product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
NFATc3 (F-1) Antibody
catalog :
sc-8405
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
F-1
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 26
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; loading ...; fig 5a
  • western blot; mouse; loading ...; fig 5b, 6b
Du M, Wang C, Yang L, Liu B, Zheng Z, Yang L, et al. The role of long noncoding RNA Nron in atherosclerosis development and plaque stability. iScience. 2022;25:103978 pubmed publisher
  • immunocytochemistry; human; loading ...
  • western blot; human; loading ...; fig 3c
Huang J, Hu M, Niu H, Wang J, Si Y, Cheng S, et al. Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels. BMC Cancer. 2021;21:750 pubmed publisher
  • western blot; mouse; fig 3a
  • western blot; human; fig 3b
Cai S, Yu D, Soroka C, Wang J, Boyer J. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis. J Hepatol. 2021;74:550-559 pubmed publisher
  • immunohistochemistry - frozen section; rat; fig 2
  • western blot; rat; 1:20
Furman J, Sompol P, Kraner S, Pleiss M, Putman E, Dunkerson J, et al. Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury. J Neurosci. 2016;36:1502-15 pubmed publisher
  • western blot; mouse; 1:100; fig 7
An C, Dong Y, Hagiwara N. Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6. BMC Dev Biol. 2011;11:59 pubmed publisher
Sarabia S xe1 nchez M, Moreno Londo xf1 o A, Casta xf1 eda Patl xe1 n M, Alvarado Ortiz E, Mart xed nez Morales J, Robles Flores M. Non-canonical Wnt/Ca2+ signaling is essential to promote self-renewal and proliferation in colon cancer stem cells. Front Oncol. 2023;13:1121787 pubmed publisher
Sompol P, Gollihue J, Weiss B, Lin R, Case S, Kraner S, et al. Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease. J Neurosci. 2023;43:1797-1813 pubmed publisher
Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko C, et al. Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer. Nat Cell Biol. 2022;24:1165-1176 pubmed publisher
Sompol P, Furman J, Pleiss M, Kraner S, Artiushin I, Batten S, et al. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in A?-Bearing Mice. J Neurosci. 2017;37:6132-6148 pubmed publisher
Lee S, Rigas N, Lee C, Bang A, Srikanth S, Gwack Y, et al. Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma. Oncotarget. 2016;7:43239-43255 pubmed publisher
Wu J, Zheng C, Wang X, Yun S, Zhao Y, Liu L, et al. MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. J Clin Invest. 2015;125:4091-106 pubmed publisher
Yamaguchi T, Omori M, Tanaka N, Fukui N. Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts. Am J Physiol Cell Physiol. 2013;305:C323-33 pubmed publisher
Chang A, Sliwoski J, Butler S, Hearn G, Lassmann J, Chacko S, et al. Calcineurin mediates bladder wall remodeling secondary to partial outlet obstruction. Am J Physiol Renal Physiol. 2011;301:F813-22 pubmed publisher
Siamakpour Reihani S, CASTER J, Bandhu Nepal D, Courtwright A, Hilliard E, Usary J, et al. The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus. PLoS ONE. 2011;6:e20412 pubmed publisher
Burn S, Webb A, Berry R, Davies J, Ferrer Vaquer A, Hadjantonakis A, et al. Calcium/NFAT signalling promotes early nephrogenesis. Dev Biol. 2011;352:288-98 pubmed publisher
Drenning J, Lira V, Soltow Q, Canon C, Valera L, Brown D, et al. Endothelial nitric oxide synthase is involved in calcium-induced Akt signaling in mouse skeletal muscle. Nitric Oxide. 2009;21:192-200 pubmed publisher
Giordano C, Rousseau A, Wagner N, Gaudel C, Murdaca J, Jehl Pietri C, et al. Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice. Pflugers Arch. 2009;458:901-13 pubmed publisher
Jahnke V, Sabido O, Freyssenet D. Control of mitochondrial biogenesis, ROS level, and cytosolic Ca2+ concentration during the cell cycle and the onset of differentiation in L6E9 myoblasts. Am J Physiol Cell Physiol. 2009;296:C1185-94 pubmed publisher
Li G, Zhang X, Li R, Wang Y, Wang Y, Han K, et al. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. J Biol Chem. 2008;283:32660-8 pubmed publisher
Drenning J, Lira V, Simmons C, Soltow Q, Sellman J, Criswell D. Nitric oxide facilitates NFAT-dependent transcription in mouse myotubes. Am J Physiol Cell Physiol. 2008;294:C1088-95 pubmed publisher
Gurda G, Guo L, Lee S, Molkentin J, Williams J. Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. Mol Biol Cell. 2008;19:198-206 pubmed
Vega A, Chacón P, Monteseirín J, El Bekay R, Alba G, Martín Nieto J, et al. Expression of the transcription factor NFAT2 in human neutrophils: IgE-dependent, Ca2+- and calcineurin-mediated NFAT2 activation. J Cell Sci. 2007;120:2328-37 pubmed
Lejard V, Brideau G, Blais F, Salingcarnboriboon R, Wagner G, Roehrl M, et al. Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J Biol Chem. 2007;282:17665-75 pubmed
Jabr R, Wilson A, Riddervold M, Jenkins A, Perrino B, Clapp L. Nuclear translocation of calcineurin Abeta but not calcineurin Aalpha by platelet-derived growth factor in rat aortic smooth muscle. Am J Physiol Cell Physiol. 2007;292:C2213-25 pubmed
Yaghi A, Sims S. Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005;289:L1061-74 pubmed
De Arcangelis V, Coletti D, Canato M, Molinaro M, Adamo S, Reggiani C, et al. Hypertrophy and transcriptional regulation induced in myogenic cell line L6-C5 by an increase of extracellular calcium. J Cell Physiol. 2005;202:787-95 pubmed
product information
Product Name :
NFATc3 (F-1) Antibody
Gene Name :
NFATC3
Size :
200 µg/ml
Catalog Number :
sc-8405
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
NFATc3
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
321-395 (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA