product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Ob-R (B-3) Antibody
catalog :
sc-8391
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-3
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry knockout validation
citations: 26
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
de Lartigue G, Ronveaux C, Raybould H. Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Mol Metab. 2014;3:595-607 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 10
Yi X, Gao H, Chen D, Tang D, Huang W, Li T, et al. Effects of obesity and exercise on testicular leptin signal transduction and testosterone biosynthesis in male mice. Am J Physiol Regul Integr Comp Physiol. 2017;312:R501-R510 pubmed publisher
  • western blot; human; fig 2
Malaise O, Relic B, Charlier E, Zeddou M, Neuville S, Deroyer C, et al. Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Arthritis Res Ther. 2016;18:219 pubmed
  • immunoprecipitation; mouse; fig 7
  • western blot; mouse; 1:1000; fig 7
Guo D, Cui H, Zhang Q, Morgan D, Thedens D, Nishimura D, et al. The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane. PLoS Genet. 2016;12:e1005890 pubmed publisher
  • immunohistochemistry; human; 1:25; loading ...; fig 1b
  • western blot; human; 1:500; loading ...; fig 3
Choi E, Byeon S, Kim S, Lee H, Kwon H, Ahn H, et al. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PLoS ONE. 2015;10:e0130839 pubmed publisher
  • immunohistochemistry; human; fig 2
Tsai P, Davis J, Bryant Greenwood G. Systemic and placental leptin and its receptors in pregnancies associated with obesity. Reprod Sci. 2015;22:189-97 pubmed publisher
Llanos A, Lin Y, Chen W, Yao S, Norin J, Chekmareva M, et al. Immunohistochemical analysis of adipokine and adipokine receptor expression in the breast tumor microenvironment: associations of lower leptin receptor expression with estrogen receptor-negative status and triple-negative subtype. Breast Cancer Res. 2020;22:18 pubmed publisher
Whitfield J, Chiarini A, Dal Prà I, Armato U, Chakravarthy B. The Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's Neuropathology. Cells. 2015;4:253-74 pubmed publisher
Huebner L, Engeli S, Wrann C, Goudeva L, Laue T, Kielstein H. Human NK cell subset functions are differentially affected by adipokines. PLoS ONE. 2013;8:e75703 pubmed publisher
Albrizio M, Roscino M, Trisolini C, Binetti F, Rizzo A, Sciorsci R. The expression of leptin receptor in the ovary of the queen: leptin receptor expression in queen ovary. Res Vet Sci. 2013;95:629-31 pubmed publisher
Ptak A, Gregoraszczuk E. Bisphenol A induces leptin receptor expression, creating more binding sites for leptin, and activates the JAK/Stat, MAPK/ERK and PI3K/Akt signalling pathways in human ovarian cancer cell. Toxicol Lett. 2012;210:332-7 pubmed publisher
Zeddou M, Relic B, Malaise O, Charlier E, Desoroux A, Beguin Y, et al. Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells. Stem Cells Dev. 2012;21:1948-55 pubmed publisher
Estadella D, Oyama L, Bueno A, Habitante C, Souza G, Ribeiro E, et al. A palatable hyperlipidic diet causes obesity and affects brain glucose metabolism in rats. Lipids Health Dis. 2011;10:168 pubmed publisher
Yan B, Choi J, Yoo K, Lee C, Hwang I, You S, et al. Leptin's neuroprotective action in experimental transient ischemic damage of the gerbil hippocampus is linked to altered leptin receptor immunoreactivity. J Neurol Sci. 2011;303:100-8 pubmed publisher
Li Y, Wu X, Zhou S, Owyang C. Low-affinity CCK-A receptors are coexpressed with leptin receptors in rat nodose ganglia: implications for leptin as a regulator of short-term satiety. Am J Physiol Gastrointest Liver Physiol. 2011;300:G217-27 pubmed publisher
Boukouvalas G, Gerozissis K, Markaki E, Kitraki E. High-fat feeding influences the endocrine responses of pubertal rats to an acute stress. Neuroendocrinology. 2010;92:235-45 pubmed publisher
Lou P, Yang G, Huang L, Cui Y, Pourbahrami T, Radda G, et al. Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor. PLoS ONE. 2010;5:e11669 pubmed publisher
Compère V, Lanfray D, Castel H, Morin F, Leprince J, Dureuil B, et al. Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells. J Mol Endocrinol. 2010;44:295-9 pubmed publisher
Arias Alvarez M, Garcia Garcia R, Torres Rovira L, Gonzalez Bulnes A, Rebollar P, Lorenzo P. Influence of leptin on in vitro maturation and steroidogenic secretion of cumulus-oocyte complexes through JAK2/STAT3 and MEK 1/2 pathways in the rabbit model. Reproduction. 2010;139:523-32 pubmed publisher
Boukouvalas G, Gerozissis K, Kitraki E. Adult consequences of post-weaning high fat feeding on the limbic-HPA axis of female rats. Cell Mol Neurobiol. 2010;30:521-30 pubmed publisher
Boukouvalas G, Gerozissis K, Kitraki E. Fat feeding of rats during pubertal growth leads to neuroendocrine alterations in adulthood. Cell Mol Neurobiol. 2010;30:91-9 pubmed publisher
Koros C, Boukouvalas G, Gerozissis K, Kitraki E. Fat diet affects leptin receptor levels in the rat cerebellum. Nutrition. 2009;25:85-7 pubmed publisher
Dall Aglio C, Ceccarelli P, Pascucci L, Brecchia G, Boiti C. Receptors for leptin and estrogen in the subcommissural organ of rabbits are differentially modulated by fasting. Brain Res. 2006;1124:62-9 pubmed
Chen H, Fan J, Cui S. Detection and estrogen regulation of leptin receptor expression in rat dorsal root ganglion. Histochem Cell Biol. 2006;126:363-9 pubmed
Perego L, Pizzocri P, Corradi D, Maisano F, Paganelli M, Fiorina P, et al. Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J Clin Endocrinol Metab. 2005;90:4087-93 pubmed
Zerani M, Boiti C, Dall Aglio C, Pascucci L, Maranesi M, Brecchia G, et al. Leptin receptor expression and in vitro leptin actions on prostaglandin release and nitric oxide synthase activity in the rabbit oviduct. J Endocrinol. 2005;185:319-25 pubmed
product information
Product Name :
Ob-R (B-3) Antibody
Gene Name :
LEPR
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8391
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Ob-R
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminal (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA