human cells. J Cell Biol. 2016;214:769-81 pubmed publisher

Padhan N, Nordling T, Sundstrom M, Akerud P, Birgisson H, Nygren P, et al. High sensitivity isoelectric focusing to establish a signaling biomarker for the diagnosis of human colorectal cancer. BMC Cancer. 2016;16:683 pubmed publisher

Gal J, Kuang L, Barnett K, Zhu B, Shissler S, Korotkov K, et al. ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics. Acta Neuropathol. 2016;132:563-76 pubmed publisher

Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher

Pivonello C, Negri M, De Martino M, Napolitano M, De Angelis C, Provvisiero D, et al. The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma. Oncotarget. 2016;7:9718-31 pubmed publisher

Wanzel M, Vischedyk J, Gittler M, Gremke N, Seiz J, Hefter M, et al. CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol. 2016;12:22-8 pubmed publisher

Jang C, Lahens N, Hogenesch J, Sehgal A. Ribosome profiling reveals an important role for translational control in circadian gene expression. Genome Res. 2015;25:1836-47 pubmed publisher

Chichger H, Braza J, Duong H, Stark M, Harrington E. Neovascularization in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. Am J Physiol Lung Cell Mol Physiol. 2015;309:L700-9 pubmed publisher

Gallo D, Gesmundo I, Trovato L, Pera G, Gargantini E, Minetto M, et al. GH-Releasing Hormone Promotes Survival and Prevents TNF-α-Induced Apoptosis and Atrophy in C2C12 Myotubes. Endocrinology. 2015;156:3239-52 pubmed publisher

Milkereit R, Persaud A, Vanoaica L, Guetg A, Verrey F, Rotin D. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation. Nat Commun. 2015;6:7250 pubmed publisher

Salvatierra C, Reis S, Pessoa A, De Souza L, Stoppiglia L, Veloso R, et al. Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats. An Acad Bras Cienc. 2015;87:1007-18 pubmed publisher

Pène V, Li Q, Sodroski C, Hsu C, Liang T. Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection. J Virol. 2015;89:5462-77 pubmed publisher

Loeuillard E, Bertrand J, Herranen A, Melchior C, Guérin C, Coëffier M, et al. 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling. World J Gastroenterol. 2014;20:18207-15 pubmed publisher

Bernusso V, Machado Neto J, Pericole F, Vieira K, Duarte A, Traina F, et al. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochim Biophys Acta. 2015;1853:388-95 pubmed publisher

Rajgor D, Mellad J, Soong D, Rattner J, Fritzler M, Shanahan C. Mammalian microtubule P-body dynamics are mediated by nesprin-1. J Cell Biol. 2014;205:457-75 pubmed publisher

Chen K, Wang C, Tsai M, Wu C, Yang H, Chen L, et al. Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma. Cell Death Dis. 2014;5:e1244 pubmed publisher

Manzoni C, Mamais A, Dihanich S, McGoldrick P, Devine M, Zerle J, et al. Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation. Biochem Biophys Res Commun. 2013;441:862-6 pubmed publisher

Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher

Jung J, Macalino S, Cui M, Kim J, Kim H, Song D, et al. Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Cell Metab. 2019;29:1306-1319.e7 pubmed publisher

Dionne L, Shim K, Hoshi M, Cheng T, Wang J, Marthiens V, et al. Centrosome amplification disrupts renal development and causes cystogenesis. J Cell Biol. 2018;217:2485-2501 pubmed publisher

Sager R, Woodford M, Shapiro O, Mollapour M, Bratslavsky G. Sporadic renal angiomyolipoma in a patient with Birt-Hogg-Dubé: chaperones in pathogenesis. Oncotarget. 2018;9:22220-22229 pubmed publisher

Manzoni C, Mamais A, Dihanich S, Soutar M, Plun Favreau H, Bandopadhyay R, et al. mTOR independent alteration in ULK1 Ser758 phosphorylation following chronic LRRK2 kinase inhibition. Biosci Rep. 2018;38: pubmed publisher

Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein J, et al. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat Commun. 2018;9:299 pubmed publisher

Lyu J, Yang E, Head S, Ai N, Zhang B, Wu C, et al. Pharmacological blockade of cholesterol trafficking by cepharanthine in endothelial cells suppresses angiogenesis and tumor growth. Cancer Lett. 2017;409:91-103 pubmed publisher

Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, et al. Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Gastroenterology. 2017;153:1568-1580.e10 pubmed publisher

Rajgor D, Hanley J, Shanahan C. Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies. Mol Biol Cell. 2016;27:3894-3902 pubmed

Manzoni C, Mamais A, Roosen D, Dihanich S, Soutar M, Plun Favreau H, et al. mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1. Sci Rep. 2016;6:35106 pubmed publisher

Li Z, Yang Z, Passaniti A, Lapidus R, Liu X, Cullen K, et al. A positive feedback loop involving EGFR/Akt/mTORC1 and IKK/NF-kB regulates head and neck squamous cell carcinoma proliferation. Oncotarget. 2016;7:31892-906 pubmed publisher

Wang H, Atkins S, Fernando R, Wei R, Smith T. Pentraxin-3 Is a TSH-Inducible Protein in Human Fibrocytes and Orbital Fibroblasts. Endocrinology. 2015;156:4336-44 pubmed publisher

Kreit M, Vertommen D, Gillet L, Michiels T. The Interferon-Inducible Mouse Apolipoprotein L9 and Prohibitins Cooperate to Restrict Theiler's Virus Replication. PLoS ONE. 2015;10:e0133190 pubmed publisher

Wiegand K, Hennessy B, Leung S, Wang Y, Ju Z, McGahren M, et al. A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation. BMC Cancer. 2014;14:120 pubmed publisher

Bire S, Gosset D, Jégot G, Midoux P, Pichon C, Rouleux Bonnin F. Exogenous mRNA delivery and bioavailability in gene transfer mediated by piggyBac transposition. BMC Biotechnol. 2013;13:75 pubmed publisher

Manzoni C, Mamais A, Dihanich S, Abeti R, Soutar M, Plun Favreau H, et al. Inhibition of LRRK2 kinase activity stimulates macroautophagy. Biochim Biophys Acta. 2013;1833:2900-2910 pubmed publisher

Sama R, Ward C, Kaushansky L, Lemay N, Ishigaki S, Urano F, et al. FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol. 2013;228:2222-31 pubmed publisher

Murugan A, Alzahrani A, Xing M. Mutations in critical domains confer the human mTOR gene strong tumorigenicity. J Biol Chem. 2013;288:6511-21 pubmed publisher

Tan W, Jia W, Sun V, Mihm M, Nelson J. Topical rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of photocoagulated cutaneous blood vessels. Lasers Surg Med. 2012;44:796-804 pubmed publisher

Li H, Li J, Li Y, Singh P, Cao L, Xu L, et al. Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2012;303:H1319-31 pubmed publisher

Sun Y, Zou M, Hu C, Qin Y, Song X, Lu N, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013;51:53-60 pubmed publisher

Hu C, Zou M, Zhao L, Lu N, Sun Y, Gou S, et al. E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. Toxicol Lett. 2012;210:78-86 pubmed publisher

Favier J, Igaz P, Burnichon N, Amar L, Libe R, Badoual C, et al. Rationale for anti-angiogenic therapy in pheochromocytoma and paraganglioma. Endocr Pathol. 2012;23:34-42 pubmed publisher

Nacev B, Grassi P, Dell A, Haslam S, Liu J. The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells. J Biol Chem. 2011;286:44045-56 pubmed publisher

Coeffier M, Claeyssens S, Bensifi M, Lecleire S, Boukhettala N, Maurer B, et al. Influence of leucine on protein metabolism, phosphokinase expression, and cell proliferation in human duodenum1,3. Am J Clin Nutr. 2011;93:1255-62 pubmed publisher

Carbonaro M, O Brate A, Giannakakou P. Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol. 2011;192:83-99 pubmed publisher

Burnichon N, Lepoutre Lussey C, Laffaire J, Gadessaud N, Molinie V, Hernigou A, et al. A novel TMEM127 mutation in a patient with familial bilateral pheochromocytoma. Eur J Endocrinol. 2011;164:141-5 pubmed publisher

Bosco D, Lemay N, Ko H, Zhou H, Burke C, Kwiatkowski T, et al. Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules. Hum Mol Genet. 2010;19:4160-75 pubmed publisher

Gal J, Zhang J, Kwinter D, Zhai J, Jia H, Jia J, et al. Nuclear localization sequence of FUS and induction of stress granules by ALS mutants. Neurobiol Aging. 2011;32:2323.e27-40 pubmed publisher

Li C, Ohn T, Ivanov P, Tisdale S, Anderson P. eIF5A promotes translation elongation, polysome disassembly and stress granule assembly. PLoS ONE. 2010;5:e9942 pubmed publisher

Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, et al. Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Genes Cells. 2010;15:339-49 pubmed publisher

Abdeen A, Chou A, Healey J, Khanna C, Osborne T, Hewitt S, et al. Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. Cancer. 2009;115:5243-50 pubmed publisher

Wittmann S, Daniel C, Braun A, Vogelbacher R, Shimizu F, Kawachi H, et al. The mTOR inhibitor everolimus attenuates the time course of chronic anti-Thy1 nephritis in the rat. Nephron Exp Nephrol. 2008;108:e45-56 pubmed publisher

Sivan G, Kedersha N, Elroy Stein O. Ribosomal slowdown mediates translational arrest during cellular division. Mol Cell Biol. 2007;27:6639-46 pubmed

Keller K, Daniel C, Schocklmann H, Endlich K, Kerjaschki D, Johnson R, et al. Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy. Nephrol Dial Transplant. 2006;21:2724-35 pubmed