product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Met (B-2) Antibody
catalog :
sc-8057
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, other
citations: 31
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse
Fu H, Gui Y, Liu S, Wang Y, Bastacky S, Qiao Y, et al. The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment. iScience. 2021;24:103112 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5e
Lopušná K, Nowialis P, Opavska J, Abraham A, Riva A, Opavsky R. Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling. EBioMedicine. 2021;63:103191 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Du Z, Dong J, Li M, Zhang J, Bi J, Ren Y, et al. Overexpression of Platelet-Derived Growth Factor Receptor Α D842V Mutants Prevents Liver Regeneration and Chemically Induced Hepatocarcinogenesis via Inhibition of MET and EGFR. J Cancer. 2020;11:4614-4624 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
Zhao Y, Xie Z, Lin J, Liu P. MiR-144-3p inhibits cell proliferation and induces apoptosis in multiple myeloma by targeting c-Met. Am J Transl Res. 2017;9:2437-2446 pubmed
  • immunoprecipitation; human; fig 6
  • immunoprecipitation; mouse; fig 1
Barrow McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche B, et al. Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun. 2016;7:11942 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 1a
Kato T, Oka K, Nakamura T, Ito A. Decreased expression of Met during differentiation in rat lung. Eur J Histochem. 2016;60:2575 pubmed publisher
  • other; mouse; loading ...; fig 2a
Towner R, Ihnat M, Saunders D, Bastian A, Smith N, Pavana R, et al. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer. 2015;15:522 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
  • immunocytochemistry; mouse; 1:50
  • western blot; mouse
Berruti G, Paiardi C. USP8/UBPy-regulated sorting and the development of sperm acrosome: the recruitment of MET. Reproduction. 2015;149:633-44 pubmed publisher
  • western blot; rat; 1:200
Ekman M, Uvelius B, Albinsson S, Swärd K. HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Lab Invest. 2014;94:557-68 pubmed publisher
  • immunocytochemistry; mouse; 1:250
  • immunohistochemistry; mouse
  • western blot; mouse; 1:500
Eagleson K, Milner T, Xie Z, Levitt P. Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus. J Comp Neurol. 2013;521:3241-59 pubmed publisher
  • western blot; mouse
Zhou D, Tan R, Lin L, Zhou L, Liu Y. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 2013;84:509-20 pubmed publisher
Qiu W, Xiao Z, Yang Y, Jiang L, Song S, Qi X, et al. USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma. Cell Death Dis. 2023;14:207 pubmed publisher
Luo X, Xu Y, Li Y, Zhang G, Huang S, Liu X, et al. BAP1 deletion abrogates growth and metastasis of murine cutaneous melanoma. Melanoma Res. 2021;31:119-129 pubmed publisher
Salian Mehta S, Xu M, Wierman M. AXL and MET crosstalk to promote gonadotropin releasing hormone (GnRH) neuronal cell migration and survival. Mol Cell Endocrinol. 2013;374:92-100 pubmed publisher
Meyer R, D Alessandro L, Kar S, Kramer B, She B, Kaschek D, et al. Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration. Front Physiol. 2012;3:451 pubmed publisher
Ohnishi H, Oka K, Mizuno S, Nakamura T. Identification of mannose receptor as receptor for hepatocyte growth factor ?-chain: novel ligand-receptor pathway for enhancing macrophage phagocytosis. J Biol Chem. 2012;287:13371-81 pubmed publisher
Ueshima K, Kitaoka K, Nakase J, Xu Q, Matsumoto K, Tsuchiya H. Promotion of rabbit ligament healing by local delivery of hepatocyte growth factor. J Orthop Sci. 2011;16:451-7 pubmed publisher
Tönges L, Ostendorf T, Lamballe F, Genestine M, Dono R, Koch J, et al. Hepatocyte growth factor protects retinal ganglion cells by increasing neuronal survival and axonal regeneration in vitro and in vivo. J Neurochem. 2011;117:892-903 pubmed publisher
Judson M, Amaral D, Levitt P. Conserved subcortical and divergent cortical expression of proteins encoded by orthologs of the autism risk gene MET. Cereb Cortex. 2011;21:1613-26 pubmed publisher
Judson M, Eagleson K, Wang L, Levitt P. Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain. J Comp Neurol. 2010;518:4463-78 pubmed publisher
Gordin M, Tesio M, Cohen S, Gore Y, Lantner F, Leng L, et al. c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74. J Immunol. 2010;185:2020-31 pubmed publisher
Garteiser P, Doblas S, Watanabe Y, Saunders D, Hoyle J, Lerner M, et al. Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging. J Magn Reson Imaging. 2010;31:796-806 pubmed publisher
Pietronave S, Forte G, Locarno D, Merlin S, Zamperone A, Nicotra G, et al. Agonist monoclonal antibodies against HGF receptor protect cardiac muscle cells from apoptosis. Am J Physiol Heart Circ Physiol. 2010;298:H1155-65 pubmed publisher
Dai J, DeFrances M, Zou C, Johnson C, Zarnegar R. The Met protooncogene is a transcriptional target of NF kappaB: implications for cell survival. J Cell Biochem. 2009;107:1222-36 pubmed publisher
Judson M, BERGMAN M, Campbell D, Eagleson K, Levitt P. Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain. J Comp Neurol. 2009;513:511-31 pubmed publisher
Borkham Kamphorst E, Kovalenko E, van Roeyen C, Gassler N, Bomble M, Ostendorf T, et al. Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injury. Lab Invest. 2008;88:1090-100 pubmed publisher
Towner R, Smith N, Doblas S, Tesiram Y, Garteiser P, Saunders D, et al. In vivo detection of c-Met expression in a rat C6 glioma model. J Cell Mol Med. 2008;12:174-86 pubmed publisher
Crepaldi T, Bersani F, Scuoppo C, Accornero P, Prunotto C, Taulli R, et al. Conditional activation of MET in differentiated skeletal muscle induces atrophy. J Biol Chem. 2007;282:6812-22 pubmed
Nishikawa J, Sakuma K, Sorimachi Y, Yoshimoto K, Yasuhara M. Increase of Cardiotrophin-1 immunoreactivity in regenerating and overloaded but not denervated muscles of rats. Neuropathology. 2005;25:54-65 pubmed
Taulli R, Accornero P, Follenzi A, Mangano T, Morotti A, Scuoppo C, et al. RNAi technology and lentiviral delivery as a powerful tool to suppress Tpr-Met-mediated tumorigenesis. Cancer Gene Ther. 2005;12:456-63 pubmed
Oh K, Iimuro Y, Takeuchi M, Kaneda Y, Iwasaki T, Terada N, et al. Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 2005;288:G729-35 pubmed
product information
Product Name :
Met (B-2) Antibody
Size :
200 µg/ml
Catalog Number :
sc-8057
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Met
reactive species  :
m, r
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminal (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA