product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
TRAF6 (D-10) Antibody
catalog :
sc-8409
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-10
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3e
Kim M, Kim J, Hong S, Kwon B, Kim E, Jung H, et al. Effects of Melandrium firmum Rohrbach on RANKL‑induced osteoclast differentiation and OVX rats. Mol Med Rep. 2021;24: pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Du T, Yan Z, Zhu S, Chen G, Wang L, Ye Z, et al. QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism. Cell Death Dis. 2020;11:330 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Kim Y, Kim J, Gu S, Jo S, Kim S, Young Kim S, et al. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10:4570 pubmed publisher
  • immunoprecipitation; rat; 1:200; loading ...; fig 4a
  • western blot; rat; 1:200; loading ...; fig 3b
Peng L, Zhou Y, Jiang N, Wang T, Zhu J, Chen Y, et al. DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke. J Neuroinflammation. 2020;17:81 pubmed publisher
  • western blot; human; loading ...; fig 5d
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, et al. Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS Pathog. 2019;15:e1008002 pubmed publisher
  • western blot; human; loading ...; fig 4e
Liu P, Shah R, Li Y, Arora A, Ung P, Raman R, et al. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol. 2019;21:203-213 pubmed publisher
  • western blot; human; loading ...
Ma C, Lin W, Liu Z, Tang W, Gautam R, Li H, et al. NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep. 2017;18:586-602 pubmed publisher
  • immunocytochemistry; human; 1:100
  • western blot; human; 1:1000; loading ...; fig 3e
Lu W, Liu S, Li B, Xie Y, Izban M, Ballard B, et al. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene. 2017;36:1364-1373 pubmed publisher
  • western blot; rat; loading ...; fig 3a
Stucky A, Bakshi K, Friedman E, Wang H. Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling. PLoS ONE. 2016;11:e0160585 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 5a
Kinsella S, König H, Prehn J. Bid Promotes K63-Linked Polyubiquitination of Tumor Necrosis Factor Receptor Associated Factor 6 (TRAF6) and Sensitizes to Mutant SOD1-Induced Proinflammatory Signaling in Microglia. Eneuro. 2016;3: pubmed publisher
  • western blot; human; fig 6n
Wu H, Hwang Verslues W, Lee W, Huang C, Wei P, Chen C, et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015;212:333-49 pubmed publisher
  • immunoprecipitation; human; 1:20
  • western blot; human; 1:200
Cañeda Guzmán I, Salaiza Suazo N, Fernández Figueroa E, Carrada Figueroa G, Aguirre García M, Becker I. NK cell activity differs between patients with localized and diffuse cutaneous leishmaniasis infected with Leishmania mexicana: a comparative study of TLRs and cytokines. PLoS ONE. 2014;9:e112410 pubmed publisher
  • immunoprecipitation; mouse; 2 ug
  • western blot; mouse; 1:1000
Yu B, Chang J, Liu Y, Li J, Kevork K, Al Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-?B. Nat Med. 2014;20:1009-17 pubmed publisher
  • western blot; human
van Gent M, Braem S, de Jong A, Delagic N, Peeters J, Boer I, et al. Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling. PLoS Pathog. 2014;10:e1003960 pubmed publisher
  • immunoprecipitation; human
  • western blot; human; 1:1000
Huang C, Yang C, Jeng Y, Chen C, Wu H, Chang Y, et al. Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-?B-mediated antiapoptotic pathway. Oncogene. 2014;33:2968-77 pubmed publisher
Liao H, Zhang N, Meng Y, Feng H, Yang J, Li W, et al. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. Oxid Med Cell Longev. 2019;2019:6304058 pubmed publisher
Arora H, Wilcox S, Johnson L, Munro L, Eyford B, Pfeifer C, et al. The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Immunity. 2019;50:418-431.e6 pubmed publisher
Liu J, Yuan Y, Xu J, Xiao K, Xu Y, Guo T, et al. β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling. Front Immunol. 2018;9:2930 pubmed publisher
Luong P, Hedl M, Yan J, Zuo T, Fu T, Jiang X, et al. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. elife. 2018;7: pubmed publisher
Tin A, Park A, Sundar S, Firestone G. Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells. BMC Biol. 2014;12:72 pubmed publisher
Liu L, Gu H, Liu H, Jiao Y, Li K, Zhao Y, et al. Protective effect of resveratrol against IL-1?-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-?B signaling pathway: an "in vitro study". Int J Mol Sci. 2014;15:6925-40 pubmed publisher
Yao L, Kan E, Kaur C, Dheen S, Hao A, Lu J, et al. Notch-1 signaling regulates microglia activation via NF-?B pathway after hypoxic exposure in vivo and in vitro. PLoS ONE. 2013;8:e78439 pubmed publisher
Lin X, Xu W, Luo J, Guo X, Sun T, Zhao X, et al. WW domain containing E3 ubiquitin protein ligase 1 (WWP1) negatively regulates TLR4-mediated TNF-? and IL-6 production by proteasomal degradation of TNF receptor associated factor 6 (TRAF6). PLoS ONE. 2013;8:e67633 pubmed publisher
Takamatsu S, Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, et al. Functional characterization of domains of IPS-1 using an inducible oligomerization system. PLoS ONE. 2013;8:e53578 pubmed publisher
Tateda K, Okazaki S, Nagoya S, Katada R, Mizuo K, Watanabe S, et al. The suppression of TRIM21 and the accumulation of IFN-? play crucial roles in the pathogenesis of osteonecrosis of the femoral head. Lab Invest. 2012;92:1318-29 pubmed publisher
Cheng J, Liu J, Shi Z, Jules J, Xu D, Luo S, et al. Molecular mechanisms of the biphasic effects of interferon-? on osteoclastogenesis. J Interferon Cytokine Res. 2012;32:34-45 pubmed publisher
Huang Y, Liu H, Ge R, Zhou Y, Lou X, Wang C. UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria. J Immunol. 2012;188:358-66 pubmed publisher
Zucchelli S, Marcuzzi F, Codrich M, Agostoni E, Vilotti S, Biagioli M, et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation. J Biol Chem. 2011;286:25108-17 pubmed publisher
Kenchappa R, Tep C, Korade Z, Urra S, Bronfman F, Yoon S, et al. p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. J Biol Chem. 2010;285:20358-68 pubmed publisher
Bhaumik D, Scott G, Schokrpur S, Patil C, Orjalo A, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009;1:402-11 pubmed
Pacifico F, Crescenzi E, Mellone S, Iannetti A, Porrino N, Liguoro D, et al. Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. J Clin Endocrinol Metab. 2010;95:1421-30 pubmed publisher
McCully R, Pomerantz J. The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. Mol Cell Biol. 2008;28:5668-86 pubmed publisher
Wang S, Shi Z, Liu W, Jules J, Feng X. Development and validation of vectors containing multiple siRNA expression cassettes for maximizing the efficiency of gene silencing. BMC Biotechnol. 2006;6:50 pubmed
product information
Product Name :
TRAF6 (D-10) Antibody
Gene Name :
TRAF6
Size :
200 µg/ml
Catalog Number :
sc-8409
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
TRAF6
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1-274 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA