product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p-IkappaB-alpha (B-9) Antibody
catalog :
sc-8404
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
B-9
reactivity :
human, mouse, brown rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 69
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4a
Zoi I, Karamouzis M, Xingi E, Sarantis P, Thomaidou D, Lembessis P, et al. Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas. Breast Cancer Res. 2019;21:132 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Cho H, Kim J, Jang H, Lee T, Jung M, Kim T, et al. Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice. Sci Rep. 2017;7:46065 pubmed publisher
  • western blot; human; loading ...; fig 4a
Jiang D, Gao F, Zhang Y, Wong D, Li Q, Tse H, et al. Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage. Cell Death Dis. 2016;7:e2467 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 7a
Okabe T, Chavan R, Fonseca Costa S, Brenna A, Ripperger J, Albrecht U. REV-ERB? influences the stability and nuclear localization of the glucocorticoid receptor. J Cell Sci. 2016;129:4143-4154 pubmed
  • western blot; human; 1:400; fig 4
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, et al. The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1. Sci Rep. 2016;6:27597 pubmed publisher
  • western blot; brown rat; 1:250; fig 6
Tang S, Su H, Zhang Q, Tang H, Wang C, Zhou Q, et al. Sitagliptin inhibits endothelin-1 expression in the aortic endothelium of rats with streptozotocin-induced diabetes by suppressing the nuclear factor-?B/I?B? system through the activation of AMP-activated protein kinase. Int J Mol Med. 2016;37:1558-66 pubmed publisher
  • western blot; human; 1:200; fig 1
Tu Q, Xiong Y, Fan L, Qiao B, Xia Z, Hu L, et al. Peroxiredoxin 6 attenuates ischemia‑ and hypoxia‑induced liver damage of brain‑dead donors. Mol Med Rep. 2016;13:753-61 pubmed publisher
  • western blot; human; fig 1
Sakurikar N, Thompson R, Montano R, Eastman A. A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase. Oncotarget. 2016;7:1380-94 pubmed publisher
  • western blot; human; 1:500; fig 4
El Khattouti A, Selimovic D, Hannig M, Taylor E, Abd Elmageed Z, Hassan S, et al. Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition. J Cell Mol Med. 2016;20:266-86 pubmed publisher
  • western blot; mouse; loading ...; fig 11b
Singh S, Chhunchha B, Fatma N, Kubo E, Singh S, Singh D. Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells. Am J Physiol Cell Physiol. 2016;310:C1-16 pubmed publisher
  • western blot; human; 1:500
Lavoz C, Alique M, Rodrígues Díez R, Pato J, Keri G, Mezzano S, et al. Gremlin regulates renal inflammation via the vascular endothelial growth factor receptor 2 pathway. J Pathol. 2015;236:407-20 pubmed publisher
  • western blot; mouse; fig 1
Liu E, Xu N, O Prey J, Lao L, Joshi S, Long J, et al. Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proc Natl Acad Sci U S A. 2015;112:773-8 pubmed publisher
  • western blot; mouse; 1:1000
Chen H, Sohn J, Zhang L, Tian J, Chen S, Bjeldanes L. Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in I?B?/MAPK/ERK signaling pathways. Eur J Pharmacol. 2014;724:168-74 pubmed publisher
Lin Y, Huang S, Wu J, Chu T, Huang S, Lee C, et al. Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis. BMC Cancer. 2019;19:1083 pubmed publisher
Choi S, Martínez T, Kim S, Donaldson C, Shokhirev M, Saghatelian A, et al. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. Genes Dev. 2019;33:418-435 pubmed publisher
Choi J, Yeo I, Kim K, Choi W, Jung J, Han S, et al. K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression. J Neuroinflammation. 2018;15:224 pubmed publisher
Jiang M, Xu C, Guo Y, Luo Q, Li L, Liu H, et al. ?-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-?B signaling pathway-mediated inflammation in mice. World J Gastroenterol. 2018;24:216-225 pubmed publisher
Lennikov A, Mirabelli P, Mukwaya A, Schaupper M, Thangavelu M, Lachota M, et al. Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis. Angiogenesis. 2018;21:267-285 pubmed publisher
Barker E, Kim B, Yoon J, Tochtrop G, Letterio J, Choi S. Potent Suppression of Both Spontaneous and Carcinogen-induced Colitis-associated Colorectal Cancer in Mice by Dietary Celastrol Supplementation. Carcinogenesis. 2017;: pubmed publisher
Fasano E, Serini S, Mondella N, Trombino S, Celleno L, Lanza P, et al. Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines. Biomed Res Int. 2014;2014:327452 pubmed publisher
Zhu H, Bian C, Yuan J, Chu W, Xiang X, Chen F, et al. Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-?B signaling pathway in experimental traumatic brain injury. J Neuroinflammation. 2014;11:59 pubmed publisher
Yang N, Farrell A, Niedelman W, Melo M, Lu D, Julien L, et al. Genetic basis for phenotypic differences between different Toxoplasma gondii type I strains. BMC Genomics. 2013;14:467 pubmed publisher
Wang Y, Li C, Pan L, Gao Z. 7,8-Dihydroxycoumarin inhibits A549 human lung adenocarcinoma cell proliferation by inducing apoptosis via suppression of Akt/NF-?B signaling. Exp Ther Med. 2013;5:1770-1774 pubmed
Zara S, De Colli M, Rapino M, Di Valerio V, Marconi G, Cataldi A, et al. NF-?B involvement in hyperoxia-induced myocardial damage in newborn rat hearts. Histochem Cell Biol. 2013;140:575-83 pubmed publisher
Qin X, Sun Z, Zhang X, Dai X, Mao S, Zhang Y. TLR4 signaling is involved in the protective effect of propofol in BV2 microglia against OGD/reoxygenation. J Physiol Biochem. 2013;69:707-18 pubmed publisher
Gai L, Cai N, Wang L, Xu X, Kong X. Ursolic acid induces apoptosis via Akt/NF-?B signaling suppression in T24 human bladder cancer cells. Mol Med Rep. 2013;7:1673-7 pubmed publisher
Kastamoulas M, Chondrogiannis G, Kanavaros P, Vartholomatos G, Bai M, Briasoulis E, et al. Cytokine effects on cell survival and death of A549 lung carcinoma cells. Cytokine. 2013;61:816-25 pubmed publisher
Chhunchha B, Fatma N, Kubo E, Rai P, Singh S, Singh D. Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-?B regulation. Am J Physiol Cell Physiol. 2013;304:C636-55 pubmed publisher
Patruno A, Franceschelli S, Pesce M, Maccallini C, Fantacuzzi M, Speranza L, et al. Novel aminobenzyl-acetamidine derivative modulate the differential regulation of NOSs in LPS induced inflammatory response: role of PI3K/Akt pathway. Biochim Biophys Acta. 2012;1820:2095-104 pubmed publisher
Bhatt K, Sodhi A, Chakraborty R. Peptidoglycan induced expression of peroxisome proliferator-activated receptor ? in mouse peritoneal macrophages: role of ERK and JNK MAP kinases. Cytokine. 2012;60:778-86 pubmed publisher
Jiang T, Gao L, Guo J, Lu J, Wang Y, Zhang Y. Suppressing inflammation by inhibiting the NF-?B pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia. Br J Pharmacol. 2012;167:1520-32 pubmed publisher
Qin X, Sun Z, Dai X, Mao S, Zhang J, Jia M, et al. Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation. Neurol Res. 2012;34:379-89 pubmed publisher
Mao S, Hua R, Zhao X, Qin X, Sun Z, Zhang Y, et al. Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4/MyD88/NF-?B pathway. J Neurotrauma. 2012;29:1941-59 pubmed publisher
Tian F, Zhang C, Tian W, Jiang Y, Zhang X. Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice. Oncol Rep. 2012;28:232-40 pubmed publisher
Ndour P, Brocqueville G, Ouk T, Goormachtigh G, Morales O, Mougel A, et al. Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells. J Virol. 2012;86:3934-43 pubmed publisher
Tian F, Fan T, Jiang Y, Zhang X, Wang X. A small interfering RNA targeting NF-?B p65 alone or combined with 5-FU inhibits growth of esophageal squamous cell carcinoma in nude mice. Pathol Res Pract. 2012;208:32-8 pubmed publisher
Park H, Lee J, Chung M, Park Y, Bower A, Koo S, et al. Green tea extract suppresses NF?B activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis. J Nutr. 2012;142:57-63 pubmed publisher
Huang Z, Liang C, HAN S, Wu Z. Vitamin E ameliorates ox-LDL-induced foam cells formation through modulating the activities of oxidative stress-induced NF-?B pathway. Mol Cell Biochem. 2012;363:11-9 pubmed publisher
Ma X, Yang L, Xiao L, Tang M, Liu L, Li Z, et al. Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-κB regulated ATM expression. PLoS ONE. 2011;6:e24647 pubmed publisher
Wu C, Li T, Hsu S, Su Y, Kao S, Fong Y, et al. IGF-I enhances ?5?1 integrin expression and cell motility in human chondrosarcoma cells. J Cell Physiol. 2011;226:3270-7 pubmed publisher
Medina Tamayo J, Ibarra Sanchez A, Padilla Trejo A, Gonzalez Espinosa C. IgE-dependent sensitization increases responsiveness to LPS but does not modify development of endotoxin tolerance in mast cells. Inflamm Res. 2011;60:19-27 pubmed publisher
Gao Z, Zhang D, Guo C. Paclitaxel efficacy is increased by parthenolide via nuclear factor-kappaB pathways in in vitro and in vivo human non-small cell lung cancer models. Curr Cancer Drug Targets. 2010;10:705-15 pubmed
Andújar I, Recio M, Bacelli T, Giner R, Rios J. Shikonin reduces oedema induced by phorbol ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus. Br J Pharmacol. 2010;160:376-88 pubmed publisher
Jin X, Qiu L, Zhang D, Zhang M, Wang Z, Guo Z, et al. Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-kappaB and mitochondrial cytochrome c cascade. J Cell Mol Med. 2009;13:4596-607 pubmed publisher
Webster C, Kelly S, Koike M, Chock V, Giffard R, Yenari M. Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia. Neurobiol Dis. 2009;33:301-12 pubmed publisher
Zhang Y, Wei E, Hu X, Qiao W, Shi Y, Xu M, et al. The role of nuclear factor-kappaB in the effect of angiotensin II in the paraventricular nucleus in protecting the gastric mucosa from ischemia-reperfusion injury in rats. J Gastroenterol. 2008;43:687-98 pubmed publisher
Korkolopoulou P, Levidou G, Saetta A, El Habr E, Eftichiadis C, Demenagas P, et al. Expression of nuclear factor-kappaB in human astrocytomas: relation to pI kappa Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival. Hum Pathol. 2008;39:1143-52 pubmed publisher
Vu H, Juvekar A, Ghosh C, Ramaswami S, Le D, Vancurova I. Proteasome inhibitors induce apoptosis of prostate cancer cells by inducing nuclear translocation of IkappaBalpha. Arch Biochem Biophys. 2008;475:156-63 pubmed publisher
Jin X, Wang Z, Qiu L, Zhang D, Guo Z, Gao Z, et al. Potential biomarkers involving IKK/RelA signal in early stage non-small cell lung cancer. Cancer Sci. 2008;99:582-9 pubmed publisher
Yu J, Qian H, Li Y, Wang Y, Zhang X, Liang X, et al. Arsenic trioxide (As2O3) reduces the invasive and metastatic properties of cervical cancer cells in vitro and in vivo. Gynecol Oncol. 2007;106:400-6 pubmed
Verkoczy L, Duong B, Skog P, Ait Azzouzene D, Puri K, VELA J, et al. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J Immunol. 2007;178:6332-41 pubmed
Zheng Z, Kim J, Ma H, Lee J, Yenari M. Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke. J Cereb Blood Flow Metab. 2008;28:53-63 pubmed
Levidou G, Korkolopoulou P, Nikiteas N, Tzanakis N, Thymara I, Saetta A, et al. Expression of nuclear factor kappaB in human gastric carcinoma: relationship with I kappaB a and prognostic significance. Virchows Arch. 2007;450:519-27 pubmed
Cho H, Morgan D, Bauer A, Kleeberger S. Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med. 2007;175:829-39 pubmed
Shimizu S, Tahara M, Ogata S, Hashimoto K, Morishige K, Tasaka K, et al. Involvement of nuclear factor-kB activation through RhoA/Rho-kinase pathway in LPS-induced IL-8 production in human cervical stromal cells. Mol Hum Reprod. 2007;13:181-7 pubmed
Taylor R, Bresnahan W. Human cytomegalovirus IE86 attenuates virus- and tumor necrosis factor alpha-induced NFkappaB-dependent gene expression. J Virol. 2006;80:10763-71 pubmed
Hanashiro K, Sunagawa M, Tokeshi Y, Nakasone T, Ohta S, Nakamura M, et al. Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells. Eur J Pharmacol. 2006;547:174-83 pubmed
Hafeez B, Ahmed S, Wang N, Gupta S, Zhang A, Haqqi T. Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB. Toxicol Appl Pharmacol. 2006;216:11-9 pubmed
Tian F, Zang W, Hou W, Liu H, Xue L. Nuclear factor-kB signaling pathway constitutively activated in esophageal squamous cell carcinoma cell lines and inhibition of growth of cells by small interfering RNA. Acta Biochim Biophys Sin (Shanghai). 2006;38:318-26 pubmed
Wang X, Hu B, Weiss R, Wang Y. The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joining. Oncogene. 2006;25:1980-3 pubmed
Hu B, Wang H, Wang X, Lu H, Huang C, Powell S, et al. Fhit and CHK1 have opposing effects on homologous recombination repair. Cancer Res. 2005;65:8613-6 pubmed
Fang C, Bernardes Silva M, Coleman M, Perry V. The cellular distribution of the Wld s chimeric protein and its constituent proteins in the CNS. Neuroscience. 2005;135:1107-18 pubmed
Mun H, Aosai F, Norose K, Piao L, Fang H, Akira S, et al. Toll-like receptor 4 mediates tolerance in macrophages stimulated with Toxoplasma gondii-derived heat shock protein 70. Infect Immun. 2005;73:4634-42 pubmed
Cho H, Jedlicka A, Clarke R, Kleeberger S. Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash. Physiol Genomics. 2005;22:108-17 pubmed
Yagyu T, Kobayashi H, Matsuzaki H, Wakahara K, Kondo T, Kurita N, et al. Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation. J Clin Endocrinol Metab. 2005;90:3017-21 pubmed
Dieckhoff K, Graf P, Beinhauer B, Schwaerzler C, Carballido J, Neumann C, et al. Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients. Exp Dermatol. 2005;14:17-25 pubmed
Wang H, Hu B, Liu R, Wang Y. CHK1 affecting cell radiosensitivity is independent of non-homologous end joining. Cell Cycle. 2005;4:300-3 pubmed
Lysiak J, Bang H, Nguyen Q, Turner T. Activation of the nuclear factor kappa B pathway following ischemia-reperfusion of the murine testis. J Androl. 2005;26:129-35 pubmed
Hu B, Han S, Wang X, Ottey M, Potoczek M, Dicker A, et al. Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. J Cell Physiol. 2005;202:518-23 pubmed
product information
Product Name :
p-IkappaB-alpha (B-9) Antibody
Gene Name :
NFKBIA
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8404
Modification :
phosporylated
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
p-IkappaB-alpha
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
Ser 32 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA