product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Cdc42 (B-8) Antibody
catalog :
sc-8401
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 7
Mao X, Fan C, Yu X, Chen B, Jin F. DDEFL1 correlated with Rho GTPases activity in breast cancer. Oncotarget. 2017;8:112487-112497 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 6b
Scott N, Rogers L, Prudova A, Brown N, Fortelny N, Overall C, et al. Interactome disassembly during apoptosis occurs independent of caspase cleavage. Mol Syst Biol. 2017;13:906 pubmed publisher
  • western blot; human; 1:1000
Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed publisher
  • western blot; rat; fig 6
Fan S, Numata Y, Numata M. Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration. Mol Biol Cell. 2016;27:702-15 pubmed publisher
  • western blot; mouse; 1:500; fig 4
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  • flow cytometry; human; fig 8
Oprea T, Sklar L, Agola J, Guo Y, Silberberg M, Roxby J, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS ONE. 2015;10:e0142182 pubmed publisher
  • western blot; human; 1:1000
Seo H, Woo J, Shin Y, Ko S. Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray. Mol Med Rep. 2015;12:800-18 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Ko H, Guo L, Su B, Gao L, Gelman I. Suppression of chemotaxis by SSeCKS via scaffolding of phosphoinositol phosphates and the recruitment of the Cdc42 GEF, Frabin, to the leading edge. PLoS ONE. 2014;9:e111534 pubmed publisher
  • immunohistochemistry - free floating section; mouse
  • immunocytochemistry; mouse
Toyo oka K, Wachi T, Hunt R, Baraban S, Taya S, Ramshaw H, et al. 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014;34:12168-81 pubmed publisher
  • western blot; mouse; fig s11
Reginensi A, Scott R, Gregorieff A, Bagherie Lachidan M, Chung C, Lim D, et al. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013;9:e1003380 pubmed publisher
  • western blot; human
Johnson K, D Mello S. p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival. J Neurosci Res. 2005;79:809-15 pubmed
Morgan C, Hedman A, Li Z, Sacks D. Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras. Sci Rep. 2019;9:11057 pubmed publisher
Niu X, Su L, Qi S, Gao Z, Zhang Q, Zhang S. GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway. Cell Death Dis. 2018;9:971 pubmed publisher
Hernández Vásquez M, Adame García S, Hamoud N, Chidiac R, Reyes Cruz G, Gratton J, et al. Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock. J Biol Chem. 2017;292:12178-12191 pubmed publisher
Bretou M, Jouannot O, Fanget I, Pierobon P, Larochette N, Gestraud P, et al. Cdc42 controls the dilation of the exocytotic fusion pore by regulating membrane tension. Mol Biol Cell. 2014;25:3195-209 pubmed publisher
Ruppersburg C, Hartzell H. The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis. Mol Biol Cell. 2014;25:1793-807 pubmed publisher
Cheng W, Chiao M, Liang Y, Yang Y, Shen C, Yang C. Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity. Mol Biol Rep. 2013;40:5315-26 pubmed publisher
Carito V, Bonuccelli G, Martinez Outschoorn U, Whitaker Menezes D, Caroleo M, Cione E, et al. Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle. 2012;11:3403-14 pubmed publisher
He Q, Wang G, Dasgupta S, Dinkins M, Zhu G, Bieberich E. Characterization of an apical ceramide-enriched compartment regulating ciliogenesis. Mol Biol Cell. 2012;23:3156-66 pubmed publisher
Papadimitriou E, Kardassis D, Moustakas A, Stournaras C. TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2. Cell Physiol Biochem. 2011;28:229-38 pubmed publisher
Zhu X, Wang J, Moriguchi K, Liow L, Ahmed S, Kaverina I, et al. Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells. Exp Cell Res. 2011;317:2384-9 pubmed publisher
Yang C, Li Z, Rana T. microRNAs modulate iPS cell generation. RNA. 2011;17:1451-60 pubmed publisher
Al Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein D, et al. Acute-phase protein ?1-antitrypsin inhibits neutrophil calpain I and induces random migration. Mol Med. 2011;17:865-74 pubmed publisher
Taiyab A, Rao C. HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion. Biochim Biophys Acta. 2011;1813:213-21 pubmed publisher
Udo K, Aoki S, Uchihashi K, Kawasaki M, Matsunobu A, Tokuda Y, et al. Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture. Kidney Int. 2010;78:60-8 pubmed publisher
Liang S, Fu A, Zhang Q, Tang M, Zhou J, Wei Y, et al. Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis. Proteomics. 2010;10:1474-83 pubmed publisher
Morand P, Drab M, Rajalingam K, Nassif X, Meyer T. Neisseria meningitidis differentially controls host cell motility through PilC1 and PilC2 components of type IV Pili. PLoS ONE. 2009;4:e6834 pubmed publisher
Liu Z, Adams H, Whitehead I. The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration. J Biol Chem. 2009;284:15771-80 pubmed publisher
Gadea G, Sanz Moreno V, Self A, Godi A, Marshall C. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Curr Biol. 2008;18:1456-65 pubmed publisher
Gaggioli C, Hooper S, Hidalgo Carcedo C, Grosse R, Marshall J, Harrington K, et al. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol. 2007;9:1392-400 pubmed
Kobune M, Chiba H, Kato J, Kato K, Nakamura K, Kawano Y, et al. Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism. Mol Cancer Ther. 2007;6:1774-84 pubmed
Krishnamurthy K, Wang G, Silva J, Condie B, Bieberich E. Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis. J Biol Chem. 2007;282:3379-90 pubmed
Wheeler A, Wells C, Smith S, Vega F, Henderson R, Tybulewicz V, et al. Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci. 2006;119:2749-57 pubmed
Miyake Y, Inoue N, Nishimura K, Kinoshita N, Hosoya H, Yonemura S. Actomyosin tension is required for correct recruitment of adherens junction components and zonula occludens formation. Exp Cell Res. 2006;312:1637-50 pubmed
product information
Product Name :
Cdc42 (B-8) Antibody
Gene Name :
CDC42
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8401
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Cdc42
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA