product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PKC alpha (H-7) Antibody
catalog :
sc-8393
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H-7
reactivity :
African green monkey, Shaw's jird, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 66
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; Shaw's jird; 1:200; loading ...; tbl 1
Hammoum I, Benlarbi M, Dellaa A, Szabó K, Dékány B, Csaba D, et al. Study of retinal neurodegeneration and maculopathy in diabetic Meriones shawi: A particular animal model with human-like macula. J Comp Neurol. 2017;525:2890-2914 pubmed publisher
  • western blot; human; loading ...; fig 4a
Tsai C, Lin Y, Huang C, Shih C, Tsai Y, Tsao N, et al. Thrombomodulin regulates monocye differentiation via PKC? and ERK1/2 pathway in vitro and in atherosclerotic artery. Sci Rep. 2016;6:38421 pubmed publisher
  • western blot; mouse; fig 5a
Yu H, Yang T, Gao P, Wei X, Zhang H, Xiong S, et al. Caffeine intake antagonizes salt sensitive hypertension through improvement of renal sodium handling. Sci Rep. 2016;6:25746 pubmed publisher
  • immunohistochemistry; scFv; 1:500; fig 3
  • immunohistochemistry; mouse; 1:500; fig 3
  • immunohistochemistry; African green monkey; 1:500; fig 3
Bouskila J, Javadi P, Elkrief L, Casanova C, Bouchard J, Ptito M. A Comparative Analysis of the Endocannabinoid System in the Retina of Mice, Tree Shrews, and Monkeys. Neural Plast. 2016;2016:3127658 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3e
Grishchuk Y, Stember K, Matsunaga A, Olivares A, CRUZ N, King V, et al. Retinal Dystrophy and Optic Nerve Pathology in the Mouse Model of Mucolipidosis IV. Am J Pathol. 2016;186:199-209 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; tbl 2
Farshi P, Fyk Kolodziej B, Krolewski D, Walker P, Ichinose T. Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina. J Comp Neurol. 2016;524:2059-79 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 8
Knoflach D, Schicker K, Glösmann M, Koschak A. Gain-of-function nature of Cav1.4 L-type calcium channels alters firing properties of mouse retinal ganglion cells. Channels (Austin). 2015;9:298-306 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 2
van Wyk M, Pielecka Fortuna J, Löwel S, Kleinlogel S. Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool. PLoS Biol. 2015;13:e1002143 pubmed publisher
  • western blot; human; 1:250; fig 1,2,3,4,5,6,7
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher
  • western blot; human; fig 1e
Jiang Z, Kong C, Zhang Z, Zhu Y, Zhang Y, Chen X. Reduction of protein kinase C α (PKC-α) promote apoptosis via down-regulation of Dicer in bladder cancer. J Cell Mol Med. 2015;19:1085-93 pubmed publisher
  • western blot; rat
Domínguez Alonso A, Valdés Tovar M, Solís Chagoyán H, Benítez King G. Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex. Int J Mol Sci. 2015;16:1907-27 pubmed publisher
  • western blot; mouse
Kapodistria K, Tsilibary E, Politis P, Moustardas P, Charonis A, Kitsiou P. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Mol Cell Endocrinol. 2015;400:112-28 pubmed publisher
  • immunohistochemistry; rat; 1:250
Gaillard F, Kuny S, Sauve Y. Retinal distribution of Disabled-1 in a diurnal murine rodent, the Nile grass rat Arvicanthis niloticus. Exp Eye Res. 2014;125:236-43 pubmed publisher
  • western blot; mouse
Kong J, Liu B, Wu S, Wang Y, Jiang Q, Guo E. Enhancement of interaction of BSEP and HAX-1 on the canalicular membrane of hepatocytes in a mouse model of cholesterol cholelithiasis. Int J Clin Exp Pathol. 2014;7:1644-50 pubmed
  • immunohistochemistry - paraffin section; human; 1:50
  • western blot; human; 1:1000
Shishido S, Delahaye A, Beck A, Nguyen T. The anticancer effect of PQ1 in the MMTV-PyVT mouse model. Int J Cancer. 2014;134:1474-83 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:500
Zabouri N, Bouchard J, Casanova C. Cannabinoid receptor type 1 expression during postnatal development of the rat retina. J Comp Neurol. 2011;519:1258-80 pubmed publisher
He F, Nichols R, Kailasam L, Wensel T, Agosto M. Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells. Invest Ophthalmol Vis Sci. 2019;60:2861-2874 pubmed publisher
McLaughlin T, Dhimal N, Li J, Wang J, Zhang S. p58IPK Is an Endogenous Neuroprotectant for Retinal Ganglion Cells. Front Aging Neurosci. 2018;10:267 pubmed publisher
Yao K, Qiu S, Wang Y, Park S, Mohns E, Mehta B, et al. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature. 2018;560:484-488 pubmed publisher
Goode B, Mondal G, Hyun M, Ruiz D, Lin Y, Van Ziffle J, et al. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018;9:810 pubmed publisher
Travis A, Heflin S, Hirano A, Brecha N, Arshavsky V. Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells. J Neurosci. 2018;38:723-732 pubmed publisher
Xie J, Chen S, Chen H, Pan H. Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology. 2017;123:477-487 pubmed publisher
Bhalla M, Law D, Dowd G, Ireton K. Host Serine/Threonine Kinases mTOR and Protein Kinase C-? Promote InlB-Mediated Entry of Listeria monocytogenes. Infect Immun. 2017;85: pubmed publisher
Beier C, Hovhannisyan A, Weiser S, Kung J, Lee S, Lee D, et al. Deafferented Adult Rod Bipolar Cells Create New Synapses with Photoreceptors to Restore Vision. J Neurosci. 2017;37:4635-4644 pubmed publisher
Cécyre B, Monette M, Beudjekian L, Casanova C, Bouchard J. Localization of diacylglycerol lipase alpha and monoacylglycerol lipase during postnatal development of the rat retina. Front Neuroanat. 2014;8:150 pubmed publisher
Wang N, Liang H, Zhou Y, Wang C, Zhang S, Pan Y, et al. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PLoS ONE. 2014;9:e105570 pubmed publisher
KOCALIS H, Hagan S, George L, Turney M, Siuta M, Laryea G, et al. Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis. Mol Metab. 2014;3:394-407 pubmed publisher
Li Y, Hao H, Tzatzalos E, Lin R, Doh S, Liu L, et al. Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells. Biol Open. 2014;3:172-84 pubmed publisher
Bouskila J, Javadi P, Casanova C, Ptito M, Bouchard J. Rod photoreceptors express GPR55 in the adult vervet monkey retina. PLoS ONE. 2013;8:e81080 pubmed publisher
Lu Q, Ivanova E, Ganjawala T, Pan Z. Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines. Mol Vis. 2013;19:1310-20 pubmed
Shishido S, Prasain K, Beck A, Nguyen T, Hua D, Nguyen T. Bioavailability and efficacy of a gap junction enhancer (PQ7) in a mouse mammary tumor model. PLoS ONE. 2013;8:e67174 pubmed publisher
Muili K, Jin S, Orabi A, Eisses J, Javed T, Le T, et al. Pancreatic acinar cell nuclear factor ?B activation because of bile acid exposure is dependent on calcineurin. J Biol Chem. 2013;288:21065-73 pubmed publisher
Scott S, Xiang Y, Mathews T, Cho H, Myers D, Armstrong M, et al. Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. J Biol Chem. 2013;288:20477-87 pubmed publisher
Bouskila J, Javadi P, Casanova C, Ptito M, Bouchard J. Müller cells express the cannabinoid CB2 receptor in the vervet monkey retina. J Comp Neurol. 2013;521:2399-415 pubmed publisher
Liu C, Wang I, Wei F, Chien C. Neuronal intermediate filament ?-internexin is expressed by neuronal lineages in the developing chicken retina. Exp Eye Res. 2013;110:18-25 pubmed publisher
Lin S, Chen W, Lin K, Chen S, Chang C, Lin S, et al. Clinicopathological correlation and prognostic significance of protein kinase c? overexpression in human gastric carcinoma. PLoS ONE. 2013;8:e56675 pubmed publisher
Miao Z, Guo W, Lu S, Lv W, Li C, Wang Y, et al. Hypothermia induced by adenosine 5'-monophosphate attenuates early stage injury in an acute gouty arthritis rat model. Rheumatol Int. 2013;33:2085-92 pubmed publisher
Goel M, Dhingra N. Müller glia express rhodopsin in a mouse model of inherited retinal degeneration. Neuroscience. 2012;225:152-61 pubmed publisher
Hori K, Nagai T, Izumi Y, Kimura M, Hasuike Y, Nakayama Y, et al. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor. Am J Physiol Renal Physiol. 2012;303:F1080-8 pubmed publisher
Yi P, Schrott L, Castor T, Alexander J. Bryostatin-1 vs. TPPB: dose-dependent APP processing and PKC-?, -?, and -? isoform activation in SH-SY5Y neuronal cells. J Mol Neurosci. 2012;48:234-44 pubmed publisher
Bouskila J, Burke M, Zabouri N, Casanova C, Ptito M, Bouchard J. Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys. Neuroscience. 2012;202:117-30 pubmed publisher
Francis H, Demorrow S, Franchitto A, Venter J, Mancinelli R, White M, et al. Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms. Lab Invest. 2012;92:282-94 pubmed publisher
Zabouri N, Ptito M, Casanova C, Bouchard J. Fatty acid amide hydrolase expression during retinal postnatal development in rats. Neuroscience. 2011;195:145-65 pubmed publisher
Fujita Hamabe W, Nakamoto K, Tokuyama S. Involvement of NCAM and FGF receptor signaling in the development of analgesic tolerance to morphine. Eur J Pharmacol. 2011;672:77-82 pubmed publisher
Zhang H, Cai C, Zhang X, Li T, Jia X, Li B, et al. Breviscapine attenuates acute pancreatitis by inhibiting expression of PKC? and NF-?B in pancreas. World J Gastroenterol. 2011;17:1825-30 pubmed publisher
Hao F, Pysz M, Curry K, Haas K, Seedhouse S, Black A, et al. Protein kinase C? signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. J Biol Chem. 2011;286:18104-17 pubmed publisher
Chen Y, Yu G, Yu D, Zhu M. PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. J Exp Clin Cancer Res. 2010;29:104 pubmed publisher
Ribeiro R, Vanzela E, Oliveira C, Bonfleur M, Boschero A, Carneiro E. Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets. Br J Nutr. 2010;104:1148-55 pubmed publisher
Chuize K, Yuyan Z, Zhe Z, Tao L, Meng Y, Qi Y. Protein kinase C-alpha is expressed and activated during the development of renal cell carcinoma. Urology. 2010;76:514.e1-5 pubmed publisher
Gesslein B, Håkansson G, Carpio R, Gustafsson L, Perez M, Malmsjo M. Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. Mol Vis. 2010;16:392-407 pubmed
Carter C, Misra M. Effects of short-term cigarette smoke exposure on Fischer 344 rats and on selected lung proteins. Toxicol Pathol. 2010;38:402-15 pubmed publisher
Haughian J, Reno E, Thorne A, Bradford A. Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. Int J Cancer. 2009;125:2556-64 pubmed publisher
Giaroni C, Zanetti E, Pascale A, Oldrini R, Canciani L, Giuliani D, et al. Involvement of Ca2+-dependent PKCs in the adaptive changes of mu-opioid pathways to sympathetic denervation in the guinea pig colon. Biochem Pharmacol. 2009;78:1233-41 pubmed publisher
Jensen T, Maarbjerg S, Rose A, Leitges M, Richter E. Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake. Am J Physiol Endocrinol Metab. 2009;297:E340-8 pubmed publisher
Nagar S, Krishnamoorthy V, Cherukuri P, Jain V, Dhingra N. Early remodeling in an inducible animal model of retinal degeneration. Neuroscience. 2009;160:517-29 pubmed publisher
Pysz M, Leontieva O, Bateman N, Uronis J, Curry K, Threadgill D, et al. PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. Exp Cell Res. 2009;315:1415-28 pubmed publisher
Lü L, Mak Y, Fang M, Yew D. The difference in gliosis induced by ?-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains. Biogerontology. 2009;10:695-710 pubmed publisher
Leontieva O, Ionov Y. RNA-binding motif protein 35A is a novel tumor suppressor for colorectal cancer. Cell Cycle. 2009;8:490-7 pubmed
Wang C, Wang Y, Tzeng D, Yang J. Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling. Toxicol Appl Pharmacol. 2009;235:244-52 pubmed publisher
Woo J, Li D, Wilsbach K, Orita H, Coulter J, Tully E, et al. Coix seed extract, a commonly used treatment for cancer in China, inhibits NFkappaB and protein kinase C signaling. Cancer Biol Ther. 2007;6:2005-11 pubmed
Zhang S, Liu Y, Huang G, Liu L. Aconitine alters connexin43 phosphorylation status and [Ca2+] oscillation patterns in cultured ventricular myocytes of neonatal rats. Toxicol In Vitro. 2007;21:1476-85 pubmed
Elvidge G, Glenny L, Appelhoff R, Ratcliffe P, Ragoussis J, Gleadle J. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem. 2006;281:15215-26 pubmed
Hizli A, Black A, Pysz M, Black J. Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells. J Biol Chem. 2006;281:14596-603 pubmed
Fährmann M, Kaufhold M. Functional partitioning of epithelial protein kinase CaMKII in signal transduction. Biochim Biophys Acta. 2006;1763:101-9 pubmed
Avila G, Zheng X, Cui X, Ryan A, Hansson A, Suh J, et al. Inhibitory effects of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans retinoic acid on the growth of cultured human pancreas cancer cells and pancreas tumor xenografts in immunodeficient mice. J Pharmacol Exp Ther. 2005;315:170-87 pubmed
Russell C, Acevedo Duncan M. Effects of the PKC inhibitor PD 406976 on cell cycle progression, proliferation, PKC isozymes and apoptosis in glioma and SVG-transformed glial cells. Cell Prolif. 2005;38:87-106 pubmed
product information
Product Name :
PKC alpha (H-7) Antibody
Gene Name :
PRKCA
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8393
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
PKC alpha
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA