product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Bcl-xL (H-5) Antibody
catalog :
sc-8392
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H-5
reactivity :
human, mouse, rat, domestic rabbit
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 114
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4a
Lassiter R, Merchen T, Fang X, Wang Y. Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation. Front Immunol. 2021;12:671025 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2d
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; fig 2k
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
  • western blot; human; loading ...; fig 4f
Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
De R, Sarkar S, Mazumder S, Debsharma S, Siddiqui A, Saha S, et al. Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74-NF-κB signaling. J Biol Chem. 2018;293:19740-19760 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4b
Hobeika E, Dautzenberg M, Levit Zerdoun E, Pelanda R, Reth M. Conditional Selection of B Cells in Mice With an Inducible B Cell Development. Front Immunol. 2018;9:1806 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Zhao L, Liu J, He C, Yan R, Zhou K, Cui Q, et al. Protein kinase A determines platelet life span and survival by regulating apoptosis. J Clin Invest. 2017;127:4338-4351 pubmed publisher
  • flow cytometry; human; loading ...; fig 1d
Schafer C, Göder A, Beyer M, Kiweler N, Mahendrarajah N, Rauch A, et al. Class I histone deacetylases regulate p53/NF-?B crosstalk in cancer cells. Cell Signal. 2017;29:218-225 pubmed publisher
  • western blot; human; loading ...; fig 3e
Jinesh G, Molina J, Huang L, Laing N, Mills G, Bar Eli M, et al. Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis. Cell Death Discov. 2016;2:16003 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1g
Shi Y, He Z, Jia Z, Xu C. Inhibitory effect of metformin combined with gemcitabine on pancreatic cancer cells in vitro and in vivo. Mol Med Rep. 2016;14:2921-8 pubmed publisher
  • western blot; human; fig 5e
Weyhenmeyer B, Noonan J, Würstle M, Lincoln F, Johnston G, Rehm M, et al. Predicting the cell death responsiveness and sensitization of glioma cells to TRAIL and temozolomide. Oncotarget. 2016;7:61295-61311 pubmed publisher
  • western blot; human; fig s6
O Neill K, Huang K, Zhang J, Chen Y, Luo X. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane. Genes Dev. 2016;30:973-88 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Zámbó V, Tóth M, Schlachter K, Szelényi P, Sarnyai F, Lotz G, et al. Cytosolic localization of NADH cytochrome b₅ oxidoreductase (Ncb5or). FEBS Lett. 2016;590:661-71 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
  • western blot; mouse
Park J, Park J, Park D, Kim D, Kim H. Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer. Stem Cells. 2016;34:1177-87 pubmed publisher
  • western blot; rat; fig 5f
Jia Z, Wang J, Shi Q, Liu S, Wang W, Tian Y, et al. SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition. Apoptosis. 2016;21:174-83 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200; fig 1
Shishkina G, Kalinina T, Bulygina V, Lanshakov D, Babluk E, Dygalo N. Anti-Apoptotic Protein Bcl-xL Expression in the Midbrain Raphe Region Is Sensitive to Stress and Glucocorticoids. PLoS ONE. 2015;10:e0143978 pubmed publisher
  • western blot; human; loading ...; fig 2d
Green A, Maciel T, Hospital M, Yin C, Mazed F, Townsend E, et al. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia. Sci Adv. 2015;1:e1500221 pubmed publisher
  • western blot; human; loading ...; fig 4b
Ramírez de Arellano A, Lopez Pulido E, Martínez Neri P, Estrada Chávez C, González Lucano R, Fafutis Morris M, et al. STAT3 activation is required for the antiapoptotic effects of prolactin in cervical cancer cells. Cancer Cell Int. 2015;15:83 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; tbl 3
Schmidt L, Kümmel A, Görlich D, Mohr M, Bröckling S, Mikesch J, et al. PD-1 and PD-L1 Expression in NSCLC Indicate a Favorable Prognosis in Defined Subgroups. PLoS ONE. 2015;10:e0136023 pubmed publisher
  • western blot; human; loading ...; fig st2
Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit; 1:20; fig 3
Liu B, Huang W, Xiao X, Xu Y, Ma S, Xia Z. Neuroprotective Effect of Ulinastatin on Spinal Cord Ischemia-Reperfusion Injury in Rabbits. Oxid Med Cell Longev. 2015;2015:624819 pubmed publisher
  • western blot; human; fig 4
Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, et al. The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget. 2015;6:23427-44 pubmed
  • western blot; human; fig 4
Heinemann A, Cullinane C, De Paoli Iseppi R, Wilmott J, Gunatilake D, Madore J, et al. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. 2015;6:21507-21 pubmed
  • western blot; human; loading ...; fig 2a
Kotipatruni R, Ren X, Thotala D, Jaboin J. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. 2015;6:17594-604 pubmed
  • western blot; mouse; loading ...; fig 7d
Raimondi L, De Luca A, Amodio N, Manno M, Raccosta S, Taverna S, et al. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget. 2015;6:13772-89 pubmed
  • immunocytochemistry; human
  • western blot; rat
Zhang L, Wang H, Ding K, Xu J. FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells. Toxicol Lett. 2015;236:43-59 pubmed publisher
  • western blot; rat; loading ...; fig 6b
McMillan E, Paré M, Baechler B, Graham D, Rush J, Quadrilatero J. Autophagic signaling and proteolytic enzyme activity in cardiac and skeletal muscle of spontaneously hypertensive rats following chronic aerobic exercise. PLoS ONE. 2015;10:e0119382 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 2a
Yang M, Zhao H, Guo L, Zhang Q, Zhao L, Bai S, et al. Autophagy-based survival prognosis in human colorectal carcinoma. Oncotarget. 2015;6:7084-103 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 5A
Xiao Y, Ma C, Yi J, Wu S, Luo G, Xu X, et al. Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression. Physiol Rep. 2015;3: pubmed publisher
  • western blot; human
Machado Neto J, Lazarini M, Favaro P, de Melo Campos P, Scopim Ribeiro R, Franchi Junior G, et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta. 2015;1853:583-93 pubmed publisher
  • western blot; human
Bernusso V, Machado Neto J, Pericole F, Vieira K, Duarte A, Traina F, et al. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochim Biophys Acta. 2015;1853:388-95 pubmed publisher
  • western blot; human; 1:2000
Nie C, Luo Y, Zhao X, Luo N, Tong A, Liu X, et al. Caspase-9 mediates Puma activation in UCN-01-induced apoptosis. Cell Death Dis. 2014;5:e1495 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 5
  • western blot; human; 1:500; fig 5
Zheng R, Hu W, Sui C, Ma N, Jiang Y. Effects of doxorubicin and gemcitabine on the induction of apoptosis in breast cancer cells. Oncol Rep. 2014;32:2719-25 pubmed publisher
  • western blot; human
Gibot L, Chabaud S, Bouhout S, Bolduc S, Auger F, Moulin V. Anticancer properties of chitosan on human melanoma are cell line dependent. Int J Biol Macromol. 2015;72:370-9 pubmed publisher
  • flow cytometry; human
Kivisakk P, Francois K, Mbianda J, Gandhi R, Weiner H, Khoury S. Effect of natalizumab treatment on circulating plasmacytoid dendritic cells: a cross-sectional observational study in patients with multiple sclerosis. PLoS ONE. 2014;9:e103716 pubmed publisher
  • western blot; human
Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, et al. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS ONE. 2014;9:e101526 pubmed publisher
  • western blot; human; 1:100
Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, et al. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049 pubmed publisher
  • immunoprecipitation; mouse
  • western blot; mouse
Bai L, Chen J, McEachern D, Liu L, Zhou H, Aguilar A, et al. BM-1197: a novel and specific Bcl-2/Bcl-xL inhibitor inducing complete and long-lasting tumor regression in vivo. PLoS ONE. 2014;9:e99404 pubmed publisher
Lee J, Lee H, Ryu K, Kim M, Ko D, Chung K, et al. KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. J Clin Med. 2020;9: pubmed publisher
Jin B, An H. Baicalin alleviates benign prostate hyperplasia through androgen-dependent apoptosis. Aging (Albany NY). 2020;12:2142-2155 pubmed publisher
Huang K, O Neill K, Li J, Zhou W, Han N, Pang X, et al. BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis. Cell Res. 2019;29:942-952 pubmed publisher
Arboatti A, Lambertucci F, Sedlmeier M, Pisani G, Monti J, Alvarez M, et al. Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice. Biomed Res Int. 2018;2018:9472939 pubmed publisher
Li X, Ma H, Li L, Chen Y, Sun X, Dong Z, et al. Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth. Oncogene. 2018;37:2469-2480 pubmed publisher
Liu J, Wu P, Wang Y, Du Y, A N, Liu S, et al. Ad-HGF improves the cardiac remodeling of rat following myocardial infarction by upregulating autophagy and necroptosis and inhibiting apoptosis. Am J Transl Res. 2016;8:4605-4627 pubmed
Castro L, Kviecinski M, Ourique F, Parisotto E, Grinevicius V, Correia J, et al. Albendazole as a promising molecule for tumor control. Redox Biol. 2016;10:90-99 pubmed publisher
Lagopati N, Tsilibary E, Falaras P, Papazafiri P, Pavlatou E, Kotsopoulou E, et al. Effect of nanostructured TiO? crystal phase on photoinduced apoptosis of breast cancer epithelial cells. Int J Nanomedicine. 2014;9:3219-30 pubmed publisher
Chen K, Hou Y, Wang K, Li J, Xia Y, Yang X, et al. Reexpression of Let-7g microRNA inhibits the proliferation and migration via K-Ras/HMGA2/snail axis in hepatocellular carcinoma. Biomed Res Int. 2014;2014:742417 pubmed publisher
Jiao S, Wu M, Ye F, Tang H, Xie X, Xie X. BikDDA, a mutant of Bik with longer half-life expression protein, can be a novel therapeutic gene for triple-negative breast cancer. PLoS ONE. 2014;9:e92172 pubmed publisher
Chang K, Yan M, Yao C, Lin P, Lai G. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013;6:1435-1438 pubmed
Cawley K, Logue S, Gorman A, Zeng Q, Patterson J, Gupta S, et al. Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion. PLoS ONE. 2013;8:e73870 pubmed publisher
Passante E, Würstle M, Hellwig C, Leverkus M, Rehm M. Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells. Cell Death Differ. 2013;20:1521-31 pubmed publisher
Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, et al. Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine. Gut Pathog. 2013;5:22 pubmed publisher
Bai T, Dong D, Pei L. Resveratrol mitigates isoflurane-induced neuroapoptosis by inhibiting the activation of the Akt-regulated mitochondrial apoptotic signaling pathway. Int J Mol Med. 2013;32:819-26 pubmed publisher
Zhang Z, Liu Y, Song T, Xue Z, Shen X, Liang F, et al. An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1. Br J Cancer. 2013;108:1870-8 pubmed publisher
Bishayee A, Mandal A, Thoppil R, Darvesh A, Bhatia D. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Int J Cancer. 2013;133:1054-63 pubmed publisher
Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed publisher
Zhu Y, Massen S, Terenzio M, Lang V, Chen Lindner S, Eils R, et al. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. J Biol Chem. 2013;288:1099-113 pubmed publisher
Durdu S, Deniz G, Balci D, Zaim C, Dogan A, Can A, et al. Apoptotic vascular smooth muscle cell depletion via BCL2 family of proteins in human ascending aortic aneurysm and dissection. Cardiovasc Ther. 2012;30:308-16 pubmed publisher
Zang Y, Thomas S, Chan E, Kirk C, Freilino M, Delancey H, et al. Carfilzomib and ONX 0912 inhibit cell survival and tumor growth of head and neck cancer and their activities are enhanced by suppression of Mcl-1 or autophagy. Clin Cancer Res. 2012;18:5639-49 pubmed publisher
Hwang J, Ting W, Wu H, Chen Y, Tsai F, Chen P, et al. KHC-4 anti-cancer effects on human PC3 prostate cancer cell line. Am J Chin Med. 2012;40:1063-71 pubmed publisher
Hong M, Gao J, Cui J, Wang K, Tian Y, Li R, et al. Effect of c-Jun NH?-terminal kinase-mediated p53 expression on neuron autophagy following traumatic brain injury in rats. Chin Med J (Engl). 2012;125:2019-24 pubmed
Gong J, Zhang J, Li B, Zeng C, You K, Chen M, et al. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene. 2013;32:3071-9 pubmed publisher
Szepeshazi K, Schally A, Keller G, Block N, Benten D, Halmos G, et al. Receptor-targeted therapy of human experimental urinary bladder cancers with cytotoxic LH-RH analog AN-152 [AEZS- 108]. Oncotarget. 2012;3:686-99 pubmed
Jinesh G, Lee E, Tran J, Kamat A. Lenalidomide augments the efficacy of bacillus Calmette-Guerin (BCG) immunotherapy in vivo. Urol Oncol. 2013;31:1676-1682 pubmed publisher
Lin C, Zhao X, Li L, Liu H, Cao K, Wan Y, et al. NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin. PLoS ONE. 2012;7:e36722 pubmed publisher
Ren K, Lu J, Porollo A, Du C. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. J Biol Chem. 2012;287:14792-802 pubmed publisher
Dinicola S, Cucina A, Pasqualato A, D Anselmi F, Proietti S, Lisi E, et al. Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines. Int J Mol Sci. 2012;13:651-64 pubmed publisher
Yamada H, Yao Y, Wang X, Zhang Y, Huang Y, Dai W, et al. Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell Cycle. 2012;11:479-88 pubmed publisher
Kim Y, Choi M, Ryu J, Lee D, Jeon B, Roh G, et al. Clusterin interaction with Bcl-xL is associated with seizure-induced neuronal death. Epilepsy Res. 2012;99:240-51 pubmed publisher
Glienke W, Maute L, Wicht J, Bergmann L. The dual PI3K/mTOR inhibitor NVP-BGT226 induces cell cycle arrest and regulates Survivin gene expression in human pancreatic cancer cell lines. Tumour Biol. 2012;33:757-65 pubmed publisher
Hu W, Wang F, Tang J, Liu X, Yuan Z, Nie C, et al. Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. J Biol Chem. 2012;287:68-80 pubmed publisher
Karadeniz A, Simsek N, Karakus E, Yildirim S, Kara A, Can I, et al. Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin. Oxid Med Cell Longev. 2011;2011:981793 pubmed publisher
Zekri A, Bahnassy A, Hafez M, Hassan Z, Kamel M, Loutfy S, et al. Characterization of chronic HCV infection-induced apoptosis. Comp Hepatol. 2011;10:4 pubmed publisher
Xu B, Strom J, Chen Q. Dexamethasone induces transcriptional activation of Bcl-xL gene and inhibits cardiac injury by myocardial ischemia. Eur J Pharmacol. 2011;668:194-200 pubmed publisher
Han J, Tao Z, Chen S, Kong Y, Xiao B. Adenovirus-mediated transfer of tris-shRNAs induced apoptosis of nasopharyngeal carcinoma cell in vitro and in vivo. Cancer Lett. 2011;309:162-9 pubmed publisher
Francis K, Wei L. Human embryonic stem cell neural differentiation and enhanced cell survival promoted by hypoxic preconditioning. Cell Death Dis. 2010;1:e22 pubmed publisher
Leksa V, Loewe R, Binder B, Schiller H, Eckerstorfer P, Forster F, et al. Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Circ Res. 2011;108:676-85 pubmed publisher
Thomas C, Zoubeidi A, Kuruma H, Fazli L, Lamoureux F, Beraldi E, et al. Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo. Mol Cancer Ther. 2011;10:347-59 pubmed publisher
Glienke W, Hausmann E, Bergmann L. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour Biol. 2011;32:493-500 pubmed publisher
Lerman G, Volman E, Sidi Y, Avni D. Small-interfering RNA targeted at antiapoptotic mRNA increases keratinocyte sensitivity to apoptosis. Br J Dermatol. 2011;164:947-56 pubmed publisher
D Anselmi F, Cucina A, Biava P, Proietti S, Coluccia P, Frati L, et al. Zebrafish stem cell differentiation stage factors suppress Bcl-xL release and enhance 5-Fu-mediated apoptosis in colon cancer cells. Curr Pharm Biotechnol. 2011;12:261-7 pubmed
Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk J, Kuwana T. BH3 domains other than Bim and Bid can directly activate Bax/Bak. J Biol Chem. 2011;286:491-501 pubmed publisher
Hung T, Chen S, Li M, Yeh Y, Hsieh T. Differential effects of concomitant use of vitamins C and E on trophoblast apoptosis and autophagy between normoxia and hypoxia-reoxygenation. PLoS ONE. 2010;5:e12202 pubmed publisher
Mowery Y, Weinberg J, Kennedy M, Bond K, Moore J, Lanasa M, et al. LMP-420: a novel purine nucleoside analog with potent cytotoxic effects for CLL cells and minimal toxicity for normal hematopoietic cells. Leukemia. 2010;24:1580-7 pubmed publisher
Suphim B, Prawan A, Kukongviriyapan U, Kongpetch S, Buranrat B, Kukongviriyapan V. Redox modulation and human bile duct cancer inhibition by curcumin. Food Chem Toxicol. 2010;48:2265-72 pubmed publisher
Buranrat B, Prawan A, Kukongviriyapan U, Kongpetch S, Kukongviriyapan V. Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells. World J Gastroenterol. 2010;16:2362-70 pubmed
Maranesi M, Zerani M, Lilli L, Dall Aglio C, Brecchia G, Gobbetti A, et al. Expression of luteal estrogen receptor, interleukin-1, and apoptosis-associated genes after PGF2alpha administration in rabbits at different stages of pseudopregnancy. Domest Anim Endocrinol. 2010;39:116-30 pubmed publisher
Zhang Y, Wang W, Sun Z, Feng D, Deng Y, Liu Y, et al. Granulocyte colony-stimulating factor treatment prevents cognitive impairment following status epilepticus in rats. Biol Pharm Bull. 2010;33:572-9 pubmed
Hasselblom S, Hansson U, Olsson M, Torén L, Bergström A, Nilsson Ehle H, et al. High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Br J Haematol. 2010;149:560-8 pubmed publisher
Micali N, Longobardi E, Iotti G, Ferrai C, Castagnaro L, Ricciardi M, et al. Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress. Nucleic Acids Res. 2010;38:3595-604 pubmed publisher
Liebelt B, Papapetrou P, Ali A, Guo M, Ji X, Peng C, et al. Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2. Neuroscience. 2010;166:1091-100 pubmed publisher
Goldsmith K, Lestini B, Gross M, Ip L, Bhumbla A, Zhang X, et al. BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists. Cell Death Differ. 2010;17:872-82 pubmed publisher
Zhuang L, Scolyer R, Murali R, McCarthy S, Zhang X, Thompson J, et al. Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. Mod Pathol. 2010;23:45-53 pubmed publisher
Ling Y, Li T, Perez Soler R, Haigentz M. Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib. Cancer Chemother Pharmacol. 2009;64:539-48 pubmed publisher
Micali N, Ferrai C, Fernandez Diaz L, Blasi F, Crippa M. Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels. Mol Cell Biol. 2009;29:1143-51 pubmed publisher
Xiao D, Zeng Y, Hahm E, Kim Y, Ramalingam S, Singh S. Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells. Environ Mol Mutagen. 2009;50:201-12 pubmed publisher
Kobayashi H, Minatoguchi S, Yasuda S, Bao N, Kawamura I, Iwasa M, et al. Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair. Cardiovasc Res. 2008;79:611-20 pubmed publisher
Hung T, Chen S, Liou J, Hsu J, Li M, Yeh Y, et al. Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta. Placenta. 2008;29:565-83 pubmed publisher
Lovekamp Swan T, Glendenning M, Schreihofer D. A high soy diet reduces programmed cell death and enhances bcl-xL expression in experimental stroke. Neuroscience. 2007;148:644-52 pubmed
Mineva N, Rothstein T, Meyers J, Lerner A, Sonenshein G. CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis. J Biol Chem. 2007;282:17475-85 pubmed
Zhuang L, Lee C, Scolyer R, McCarthy S, Zhang X, Thompson J, et al. Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod Pathol. 2007;20:416-26 pubmed
Wang Z, Spittau B, Behrendt M, Peters B, Krieglstein K. Human TIEG2/KLF11 induces oligodendroglial cell death by downregulation of Bcl-XL expression. J Neural Transm (Vienna). 2007;114:867-75 pubmed
Cammenga J, Niebuhr B, Horn S, Bergholz U, Putz G, Buchholz F, et al. RUNX1 DNA-binding mutants, associated with minimally differentiated acute myelogenous leukemia, disrupt myeloid differentiation. Cancer Res. 2007;67:537-45 pubmed
Graessmann M, Berg B, Fuchs B, Klein A, Graessmann A. Chemotherapy resistance of mouse WAP-SVT/t breast cancer cells is mediated by osteopontin, inhibiting apoptosis downstream of caspase-3. Oncogene. 2007;26:2840-50 pubmed
Vesely D, Hoffman B, Liebermann D. Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells. Oncogene. 2007;26:3041-50 pubmed
Xiao D, Lew K, Zeng Y, Xiao H, Marynowski S, Dhir R, et al. Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential. Carcinogenesis. 2006;27:2223-34 pubmed
Chemnitz J, Driesen J, Classen S, Riley J, Debey S, Beyer M, et al. Prostaglandin E2 impairs CD4+ T cell activation by inhibition of lck: implications in Hodgkin's lymphoma. Cancer Res. 2006;66:1114-22 pubmed
Jiang Z, Lu X, Nelson V, Yang X, Pan W, Chen R, et al. A multifunctional cytoprotective agent that reduces neurodegeneration after ischemia. Proc Natl Acad Sci U S A. 2006;103:1581-6 pubmed
Reindl C, Bagrintseva K, Vempati S, Schnittger S, Ellwart J, Wenig K, et al. Point mutations in the juxtamembrane domain of FLT3 define a new class of activating mutations in AML. Blood. 2006;107:3700-7 pubmed
Civas A, Genin P, Morin P, Lin R, Hiscott J. Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon. J Biol Chem. 2006;281:4856-66 pubmed
Lewis J, Meeke K, Osipo C, Ross E, Kidawi N, Li T, et al. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J Natl Cancer Inst. 2005;97:1746-59 pubmed
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Yao X, Liu J, Lee E, Ling G, McCabe J. Progesterone differentially regulates pro- and anti-apoptotic gene expression in cerebral cortex following traumatic brain injury in rats. J Neurotrauma. 2005;22:656-68 pubmed
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product information
Product Name :
Bcl-xL (H-5) Antibody
Gene Name :
BCL2L1
Size :
200 µg/ml
Catalog Number :
sc-8392
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Bcl-xL
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
C-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA