product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
c-Src (B-12) Antibody
catalog :
sc-8056
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-12
reactivity :
human, mouse, rat, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 52
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig s9b
Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, et al. The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries. Nat Commun. 2017;8:14797 pubmed publisher
  • western blot; rat; loading ...
Belliard A, Gulati G, Duan Q, Alves R, Brewer S, Madan N, et al. Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning. Physiol Rep. 2016;4: pubmed
  • western blot; human; fig 2
DeRita R, Zerlanko B, Singh A, Lu H, Iozzo R, Benovic J, et al. c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes. J Cell Biochem. 2017;118:66-73 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
  • immunoprecipitation; human; 1:50; fig 4
  • immunocytochemistry; human; 1:100; fig 4
  • western blot; human; 1:200; fig 1
Su L, Li X, Wu X, Hui B, Han S, Gao J, et al. Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar. Sci Rep. 2016;6:26023 pubmed publisher
  • western blot; human; 1:200; fig 1
Wu X, Yang L, Zheng Z, Li Z, Shi J, Li Y, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway. Int J Mol Med. 2016;37:639-48 pubmed publisher
  • western blot; rat; loading ...; fig 8a
Peng K, Tian X, Qian Y, Skibba M, Zou C, Liu Z, et al. Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II. J Cell Mol Med. 2016;20:482-94 pubmed publisher
  • immunocytochemistry; mouse
Matsuoka H, Inoue M. Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor. Am J Physiol Cell Physiol. 2015;309:C251-63 pubmed publisher
  • western blot; human
Chien P, Lin C, Hsiao L, Yang C. c-Src/Pyk2/EGFR/PI3K/Akt/CREB-activated pathway contributes to human cardiomyocyte hypertrophy: Role of COX-2 induction. Mol Cell Endocrinol. 2015;409:59-72 pubmed publisher
  • western blot; human; 1:1000; fig 5
Carnesecchi J, Malbouyres M, de Mets R, Balland M, Beauchef G, Vié K, et al. Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30. PLoS ONE. 2015;10:e0120672 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Choi C, Kim Y, Sohn J, Lee H, Kim W. Focal adhesion kinase and Src expression in premalignant and malignant skin lesions. Exp Dermatol. 2015;24:361-4 pubmed publisher
  • immunocytochemistry; human; 1:50
  • western blot; human; 1:200
Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed publisher
  • western blot; mouse; fig 8
Sheng L, Leshchyns ka I, Sytnyk V. Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels. J Neurosci. 2015;35:1739-52 pubmed publisher
  • western blot; pigs
Gable M, Abdallah S, Najjar S, Liu L, Askari A. Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase. Biochem Biophys Res Commun. 2014;446:1151-4 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:150
  • immunoprecipitation; human
  • western blot; human; 1:1000
Bouchekioua Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedER? is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher
  • western blot; human
Cao M, Hou D, Liang H, Gong F, Wang Y, Yan X, et al. miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1. Eur J Cancer. 2014;50:1013-24 pubmed publisher
  • western blot; mouse
Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  • immunohistochemistry; human
Zou D, Yoon H, Anjomshoaa A, Perez D, Fukuzawa R, Guilford P, et al. Increased levels of active c-Src distinguish invasive from in situ lobular lesions. Breast Cancer Res. 2009;11:R45 pubmed publisher
Sprenger A, Carr H, Ulu A, Frost J. Src stimulates Abl-dependent phosphorylation of the guanine exchange factor Net1A to promote its cytosolic localization and cell motility. J Biol Chem. 2023;299:104887 pubmed publisher
Nandi I, Smith H, Sanguin Gendreau V, Ji L, Pacis A, Papavasiliou V, et al. Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. J Clin Invest. 2023;133: pubmed publisher
Nkosi D, Sun L, Duke L, Patel N, Surapaneni S, Singh M, et al. Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. MBio. 2020;11: pubmed publisher
Noblanc A, Klaassen A, Robaire B. The Exacerbation of Aging and Oxidative Stress in the Epididymis of Sod1 Null Mice. Antioxidants (Basel). 2020;9: pubmed publisher
Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, et al. γ-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A. Mol Cell. 2019;76:857-871.e9 pubmed publisher
Brown C, Amante J, Mercurio A. Cell clustering mediated by the adhesion protein PVRL4 is necessary for α6β4 integrin-promoted ferroptosis resistance in matrix-detached cells. J Biol Chem. 2018;293:12741-12748 pubmed publisher
Zuo Y, Ulu A, Chang J, Frost J. Contributions of the RhoA guanine nucleotide exchange factor Net1 to polyoma middle T antigen-mediated mammary gland tumorigenesis and metastasis. Breast Cancer Res. 2018;20:41 pubmed publisher
Li W, Xu L, Che X, Li H, Zhang Y, Song N, et al. C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells. BMC Cancer. 2018;18:507 pubmed publisher
Paladino D, Yue P, Furuya H, Acoba J, Rosser C, Turkson J. A novel nuclear Src and p300 signaling axis controls migratory and invasive behavior in pancreatic cancer. Oncotarget. 2016;7:7253-67 pubmed publisher
Farnoodian M, Kinter J, Yadranji Aghdam S, Zaitoun I, Sorenson C, Sheibani N. Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells. Physiol Rep. 2015;3: pubmed publisher
Xiao X, Chen B, Liu X, Liu P, Zheng G, Ye F, et al. Diallyl disulfide suppresses SRC/Ras/ERK signaling-mediated proliferation and metastasis in human breast cancer by up-regulating miR-34a. PLoS ONE. 2014;9:e112720 pubmed publisher
Wang N, Liang H, Zhou Y, Wang C, Zhang S, Pan Y, et al. miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. PLoS ONE. 2014;9:e105570 pubmed publisher
Poulard C, Rambaud J, Hussein N, Corbo L, Le Romancer M. JMJD6 regulates ER? methylation on arginine. PLoS ONE. 2014;9:e87982 pubmed publisher
Zhang P, Zhang P, Zhou M, Jiang H, Zhang H, Shi B, et al. Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer. Carcinogenesis. 2013;34:2639-46 pubmed publisher
Lydka M, Bilinska B, Cheng C, Mruk D. Tumor necrosis factor ?-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton. Spermatogenesis. 2012;2:294-303 pubmed
Xiao X, Cheng C, Mruk D. Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat. J Endocrinol. 2013;216:73-86 pubmed publisher
Poulard C, Treilleux I, Lavergne E, Bouchekioua Bouzaghou K, Goddard Leon S, Chabaud S, et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012;4:1200-13 pubmed publisher
Hsieh H, Lin C, Chan H, Yang C, Yang C. c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells. J Neuroinflammation. 2012;9:152 pubmed publisher
Mok K, Mruk D, Lee W, Cheng C. A study to assess the assembly of a functional blood-testis barrier in developing rat testes. Spermatogenesis. 2011;1:270-280 pubmed
Li M, Xiao X, Mruk D, Lam Y, Lee W, Lui W, et al. Actin-binding protein drebrin E is involved in junction dynamics during spermatogenesis. Spermatogenesis. 2011;1:123-136 pubmed publisher
Liu L, Ivanov A, Gable M, Jolivel F, Morrill G, Askari A. Comparative properties of caveolar and noncaveolar preparations of kidney Na+/K+-ATPase. Biochemistry. 2011;50:8664-73 pubmed publisher
Stavik B, Skretting G, Aasheim H, Tinholt M, Zernichow L, Sletten M, et al. Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility. BMC Cancer. 2011;11:357 pubmed publisher
Li Z, Zhang Z, Xie J, Li X, Tian J, Cai T, et al. Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells. J Biol Chem. 2011;286:32394-403 pubmed publisher
O Reilly L, Watkins S, Smithgall T. An unexpected role for the clock protein timeless in developmental apoptosis. PLoS ONE. 2011;6:e17157 pubmed publisher
Hamzeh M, Robaire B. Androgens activate mitogen-activated protein kinase via epidermal growth factor receptor/insulin-like growth factor 1 receptor in the mouse PC-1 cell line. J Endocrinol. 2011;209:55-64 pubmed publisher
Kang M, Kim K, Yoon Y, Kang Y, Kim H, Youn C, et al. Ape1/Ref-1 Stimulates GDNF/GFRalpha1-mediated Downstream Signaling and Neuroblastoma Proliferation. Korean J Physiol Pharmacol. 2009;13:349-56 pubmed publisher
Wang H, Ren D. UNC80 functions as a scaffold for Src kinases in NALCN channel function. Channels (Austin). 2009;3:161-3 pubmed
Kim M, Kim H, Acharya S, Sohn H, Jun J, Chang I, et al. Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression. Mol Cell Biol. 2009;29:2264-77 pubmed publisher
Golembieski W, Thomas S, Schultz C, Yunker C, McClung H, Lemke N, et al. HSP27 mediates SPARC-induced changes in glioma morphology, migration, and invasion. Glia. 2008;56:1061-75 pubmed publisher
Ariyoshi W, Takahashi T, Kanno T, Ichimiya H, Shinmyouzu K, Takano H, et al. Heparin inhibits osteoclastic differentiation and function. J Cell Biochem. 2008;103:1707-17 pubmed publisher
Bernard Trifilo J, Lim S, Hou S, Schlaepfer D, Ilic D. Analyzing FAK and Pyk2 in early integrin signaling events. Curr Protoc Cell Biol. 2006;Chapter 14:Unit 14.7 pubmed publisher
Ackermann G, Marenholz I, Wolfer D, Chan W, Schäfer B, Erne P, et al. S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses. Biochim Biophys Acta. 2006;1763:1307-19 pubmed
Menon M, Fang J, Wojchowski D. Core erythropoietin receptor signals for late erythroblast development. Blood. 2006;107:2662-72 pubmed
Libertini S, Robinson B, Dhillon N, Glick D, George M, Dandekar S, et al. Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Res. 2005;65:10700-8 pubmed
Arias Salgado E, Haj F, Dubois C, Moran B, Kasirer Friede A, Furie B, et al. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005;170:837-45 pubmed
product information
Product Name :
c-Src (B-12) Antibody
Gene Name :
SRC, YES1, FYN, FGR
Size :
200 µg/ml
Catalog Number :
sc-8056
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
c-Src
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA