product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Ub (P4D1) Antibody
catalog :
sc-8017
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
P4D1
reactivity :
African green monkey, kangaroo rats, Japanese rice fish, human, mouse, rat, bovine, S. cerevisiae, Drosophila melanogaster, Xenopus laevis, thale cress, domestic rabbit, rhesus macaque, E. coli
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
citations: 460
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 666 ng/ml; loading ...; fig 5b
Choi J, Zhong X, McAlpine W, Liao T, Zhang D, Fang B, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019;364: pubmed publisher
  • western blot; human; loading ...; fig 2g
Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park J, et al. Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity. Cell. 2019;177:1187-1200.e16 pubmed publisher
  • western blot; Xenopus laevis; loading ...; fig e5h
Wu R, Semlow D, Kamimae Lanning A, Kochenova O, Chistol G, Hodskinson M, et al. TRAIP is a master regulator of DNA interstrand crosslink repair. Nature. 2019;567:267-272 pubmed publisher
  • immunoprecipitation; human; 1:1000; loading ...; fig 6
  • western blot; human; 1:1000; loading ...; fig 6
Cartier E, Garcia Olivares J, Janezic E, Viana J, Moore M, Lin M, et al. The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake. Front Cell Neurosci. 2019;13:35 pubmed publisher
  • western blot; human; loading ...; fig 2f
Paul D, Islam S, Manne R, Dinesh U, Malonia S, Maity B, et al. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function. J Pathol. 2019;248:266-279 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Gallot Y, Bohnert K, Straughn A, Xiong G, Hindi S, Kumar A. PERK regulates skeletal muscle mass and contractile function in adult mice. FASEB J. 2019;33:1946-1962 pubmed publisher
  • western blot; human; 1:100; loading ...; fig s8d
Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4d
Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher
  • western blot; human; loading ...; fig 1h
Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018;361:290-295 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Wilson K, Liu H, Healey G, Vuong V, Ishido S, Herold M, et al. MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway. PLoS ONE. 2018;13:e0200540 pubmed publisher
  • western blot; human; loading ...; fig 4c, 6b
Yang C, Chiu L, Chang C, Chuang H, Tan T. Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation. FASEB J. 2018;:fj201800244RR pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4j
Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton B, et al. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018;9:2269 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 6a
  • western blot; mouse; 1:500; loading ...; fig 6b
Liu H, Jiang W, Chen X, Chang G, Zhao L, Li X, et al. Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype. Metabolism. 2018;85:259-270 pubmed publisher
  • western blot; human; loading ...; fig 6c
Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 1a
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5a
Juenemann K, Jansen A, van Riel L, Merkx R, Mulder M, An H, et al. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018;8:1405 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2i
Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat Carotta S, et al. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018;21:207-217 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4b
Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2a
Chiang C, Pauli E, Biryukov J, Feister K, Meng M, White E, et al. The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling. J Virol. 2018;92: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Zhu T, Yong X, Xia D, Widagdo J, Anggono V. Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein. J Mol Biol. 2018;430:363-371 pubmed publisher
  • western blot; E. coli; 1:5000; fig 2c
Mot A, Prell E, Klecker M, Naumann C, Faden F, Westermann B, et al. Real-time detection of N-end rule-mediated ubiquitination via fluorescently labeled substrate probes. New Phytol. 2018;217:613-624 pubmed publisher
  • western blot; mouse; fig 6e
Malty R, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, et al. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017;5:564-577.e12 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 5b
Nguyen A, Prado M, Schmidt P, Sendamarai A, Wilson Grady J, Min M, et al. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017;357: pubmed publisher
  • western blot; human; loading ...; fig 2b
Sheng X, You Q, Zhu H, Chang Z, Li Q, Wang H, et al. Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLoS Pathog. 2017;13:e1006534 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6d
Wang W, Xia Z, Farré J, Subramani S. TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import. J Cell Biol. 2017;216:2843-2858 pubmed publisher
  • western blot; human; loading ...; fig 6b
Perez Leal O, Barrero C, Merali S. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. J Biol Chem. 2017;292:14108-14121 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 3a
Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, et al. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 2017;8:e2763 pubmed publisher
  • western blot; human; loading ...; fig 4b
Zhou Y, Wu B, Li J, Nan G, Jiang J, Chen Z. Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion. Exp Cell Res. 2017;357:9-16 pubmed publisher
  • western blot; human; loading ...; fig 1c
Zhao H, Zhang L, Zhang Y, Zhao L, Wan Q, Wang B, et al. Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells. Oncotarget. 2017;8:36383-36398 pubmed publisher
  • western blot; human; loading ...; fig 1a
Fischer A, Harrison K, Ramirez Y, Auer D, Chowdhury S, Prusty B, et al. Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense. elife. 2017;6: pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 3c
Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3c
Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
  • immunocytochemistry; human; loading ...
Jeong J, VanHouten J, Kim W, Dann P, Sullivan C, Choi J, et al. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. J Biol Chem. 2017;292:6555-6568 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 7c
  • western blot; rat; loading ...; fig 7a
Zhu Y, Zhang Q, Zhang W, Li N, Dai Y, Tu J, et al. Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia. Sci Rep. 2017;7:42660 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 1a
Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, et al. CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017;18:1499-1511 pubmed publisher
  • western blot; human; loading ...; fig 4d
Hu Y, Li W, Gao T, Cui Y, Jin Y, Li P, et al. The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. J Virol. 2017;91: pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3b
Liu X, Zhao B, Sun L, Bhuripanyo K, Wang Y, Bi Y, et al. Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes. Nat Commun. 2017;8:14286 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1d
Shin S, Kim J, Lee J, Son Y, Lee M, Kim H, et al. Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro. Exp Mol Med. 2017;49:e287 pubmed publisher
  • western blot; S. cerevisiae; fig 3a
Weisshaar N, Welsch H, Guerra Moreno A, Hanna J. Phospholipase Lpl1 links lipid droplet function with quality control protein degradation. Mol Biol Cell. 2017;28:716-725 pubmed publisher
  • western blot; human; 1:200; loading ...; fig s4b
Coccia M, Rossi A, Riccio A, Trotta E, Santoro M. Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance. Proc Natl Acad Sci U S A. 2017;114:1045-1050 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4c
Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;36:3274-3286 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6d
Li M, Lau Z, Cheung P, Aguilar E, Schneider W, Bozzacco L, et al. TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). PLoS Pathog. 2017;13:e1006145 pubmed publisher
  • western blot; human; fig 7
Kumazoe M, Takai M, Bae J, Hiroi S, Huang Y, Takamatsu K, et al. FOXO3 is essential for CD44 expression in pancreatic cancer cells. Oncogene. 2017;36:2643-2654 pubmed publisher
  • western blot; mouse; 1:250; loading ...; fig 6b
Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, et al. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017;18:54-63 pubmed publisher
  • western blot; human; loading ...; fig 2c
Matsuura K, Huang N, Cocce K, Zhang L, Kornbluth S. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 2017;36:1698-1706 pubmed publisher
  • western blot; human; loading ...; fig s3b
Yu J, Lei R, Zhuang X, Li X, Li G, Lev S, et al. MicroRNA-182 targets SMAD7 to potentiate TGF?-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun. 2016;7:13884 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 4e
Cai H, Liu A. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016;113:14751-14756 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Dhar J, Barik S. Unique nonstructural proteins of Pneumonia Virus of Mice (PVM) promote degradation of interferon (IFN) pathway components and IFN-stimulated gene proteins. Sci Rep. 2016;6:38139 pubmed publisher
  • western blot; human; loading ...; fig 3d
Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, et al. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget. 2016;7:86011-86025 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5D
Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed publisher
  • western blot; mouse; loading ...; fig 10a
Huang S, Zhou A, Nguyen D, Zhang H, Benz E. Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation. J Biol Chem. 2016;291:25591-25607 pubmed
  • western blot; human; 1:500; loading ...; fig 5b
Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim K, et al. Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep. 2016;6:34784 pubmed publisher
  • western blot; mouse; 1:250; loading ...; fig 3a
Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton Smith J, et al. Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia. Nat Genet. 2016;48:1349-1358 pubmed publisher
  • immunocytochemistry; rat; 1:500; loading ...; fig 2b
Shlevkov E, Kramer T, Schapansky J, LaVoie M, Schwarz T. Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc Natl Acad Sci U S A. 2016;113:E6097-E6106 pubmed
  • western blot; human; loading ...; fig 3e
Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, et al. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016;30:1956-70 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6d
  • western blot; human; loading ...; fig 6a
Chi H, Chen S, Tsai C, Chuang W, Huang Y, Tsai M, et al. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016;12:2271-2285 pubmed
  • western blot; human; 1:1000; fig 7
Fernández Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
  • western blot; human; fig 5
  • western blot; mouse; fig 5
Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed publisher
  • western blot; human; 1:1000; fig s15
Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  • western blot; human; loading ...; fig 1f
BRANDT C, McFie P, Stone S. Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome. Biochem J. 2016;473:3621-3637 pubmed
  • western blot; human; loading ...; fig 5f
Hirano A, Shi G, Jones C, Lipzen A, Pennacchio L, Xu Y, et al. A Cryptochrome 2 mutation yields advanced sleep phase in humans. elife. 2016;5: pubmed publisher
  • western blot; human; 1:500; fig s2
Vingill S, Brockelt D, Lancelin C, Tatenhorst L, Dontcheva G, Preisinger C, et al. Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice. EMBO J. 2016;35:2008-25 pubmed publisher
  • western blot; rat; loading ...; fig 3b
Won S, Incontro S, Nicoll R, Roche K. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Proc Natl Acad Sci U S A. 2016;113:E4736-44 pubmed publisher
  • western blot; human
Singh A, Fedele C, Lu H, Nevalainen M, Keen J, Languino L. Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. Mol Cancer Res. 2016;14:1136-1146 pubmed
  • western blot; human; 1:1000; fig 3
Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, et al. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. PLoS Pathog. 2016;12:e1005764 pubmed publisher
  • western blot; mouse; loading ...; fig s4a
Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, et al. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med. 2016;22:906-14 pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Rackov G, Hernandez Jimenez E, Shokri R, Carmona Rodríguez L, Manes S, Alvarez Mon M, et al. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-?B and IFN-?. J Clin Invest. 2016;126:3089-103 pubmed publisher
  • immunohistochemistry - frozen section; domestic rabbit; fig 4
  • western blot; domestic rabbit; fig 4
Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 4a
Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher
  • western blot; human; loading ...; fig 4a
Shao W, Zumer K, Fujinaga K, Peterlin B. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem. 2016;291:17953-63 pubmed publisher
  • western blot; human; 1:500; loading ...; tbl 3
Simile M, Latte G, Demartis M, Brozzetti S, Calvisi D, Porcu A, et al. Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. Oncotarget. 2016;7:49194-49216 pubmed publisher
  • western blot; human; 1:500; loading ...; fig s2d
Lee J, Takahama S, Zhang G, Tomarev S, Ye Y. Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells. Nat Cell Biol. 2016;18:765-76 pubmed publisher
  • immunoprecipitation; human; fig 4d
Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed publisher
  • western blot; human; loading ...; fig 1a
Palazón Riquelme P, Lopez Castejon G. Method to Measure Ubiquitination of NLRs. Methods Mol Biol. 2016;1417:223-9 pubmed publisher
  • western blot; mouse; fig 5
Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
  • western blot; mouse; fig 3b
Passalacqua K, Charbonneau M, Donato N, Showalter H, Sun D, Wen B, et al. Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens. Antimicrob Agents Chemother. 2016;60:4183-96 pubmed publisher
  • western blot; human; loading ...; fig 5b
Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher
  • western blot; thale cress; 1:1000; fig s12
Yang B, Han X, Yin L, Xing M, Xu Z, Xue H. Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling. Nat Commun. 2016;7:11388 pubmed publisher
  • western blot; human; loading ...; fig 4a
Qiu J, Sheedlo M, Yu K, Tan Y, Nakayasu E, Das C, et al. Ubiquitination independent of E1 and E2 enzymes by bacterial effectors. Nature. 2016;533:120-4 pubmed publisher
  • western blot; human; loading ...; fig 1a
Rorsman C, Tsioumpekou M, Heldin C, Lennartsson J. The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem. 2016;291:11608-18 pubmed publisher
  • western blot; human; fig 2
Richter B, Sliter D, Herhaus L, Stolz A, Wang C, Beli P, et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016;113:4039-44 pubmed publisher
  • western blot; human; 1:500; fig 2
Decorsière A, Mueller H, van Breugel P, Abdul F, Gerossier L, Beran R, et al. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016;531:386-9 pubmed publisher
  • western blot; human; loading ...; fig 4e
Jin H, Lee K, Kim Y, Oh H, Maeng Y, Kim T, et al. Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene. 2016;35:5106-18 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5c
Frum R, Love I, Damle P, Mukhopadhyay N, Palit Deb S, Deb S, et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016;14:423-36 pubmed publisher
  • western blot; human; 1:5000; fig 3d
Choi W, de Poot S, Lee J, Kim J, Han D, Kim Y, et al. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016;7:10963 pubmed publisher
  • western blot; human; loading ...; fig 3a
Llambi F, Wang Y, Victor B, Yang M, Schneider D, Gingras S, et al. BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell. 2016;165:421-33 pubmed publisher
  • western blot; S. cerevisiae; fig s1
Choe Y, Park S, Hassemer T, Körner R, Vincenz Donnelly L, Hayer Hartl M, et al. Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature. 2016;531:191-5 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Wei J, Xiong Z, Lee J, Cheng J, Duffney L, Matas E, et al. Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress. J Neurosci. 2016;36:2119-30 pubmed publisher
  • western blot; African green monkey; 1:1000; fig 6
Tung H, Wei S, Lo H, Chao Y. Baculovirus IE2 Stimulates the Expression of Heat Shock Proteins in Insect and Mammalian Cells to Facilitate Its Proper Functioning. PLoS ONE. 2016;11:e0148578 pubmed publisher
  • immunoprecipitation; rat; 1:1000; fig 5
Kwon D, Eom G, Ko J, Shin S, Joung H, Choe N, et al. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun. 2016;7:10492 pubmed publisher
  • western blot; human; fig 3
Díaz Barreiro A, Bernal Quirós M, Georg I, Marañón C, Alarcón Riquelme M, Castillejo López C. The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function. Genes Immun. 2016;17:128-38 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; mouse; 1:200; fig 4
Gong G, Song M, Csordás G, Kelly D, Matkovich S, Dorn G. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015;350:aad2459 pubmed publisher
  • western blot; human; loading ...; fig 7b
Ying M, Zhang L, Zhou Q, Shao X, Cao J, Zhang N, et al. The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα. Oncogene. 2016;35:4358-67 pubmed publisher
  • immunoprecipitation; human; fig s3
Jeong J, VanHouten J, Dann P, Kim W, Sullivan C, Yu H, et al. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A. 2016;113:E282-90 pubmed publisher
  • western blot; human; 1:500; fig 3
Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun. 2016;7:10201 pubmed publisher
  • western blot; human; fig 2A
Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, et al. Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS ONE. 2015;10:e0145023 pubmed publisher
  • western blot; mouse; fig 2
Giampietro C, Disanza A, Bravi L, Barrios Rodiles M, Corada M, Frittoli E, et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol. 2015;211:1177-92 pubmed publisher
  • western blot; human; fig 2
Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, et al. USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation. Int J Clin Exp Pathol. 2015;8:10707-15 pubmed
  • western blot; human; fig 5
Cristini A, Park J, Capranico G, Legube G, Favre G, Sordet O. DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions. Nucleic Acids Res. 2016;44:1161-78 pubmed publisher
  • western blot; human; 1:250; fig s3e
Maxfield K, Taus P, Corcoran K, Wooten J, Macion J, Zhou Y, et al. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. Nat Commun. 2015;6:8840 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Larabee C, Georgescu C, Wren J, Plafker S. Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons. BMC Neurosci. 2015;16:76 pubmed publisher
  • western blot; Xenopus laevis; fig 5
Yue J, Ben Messaoud N, López J. Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1-2 and Bid. J Biol Chem. 2015;290:30375-89 pubmed publisher
  • western blot; human; fig 4
Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, et al. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. 2015;527:389-93 pubmed publisher
  • western blot; mouse; fig 1
Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, et al. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J Cell Sci. 2015;128:4453-61 pubmed publisher
  • western blot; human; fig 2
Li Z, Hao Q, Luo J, Xiong J, Zhang S, Wang T, et al. USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. Oncogene. 2016;35:2902-12 pubmed publisher
  • western blot; human; fig 1
Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper D. Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Carcinogenesis. 2015;36:1263-74 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Homma T, Kurahashi T, Lee J, Kang E, Fujii J. SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes. Arch Biochem Biophys. 2015;583:65-72 pubmed publisher
  • western blot; Drosophila melanogaster; 1:1000; fig 2b
Zhou Z, Xu C, Chen P, Liu C, Pang S, Yao X, et al. Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates. Sci Rep. 2015;5:12709 pubmed publisher
  • western blot; human
Lee C, Yang Y, Chen C, Liu J. Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death. Oncogene. 2016;35:1988-95 pubmed publisher
  • western blot; human; 1:1000; fig 2
Chen S, Okada M, Nakato R, Izumi K, Bando M, Shirahige K. The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin. J Biol Chem. 2015;290:21713-23 pubmed publisher
  • western blot; human; fig 6
Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  • western blot; human
Toruń A, Szymańska E, Castanon I, Wolińska Nizioł L, Bartosik A, Jastrzębski K, et al. Endocytic Adaptor Protein Tollip Inhibits Canonical Wnt Signaling. PLoS ONE. 2015;10:e0130818 pubmed publisher
  • western blot; mouse; 1:250
Kubli D, Cortez M, Moyzis A, Najor R, Lee Y, Gustafsson Ã. PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes. PLoS ONE. 2015;10:e0130707 pubmed publisher
  • western blot; human; fig s5
Ma S, Yin N, Qi X, Pfister S, Zhang M, Ma R, et al. Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). Oncotarget. 2015;6:13320-33 pubmed
  • western blot; human; 1:500; fig 1e
Hendriks I, D Souza R, Chang J, Mann M, Vertegaal A. System-wide identification of wild-type SUMO-2 conjugation sites. Nat Commun. 2015;6:7289 pubmed publisher
  • western blot; mouse; 1:100; fig 2a
Song M, Gong G, Burelle Y, Gustafsson Ã, Kitsis R, Matkovich S, et al. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015;117:346-51 pubmed publisher
  • western blot; human
Kharat S, Tripathi V, Damodaran A, Priyadarshini R, Chandra S, Tikoo S, et al. Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability. Oncogene. 2016;35:1025-38 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 3
Robinson H, Deykin A, Bronovitsky E, Ovchinnikov R, Ustyugov A, Shelkovnikova T, et al. Early lethality and neuronal proteinopathy in mice expressing cytoplasm-targeted FUS that lacks the RNA recognition motif. Amyotroph Lateral Scler Frontotemporal Degener. 2015;16:402-9 pubmed publisher
  • western blot; human; fig 9a
Watanabe M, Takahashi H, Saeki Y, Ozaki T, Itoh S, Suzuki M, et al. The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ. elife. 2015;4:e05615 pubmed publisher
  • western blot; human; fig 2
González Prieto R, Cuijpers S, Kumar R, Hendriks I, Vertegaal A. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle. 2015;14:1859-72 pubmed publisher
  • western blot; bovine; 1:1000
Boutell C, Davido D. A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro. Methods. 2015;90:3-7 pubmed publisher
  • western blot; human; fig 4c
Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 3b
Zhang R, Wang R, Chen Q, Chang H. Inhibition of autophagy using 3-methyladenine increases cisplatin-induced apoptosis by increasing endoplasmic reticulum stress in U251 human glioma cells. Mol Med Rep. 2015;12:1727-32 pubmed publisher
  • immunohistochemistry; Japanese rice fish; 1:50; fig 4
  • western blot; Japanese rice fish; 1:50; fig 4
Uemura N, Koike M, Ansai S, Kinoshita M, Ishikawa Fujiwara T, Matsui H, et al. Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. PLoS Genet. 2015;11:e1005065 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed publisher
  • western blot; mouse; 1:1000
Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015;22:1775-84 pubmed publisher
  • other; mouse; loading ...; fig 1e
  • western blot; mouse; loading ...; fig 1a
Zhang Q, Kuang H, Chen C, Yan J, Do Umehara H, Liu X, et al. The kinase Jnk2 promotes stress-induced mitophagy by targeting the small mitochondrial form of the tumor suppressor ARF for degradation. Nat Immunol. 2015;16:458-66 pubmed publisher
  • western blot; human; 1:500; fig 4a
Friebe S, Deuquet J, van der Goot F. Differential dependence on N-glycosylation of anthrax toxin receptors CMG2 and TEM8. PLoS ONE. 2015;10:e0119864 pubmed publisher
  • western blot; mouse
Williams J, Ni H, Haynes A, Manley S, Li Y, Jaeschke H, et al. Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice. J Biol Chem. 2015;290:10934-46 pubmed publisher
  • western blot; human; fig 5
Li C, Jung S, Lee S, Jeong D, Yang Y, Kim K, et al. Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP. Oncotarget. 2015;6:7522-35 pubmed
  • immunoprecipitation; rat; loading ...; fig 1a
  • western blot; rat; loading ...; fig 2b
Widagdo J, Chai Y, Ridder M, Chau Y, Johnson R, Sah P, et al. Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation. Cell Rep. 2015;10:783-795 pubmed publisher
  • western blot; mouse
Kathania M, Zeng M, Yadav V, Moghaddam S, Yang B, Venuprasad K. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015;194:2160-7 pubmed publisher
  • western blot; human
Huo L, Li C, Huang T, Lam Y, Xia W, Tu C, et al. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am J Transl Res. 2014;6:649-63 pubmed
  • western blot; bovine; fig 4
Marsolier J, Perichon M, Debarry J, Villoutreix B, Chluba J, Lopez T, et al. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature. 2015;520:378-82 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2b
Shim H, Wei M, Brandhorst S, Longo V. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015;75:1056-67 pubmed publisher
  • western blot; human; 1:5000; fig 4
Hong A, Lee J, Chung K. Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination. J Cell Physiol. 2015;230:1651-60 pubmed publisher
  • western blot; human; 1:3000; fig 3
Gabriel D, Roedl D, Gordon L, Djabali K. Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts. Aging Cell. 2015;14:78-91 pubmed publisher
  • western blot; human
Deegan S, Koryga I, Glynn S, Gupta S, Gorman A, Samali A. A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy. Biochem Biophys Res Commun. 2015;456:305-11 pubmed publisher
  • western blot; human
Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, et al. Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway. PLoS Pathog. 2014;10:e1004522 pubmed publisher
  • immunoprecipitation; human; fig 1
Tao L, Chen C, Song H, Piccioni M, Shi G, Li B. Deubiquitination and stabilization of IL-33 by USP21. Int J Clin Exp Pathol. 2014;7:4930-7 pubmed
  • western blot; human; 1:1000; loading ...; fig 4b
Wang T, Jiang X, Chen G, Xu J. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. Neurobiol Aging. 2015;36:527-35 pubmed publisher
  • western blot; kangaroo rats; 1:500; fig 1
Pilchova I, Klacanova K, Chomova M, Tatarkova Z, Dobrota D, Racay P. Possible contribution of proteins of Bcl-2 family in neuronal death following transient global brain ischemia. Cell Mol Neurobiol. 2015;35:23-31 pubmed publisher
  • western blot; rhesus macaque; fig 2
Sutinen P, Rahkama V, Rytinki M, Palvimo J. Nuclear mobility and activity of FOXA1 with androgen receptor are regulated by SUMOylation. Mol Endocrinol. 2014;28:1719-28 pubmed publisher
  • western blot; mouse; fig s4
Xu R, Hu Q, Ma Q, Liu C, Wang G. The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis. 2014;5:e1373 pubmed publisher
  • western blot; mouse
Biswas C, Shah N, Muthu M, La P, Fernando A, Sengupta S, et al. Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses. J Biol Chem. 2014;289:26882-94 pubmed publisher
  • western blot; human
Hamouda M, Belhacene N, Puissant A, Colosetti P, Robert G, Jacquel A, et al. The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells. Oncotarget. 2014;5:6252-66 pubmed
  • western blot; rat; fig 6
  • western blot; mouse; fig 3
Li S, Wang W, Niu T, Wang H, Li B, Shao L, et al. Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction. Oxid Med Cell Longev. 2014;2014:748524 pubmed publisher
  • western blot; human; 1:500; fig 6
Tu K, Yang W, Li C, Zheng X, Lu Z, Guo C, et al. Fbxw7 is an independent prognostic marker and induces apoptosis and growth arrest by regulating YAP abundance in hepatocellular carcinoma. Mol Cancer. 2014;13:110 pubmed publisher
  • flow cytometry; human; 1:400
  • immunoprecipitation; human; 1:400
  • western blot; human; 1:400
van de Weijer M, Bassik M, Luteijn R, Voorburg C, Lohuis M, Kremmer E, et al. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014;5:3832 pubmed publisher
  • western blot; human; 1:1000; fig 3e
Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed publisher
  • western blot; human; fig 2
Aslanian A, Yates J, Hunter T. Mass spectrometry-based quantification of the cellular response to methyl methanesulfonate treatment in human cells. DNA Repair (Amst). 2014;15:29-38 pubmed publisher
  • western blot; human; fig 1
Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y. Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2. Mol Pharmacol. 2014;85:482-91 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Han J, Hou W, Goldstein L, Stolz D, Watkins S, Rabinowich H. A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS. J Biol Chem. 2014;289:6485-97 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2G
Lee H, Kim Y, Kim D. Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking. Eur J Immunol. 2014;44:1156-69 pubmed publisher
  • western blot; human
Sisinni L, Maddalena F, Lettini G, Condelli V, Matassa D, Esposito F, et al. TRAP1 role in endoplasmic reticulum stress protection favors resistance to anthracyclins in breast carcinoma cells. Int J Oncol. 2014;44:573-82 pubmed publisher
  • western blot; human
Liu X, Xiao W, Wang X, Li Y, Han J, Li Y. The p38-interacting protein (p38IP) regulates G2/M progression by promoting ?-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5. J Biol Chem. 2013;288:36648-61 pubmed publisher
  • western blot; human
Dho S, Deverman B, Lapid C, Manson S, Gan L, Riehm J, et al. Control of cellular Bcl-xL levels by deamidation-regulated degradation. PLoS Biol. 2013;11:e1001588 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; fig 1c
Tikoo S, Madhavan V, Hussain M, Miller E, Arora P, Zlatanou A, et al. Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination. EMBO J. 2013;32:1778-92 pubmed publisher
  • western blot; human
Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, et al. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science. 2010;329:1215-8 pubmed publisher
  • western blot; human
Tank E, True H. Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates. PLoS Genet. 2009;5:e1000382 pubmed publisher
  • immunocytochemistry; human
  • immunohistochemistry; human
Isaacs A, Powell C, Webb T, Linehan J, Collinge J, Brandner S. Lack of TAR-DNA binding protein-43 (TDP-43) pathology in human prion diseases. Neuropathol Appl Neurobiol. 2008;34:446-56 pubmed publisher
Wang H, Liu K, Chi Z, Zhou X, Ren G, Zhou R, et al. Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer. Aging (Albany NY). 2019;11:11329-11346 pubmed publisher
Puri R, Cheng X, Lin M, Huang N, Sheng Z. Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts. Nat Commun. 2019;10:3645 pubmed publisher
Desmons A, Okwieka A, Doué M, Gorisse L, Vuiblet V, Pietrement C, et al. Proteasome-dependent degradation of intracellular carbamylated proteins. Aging (Albany NY). 2019;11:3624-3638 pubmed publisher
Shami Shah A, Batrouni A, Kim D, Punyala A, Cao W, Han C, et al. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Cell Rep. 2019;27:2157-2170.e8 pubmed publisher
Yu Z, Li Y, Wang Y, Chen Y, Wu M, Wang Z, et al. TGF-β prevents the denervation-induced reduction of bone formation and promotes the bone regeneration through inhibiting ubiquitin-proteasome pathway. Biosci Rep. 2019;39: pubmed publisher
Akande O, Damle P, Pop M, Sherman N, Szomju B, Litovchick L, et al. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell Rep. 2019;26:3323-3335.e4 pubmed publisher
Seo M, Lee D, Kim I, Lee D, Choi M, Lee J, et al. Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis. Cell Death Dis. 2019;10:187 pubmed publisher
Arora H, Wilcox S, Johnson L, Munro L, Eyford B, Pfeifer C, et al. The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock. Immunity. 2019;50:418-431.e6 pubmed publisher
Liu S, Liu L, Xu G, Cao Z, Wang Q, Li S, et al. Epigenetic Modification Is Regulated by the Interaction of Influenza A Virus Nonstructural Protein 1 with the De Novo DNA Methyltransferase DNMT3B and Subsequent Transport to the Cytoplasm for K48-Linked Polyubiquitination. J Virol. 2019;93: pubmed publisher
Liebelt F, Sebastian R, Moore C, Mulder M, Ovaa H, Shoulders M, et al. SUMOylation and the HSF1-Regulated Chaperone Network Converge to Promote Proteostasis in Response to Heat Shock. Cell Rep. 2019;26:236-249.e4 pubmed publisher
Dong L, Xue L, Zhang C, Li H, Cai Z, Guo R. HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma. Mol Med Rep. 2019;19:524-532 pubmed publisher
Kim S, Jin H, Seo H, Lee H, Lee Y. Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death Differ. 2019;26:812-825 pubmed publisher
Liu J, Yuan Y, Xu J, Xiao K, Xu Y, Guo T, et al. β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling. Front Immunol. 2018;9:2930 pubmed publisher
Cui C, Zhang Y, Wang C, Yuan F, Li H, Yao Y, et al. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nat Commun. 2018;9:4648 pubmed publisher
Foster B, Stolz P, Mulholland C, Montoya A, Kramer H, Bultmann S, et al. Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin. Mol Cell. 2018;72:739-752.e9 pubmed publisher
Lee D, Takayama S, Goldberg A. ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation. Proc Natl Acad Sci U S A. 2018;115:E9550-E9559 pubmed publisher
Zhao K, Shen C, Li L, Wu H, Xing G, Dong Z, et al. Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. J Neurosci. 2018;38:8860-8873 pubmed publisher
Zheng Y, Liu Q, Wu Y, Ma L, Zhang Z, Liu T, et al. Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis. EMBO J. 2018;37: pubmed publisher
Huseinovic A, Dekker S, Boogaard B, Vermeulen N, Kooter J, Vos J. Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion. Amino Acids. 2018;50:1377-1390 pubmed publisher
Chen Q, Li Y, Wang J, Li R, Chen B. cpubi4 Is Essential for Development and Virulence in Chestnut Blight Fungus. Front Microbiol. 2018;9:1286 pubmed publisher
Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, et al. NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. J Exp Med. 2018;215:2197-2209 pubmed publisher
Wang Q, He Q, Chen Y, Shao W, Yuan C, Wang Y. JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss. J Neuroinflammation. 2018;15:184 pubmed publisher
Patil G, Zhao M, Song K, Hao W, Bouchereau D, Wang L, et al. TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Influenza A Virus Infection. J Virol. 2018;92: pubmed publisher
Wu C, Luo K, Zhao F, Yin P, Song Y, Deng M, et al. USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization. Cell Death Differ. 2018;25:1855-1869 pubmed publisher
Feng Q, Miao Y, Ge J, Yuan Y, Zuo Y, Qian L, et al. ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3. J Immunol. 2018;201:675-687 pubmed publisher
Xing J, Zhang A, Minze L, Li X, Zhang Z. TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus. J Immunol. 2018;201:183-192 pubmed publisher
You J, Dooley M, Kim C, Kim E, Xu W, Goodman C, et al. A DGKζ-FoxO-ubiquitin proteolytic axis controls fiber size during skeletal muscle remodeling. Sci Signal. 2018;11: pubmed publisher
Yang J, Huang M, Zhou L, He X, Jiang X, Zhang Y, et al. Cereblon suppresses the lipopolysaccharide-induced inflammatory response by promoting the ubiquitination and degradation of c-Jun. J Biol Chem. 2018;293:10141-10157 pubmed publisher
Zhang L, Liu J, Qian L, Feng Q, Wang X, Yuan Y, et al. Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome. PLoS Pathog. 2018;14:e1007067 pubmed publisher
Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin F, et al. Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Sci Adv. 2018;4:eaar2824 pubmed publisher
White M, Schroeder R, Zhu K, Xiong K, McConkey D. HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells. Oncogene. 2018;37:4413-4427 pubmed publisher
Singh R, Karri D, Shen H, Shao J, Dasgupta S, Huang S, et al. TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. J Clin Invest. 2018;128:3129-3143 pubmed publisher
Li H, Zhang P, Zhang Q, Li C, Zou W, Chang Z, et al. WWP2 is a physiological ubiquitin ligase for phosphatase and tensin homolog (PTEN) in mice. J Biol Chem. 2018;293:8886-8899 pubmed publisher
Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, et al. IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling. elife. 2018;7: pubmed publisher
Pennington S, Klutho P, Xie L, Broadhurst K, Koval O, McCormick M, et al. Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox Biol. 2018;16:401-413 pubmed publisher
Mygind K, Störiko T, Freiberg M, Samsøe Petersen J, Schwarz J, Andersen O, et al. Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface. J Biol Chem. 2018;293:8077-8088 pubmed publisher
Guittard G, Dios Esponera A, Palmer D, Akpan I, Barr V, Manna A, et al. The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells. Sci Rep. 2018;8:5336 pubmed publisher
Li Z, Kong Y, Song L, Luo Q, Liu J, Shao C, et al. Plk1-Mediated Phosphorylation of TSC1 Enhances the Efficacy of Rapamycin. Cancer Res. 2018;78:2864-2875 pubmed publisher
Cubas Gaona L, Diaz Beneitez E, Ciscar M, Rodriguez J, Rodriguez D. Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha. J Virol. 2018;92: pubmed publisher
Lin C, Kitagawa M, Tang X, Hou M, Wu J, Qu D, et al. CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. Nat Commun. 2018;9:1039 pubmed publisher
Ali M, Mocarski E. Proteasome inhibition blocks necroptosis by attenuating death complex aggregation. Cell Death Dis. 2018;9:346 pubmed publisher
Li L, Liu T, Li Y, Wu C, Luo K, Yin Y, et al. The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization. Oncogene. 2018;37:2422-2431 pubmed publisher
Oerlemans R, Berkers C, Assaraf Y, Scheffer G, Peters G, Verbrugge S, et al. Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide. Invest New Drugs. 2018;36:797-809 pubmed publisher
Park H, Liu G, Thulasi Raman S, Landreth S, Liu Q, Zhou Y. NS1 Protein of 2009 Pandemic Influenza A Virus Inhibits Porcine NLRP3 Inflammasome-Mediated Interleukin-1 Beta Production by Suppressing ASC Ubiquitination. J Virol. 2018;92: pubmed publisher
Yamano K, Wang C, Sarraf S, Münch C, Kikuchi R, Noda N, et al. Endosomal Rab cycles regulate Parkin-mediated mitophagy. elife. 2018;7: pubmed publisher
Urbina F, Gomez S, Gupton S. Spatiotemporal organization of exocytosis emerges during neuronal shape change. J Cell Biol. 2018;217:1113-1128 pubmed publisher
Choi H, Park A, Kang S, Lee E, Lee T, Ra E, et al. Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses. Nat Commun. 2018;9:125 pubmed publisher
Fu C, Tyagi R, Chin A, Rojas T, Li R, Guha P, et al. Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation. Circ Res. 2018;122:457-472 pubmed publisher
Yoo L, Chung K. The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death. J Biol Chem. 2018;293:1286-1297 pubmed publisher
Wu C, Esfandiari A, Ho Y, Wang N, Mahdi A, Aptullahoglu E, et al. Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. Br J Cancer. 2018;118:495-508 pubmed publisher
Shirafuji T, Ueyama T, Adachi N, Yoshino K, Sotomaru Y, Uwada J, et al. The Role of Cysteine String Protein α Phosphorylation at Serine 10 and 34 by Protein Kinase Cγ for Presynaptic Maintenance. J Neurosci. 2018;38:278-290 pubmed publisher
Yoo B, Khan I, Koomson A, Gowda P, Sasazuki T, Shirasawa S, et al. Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells. Autophagy. 2018;14:134-151 pubmed publisher
Tahrir F, Shanmughapriya S, Ahooyi T, Knezevic T, Gupta M, Kontos C, et al. Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. J Cell Physiol. 2018;233:748-758 pubmed publisher
Wang Y, Liu X, Zhou L, Duong D, Bhuripanyo K, Zhao B, et al. Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer. Nat Commun. 2017;8:2232 pubmed publisher
Xing J, Zhang A, Zhang H, Wang J, Li X, Zeng M, et al. TRIM29 promotes DNA virus infections by inhibiting innate immune response. Nat Commun. 2017;8:945 pubmed publisher
Linares J, Cordes T, Duran A, Reina Campos M, Valencia T, Ahn C, et al. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell Metab. 2017;26:817-829.e6 pubmed publisher
Sapir T, Levy T, Kozer N, Shin I, Zamor V, Haffner Krausz R, et al. Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases. Cereb Cortex. 2017;:1-14 pubmed publisher
Waraky A, Lin Y, Warsito D, Haglund F, Aleem E, Larsson O. Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage. J Biol Chem. 2017;292:18227-18239 pubmed publisher
Turczyk L, Kitowska K, Mieszkowska M, Mieczkowski K, Czaplinska D, Piasecka D, et al. FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ER?-Positive Breast Cancer Cells. Neoplasia. 2017;19:791-804 pubmed publisher
Gournas C, Saliba E, Krammer E, Barthelemy C, Prevost M, Andre B. Transition of yeast Can1 transporter to the inward-facing state unveils an ?-arrestin target sequence promoting its ubiquitylation and endocytosis. Mol Biol Cell. 2017;28:2819-2832 pubmed publisher
Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res. 2017;77:4342-4354 pubmed publisher
Wang J, Kho D, Zhou J, Davis R, Wu G. MKP-1 suppresses PARP-1 degradation to mediate cisplatin resistance. Oncogene. 2017;36:5939-5947 pubmed publisher
Hamdan N, Kritsiligkou P, Grant C. ER stress causes widespread protein aggregation and prion formation. J Cell Biol. 2017;216:2295-2304 pubmed publisher
Zhu W, He X, Hua Y, Li Q, Wang J, Gan X. The E3 ubiquitin ligase WWP2 facilitates RUNX2 protein transactivation in a mono-ubiquitination manner during osteogenic differentiation. J Biol Chem. 2017;292:11178-11188 pubmed publisher
Yue F, Li W, Zou J, Jiang X, Xu G, Huang H, et al. Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy. Cancer Res. 2017;77:2938-2951 pubmed publisher
Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
Rossi S, Gesualdo C, Maisto R, Trotta M, Di Carluccio N, Brigida A, et al. High Levels of Serum Ubiquitin and Proteasome in a Case of HLA-B27 Uveitis. Int J Mol Sci. 2017;18: pubmed publisher
Song A, Zhang Y, Han L, Yegutkin G, Liu H, Sun K, et al. Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent. Nat Commun. 2017;8:14108 pubmed publisher
Liu Y, Weng Y, Lin H, Tang S, Chen C, Liang C, et al. Aqueous extract of Polygonum bistorta modulates proteostasis by ROS-induced ER stress in human hepatoma cells. Sci Rep. 2017;7:41437 pubmed publisher
Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I. Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA. Nat Commun. 2017;8:14004 pubmed publisher
Lang X, Tang T, Jin T, Ding C, Zhou R, Jiang W. TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. J Exp Med. 2017;214:459-473 pubmed publisher
Gabriel D, Gordon L, Djabali K. Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype. PLoS ONE. 2016;11:e0168988 pubmed publisher
Kuo W, Lo J, Ho T, Pai P, Chiang S, Chen P, et al. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016;7:e2455 pubmed publisher
Perrody E, Abrami L, Feldman M, Kunz B, Urbé S, van der Goot F. Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6. elife. 2016;5: pubmed publisher
Lewis C, Voelkel Johnson C, Smith C. Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640. Oncotarget. 2016;7:60181-60192 pubmed publisher
Czaplinska D, Mieczkowski K, Supernat A, Skladanowski A, Kordek R, Biernat W, et al. Interactions between FGFR2 and RSK2-implications for breast cancer prognosis. Tumour Biol. 2016;37:13721-13731 pubmed
Anderson D, Cannavino J, Li H, Anderson K, Nelson B, McAnally J, et al. Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proc Natl Acad Sci U S A. 2016;113:E4494-503 pubmed publisher
Woodford M, Dunn D, Blanden A, Capriotti D, Loiselle D, Prodromou C, et al. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nat Commun. 2016;7:12037 pubmed publisher
Wang C, Long W, Peng C, Hu L, Zhang Q, Wu A, et al. HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains. PLoS Pathog. 2016;12:e1005584 pubmed publisher
Chan Y, Gack M. A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity. Nat Immunol. 2016;17:523-30 pubmed publisher
Lee B, Miyata M, Lim J, Li J. Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88. Proc Natl Acad Sci U S A. 2016;113:E165-71 pubmed publisher
Adams A, Bolanos L, Dexheimer P, Karns R, Aronow B, Komurov K, et al. IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget. 2015;6:43395-407 pubmed publisher
Jitsuki S, Nakajima W, Takemoto K, Sano A, Tada H, Takahashi Jitsuki A, et al. Nogo Receptor Signaling Restricts Adult Neural Plasticity by Limiting Synaptic AMPA Receptor Delivery. Cereb Cortex. 2016;26:427-439 pubmed publisher
Modi P, Jaiswal S, Sharma P. Regulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34a. Mol Cell Biol. 2016;36:84-94 pubmed publisher
Blanc M, David F, Abrami L, Migliozzi D, Armand F, Bürgi J, et al. SwissPalm: Protein Palmitoylation database. F1000Res. 2015;4:261 pubmed publisher
Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, et al. Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells. Nat Commun. 2015;6:7999 pubmed publisher
Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher
Piao L, Suzuki T, Dohmae N, Nakamura Y, Hamamoto R. SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells. Oncotarget. 2015;6:16939-50 pubmed
Xie M, Roy R. AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS ONE. 2015;10:e0130480 pubmed publisher
Chang L, Monteiro M. Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations. PLoS ONE. 2015;10:e0130162 pubmed publisher
Milan E, Perini T, Resnati M, Orfanelli U, Oliva L, Raimondi A, et al. A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells. Autophagy. 2015;11:1161-78 pubmed publisher
Feng X, Li Z, Du Y, Fu H, Klein J, Cai H, et al. Downregulation of urea transporter UT-A1 activity by 14-3-3 protein. Am J Physiol Renal Physiol. 2015;309:F71-8 pubmed publisher
Felsenberg J, Dyck Y, Feige J, Ludwig J, Plath J, Froese A, et al. Differences in long-term memory stability and AmCREB level between forward and backward conditioned honeybees (Apis mellifera). Front Behav Neurosci. 2015;9:91 pubmed publisher
Gupta M, Shin D, Ramakrishna L, Goussetis D, Platanias L, Xiong H, et al. IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes. Nat Commun. 2015;6:6379 pubmed publisher
Haller M, Hock A, Giampazolias E, Oberst A, Green D, Debnath J, et al. Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 2014;10:2269-78 pubmed publisher
Morimoto D, Walinda E, Fukada H, Sou Y, Kageyama S, Hoshino M, et al. The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates. Nat Commun. 2015;6:6116 pubmed publisher
Jin J, Xiao Y, Hu H, Zou Q, Li Y, Gao Y, et al. Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages. Nat Commun. 2015;6:5930 pubmed publisher
Morelli E, Ginefra P, Mastrodonato V, Beznoussenko G, Rusten T, Bilder D, et al. Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy. 2014;10:2251-68 pubmed publisher
Stadelmann B, Aeschbacher D, Huber C, Spiliotis M, Muller J, Hemphill A. Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes. PLoS Negl Trop Dis. 2014;8:e3352 pubmed publisher
Dossena M, Bedini G, Rusmini P, Giorgetti E, Canazza A, Tosetti V, et al. Human adipose-derived mesenchymal stem cells as a new model of spinal and bulbar muscular atrophy. PLoS ONE. 2014;9:e112746 pubmed publisher
Lu Y, Roy R. Centrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegans. PLoS ONE. 2014;9:e110958 pubmed publisher
MacNeil L, Glover E, Bergstra T, Safdar A, Tarnopolsky M. The order of exercise during concurrent training for rehabilitation does not alter acute genetic expression, mitochondrial enzyme activity or improvements in muscle function. PLoS ONE. 2014;9:e109189 pubmed publisher
Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, et al. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211:2119-34 pubmed publisher
Nilsson M, MacNeil L, Kitaoka Y, Alqarni F, Suri R, Akhtar M, et al. Redox state and mitochondrial respiratory chain function in skeletal muscle of LGMD2A patients. PLoS ONE. 2014;9:e102549 pubmed publisher
Mathieu J, Schwizer S, Martin G. Pto kinase binds two domains of AvrPtoB and its proximity to the effector E3 ligase determines if it evades degradation and activates plant immunity. PLoS Pathog. 2014;10:e1004227 pubmed publisher
Zeman M, Lin J, Freire R, Cimprich K. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 2014;206:183-97 pubmed publisher
Li X, Chen C, Wang F, Huang W, Liang Z, Xiao Y, et al. KCTD1 suppresses canonical Wnt signaling pathway by enhancing ?-catenin degradation. PLoS ONE. 2014;9:e94343 pubmed publisher
Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti T, Lamkanfi M. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 2014;5:3209 pubmed publisher
Pagotto A, Caballero O, Volkmar N, Devalle S, Simpson A, Lu X, et al. Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells. PLoS ONE. 2013;8:e83212 pubmed publisher
Gallego Sánchez A, Ufano S, Andrés S, Bueno A. Analysis of the tolerance to DNA alkylating damage in MEC1 and RAD53 checkpoint mutants of Saccharomyces cerevisiae. PLoS ONE. 2013;8:e81108 pubmed publisher
Kolb A, Needham P, Rothenberg C, Guerriero C, Welling P, Brodsky J. ESCRT regulates surface expression of the Kir2.1 potassium channel. Mol Biol Cell. 2014;25:276-89 pubmed publisher
Buchberger E, El Harchi M, Payrhuber D, Zommer A, Schauer D, Simonitsch Klupp I, et al. Overexpression of the transcriptional repressor complex BCL-6/BCoR leads to nuclear aggregates distinct from classical aggresomes. PLoS ONE. 2013;8:e76845 pubmed publisher
Auner H, Moody A, Ward T, Kraus M, Milan E, May P, et al. Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells. PLoS ONE. 2013;8:e74415 pubmed publisher
Prasad R, Atul -, Kolla V, Legac J, Singhal N, Navale R, et al. Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS ONE. 2013;8:e73530 pubmed publisher
Zhang Y, Raghuwanshi R, Shen W, Montell C. Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci. 2013;16:1468-76 pubmed publisher
Tsakiri E, Iliaki K, Höhn A, Grimm S, Papassideri I, Grune T, et al. Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Free Radic Biol Med. 2013;65:1155-1163 pubmed publisher
Qu W, Xiao J, Zhang H, Chen Q, Wang Z, Shi H, et al. B19, a novel monocarbonyl analogue of curcumin, induces human ovarian cancer cell apoptosis via activation of endoplasmic reticulum stress and the autophagy signaling pathway. Int J Biol Sci. 2013;9:766-77 pubmed publisher
Rush J, Ceresa B. RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms. Mol Cell Endocrinol. 2013;381:188-97 pubmed publisher
Moser S, Bensaddek D, Ortmann B, Maure J, Mudie S, Blow J, et al. PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. Dev Cell. 2013;26:381-92 pubmed publisher
Huang P, Huang C, Chen M, Lee Y, Yue C, Wang H, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER ? Inhibition. Evid Based Complement Alternat Med. 2013;2013:376123 pubmed publisher
Li J, Liu K, Liu Y, Xu Y, Zhang F, Yang H, et al. Exosomes mediate the cell-to-cell transmission of IFN-?-induced antiviral activity. Nat Immunol. 2013;14:793-803 pubmed publisher
Yang C, Bratzel F, Hohmann N, Koch M, Turck F, Calonje M. VAL- and AtBMI1-mediated H2Aub initiate the switch from embryonic to postgerminative growth in Arabidopsis. Curr Biol. 2013;23:1324-9 pubmed publisher
Dykhuizen E, Hargreaves D, Miller E, Cui K, Korshunov A, Kool M, et al. BAF complexes facilitate decatenation of DNA by topoisomerase II?. Nature. 2013;497:624-7 pubmed publisher
Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn B, et al. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS ONE. 2013;8:e62223 pubmed publisher
Marsolier J, Pineau S, Medjkane S, Perichon M, Yin Q, Flemington E, et al. OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes. PLoS Pathog. 2013;9:e1003222 pubmed publisher
Concannon C, Lahue R. The 26S proteasome drives trinucleotide repeat expansions. Nucleic Acids Res. 2013;41:6098-108 pubmed publisher
Balamurugan K, Sharan S, Klarmann K, Zhang Y, Coppola V, Summers G, et al. FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4. Nat Commun. 2013;4:1662 pubmed publisher
Zhou Y, Dong N, Hu L, Shao F. The Shigella type three secretion system effector OspG directly and specifically binds to host ubiquitin for activation. PLoS ONE. 2013;8:e57558 pubmed publisher
Su Y, Gao C, Liu Y, Guo S, Wang A, Wang B, et al. Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol. 2013;33:1546-60 pubmed publisher
Li M, Ruan H, Hughes M, Lee J, Singh J, Jones S, et al. O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 2013;17:303-10 pubmed publisher
Sunwoo M, Hong J, Choi J, Park H, Kim S, Lee P. ?-Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy. Neurology. 2013;80:810-3 pubmed publisher
Ko J, Huang Y, Chen H, Tseng S, Chiu H, Wo T, et al. Metformin induces cytotoxicity by down-regulating thymidine phosphorylase and excision repair cross-complementation 1 expression in non-small cell lung cancer cells. Basic Clin Pharmacol Toxicol. 2013;113:56-65 pubmed publisher
Gui J, Li Z, Zhou X. Dynamic change of TNIK in response to tumor necrosis factor alpha in a TRAF2-dependent manner. Hum Cell. 2013;26:67-72 pubmed publisher
Bampi C, Grenet A, Caignard G, Vidalain P, Roux L. The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production. Virus Res. 2013;173:354-63 pubmed publisher
Numata Y, Morimura T, Nakamura S, Hirano E, Kure S, Goto Y, et al. Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease. J Biol Chem. 2013;288:7451-66 pubmed publisher
Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed publisher
Verbrugge S, Al M, Assaraf Y, Niewerth D, van Meerloo J, Cloos J, et al. Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors. Exp Hematol Oncol. 2013;2:2 pubmed publisher
Tseng S, Huang Y, Chen H, Chiu H, Huang Y, Wo T, et al. Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel. Biochem Pharmacol. 2013;85:583-94 pubmed publisher
James R, Davidson K, Bosch K, Biechele T, Robin N, Taylor R, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. PLoS ONE. 2012;7:e50457 pubmed publisher
Guzzo C, Berndsen C, Zhu J, Gupta V, Datta A, Greenberg R, et al. RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci Signal. 2012;5:ra88 pubmed publisher
Lopez Castejon G, Luheshi N, Compan V, High S, Whitehead R, Flitsch S, et al. Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome. J Biol Chem. 2013;288:2721-33 pubmed publisher
Kaikkonen S, Paakinaho V, Sutinen P, Levonen A, Palvimo J. Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells. Mol Endocrinol. 2013;27:212-23 pubmed publisher
Journo C, Bonnet A, Favre Bonvin A, Turpin J, Vinera J, C t E, et al. Human T cell leukemia virus type 2 tax-mediated NF-?B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. J Virol. 2013;87:1123-36 pubmed publisher
Jiang L, Teng G, Chan E, Au S, Wise H, Lee S, et al. Impact of cell type and epitope tagging on heterologous expression of G protein-coupled receptor: a systematic study on angiotensin type II receptor. PLoS ONE. 2012;7:e47016 pubmed publisher
Gong Y, Wang D, Dar J, Singh P, Graham L, Liu W, et al. Nuclear export signal of androgen receptor (NESAR) regulation of androgen receptor level in human prostate cell lines via ubiquitination and proteasome-dependent degradation. Endocrinology. 2012;153:5716-25 pubmed publisher
González Santamaría J, Campagna M, Ortega Molina A, Marcos Villar L, de la Cruz Herrera C, Gonzalez D, et al. Regulation of the tumor suppressor PTEN by SUMO. Cell Death Dis. 2012;3:e393 pubmed publisher
Liang L, Fan Y, Cheng J, Cheng D, Zhao Y, Cao B, et al. TAK1 ubiquitination regulates doxorubicin-induced NF-κB activation. Cell Signal. 2013;25:247-54 pubmed publisher
Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K. Dystrophic neurites express C9orf72 in Alzheimer's disease brains. Alzheimers Res Ther. 2012;4:33 pubmed publisher
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, et al. Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc Natl Acad Sci U S A. 2012;109:13561-6 pubmed publisher
Sharma N, Thomas S, Golden E, Hofman F, Chen T, Petasis N, et al. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett. 2012;326:143-54 pubmed publisher
Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, et al. ?-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-?B activation. Mol Cell Biol. 2012;32:3990-4000 pubmed publisher
Koenekoop R, Wang H, Majewski J, Wang X, Lopez I, Ren H, et al. Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet. 2012;44:1035-9 pubmed publisher
Toth J, Yang L, Dahl R, Petroski M. A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924. Cell Rep. 2012;1:309-16 pubmed publisher
Nakamura M, Kaneko S, Ito H, Jiang S, Fujita K, Wate R, et al. Activation of transforming growth factor-?/Smad signaling reduces aggregate formation of mislocalized TAR DNA-binding protein-43. Neurodegener Dis. 2013;11:182-93 pubmed publisher
Pulvino M, Liang Y, Oleksyn D, DeRan M, Van Pelt E, Shapiro J, et al. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood. 2012;120:1668-77 pubmed publisher
Bauer J, Sporn J, Cabral J, Gomez J, Jung B. Effects of activin and TGF? on p21 in colon cancer. PLoS ONE. 2012;7:e39381 pubmed publisher
Fang J, Rhyasen G, Bolanos L, Rasch C, Varney M, Wunderlich M, et al. Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood. 2012;120:858-67 pubmed publisher
Lokireddy S, Wijesoma I, Sze S, McFarlane C, Kambadur R, Sharma M. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Am J Physiol Cell Physiol. 2012;303:C512-29 pubmed publisher
Chollangi S, Thompson J, Ruiz J, Gardner K, Bruick R. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms. J Biol Chem. 2012;287:23710-7 pubmed publisher
Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I. Analysis of nuclear factor-?B (NF-?B) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-?B. J Biol Chem. 2012;287:23626-34 pubmed publisher
Li Y, Paonessa J, Zhang Y. Mechanism of chemical activation of Nrf2. PLoS ONE. 2012;7:e35122 pubmed publisher
Clarke K, ADAMS A, Manzke L, Pearson T, Borchers C, Porter R. A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1). Biochim Biophys Acta. 2012;1817:1759-67 pubmed publisher
Weng S, Tseng S, Huang Y, Chen H, Lin Y. Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells. Biochem Pharmacol. 2012;84:126-36 pubmed publisher
Nakamura M, Kaneko S, Wate R, Asayama S, Nakamura Y, Fujita K, et al. Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol. 2013;39:144-56 pubmed publisher
Fan Y, Shi Y, Liu S, Mao R, An L, Zhao Y, et al. Lys48-linked TAK1 polyubiquitination at lysine-72 downregulates TNF?-induced NF-?B activation via mediating TAK1 degradation. Cell Signal. 2012;24:1381-9 pubmed publisher
Hisada T, Ayaori M, Ohrui N, Nakashima H, Nakaya K, Uto Kondo H, et al. Statin inhibits hypoxia-induced endothelin-1 via accelerated degradation of HIF-1? in vascular smooth muscle cells. Cardiovasc Res. 2012;95:251-9 pubmed publisher
Yu X, Ajayi A, Boga N, Strom A. Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model. J Mol Neurosci. 2012;47:219-33 pubmed publisher
Ghazi Noori S, Froud K, Mizielinska S, Powell C, Smidak M, Fernández de Marco M, et al. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012;135:819-32 pubmed publisher
Jin L, Pahuja K, Wickliffe K, Gorur A, Baumgärtel C, Schekman R, et al. Ubiquitin-dependent regulation of COPII coat size and function. Nature. 2012;482:495-500 pubmed publisher
Carmony K, Kim K. PROTAC-induced proteolytic targeting. Methods Mol Biol. 2012;832:627-38 pubmed publisher
Keusekotten K, Praefcke G. Reconstitution of SUMO-dependent ubiquitylation in vitro. Methods Mol Biol. 2012;832:111-23 pubmed publisher
Valenzuela V, Collyer E, Armentano D, Parsons G, Court F, Hetz C. Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis. 2012;3:e272 pubmed publisher
Bhardwaj K, Liu P, Leibowitz J, Kao C. The coronavirus endoribonuclease Nsp15 interacts with retinoblastoma tumor suppressor protein. J Virol. 2012;86:4294-304 pubmed publisher
Dimova N, Hathaway N, Lee B, Kirkpatrick D, Berkowitz M, Gygi S, et al. APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nat Cell Biol. 2012;14:168-76 pubmed publisher
Thompson J, Salahudeen A, Chollangi S, Ruiz J, Brautigam C, Makris T, et al. Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). J Biol Chem. 2012;287:7357-65 pubmed publisher
Labbe K, McIntire C, Doiron K, LeBlanc P, Saleh M. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity. 2011;35:897-907 pubmed publisher
Bornstein B, Edison N, Gottfried Y, Lev T, Shekhtman A, Gonen H, et al. X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein. Int J Biochem Cell Biol. 2012;44:489-95 pubmed publisher
Zhang L, Ding X, Cui J, Xu H, Chen J, Gong Y, et al. Cysteine methylation disrupts ubiquitin-chain sensing in NF-?B activation. Nature. 2011;481:204-8 pubmed publisher
Mannava S, Zhuang D, Nair J, Bansal R, Wawrzyniak J, Zucker S, et al. KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells. Blood. 2012;119:1450-8 pubmed publisher
DelBove J, Rosson G, Strobeck M, Chen J, Archer T, Wang W, et al. Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene. Epigenetics. 2011;6:1444-53 pubmed publisher
Palermo R, Checquolo S, Giovenco A, Grazioli P, Kumar V, Campese A, et al. Acetylation controls Notch3 stability and function in T-cell leukemia. Oncogene. 2012;31:3807-17 pubmed publisher
Zhang X, Yuan Q, Tang W, Gu J, Osei K, Wang J. Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in ?-cells. PLoS ONE. 2011;6:e27647 pubmed publisher
Ahmed N, Zeng M, Sinha I, Polin L, Wei W, Rathinam C, et al. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol. 2011;12:1176-83 pubmed publisher
Mougeot J, Li Z, Price A, Wright F, Brooks B. Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway. BMC Med Genomics. 2011;4:74 pubmed publisher
Chen J, Tsu C, Gavin J, Milhollen M, Bruzzese F, Mallender W, et al. Mechanistic studies of substrate-assisted inhibition of ubiquitin-activating enzyme by adenosine sulfamate analogues. J Biol Chem. 2011;286:40867-77 pubmed publisher
Zhou L, Yang H. The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR. PLoS ONE. 2011;6:e23936 pubmed publisher
Roh M, Cui F, Kim H, Kang U. Regulation of NMDA receptor subunits after acute ethanol treatment in rat brain. Alcohol Alcohol. 2011;46:672-9 pubmed publisher
Lokireddy S, Mouly V, Butler Browne G, Gluckman P, Sharma M, Kambadur R, et al. Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins. Am J Physiol Cell Physiol. 2011;301:C1316-24 pubmed publisher
Melo S, Barbour K, Berger F. Cooperation between an intrinsically disordered region and a helical segment is required for ubiquitin-independent degradation by the proteasome. J Biol Chem. 2011;286:36559-67 pubmed publisher
Lewis R, Kolesnik T, Kuang Z, D Cruz A, Blewitt M, Masters S, et al. TLR regulation of SPSB1 controls inducible nitric oxide synthase induction. J Immunol. 2011;187:3798-805 pubmed publisher
Berndt J, Aoyagi A, Yang P, Anastas J, Tang L, Moon R. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/?-catenin signaling. J Cell Biol. 2011;194:737-50 pubmed publisher
Dasuri K, Zhang L, Ebenezer P, Fernandez Kim S, Bruce Keller A, Szweda L, et al. Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress. Free Radic Biol Med. 2011;51:1727-35 pubmed publisher
Sukhu L, Pintel D. The large Rep protein of adeno-associated virus type 2 is polyubiquitinated. J Gen Virol. 2011;92:2792-6 pubmed publisher
Shibata Y, Tanaka Y, Gohda J, Inoue J. Activation of the I?B kinase complex by HTLV-1 Tax requires cytosolic factors involved in Tax-induced polyubiquitination. J Biochem. 2011;150:679-86 pubmed publisher
Taylor R, Best S. Assessing ubiquitination of viral proteins: Lessons from flavivirus NS5. Methods. 2011;55:166-71 pubmed publisher
Wang F, Chan C, Chen K, Guan X, Lin H, Tong Q. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene. 2012;31:1546-57 pubmed publisher
Ko J, Tsai M, Weng S, Kuo Y, Chiu Y, Lin Y. Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2011;255:327-38 pubmed publisher
Racay P. Ischaemia-induced protein ubiquitinylation is differentially accompanied with heat-shock protein 70 expression after naïve and preconditioned ischaemia. Cell Mol Neurobiol. 2012;32:107-19 pubmed publisher
Lee S, Richardson R, Dashwood R, Baek S. Capsaicin represses transcriptional activity of ?-catenin in human colorectal cancer cells. J Nutr Biochem. 2012;23:646-55 pubmed publisher
Van Rechem C, Black J, Abbas T, Allen A, Rinehart C, Yuan G, et al. The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein. J Biol Chem. 2011;286:30462-70 pubmed publisher
Anshu A, Thomas S, Agarwal P, Ibarra Rivera T, Pirrung M, Schonthal A. Novel proteasome-inhibitory syrbactin analogs inducing endoplasmic reticulum stress and apoptosis in hematological tumor cell lines. Biochem Pharmacol. 2011;82:600-9 pubmed publisher
Leo L, Gherardini L, Barone V, De Fusco M, Pietrobon D, Pizzorusso T, et al. Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. PLoS Genet. 2011;7:e1002129 pubmed publisher
Niu X, Zhang T, Liao L, Zhou L, Lindner D, Zhou M, et al. The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene. 2012;31:776-86 pubmed publisher
Krichevsky A, Zaltsman A, Lacroix B, Citovsky V. Involvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression. Proc Natl Acad Sci U S A. 2011;108:11157-62 pubmed publisher
Hübener J, Vauti F, Funke C, Wolburg H, Ye Y, Schmidt T, et al. N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation. Brain. 2011;134:1925-42 pubmed publisher
Dasuri K, Ebenezer P, Uranga R, Gavilán E, Zhang L, Fernandez Kim S, et al. Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulation. J Neurosci Res. 2011;89:1471-7 pubmed publisher
Agnihotri S, Wolf A, Munoz D, Smith C, Gajadhar A, Restrepo A, et al. A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. J Exp Med. 2011;208:689-702 pubmed publisher
Jorge C, Ventura R, Maycock C, Outeiro T, Santos H, Costa J. Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases. Neurochem Res. 2011;36:1005-11 pubmed publisher
O Reilly L, Watkins S, Smithgall T. An unexpected role for the clock protein timeless in developmental apoptosis. PLoS ONE. 2011;6:e17157 pubmed publisher
Fan Y, Yu Y, Mao R, Tan X, Xu G, Zhang H, et al. USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation. Cell Death Differ. 2011;18:1547-60 pubmed publisher
Ramakrishna S, Suresh B, Lim K, Cha B, Lee S, Kim K, et al. PEST motif sequence regulating human NANOG for proteasomal degradation. Stem Cells Dev. 2011;20:1511-9 pubmed publisher
Yosha L, Ravid O, Ben Califa N, Neumann D. Cytosolic lysine residues enhance anterograde transport and activation of the erythropoietin receptor. Biochem J. 2011;435:509-18 pubmed publisher
Rytinki M, Lakso M, Pehkonen P, Aarnio V, Reisner K, PERAKYLA M, et al. Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans. Cell Mol Life Sci. 2011;68:3219-32 pubmed publisher
Castiel A, Danieli M, David A, Moshkovitz S, Aplan P, Kirsch I, et al. The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J Cell Sci. 2011;124:532-9 pubmed publisher
Stringer D, Piper R. A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination. J Cell Biol. 2011;192:229-42 pubmed publisher
Jiang J, Tang H. Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein. Protein Cell. 2010;1:1106-17 pubmed publisher
Gordon C, Serino A, Krause M, Campbell J, Cafarelli E, Adegoke O, et al. Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy?. PLoS ONE. 2010;5:e14032 pubmed publisher
Ranjit S, Boutet E, Gandhi P, Prot M, Tamori Y, Chawla A, et al. Regulation of fat specific protein 27 by isoproterenol and TNF-? to control lipolysis in murine adipocytes. J Lipid Res. 2011;52:221-36 pubmed publisher
Lim J, Kim H, Youdim M, Rhyu I, Choe K, Oh Y. Binding preference of p62 towards LC3-ll during dopaminergic neurotoxin-induced impairment of autophagic flux. Autophagy. 2011;7:51-60 pubmed
Ma D, Li S, Lucas E, Cowell R, Lin J. Neuronal inactivation of peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) protects mice from diet-induced obesity and leads to degenerative lesions. J Biol Chem. 2010;285:39087-95 pubmed publisher
Chen J, Wang M, Hung W. Bcr-Abl-induced tyrosine phosphorylation of Emi1 to stabilize Skp2 protein via inhibition of ubiquitination in chronic myeloid leukemia cells. J Cell Physiol. 2011;226:407-13 pubmed publisher
Jin X, Jin H, Jung H, Lee S, Lee J, Lee J. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem. 2010;285:30539-47 pubmed publisher
Dasuri K, Ebenezer P, Zhang L, Fernandez Kim S, Uranga R, Gavilán E, et al. Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins. Free Radic Biol Med. 2010;49:1290-7 pubmed publisher
Jiang H, Jans R, Xu W, Rorke E, Lin C, Chen Y, et al. Type I transglutaminase accumulation in the endoplasmic reticulum may be an underlying cause of autosomal recessive congenital ichthyosis. J Biol Chem. 2010;285:31634-46 pubmed publisher
Freiburghaus C, Welinder C, Tjörnstad U, Lindmark Månsson H, Paulsson M, Oredsson S. Identification of ubiquitin in bovine milk and its growth inhibitory effects on human cancer cell lines. J Dairy Sci. 2010;93:3442-52 pubmed publisher
Xu G, Paige J, Jaffrey S. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nat Biotechnol. 2010;28:868-73 pubmed publisher
Martinelli S, De Luca A, Stellacci E, Rossi C, Checquolo S, Lepri F, et al. Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. Am J Hum Genet. 2010;87:250-7 pubmed publisher
Chaurasia B, Mauer J, Koch L, Goldau J, Kock A, Bruning J. Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol. 2010;30:4354-66 pubmed publisher
Du J, McConnell B, Yang V. A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4. J Biol Chem. 2010;285:28298-308 pubmed publisher
Chamberlain M, Oberg J, Furber L, Poland S, Hawrysh A, Knafelc S, et al. Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. Cell Signal. 2010;22:1562-75 pubmed publisher
Scheuermann J, de Ayala Alonso A, Oktaba K, Ly Hartig N, McGinty R, Fraterman S, et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 2010;465:243-7 pubmed publisher
Poole A, Thomas R, Yu S, Vincow E, Pallanck L. The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS ONE. 2010;5:e10054 pubmed publisher
Sasaki T, Kim H, Kobayashi M, Kitamura Y, Yokota Hashimoto H, Shiuchi T, et al. Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. Endocrinology. 2010;151:2556-66 pubmed publisher
Dasuri K, Ebenezer P, Zhang L, Fernandez Kim S, Bruce Keller A, Markesbery W, et al. Increased protein hydrophobicity in response to aging and Alzheimer disease. Free Radic Biol Med. 2010;48:1330-7 pubmed publisher
Wang X, Fu A, Spiro C, Lee H. Proteomic Analysis of Vascular Endothelial Cells-Effects of Laminar Shear Stress and High Glucose. J Proteomics Bioinform. 2009;2:445 pubmed
Tresse E, Salomons F, Vesa J, Bott L, Kimonis V, Yao T, et al. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy. 2010;6:217-27 pubmed
Kohta R, Kotake Y, Hosoya T, Hiramatsu T, Otsubo Y, Koyama H, et al. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline binds with tubulin beta, a substrate of parkin, and reduces its polyubiquitination. J Neurochem. 2010;114:1291-301 pubmed publisher
Cai J, Crotty T, Reichert E, Carraway K, Stafforini D, Topham M. Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8. J Biol Chem. 2010;285:6952-9 pubmed publisher
Yen A, Yang J. Cdc20 proteolysis requires p38 MAPK signaling and Cdh1-independent APC/C ubiquitination during spindle assembly checkpoint activation by cadmium. J Cell Physiol. 2010;223:327-34 pubmed publisher
Ichikawa T, Li J, Meyer C, Janicki J, Hannink M, Cui T. Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. PLoS ONE. 2009;4:e8391 pubmed publisher
Thompson L, Aiken C, Kaltenbach L, Agrawal N, Illes K, Khoshnan A, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009;187:1083-99 pubmed publisher
Luo Z, Wijeweera A, Oh Y, Liou Y, Melamed P. Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription. Mol Cell Biol. 2010;30:745-63 pubmed publisher
Perez Sala D, Boya P, Ramos I, Herrera M, Stamatakis K. The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway. PLoS ONE. 2009;4:e8117 pubmed publisher
Farris K, Fasina O, Sukhu L, Li L, Pintel D. Adeno-associated virus small rep proteins are modified with at least two types of polyubiquitination. J Virol. 2010;84:1206-11 pubmed publisher
Kawahata I, Tokuoka H, Parvez H, Ichinose H. Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells. J Neural Transm (Vienna). 2009;116:1571-8 pubmed publisher
Melixetian M, Klein D, Sørensen C, Helin K. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Nat Cell Biol. 2009;11:1247-53 pubmed publisher
Li Y, Zhou Z, Alimandi M, Chen C. WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. Oncogene. 2009;28:2948-58 pubmed publisher
McLoughlin T, Smith S, DeLong A, Wang H, Unterman T, Esser K. FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner. Am J Physiol Cell Physiol. 2009;297:C548-55 pubmed publisher
Fallon A, Witthuhn B. Proteasome activity in a naïve mosquito cell line infected with Wolbachia pipientis wAlbB. In Vitro Cell Dev Biol Anim. 2009;45:460-6 pubmed publisher
Noels H, Somers R, Liu H, Ye H, Du M, De Wolf Peeters C, et al. Auto-ubiquitination-induced degradation of MALT1-API2 prevents BCL10 destabilization in t(11;18)(q21;q21)-positive MALT lymphoma. PLoS ONE. 2009;4:e4822 pubmed publisher
Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, et al. The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood. 2009;113:3040-9 pubmed publisher
Romorini L, Coso O, Pecci A. Bcl-XL mediates epidermal growth factor dependent cell survival in HC11 mammary epithelial cells. Biochim Biophys Acta. 2009;1793:496-505 pubmed publisher
Jurek A, Amagasaki K, Gembarska A, Heldin C, Lennartsson J. Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation. J Biol Chem. 2009;284:4626-34 pubmed publisher
Tang T, Gao M, Miyanohara A, Hammond H. Galphaq reduces cAMP production by decreasing Galphas protein abundance. Biochem Biophys Res Commun. 2008;377:679-684 pubmed publisher
Choe K, Strange K. Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am J Physiol Cell Physiol. 2008;295:C1488-98 pubmed publisher
Strnad P, Tao G, So P, Lau K, Schilling J, Wei Y, et al. "Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction. Hepatology. 2008;48:931-42 pubmed publisher
Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino A. Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer. 2008;8:229 pubmed publisher
Ermolaeva M, Michallet M, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, et al. Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008;9:1037-46 pubmed publisher
Nakagami H, Osako M, Takami Y, Hanayama R, Koriyama H, Mori M, et al. Vascular protective effects of ezetimibe in ApoE-deficient mice. Atherosclerosis. 2009;203:51-8 pubmed publisher
Schimmel J, Larsen K, Matic I, van Hagen M, Cox J, Mann M, et al. The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle. Mol Cell Proteomics. 2008;7:2107-22 pubmed publisher
Li F, Zhang L, Craddock J, Bruce Keller A, Dasuri K, Nguyen A, et al. Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart. Mech Ageing Dev. 2008;129:515-21 pubmed publisher
Chuang S, Wang L, Hong J, Lin Y. Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells. Toxicol Appl Pharmacol. 2008;230:290-7 pubmed publisher
Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie P. FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival. Bone. 2008;42:1032-9 pubmed publisher
Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, et al. Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. J Biol Chem. 2008;283:14654-64 pubmed publisher
D Anselmi F, Cucina A, Cavallaro G, Bizzarri M, Cavallaro R, Fuso A, et al. S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. Protein Pept Lett. 2008;15:58-62 pubmed
Nakamura M, Ito H, Wate R, Nakano S, Hirano A, Kusaka H. Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model. Acta Neuropathol. 2008;115:327-34 pubmed publisher
Hagen L, Kavli B, Sousa M, Torseth K, Liabakk N, Sundheim O, et al. Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. EMBO J. 2008;27:51-61 pubmed
Zuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, et al. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J Clin Invest. 2007;117:3765-73 pubmed
Gao Y, Colletti K, Pari G. Identification of human cytomegalovirus UL84 virus- and cell-encoded binding partners by using proteomics analysis. J Virol. 2008;82:96-104 pubmed
Margineantu D, Emerson C, Diaz D, Hockenbery D. Hsp90 inhibition decreases mitochondrial protein turnover. PLoS ONE. 2007;2:e1066 pubmed
Chan S, Lin S, Li P. Regulation of Cidea protein stability by the ubiquitin-mediated proteasomal degradation pathway. Biochem J. 2007;408:259-66 pubmed
Kelly S, VanSlyke J, Musil L. Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress. Mol Biol Cell. 2007;18:4279-91 pubmed
Takami Y, Nakagami H, Morishita R, Katsuya T, Cui T, Ichikawa T, et al. Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation. Arterioscler Thromb Vasc Biol. 2007;27:2184-90 pubmed
Homma S, Jin X, Wang G, Tu N, Min J, Yanasak N, et al. Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice. J Neurosci. 2007;27:7974-86 pubmed
Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, et al. Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol. 2007;27:5235-45 pubmed
Strnad P, Harada M, Siegel M, Terkeltaub R, Graham R, Khosla C, et al. Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology. 2007;132:1515-26 pubmed
Tanos B, Pendergast A. Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis. Cell Signal. 2007;19:1602-9 pubmed
Li J, Yang J. Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite. J Cell Physiol. 2007;212:481-8 pubmed
Balbis A, Parmar A, Wang Y, Baquiran G, Posner B. Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology. 2007;148:2944-54 pubmed
Berthon P, Duguez S, Favier F, Amirouche A, Feasson L, Vico L, et al. Regulation of ubiquitin-proteasome system, caspase enzyme activities, and extracellular proteinases in rat soleus muscle in response to unloading. Pflugers Arch. 2007;454:625-33 pubmed
Gal J, Strom A, Kilty R, Zhang F, Zhu H. p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis. J Biol Chem. 2007;282:11068-77 pubmed
Vermaelen M, Sirvent P, Raynaud F, Astier C, Mercier J, Lacampagne A, et al. Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy. Am J Physiol Cell Physiol. 2007;292:C1723-31 pubmed
Balasubramanian S, Eckert R. Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol Chem. 2007;282:6707-15 pubmed
Feng F, Varambally S, Tomlins S, Chun P, Lopez C, Li X, et al. Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity. Oncogene. 2007;26:3431-9 pubmed
Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, et al. Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling. J Immunol. 2006;177:7520-4 pubmed
Mori D, Yano Y, Toyo oka K, Yoshida N, Yamada M, Muramatsu M, et al. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol. 2007;27:352-67 pubmed
Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y. Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am Soc Nephrol. 2006;17:2781-91 pubmed
McFarlane C, Plummer E, Thomas M, Hennebry A, Ashby M, Ling N, et al. Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism. J Cell Physiol. 2006;209:501-14 pubmed
Son S, Yu E, Ahn Y, Choi E, Lee H, Choi J. Retinoic acid attenuates promyelocytic leukemia protein-induced cell death in breast cancer cells by activation of the ubiquitin-proteasome pathway. Cancer Lett. 2007;247:213-23 pubmed
Mitra J, Enders G, Azizkhan Clifford J, Lengel K. Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexes. Cell Cycle. 2006;5:661-6 pubmed
Angers S, Thorpe C, Biechele T, Goldenberg S, Zheng N, MacCoss M, et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol. 2006;8:348-57 pubmed
Abrami L, Leppla S, van der Goot F. Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. J Cell Biol. 2006;172:309-20 pubmed
Kim T, Jang C, Kim H, Lee J, Ahn B, Kim J. Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation. Mol Biol Cell. 2006;17:824-33 pubmed
Geetha T, Kenchappa R, Wooten M, Carter B. TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J. 2005;24:3859-68 pubmed
Ito Y, Inoue D, Kido S, Matsumoto T. c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors. Bone. 2005;37:842-9 pubmed
Vermaelen M, Marini J, Chopard A, Benyamin Y, Mercier J, Astier C. Ubiquitin targeting of rat muscle proteins during short periods of unloading. Acta Physiol Scand. 2005;185:33-40 pubmed
Cusson Hermance N, Khurana S, Lee T, Fitzgerald K, Kelliher M. Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. J Biol Chem. 2005;280:36560-6 pubmed
Lohi H, Ianzano L, Zhao X, Chan E, Turnbull J, Scherer S, et al. Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy. Hum Mol Genet. 2005;14:2727-36 pubmed
Zhang B, Srirangam A, Potter D, Roman A. HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes. Oncogene. 2005;24:2585-8 pubmed
product information
Product Name :
Ub (P4D1) Antibody
Gene Name :
UBB
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8017
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Ub
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
1-76 (bovine)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA