product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Dvl-1 (3F12) Antibody
catalog :
sc-8025
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3F12
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 1a
Gammons M, Rutherford T, Steinhart Z, Angers S, Bienz M. Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay. J Cell Sci. 2016;129:3892-3902 pubmed
  • western blot; human; 1:1000; loading ...; fig 5b
Zhang H, Yang X, Zhu L, Li Z, Zuo P, Wang P, et al. ASPM promotes hepatocellular carcinoma progression by activating Wnt/β-catenin signaling through antagonizing autophagy-mediated Dvl2 degradation. FEBS Open Bio. 2021;11:2784-2799 pubmed publisher
  • immunohistochemistry; human; 1:150; loading ...; fig 4a
Šolić I, Racetin A, Filipović N, Mardešić S, Bocina I, Galesic Ljubanovic D, et al. Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; human; loading ...; fig 4c
Liao W, Hsu C, Chan T, Yen C, Chen W, Pan H, et al. Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma. Stem Cell Reports. 2020;14:462-477 pubmed publisher
  • western blot; human; loading ...; fig 4c
Shami Shah A, Batrouni A, Kim D, Punyala A, Cao W, Han C, et al. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Cell Rep. 2019;27:2157-2170.e8 pubmed publisher
  • western blot; human; loading ...; fig 9b
Nag J, Kancharla A, Maoz M, Turm H, Agranovich D, Gupta C, et al. Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated ?-catenin stabilization. Oncotarget. 2017;8:38650-38667 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 3b
Chen S, Zhang Q, Bai B, Ouyang S, Bao Y, Li H, et al. MARK2/Par1b Insufficiency Attenuates DVL Gene Transcription via Histone Deacetylation in Lumbosacral Spina Bifida. Mol Neurobiol. 2017;54:6304-6316 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 2a
  • western blot; human; 1:200; fig s4a
Dass R, Sarshad A, Carson B, Feenstra J, Kaur A, Obrdlik A, et al. Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS Genet. 2016;12:e1006217 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5
Felli N, Errico M, Pedini F, Petrini M, Puglisi R, Bellenghi M, et al. AP2α controls the dynamic balance between miR-126&126* and miR-221&222 during melanoma progression. Oncogene. 2016;35:3016-26 pubmed publisher
  • immunocytochemistry; human; 1:100
Vestergaard M, Awan A, Warzecha C, Christensen S, Andersen C. Immunofluorescence Microscopy and mRNA Analysis of Human Embryonic Stem Cells (hESCs) Including Primary Cilia Associated Signaling Pathways. Methods Mol Biol. 2016;1307:123-40 pubmed publisher
  • immunohistochemistry; mouse; fig 6
Liu C, Lin C, Gao C, May Simera H, Swaroop A, Li T. Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3:861-70 pubmed publisher
  • western blot; human; fig 6
Revet I, Huizenga G, Koster J, Volckmann R, van Sluis P, Versteeg R, et al. MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3. Cancer Lett. 2010;289:195-207 pubmed publisher
Zhang Q, Mesner L, Calabrese G, Dirckx N, Li Z, Verardo A, et al. Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts. J Clin Invest. 2021;131: pubmed publisher
Soldano A, Okray Z, Janovská P, Tmejová K, Reynaud E, Claeys A, et al. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. PLoS Biol. 2013;11:e1001562 pubmed publisher
Veland I, Montjean R, Eley L, Pedersen L, Schwab A, Goodship J, et al. Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration. PLoS ONE. 2013;8:e60193 pubmed publisher
Li X, Xu Y, Chen Y, Chen S, Jia X, Sun T, et al. SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/?-catenin signal network. Cancer Lett. 2013;336:379-89 pubmed publisher
Rodriguez Gil D, Hu W, Greer C. Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals. PLoS ONE. 2013;8:e56561 pubmed publisher
Valente E, Logan C, Mougou Zerelli S, Lee J, Silhavy J, Brancati F, et al. Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nat Genet. 2010;42:619-25 pubmed publisher
Sutton G, Madigan M, Roufas A, McAvoy J. Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment. Clin Exp Ophthalmol. 2010;38:43-8 pubmed publisher
Guo J, Cagatay T, Zhou G, Chan C, Blythe S, Suyama K, et al. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS ONE. 2009;4:e7982 pubmed publisher
Chen M, Wang J, Lu J, Bond M, Ren X, Lyerly H, et al. The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009;48:10267-74 pubmed publisher
Svensson A, Norrby M, Libelius R, Tagerud S. Secreted frizzled related protein 1 (Sfrp1) and Wnt signaling in innervated and denervated skeletal muscle. J Mol Histol. 2008;39:329-37 pubmed publisher
Shi C, Huang N, Harrison K, Han S, Kehrl J. The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol. 2006;26:6511-21 pubmed
Mizutani K, Miyamoto S, Nagahata T, Konishi N, Emi M, Onda M. Upregulation and overexpression of DVL1, the human counterpart of the Drosophila dishevelled gene, in prostate cancer. Tumori. 2005;91:546-51 pubmed
product information
Product Name :
Dvl-1 (3F12) Antibody
Gene Name :
DVL1
Size :
200 µg/ml
Catalog Number :
sc-8025
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Dvl-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
651-695 (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA