Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; human; 1:500; loading ...; fig s10e
| Lee J, Chang J, Dominguez A, Lee H, Nam S, Chang J, et al. YAP-independent mechanotransduction drives breast cancer progression. Nat Commun. 2019;10:1848 pubmed publisher
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- western blot; mouse; 1:200; loading ...; fig 3a
| Paldor M, Levkovitch Siany O, Eidelshtein D, Adar R, Enk C, Marmary Y, et al. Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis. EMBO Mol Med. 2022;14:e15653 pubmed publisher
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- western blot; human; loading ...; fig 4b
| Zheng J, Yao L, Zhou Y, Gu X, Wang C, Bao K, et al. A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. Cell Death Dis. 2021;12:871 pubmed publisher
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- western blot; human; loading ...; fig 8b, 8c
| Gao L, Meng J, Yue C, Wu X, Su Q, Wu H, et al. Integrative analysis the characterization of peroxiredoxins in pan-cancer. Cancer Cell Int. 2021;21:366 pubmed publisher
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- western blot; human; loading ...; fig 4m
| Sun Y, Jing J, Xu H, Xu L, Hu H, Tang C, et al. N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells. J Immunother Cancer. 2021;9: pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig 6e
| Delgado E, Erickson H, Tao J, Monga S, Duncan A, Anakk S. Scaffolding Protein IQGAP1 is Dispensable But Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling. Mol Cell Biol. 2021;: pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig 5g
| Lopušná K, Nowialis P, Opavska J, Abraham A, Riva A, Opavsky R. Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling. EBioMedicine. 2021;63:103191 pubmed publisher
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- western blot; mouse; loading ...; fig 5i
| Theivanthiran B, Evans K, Devito N, Plebanek M, Sturdivant M, Wachsmuth L, et al. A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. J Clin Invest. 2020;130:2570-2586 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig s2c
| Rizzini L, Levine D, Perelis M, Bass J, Peek C, Pagano M. Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism. Curr Biol. 2019;29:1954-1962.e4 pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig e2h
- western blot; human; 1:500; loading ...; fig 1f, e2a
| Shi Y, Gao W, Lytle N, Huang P, Yuan X, Dann A, et al. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019;569:131-135 pubmed publisher
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- western blot; rat; 1:200; loading ...; fig 5
| Li J, Liu B, Shi Y, Xie K, Yin H, Yan L, et al. CXCL4 Contributes to the Pathogenesis of Chronic Liver Allograft Dysfunction. J Immunol Res. 2016;2016:9276986 pubmed publisher
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- western blot; human; fig 3
| Tsuboki J, Fujiwara Y, Horlad H, Shiraishi D, Nohara T, Tayama S, et al. Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages. Sci Rep. 2016;6:29588 pubmed publisher
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- western blot; human; fig 5
| Huang J, Yao C, Chuang S, Yeh C, Lee L, Chen R, et al. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction. BMC Cancer. 2016;16:245 pubmed publisher
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- western blot; human; loading ...; fig 2d
| Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
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- chromatin immunoprecipitation; human; fig 4
- western blot; human; fig 4
| Renga B, Francisci D, Carino A, Marchianò S, Cipriani S, Chiara Monti M, et al. The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma. Sci Rep. 2015;5:15403 pubmed publisher
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- western blot; human; fig s13
| Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, et al. Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE. 2015;10:e0119415 pubmed publisher
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| Mou W, Xu Y, Ye Y, Chen S, Li X, Gong K, et al. Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment. Cancer Lett. 2015;358:115-23 pubmed publisher
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- western blot; human; loading ...; fig 3a
| Thagia I, Shaw E, Smith E, Else K, Rigby R. Intestinal epithelial suppressor of cytokine signaling 3 enhances microbial-induced inflammatory tumor necrosis factor-α, contributing to epithelial barrier dysfunction. Am J Physiol Gastrointest Liver Physiol. 2015;308:G25-31 pubmed publisher
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- immunocytochemistry; human
| Cheray M, Nadaradjane A, Bonnet P, Routier S, Vallette F, Cartron P. Specific inhibition of DNMT1/CFP1 reduces cancer phenotypes and enhances chemotherapy effectiveness. Epigenomics. 2014;6:267-75 pubmed publisher
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| George S, Vishwamitra D, Manshouri R, Shi P, Amin H. The ALK inhibitor ASP3026 eradicates NPM-ALK? T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014;5:5750-63 pubmed
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| Tang Y, Weng X, Liu C, Li X, Chen C. Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis. Anal Cell Pathol (Amst). 2021;2021:4132488 pubmed publisher
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| Wang P, Yang W, Guo H, Dong H, Guo Y, Gan H, et al. IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death. Adv Sci (Weinh). 2021;8:e2101501 pubmed publisher
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| Lee J, Lee H, Ryu K, Kim M, Ko D, Chung K, et al. KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. J Clin Med. 2020;9: pubmed publisher
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| Webb L, Sengupta S, Edell C, Piedra Quintero Z, Amici S, Miranda J, et al. Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity. J Clin Invest. 2020;130:1683-1698 pubmed publisher
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| Meng J, Liu K, Shao Y, Feng X, Ji Z, Chang B, et al. ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death Dis. 2020;11:137 pubmed publisher
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| Chesnelong C, Hao X, Cseh O, Wang A, Luchman H, Weiss S. SLUG Directs the Precursor State of Human Brain Tumor Stem Cells. Cancers (Basel). 2019;11: pubmed publisher
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| Martínez García D, Pérez Hernández M, Korrodi Gregório L, Quesada R, Ramos R, Baixeras N, et al. The Natural-Based Antitumor Compound T21 Decreases Survivin Levels through Potent STAT3 Inhibition in Lung Cancer Models. Biomolecules. 2019;9: pubmed publisher
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| Kim H, Kim D, Choi S, Kim C, Oh S, Pyo K, et al. KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway. Proc Natl Acad Sci U S A. 2018;115:11766-11771 pubmed publisher
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| Xiong Y, Torsoni A, Wu F, Shen H, Liu Y, Zhong X, et al. Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. elife. 2018;7: pubmed publisher
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| He F, Soriano P. Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017;144:4026-4036 pubmed publisher
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| Read K, Powell M, Baker C, Sreekumar B, Ringel Scaia V, Bachus H, et al. Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells. J Immunol. 2017;199:2377-2387 pubmed publisher
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| Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed publisher
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| Zhang Z, Luo Z, Min W, Zhang L, Wu Y, Hu X. An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3? signaling in breast cancer cells. Oncotarget. 2017;8:43091-43103 pubmed publisher
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| Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al. Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed publisher
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| He B, Hao J, Sheng W, Xiang Y, Zhang J, Zhu H, et al. Fistular onion stalk extract exhibits anti-atherosclerotic effects in rats. Exp Ther Med. 2014;8:785-792 pubmed
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| Yang H, Lawrence H, Kazi A, Gevariya H, Patel R, Luo Y, et al. Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation. Oncotarget. 2014;5:2947-61 pubmed
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| Renga B, Francisci D, Schiaroli E, Carino A, Cipriani S, D Amore C, et al. The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2. PLoS ONE. 2014;9:e94798 pubmed publisher
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| Fujiwara Y, Takaishi K, Nakao J, Ikeda T, Katabuchi H, Takeya M, et al. Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. Oncol Lett. 2013;6:1619-1623 pubmed
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| Wang Z, Si X, Xu A, Meng X, Gao S, Qi Y, et al. Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications. PLoS ONE. 2013;8:e75788 pubmed publisher
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| Bogazzi F, Raggi F, Russo D, Bohlooly Y M, Sardella C, Urbani C, et al. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. 2013;154:4226-36 pubmed publisher
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| Zhang P, Zhang P, Zhou M, Jiang H, Zhang H, Shi B, et al. Exon 4 deletion variant of epidermal growth factor receptor enhances invasiveness and cisplatin resistance in epithelial ovarian cancer. Carcinogenesis. 2013;34:2639-46 pubmed publisher
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| Ding B, Bi E, Chen H, Yu J, Ye B. IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells. J Immunol. 2013;190:1827-36 pubmed publisher
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| Bu X, Zhao C, Wang W, Zhang N. GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation. Gene. 2013;512:198-205 pubmed publisher
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| Wang J, Chen S, Xu S, Yu X, Ma D, Hu X, et al. In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. Mar Drugs. 2012;10:2055-68 pubmed publisher
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| Duru N, Fan M, Candas D, Menaa C, Liu H, Nantajit D, et al. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res. 2012;18:6634-47 pubmed publisher
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| Zgheib C, Kurdi M, Zouein F, Gunter B, Stanley B, Zgheib J, et al. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS ONE. 2012;7:e43313 pubmed publisher
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| Shiraishi D, Fujiwara Y, Komohara Y, Mizuta H, Takeya M. Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation. Biochem Biophys Res Commun. 2012;425:304-8 pubmed publisher
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| Gong J, Zhang J, Li B, Zeng C, You K, Chen M, et al. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene. 2013;32:3071-9 pubmed publisher
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| Vishwamitra D, Li Y, Wilson D, Manshouri R, Curry C, Shi B, et al. MicroRNA 96 is a post-transcriptional suppressor of anaplastic lymphoma kinase expression. Am J Pathol. 2012;180:1772-80 pubmed publisher
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| Teng S, Hsu W, Chiu C, Wong M, Chang S. Overexpression of P-glycoprotein, STAT3, phospho-STAT3 and KIT in spontaneous canine cutaneous mast cell tumours before and after prednisolone treatment. Vet J. 2012;193:551-6 pubmed publisher
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| Nicolas C, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, et al. The Jak/STAT pathway is involved in synaptic plasticity. Neuron. 2012;73:374-90 pubmed publisher
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| Uluer E, Aydemir I, Inan S, Ozbilgin K, Vatansever H. Effects of 5-fluorouracil and gemcitabine on a breast cancer cell line (MCF-7) via the JAK/STAT pathway. Acta Histochem. 2012;114:641-6 pubmed publisher
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| Kienesberger P, Pulinilkunnil T, Sung M, Nagendran J, Haemmerle G, Kershaw E, et al. Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 2012;32:740-50 pubmed publisher
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| Osinalde N, Moss H, Arrizabalaga O, Omaetxebarria M, Blagoev B, Zubiaga A, et al. Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics. J Proteomics. 2011;75:177-91 pubmed publisher
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| Yin Z, Zhang Y, Li Y, Lv T, Liu J, Wang X. Prognostic significance of STAT3 expression and its correlation with chemoresistance of non-small cell lung cancer cells. Acta Histochem. 2012;114:151-8 pubmed publisher
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| O Neil B, Goff L, Kauh J, Strosberg J, Bekaii Saab T, Lee R, et al. Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2011;29:2350-6 pubmed publisher
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| Thomas C, Zoubeidi A, Kuruma H, Fazli L, Lamoureux F, Beraldi E, et al. Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo. Mol Cancer Ther. 2011;10:347-59 pubmed publisher
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| Yu R, Hu X, Xu S, Jiang Z, Yang W. Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. Eur J Pharmacol. 2011;657:10-9 pubmed publisher
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| Macha M, Matta A, Chauhan S, Siu K, Ralhan R. Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-?B and STAT3 pathways in head and neck cancer cells. Carcinogenesis. 2011;32:368-80 pubmed publisher
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| Glienke W, Hausmann E, Bergmann L. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour Biol. 2011;32:493-500 pubmed publisher
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| Fujiwara Y, Komohara Y, Ikeda T, Takeya M. Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Sci. 2011;102:206-11 pubmed publisher
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| Shen Y, Inoue N, Heese K. Neurotrophin-4 (ntf4) mediates neurogenesis in mouse embryonic neural stem cells through the inhibition of the signal transducer and activator of transcription-3 (stat3) and the modulation of the activity of protein kinase B. Cell Mol Neurobiol. 2010;30:909-16 pubmed publisher
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| Madrigal Matute J, Lopez Franco O, Blanco Colio L, Munoz Garcia B, Ramos Mozo P, Ortega L, et al. Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis. Cardiovasc Res. 2010;86:330-7 pubmed publisher
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| Siejka A, Schally A, Barabutis N. Activation of Janus kinase/signal transducer and activator of transcription 3 pathway by growth hormone-releasing hormone. Cell Mol Life Sci. 2010;67:959-64 pubmed publisher
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| Yao C, Yang C, Chuang S, Yan J, Liu C, Chen S, et al. Targeting PML-RAR? and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evid Based Complement Alternat Med. 2011;2011:984154 pubmed publisher
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| Chusid L, Pereira Argenziano L, Miskolci V, Vancurova I, Davidson D. Transcriptional control of cytokine release from monocytes of the newborn: effects of endogenous and exogenous interleukin-10 versus dexamethasone. Neonatology. 2010;97:108-16 pubmed publisher
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| Wang L, Quan J, Johnston W, Maass D, Horton J, Thomas J, et al. Age-dependent differences of interleukin-6 activity in cardiac function after burn complicated by sepsis. Burns. 2010;36:232-8 pubmed publisher
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| Yao X, Kodeboyina S, Liu L, Dzandu J, Sangerman J, Ofori Acquah S, et al. Role of STAT3 and GATA-1 interactions in gamma-globin gene expression. Exp Hematol. 2009;37:889-900 pubmed publisher
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| Zorde Khvalevsky E, Abramovitch R, Barash H, Spivak Pohis I, Rivkin L, Rachmilewitz J, et al. Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology. 2009;50:198-206 pubmed publisher
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| Shah N, Trivedi T, Tankshali R, Goswami J, Jetly D, Shukla S, et al. Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis. Head Neck. 2009;31:1544-56 pubmed publisher
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| Baral R, Bose A, Ray C, Paul S, Pal S, Haque E, et al. Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Exp Mol Pathol. 2009;87:36-41 pubmed publisher
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| Zhu P, Hata R, Cao F, Gu F, Hanakawa Y, Hashimoto K, et al. Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function. FASEB J. 2008;22:3866-77 pubmed publisher
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| Itabashi H, Maesawa C, Oikawa H, Kotani K, Sakurai E, Kato K, et al. Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines. Hepatol Res. 2008;38:601-13 pubmed publisher
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| Nechemia Arbely Y, Barkan D, Pizov G, Shriki A, Rose John S, Galun E, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008;19:1106-15 pubmed publisher
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| Lee T, Yeh J, Friedman J, Yan B, Yang X, Yeh N, et al. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer. 2008;122:1987-98 pubmed publisher
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| Williams K, Young S, Negus A, Young L, Adams D, Afford S. C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis: a novel link between complement and epithelial cell survival. PLoS ONE. 2007;2:e159 pubmed
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| Rosen D, Mercado Uribe I, Yang G, Bast R, Amin H, Lai R, et al. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. 2006;107:2730-40 pubmed
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| He H, Zhu T, Xie Y, Fan J, Kole S, Saxena S, et al. Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. J Biol Chem. 2006;281:31369-79 pubmed
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| Chang K, Wu M, Jones D, Chen F, Tseng Y. Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour. J Pathol. 2006;210:224-33 pubmed
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| Cao F, Hata R, Zhu P, Ma Y, Tanaka J, Hanakawa Y, et al. Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells. J Neurochem. 2006;98:459-70 pubmed
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| Abou Sleymane G, Chalmel F, Helmlinger D, Lardenois A, Thibault C, Weber C, et al. Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program. Hum Mol Genet. 2006;15:691-703 pubmed
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| Lai R, Rassidakis G, Lin Q, Atwell C, Medeiros L, Amin H. Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Hum Pathol. 2005;36:939-44 pubmed
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| Gagarin D, Yang Z, Butler J, Wimmer M, Du B, Cahan P, et al. Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions: potential role of STATs, cyclinD1, BAD, and Bcl-XL. J Mol Cell Cardiol. 2005;39:453-65 pubmed
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| Ahmed Choudhury J, Williams K, Young L, Adams D, Afford S. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal. 2006;18:456-68 pubmed
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| Gu F, Hata R, Ma Y, Tanaka J, Mitsuda N, Kumon Y, et al. Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. J Neurosci Res. 2005;81:163-71 pubmed
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