| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry knockout validation; human; loading ...; fig 3a
- western blot knockout validation; human; loading ...; fig 2m
- immunoprecipitation; human; loading ...; fig 5a
| Almine J, O Hare C, Dunphy G, Haga I, Naik R, Atrih A, et al. IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nat Commun. 2017;8:14392 pubmed publisher |
- western blot knockout validation; human; fig 2a
| Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, et al. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. MBio. 2019;10: pubmed publisher |
- western blot; human; loading ...; fig 1b
| Cerboni S, Jeremiah N, Gentili M, Gehrmann U, Conrad C, Stolzenberg M, et al. Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes. J Exp Med. 2017;214:1769-1785 pubmed publisher |
- immunoprecipitation; human; fig 5
- immunocytochemistry; human; tbl 4
- western blot; human; fig 5
| Ortiz D, Glassbrook J, Pellett P. Protein-Protein Interactions Suggest Novel Activities of Human Cytomegalovirus Tegument Protein pUL103. J Virol. 2016;90:7798-810 pubmed publisher |
- immunohistochemistry; human; fig 2
- ELISA; human; fig 1
| Alunno A, Caneparo V, Carubbi F, Bistoni O, Caterbi S, Bartoloni E, et al. Interferon gamma-inducible protein 16 in primary Sjögren's syndrome: a novel player in disease pathogenesis?. Arthritis Res Ther. 2015;17:208 pubmed publisher |
- immunocytochemistry; human
- immunohistochemistry; human
- western blot; human
| Chiliveru S, Rahbek S, Jensen S, Jørgensen S, Nissen S, Christiansen S, et al. Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA. J Immunol. 2014;192:2395-404 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Horan K, Hansen K, Jakobsen M, Holm C, Søby S, Unterholzner L, et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol. 2013;190:2311-9 pubmed publisher |
| Elder E, Krishna B, Williamson J, Lim E, Poole E, Sedikides G, et al. Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency. MBio. 2019;10: pubmed publisher |
| Roy A, Ghosh A, Kumar B, Chandran B. IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP. elife. 2019;8: pubmed publisher |
| Dunphy G, Flannery S, Almine J, Connolly D, Paulus C, Jønsson K, et al. Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage. Mol Cell. 2018;71:745-760.e5 pubmed publisher |
| Khare S, Ratsimandresy R, de Almeida L, Cuda C, Rellick S, Misharin A, et al. The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol. 2014;15:343-53 pubmed publisher |
| Yamauchi M, Nakano T, Nakashima T, Yasumatsu R, Hashimoto K, Toh S, et al. Interferon Inducible IFI16 Expression in p16 Positive Squamous Cell Carcinoma of the Oropharynx. ISRN Otolaryngol. 2013;2013:263271 pubmed publisher |
| Gugliesi F, Bawadekar M, de Andrea M, Dell Oste V, Caneparo V, Tincani A, et al. Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding. PLoS ONE. 2013;8:e63045 pubmed publisher |
| Tamassia N, Bazzoni F, Le Moigne V, Calzetti F, Masala C, Grisendi G, et al. IFN-? expression is directly activated in human neutrophils transfected with plasmid DNA and is further increased via TLR-4-mediated signaling. J Immunol. 2012;189:1500-9 pubmed publisher |
| Veeranki S, Duan X, Panchanathan R, Liu H, Choubey D. IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS ONE. 2011;6:e27040 pubmed publisher |
| Duan X, Ponomareva L, Veeranki S, Choubey D. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS ONE. 2011;6:e19532 pubmed publisher |
| Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res. 2011;9:589-602 pubmed publisher |
| Song L, Ponomareva L, Shen H, Duan X, Alimirah F, Choubey D. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. PLoS ONE. 2010;5:e8569 pubmed publisher |
| Fernandes Alnemri T, Yu J, Datta P, Wu J, Alnemri E. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009;458:509-13 pubmed publisher |
| Hornung V, Ablasser A, Charrel Dennis M, Bauernfeind F, Horvath G, Caffrey D, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009;458:514-8 pubmed publisher |
| Masumi A, Fukazawa H, Shimazu T, Yoshida M, Ozato K, Komuro K, et al. Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation. Oncogene. 2006;25:5113-24 pubmed |
| Alimirah F, Chen J, Xin H, Choubey D. Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein. FEBS Lett. 2006;580:1659-64 pubmed |
