| Published Application/Species/Sample/Dilution | Reference | 
|---|
| western blot knockout validation; human; 1:500; loading ...; fig s10e
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| western blot; mouse; 1:200; loading ...; fig 3a
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| western blot; human; loading ...; fig 4b
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| western blot; human; loading ...; fig 8b, 8c
 | Gao L, Meng J, Yue C, Wu X, Su Q, Wu H, et al . Integrative analysis the characterization of peroxiredoxins in pan-cancer. Cancer Cell Int. 2021;21:366 pubmed  publisher | 
| western blot; human; loading ...; fig 4m
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| western blot; mouse; 1:500; loading ...; fig 6e
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| western blot; mouse; 1:500; loading ...; fig 5g
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| western blot; mouse; loading ...; fig 5i
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| western blot; human; 1:2000; loading ...; fig s2c
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| western blot; mouse; 1:500; loading ...; fig e2hwestern blot; human; 1:500; loading ...; fig 1f, e2a
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| western blot; rat; 1:200; loading ...; fig 5
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| western blot; human; fig 3
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| western blot; human; fig 5
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| western blot; human; loading ...; fig 2d
 | Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed  publisher | 
| chromatin immunoprecipitation; human; fig 4western blot; human; fig 4
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| western blot; human; fig s13
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|  | Mou W, Xu Y, Ye Y, Chen S, Li X, Gong K, et al . Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment. Cancer Lett. 2015;358:115-23 pubmed  publisher | 
| western blot; human; loading ...; fig 3a
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| immunocytochemistry; human
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|  | Tang Y, Weng X, Liu C, Li X, Chen C. Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis. Anal Cell Pathol (Amst). 2021;2021:4132488 pubmed  publisher | 
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|  | Lee J, Lee H, Ryu K, Kim M, Ko D, Chung K, et al . KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. J Clin Med. 2020;9: pubmed  publisher | 
|  | Webb L, Sengupta S, Edell C, Piedra Quintero Z, Amici S, Miranda J, et al . Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity. J Clin Invest. 2020;130:1683-1698 pubmed  publisher | 
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|  | Chesnelong C, Hao X, Cseh O, Wang A, Luchman H, Weiss S. SLUG Directs the Precursor State of Human Brain Tumor Stem Cells. Cancers (Basel). 2019;11: pubmed  publisher | 
|  | Martínez García D, Pérez Hernández M, Korrodi Gregório L, Quesada R, Ramos R, Baixeras N, et al . The Natural-Based Antitumor Compound T21 Decreases Survivin Levels through Potent STAT3 Inhibition in Lung Cancer Models. Biomolecules. 2019;9: pubmed  publisher | 
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|  | Xiong Y, Torsoni A, Wu F, Shen H, Liu Y, Zhong X, et al . Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases. elife. 2018;7: pubmed  publisher | 
|  | He F, Soriano P. Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017;144:4026-4036 pubmed  publisher | 
|  | Read K, Powell M, Baker C, Sreekumar B, Ringel Scaia V, Bachus H, et al . Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4+ Th Cells. J Immunol. 2017;199:2377-2387 pubmed  publisher | 
|  | Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed  publisher | 
|  | Zhang Z, Luo Z, Min W, Zhang L, Wu Y, Hu X. An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3? signaling in breast cancer cells. Oncotarget. 2017;8:43091-43103 pubmed  publisher | 
|  | Yoon J, Sudo K, Kuroda M, Kato M, Lee I, Han J, et al . Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation. Nat Commun. 2015;6:7600 pubmed  publisher | 
|  | He B, Hao J, Sheng W, Xiang Y, Zhang J, Zhu H, et al . Fistular onion stalk extract exhibits anti-atherosclerotic effects in rats. Exp Ther Med. 2014;8:785-792 pubmed | 
|  | Yang H, Lawrence H, Kazi A, Gevariya H, Patel R, Luo Y, et al . Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation. Oncotarget. 2014;5:2947-61 pubmed | 
|  | Renga B, Francisci D, Schiaroli E, Carino A, Cipriani S, D Amore C, et al . The HIV matrix protein p17 promotes the activation of human hepatic stellate cells through interactions with CXCR2 and Syndecan-2. PLoS ONE. 2014;9:e94798 pubmed  publisher | 
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|  | Wang Z, Si X, Xu A, Meng X, Gao S, Qi Y, et al . Activation of STAT3 in human gastric cancer cells via interleukin (IL)-6-type cytokine signaling correlates with clinical implications. PLoS ONE. 2013;8:e75788 pubmed  publisher | 
|  | Bogazzi F, Raggi F, Russo D, Bohlooly Y M, Sardella C, Urbani C, et al . Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. 2013;154:4226-36 pubmed  publisher | 
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|  | Ding B, Bi E, Chen H, Yu J, Ye B. IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells. J Immunol. 2013;190:1827-36 pubmed  publisher | 
|  | Bu X, Zhao C, Wang W, Zhang N. GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation. Gene. 2013;512:198-205 pubmed  publisher | 
|  | Wang J, Chen S, Xu S, Yu X, Ma D, Hu X, et al . In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. Mar Drugs. 2012;10:2055-68 pubmed  publisher | 
|  | Duru N, Fan M, Candas D, Menaa C, Liu H, Nantajit D, et al . HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clin Cancer Res. 2012;18:6634-47 pubmed  publisher | 
|  | Zgheib C, Kurdi M, Zouein F, Gunter B, Stanley B, Zgheib J, et al . Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS ONE. 2012;7:e43313 pubmed  publisher | 
|  | Shiraishi D, Fujiwara Y, Komohara Y, Mizuta H, Takeya M. Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation. Biochem Biophys Res Commun. 2012;425:304-8 pubmed  publisher | 
|  | Gong J, Zhang J, Li B, Zeng C, You K, Chen M, et al . MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene. 2013;32:3071-9 pubmed  publisher | 
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|  | Teng S, Hsu W, Chiu C, Wong M, Chang S. Overexpression of P-glycoprotein, STAT3, phospho-STAT3 and KIT in spontaneous canine cutaneous mast cell tumours before and after prednisolone treatment. Vet J. 2012;193:551-6 pubmed  publisher | 
|  | Nicolas C, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, et al . The Jak/STAT pathway is involved in synaptic plasticity. Neuron. 2012;73:374-90 pubmed  publisher | 
|  | Uluer E, Aydemir I, Inan S, Ozbilgin K, Vatansever H. Effects of 5-fluorouracil and gemcitabine on a breast cancer cell line (MCF-7) via the JAK/STAT pathway. Acta Histochem. 2012;114:641-6 pubmed  publisher | 
|  | Kienesberger P, Pulinilkunnil T, Sung M, Nagendran J, Haemmerle G, Kershaw E, et al . Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 2012;32:740-50 pubmed  publisher | 
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|  | O Neil B, Goff L, Kauh J, Strosberg J, Bekaii Saab T, Lee R, et al . Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2011;29:2350-6 pubmed  publisher | 
|  | Thomas C, Zoubeidi A, Kuruma H, Fazli L, Lamoureux F, Beraldi E, et al . Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo. Mol Cancer Ther. 2011;10:347-59 pubmed  publisher | 
|  | Yu R, Hu X, Xu S, Jiang Z, Yang W. Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. Eur J Pharmacol. 2011;657:10-9 pubmed  publisher | 
|  | Macha M, Matta A, Chauhan S, Siu K, Ralhan R. Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-?B and STAT3 pathways in head and neck cancer cells. Carcinogenesis. 2011;32:368-80 pubmed  publisher | 
|  | Glienke W, Hausmann E, Bergmann L. Downregulation of STAT3 signaling induces apoptosis but also promotes anti-apoptotic gene expression in human pancreatic cancer cell lines. Tumour Biol. 2011;32:493-500 pubmed  publisher | 
|  | Fujiwara Y, Komohara Y, Ikeda T, Takeya M. Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. Cancer Sci. 2011;102:206-11 pubmed  publisher | 
|  | Shen Y, Inoue N, Heese K. Neurotrophin-4 (ntf4) mediates neurogenesis in mouse embryonic neural stem cells through the inhibition of the signal transducer and activator of transcription-3 (stat3) and the modulation of the activity of protein kinase B. Cell Mol Neurobiol. 2010;30:909-16 pubmed  publisher | 
|  | Madrigal Matute J, Lopez Franco O, Blanco Colio L, Munoz Garcia B, Ramos Mozo P, Ortega L, et al . Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis. Cardiovasc Res. 2010;86:330-7 pubmed  publisher | 
|  | Siejka A, Schally A, Barabutis N. Activation of Janus kinase/signal transducer and activator of transcription 3 pathway by growth hormone-releasing hormone. Cell Mol Life Sci. 2010;67:959-64 pubmed  publisher | 
|  | Yao C, Yang C, Chuang S, Yan J, Liu C, Chen S, et al . Targeting PML-RAR? and Oncogenic Signaling Pathways by Chinese Herbal Mixture Tien-Hsien Liquid in Acute Promyelocytic Leukemia NB4 Cells. Evid Based Complement Alternat Med. 2011;2011:984154 pubmed  publisher | 
|  | Chusid L, Pereira Argenziano L, Miskolci V, Vancurova I, Davidson D. Transcriptional control of cytokine release from monocytes of the newborn: effects of endogenous and exogenous interleukin-10 versus dexamethasone. Neonatology. 2010;97:108-16 pubmed  publisher | 
|  | Wang L, Quan J, Johnston W, Maass D, Horton J, Thomas J, et al . Age-dependent differences of interleukin-6 activity in cardiac function after burn complicated by sepsis. Burns. 2010;36:232-8 pubmed  publisher | 
|  | Yao X, Kodeboyina S, Liu L, Dzandu J, Sangerman J, Ofori Acquah S, et al . Role of STAT3 and GATA-1 interactions in gamma-globin gene expression. Exp Hematol. 2009;37:889-900 pubmed  publisher | 
|  | Zorde Khvalevsky E, Abramovitch R, Barash H, Spivak Pohis I, Rivkin L, Rachmilewitz J, et al . Toll-like receptor 3 signaling attenuates liver regeneration. Hepatology. 2009;50:198-206 pubmed  publisher | 
|  | Shah N, Trivedi T, Tankshali R, Goswami J, Jetly D, Shukla S, et al . Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis. Head Neck. 2009;31:1544-56 pubmed  publisher | 
|  | Baral R, Bose A, Ray C, Paul S, Pal S, Haque E, et al . Association of early phase of colorectal carcinogenesis with STAT3 activation and its relevance in apoptosis regulation. Exp Mol Pathol. 2009;87:36-41 pubmed  publisher | 
|  | Zhu P, Hata R, Cao F, Gu F, Hanakawa Y, Hashimoto K, et al . Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function. FASEB J. 2008;22:3866-77 pubmed  publisher | 
|  | Itabashi H, Maesawa C, Oikawa H, Kotani K, Sakurai E, Kato K, et al . Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines. Hepatol Res. 2008;38:601-13 pubmed  publisher | 
|  | Nechemia Arbely Y, Barkan D, Pizov G, Shriki A, Rose John S, Galun E, et al . IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol. 2008;19:1106-15 pubmed  publisher | 
|  | Lee T, Yeh J, Friedman J, Yan B, Yang X, Yeh N, et al . A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. Int J Cancer. 2008;122:1987-98 pubmed  publisher | 
|  | Williams K, Young S, Negus A, Young L, Adams D, Afford S. C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis: a novel link between complement and epithelial cell survival. PLoS ONE. 2007;2:e159 pubmed | 
|  | Rosen D, Mercado Uribe I, Yang G, Bast R, Amin H, Lai R, et al . The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. 2006;107:2730-40 pubmed | 
|  | He H, Zhu T, Xie Y, Fan J, Kole S, Saxena S, et al . Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. J Biol Chem. 2006;281:31369-79 pubmed | 
|  | Chang K, Wu M, Jones D, Chen F, Tseng Y. Activation of STAT3 in thymic epithelial tumours correlates with tumour type and clinical behaviour. J Pathol. 2006;210:224-33 pubmed | 
|  | Cao F, Hata R, Zhu P, Ma Y, Tanaka J, Hanakawa Y, et al . Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells. J Neurochem. 2006;98:459-70 pubmed | 
|  | Abou Sleymane G, Chalmel F, Helmlinger D, Lardenois A, Thibault C, Weber C, et al . Polyglutamine expansion causes neurodegeneration by altering the neuronal differentiation program. Hum Mol Genet. 2006;15:691-703 pubmed | 
|  | Lai R, Rassidakis G, Lin Q, Atwell C, Medeiros L, Amin H. Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma. Hum Pathol. 2005;36:939-44 pubmed | 
|  | Gagarin D, Yang Z, Butler J, Wimmer M, Du B, Cahan P, et al . Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions: potential role of STATs, cyclinD1, BAD, and Bcl-XL. J Mol Cell Cardiol. 2005;39:453-65 pubmed | 
|  | Ahmed Choudhury J, Williams K, Young L, Adams D, Afford S. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal. 2006;18:456-68 pubmed | 
|  | Gu F, Hata R, Ma Y, Tanaka J, Mitsuda N, Kumon Y, et al . Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. J Neurosci Res. 2005;81:163-71 pubmed |