product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
SA-2 (J-12) Antibody
catalog :
sc-81852
quantity :
100 µg/ml
price :
333 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
J-12
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 4
Kim J, He X, Orr B, Wutz G, Hill V, Peters J, et al. Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2. PLoS Genet. 2016;12:e1005865 pubmed publisher
  • western blot; human; fig 1d
Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, et al. Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion. Nat Struct Mol Biol. 2014;21:864-70 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 2
  • western blot; human; fig 5
Brohl A, Solomon D, Chang W, Wang J, Song Y, Sindiri S, et al. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet. 2014;10:e1004475 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Solomon D, Kim T, Diaz Martinez L, Fair J, Elkahloun A, Harris B, et al. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011;333:1039-43 pubmed publisher
Chu Z, Gu L, Hu Y, Zhang X, Li M, Chen J, et al. STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming. Nat Commun. 2022;13:1859 pubmed publisher
Bailey M, Tieu D, Habsid A, Tong A, Chan K, Moffat J, et al. Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene STAG2. Life Sci Alliance. 2021;4: pubmed publisher
Solé A, Grossetete S, Heintzé M, Babin L, Zaidi S, Revy P, et al. Unraveling Ewing sarcoma tumorigenesis originating from patient-derived Mesenchymal Stem Cells. Cancer Res. 2021;: pubmed publisher
Wagner K, Kunz K, Piller T, Tascher G, Hölper S, Stehmeier P, et al. The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics. Cell Rep. 2019;29:480-494.e5 pubmed publisher
Kim J, He X, Liu J, Duan Z, Kim T, Gerard J, et al. Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression. J Biol Chem. 2019;294:8760-8772 pubmed publisher
Liang C, Zhang Z, Chen Q, Yan H, Zhang M, Xiang X, et al. A positive feedback mechanism ensures proper assembly of the functional inner centromere during mitosis in human cells. J Biol Chem. 2019;294:1437-1450 pubmed publisher
Mauland K, Wik E, Hoivik E, Kusonmano K, Halle M, Berg A, et al. Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. Oncotarget. 2017;8:9696-9707 pubmed publisher
Shen C, Kim S, Trousil S, Frederick D, Piris A, Yuan P, et al. Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma. Nat Med. 2016;22:1056-61 pubmed publisher
Taylor C, Platt F, Hurst C, Thygesen H, Knowles M. Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes. Hum Mol Genet. 2014;23:1964-74 pubmed publisher
Balbás Martínez C, Sagrera A, Carrillo de Santa Pau E, Earl J, Márquez M, Vazquez M, et al. Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nat Genet. 2013;45:1464-9 pubmed publisher
Solomon D, Kim J, Bondaruk J, Shariat S, Wang Z, Elkahloun A, et al. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013;45:1428-30 pubmed publisher
product information
Catalog Number :
sc-81852
Product Name :
SA-2 (J-12) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
J-12
Isotype :
IgG1
Size :
100 µg/ml
List Price :
333 USD
Immunogen :
SA-2
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA