Published Application/Species/Sample/Dilution | Reference |
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- western blot; mouse; 666 ng/ml; loading ...; fig 5b
| Choi J, Zhong X, McAlpine W, Liao T, Zhang D, Fang B, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019;364: pubmed publisher
|
- western blot; human; loading ...; fig 2g
| Cadena C, Ahmad S, Xavier A, Willemsen J, Park S, Park J, et al. Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity. Cell. 2019;177:1187-1200.e16 pubmed publisher
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- western blot; Xenopus laevis; loading ...; fig e5h
| Wu R, Semlow D, Kamimae Lanning A, Kochenova O, Chistol G, Hodskinson M, et al. TRAIP is a master regulator of DNA interstrand crosslink repair. Nature. 2019;567:267-272 pubmed publisher
|
- immunoprecipitation; human; 1:1000; loading ...; fig 6
- western blot; human; 1:1000; loading ...; fig 6
| Cartier E, Garcia Olivares J, Janezic E, Viana J, Moore M, Lin M, et al. The SUMO-Conjugase Ubc9 Prevents the Degradation of the Dopamine Transporter, Enhancing Its Cell Surface Level and Dopamine Uptake. Front Cell Neurosci. 2019;13:35 pubmed publisher
|
- western blot; human; loading ...; fig 2f
| Paul D, Islam S, Manne R, Dinesh U, Malonia S, Maity B, et al. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function. J Pathol. 2019;248:266-279 pubmed publisher
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- western blot; mouse; loading ...; fig 5c
| Gallot Y, Bohnert K, Straughn A, Xiong G, Hindi S, Kumar A. PERK regulates skeletal muscle mass and contractile function in adult mice. FASEB J. 2019;33:1946-1962 pubmed publisher
|
- western blot; human; 1:100; loading ...; fig s8d
| Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 4d
| Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher
|
- western blot; human; loading ...; fig 1h
| Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, et al. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018;361:290-295 pubmed publisher
|
- western blot; mouse; loading ...; fig 3a
| Wilson K, Liu H, Healey G, Vuong V, Ishido S, Herold M, et al. MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway. PLoS ONE. 2018;13:e0200540 pubmed publisher
|
- western blot; human; loading ...; fig 4c, 6b
| Yang C, Chiu L, Chang C, Chuang H, Tan T. Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation. FASEB J. 2018;:fj201800244RR pubmed publisher
|
- western blot; human; 1:1000; loading ...; fig 4j
| Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton B, et al. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018;9:2269 pubmed publisher
|
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 6a
- western blot; mouse; 1:500; loading ...; fig 6b
| Liu H, Jiang W, Chen X, Chang G, Zhao L, Li X, et al. Skeletal muscle-specific Sidt2 knockout in mice induced muscular dystrophy-like phenotype. Metabolism. 2018;85:259-270 pubmed publisher
|
- western blot; human; loading ...; fig 6c
| Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9:1136 pubmed publisher
|
- immunocytochemistry; mouse; 1:100; loading ...; fig 1a
- immunohistochemistry; mouse; 1:100; loading ...; fig 5a
| Juenemann K, Jansen A, van Riel L, Merkx R, Mulder M, An H, et al. Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies. Sci Rep. 2018;8:1405 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 2i
| Gstrein T, Edwards A, Přistoupilová A, Leca I, Breuss M, Pilat Carotta S, et al. Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans. Nat Neurosci. 2018;21:207-217 pubmed publisher
|
- western blot; mouse; 1:500; loading ...; fig 4b
| Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
|
- western blot; human; 1:500; loading ...; fig 2a
| Chiang C, Pauli E, Biryukov J, Feister K, Meng M, White E, et al. The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling. J Virol. 2018;92: pubmed publisher
|
- western blot; human; 1:1000; loading ...; fig 3b
| Zhu T, Yong X, Xia D, Widagdo J, Anggono V. Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein. J Mol Biol. 2018;430:363-371 pubmed publisher
|
- western blot; E. coli; 1:5000; fig 2c
| Mot A, Prell E, Klecker M, Naumann C, Faden F, Westermann B, et al. Real-time detection of N-end rule-mediated ubiquitination via fluorescently labeled substrate probes. New Phytol. 2018;217:613-624 pubmed publisher
|
- western blot; mouse; fig 6e
| Malty R, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, et al. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017;5:564-577.e12 pubmed publisher
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- western blot; mouse; 1:200; loading ...; fig 5b
| Nguyen A, Prado M, Schmidt P, Sendamarai A, Wilson Grady J, Min M, et al. UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017;357: pubmed publisher
|
- western blot; human; loading ...; fig 2b
| Sheng X, You Q, Zhu H, Chang Z, Li Q, Wang H, et al. Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK. PLoS Pathog. 2017;13:e1006534 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 6d
| Wang W, Xia Z, Farré J, Subramani S. TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein import. J Cell Biol. 2017;216:2843-2858 pubmed publisher
|
- western blot; human; loading ...; fig 6b
| Perez Leal O, Barrero C, Merali S. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. J Biol Chem. 2017;292:14108-14121 pubmed publisher
|
- western blot; human; 1:500; loading ...; fig 3a
| Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, et al. Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways. Cell Death Dis. 2017;8:e2763 pubmed publisher
|
- western blot; human; loading ...; fig 4b
| Zhou Y, Wu B, Li J, Nan G, Jiang J, Chen Z. Rab22a enhances CD147 recycling and is required for lung cancer cell migration and invasion. Exp Cell Res. 2017;357:9-16 pubmed publisher
|
- western blot; human; loading ...; fig 1c
| Zhao H, Zhang L, Zhang Y, Zhao L, Wan Q, Wang B, et al. Calmodulin promotes matrix metalloproteinase 9 production and cell migration by inhibiting the ubiquitination and degradation of TBC1D3 oncoprotein in human breast cancer cells. Oncotarget. 2017;8:36383-36398 pubmed publisher
|
- western blot; human; loading ...; fig 1a
| Fischer A, Harrison K, Ramirez Y, Auer D, Chowdhury S, Prusty B, et al. Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense. elife. 2017;6: pubmed publisher
|
- immunocytochemistry; human; 1:50; loading ...; fig 3c
| Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed publisher
|
- immunocytochemistry; human; loading ...; fig 3c
| Li J, Yakushi T, Parlati F, MacKinnon A, Pérez C, Ma Y, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat Chem Biol. 2017;13:486-493 pubmed publisher
|
- immunocytochemistry; human; loading ...
| Jeong J, VanHouten J, Kim W, Dann P, Sullivan C, Choi J, et al. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. J Biol Chem. 2017;292:6555-6568 pubmed publisher
|
- immunohistochemistry - frozen section; rat; 1:100; loading ...; fig 7c
- western blot; rat; loading ...; fig 7a
| Zhu Y, Zhang Q, Zhang W, Li N, Dai Y, Tu J, et al. Protective Effect of 17β-Estradiol Upon Hippocampal Spine Density and Cognitive Function in an Animal Model of Vascular Dementia. Sci Rep. 2017;7:42660 pubmed publisher
|
- western blot; mouse; 1:500; loading ...; fig 1a
| Li G, Ji T, Chen J, Fu Y, Hou L, Feng Y, et al. CRL4DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver. Cell Rep. 2017;18:1499-1511 pubmed publisher
|
- western blot; human; loading ...; fig 4d
| Hu Y, Li W, Gao T, Cui Y, Jin Y, Li P, et al. The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination. J Virol. 2017;91: pubmed publisher
|
- immunoprecipitation; human; loading ...; fig 3b
| Liu X, Zhao B, Sun L, Bhuripanyo K, Wang Y, Bi Y, et al. Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes. Nat Commun. 2017;8:14286 pubmed publisher
|
- western blot; human; 1:5000; loading ...; fig 1d
| Shin S, Kim J, Lee J, Son Y, Lee M, Kim H, et al. Docosahexaenoic acid-mediated protein aggregates may reduce proteasome activity and delay myotube degradation during muscle atrophy in vitro. Exp Mol Med. 2017;49:e287 pubmed publisher
|
- western blot; S. cerevisiae; fig 3a
| Weisshaar N, Welsch H, Guerra Moreno A, Hanna J. Phospholipase Lpl1 links lipid droplet function with quality control protein degradation. Mol Biol Cell. 2017;28:716-725 pubmed publisher
|
- western blot; human; 1:200; loading ...; fig s4b
| Coccia M, Rossi A, Riccio A, Trotta E, Santoro M. Human NF-κB repressing factor acts as a stress-regulated switch for ribosomal RNA processing and nucleolar homeostasis surveillance. Proc Natl Acad Sci U S A. 2017;114:1045-1050 pubmed publisher
|
- western blot; human; 1:1000; loading ...; fig 4c
| Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;36:3274-3286 pubmed publisher
|
- western blot; human; 1:500; loading ...; fig 6d
| Li M, Lau Z, Cheung P, Aguilar E, Schneider W, Bozzacco L, et al. TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). PLoS Pathog. 2017;13:e1006145 pubmed publisher
|
- western blot; human; fig 7
| Kumazoe M, Takai M, Bae J, Hiroi S, Huang Y, Takamatsu K, et al. FOXO3 is essential for CD44 expression in pancreatic cancer cells. Oncogene. 2017;36:2643-2654 pubmed publisher
|
- western blot; mouse; 1:250; loading ...; fig 6b
| Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, et al. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017;18:54-63 pubmed publisher
|
- western blot; human; loading ...; fig 2c
| Matsuura K, Huang N, Cocce K, Zhang L, Kornbluth S. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 2017;36:1698-1706 pubmed publisher
|
- western blot; human; loading ...; fig s3b
| Yu J, Lei R, Zhuang X, Li X, Li G, Lev S, et al. MicroRNA-182 targets SMAD7 to potentiate TGF?-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nat Commun. 2016;7:13884 pubmed publisher
|
- western blot; human; 1:200; loading ...; fig 4e
| Cai H, Liu A. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016;113:14751-14756 pubmed publisher
|
- western blot; mouse; loading ...; fig 1c
| Dhar J, Barik S. Unique nonstructural proteins of Pneumonia Virus of Mice (PVM) promote degradation of interferon (IFN) pathway components and IFN-stimulated gene proteins. Sci Rep. 2016;6:38139 pubmed publisher
|
- western blot; human; loading ...; fig 3d
| Piasecka D, Kitowska K, Czaplinska D, Mieczkowski K, Mieszkowska M, Turczyk L, et al. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget. 2016;7:86011-86025 pubmed publisher
|
- immunocytochemistry; human; loading ...; fig 5D
| Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed publisher
|
- western blot; mouse; loading ...; fig 10a
| Huang S, Zhou A, Nguyen D, Zhang H, Benz E. Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation. J Biol Chem. 2016;291:25591-25607 pubmed
|
- western blot; human; 1:500; loading ...; fig 5b
| Sun W, Lee S, Huang X, Liu S, Inayathullah M, Kim K, et al. Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer's disease treatment. Sci Rep. 2016;6:34784 pubmed publisher
|
- western blot; mouse; 1:250; loading ...; fig 3a
| Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton Smith J, et al. Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia. Nat Genet. 2016;48:1349-1358 pubmed publisher
|
- immunocytochemistry; rat; 1:500; loading ...; fig 2b
| Shlevkov E, Kramer T, Schapansky J, LaVoie M, Schwarz T. Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc Natl Acad Sci U S A. 2016;113:E6097-E6106 pubmed
|
- western blot; human; loading ...; fig 3e
| Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, et al. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016;30:1956-70 pubmed publisher
|
- immunocytochemistry; human; loading ...; fig 6d
- western blot; human; loading ...; fig 6a
| Chi H, Chen S, Tsai C, Chuang W, Huang Y, Tsai M, et al. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016;12:2271-2285 pubmed
|
- western blot; human; 1:1000; fig 7
| Fernández Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
|
- western blot; human; fig 5
- western blot; mouse; fig 5
| Vahid S, Thaper D, Gibson K, Bishop J, Zoubeidi A. Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer. Sci Rep. 2016;6:31842 pubmed publisher
|
- western blot; human; 1:1000; fig s15
| Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
|
- western blot; human; loading ...; fig 1f
| BRANDT C, McFie P, Stone S. Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome. Biochem J. 2016;473:3621-3637 pubmed
|
- western blot; human; loading ...; fig 5f
| Hirano A, Shi G, Jones C, Lipzen A, Pennacchio L, Xu Y, et al. A Cryptochrome 2 mutation yields advanced sleep phase in humans. elife. 2016;5: pubmed publisher
|
- western blot; human; 1:500; fig s2
| Vingill S, Brockelt D, Lancelin C, Tatenhorst L, Dontcheva G, Preisinger C, et al. Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice. EMBO J. 2016;35:2008-25 pubmed publisher
|
- western blot; rat; loading ...; fig 3b
| Won S, Incontro S, Nicoll R, Roche K. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Proc Natl Acad Sci U S A. 2016;113:E4736-44 pubmed publisher
|
| Singh A, Fedele C, Lu H, Nevalainen M, Keen J, Languino L. Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. Mol Cancer Res. 2016;14:1136-1146 pubmed
|
- western blot; human; 1:1000; fig 3
| Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, et al. Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus. PLoS Pathog. 2016;12:e1005764 pubmed publisher
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- western blot; mouse; loading ...; fig s4a
| Xiao Y, Tang J, Guo H, Zhao Y, Tang R, Ouyang S, et al. Targeting CBLB as a potential therapeutic approach for disseminated candidiasis. Nat Med. 2016;22:906-14 pubmed publisher
|
- western blot; mouse; loading ...; fig 6c
| Rackov G, Hernandez Jimenez E, Shokri R, Carmona Rodríguez L, Manes S, Alvarez Mon M, et al. p21 mediates macrophage reprogramming through regulation of p50-p50 NF-?B and IFN-?. J Clin Invest. 2016;126:3089-103 pubmed publisher
|
- immunohistochemistry - frozen section; domestic rabbit; fig 4
- western blot; domestic rabbit; fig 4
| Chen X, Wagener J, Ghribi O, Geiger J. Role of Endolysosomes in Skeletal Muscle Pathology Observed in a Cholesterol-Fed Rabbit Model of Alzheimer's Disease. Front Aging Neurosci. 2016;8:129 pubmed publisher
|
- immunohistochemistry; mouse; 1:1000; loading ...; fig 4a
| Shiihashi G, Ito D, Yagi T, Nihei Y, Ebine T, Suzuki N. Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice. Brain. 2016;139:2380-94 pubmed publisher
|
- western blot; human; loading ...; fig 4a
| Shao W, Zumer K, Fujinaga K, Peterlin B. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem. 2016;291:17953-63 pubmed publisher
|
- western blot; human; 1:500; loading ...; tbl 3
| Simile M, Latte G, Demartis M, Brozzetti S, Calvisi D, Porcu A, et al. Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease. Oncotarget. 2016;7:49194-49216 pubmed publisher
|
- western blot; human; 1:500; loading ...; fig s2d
| Lee J, Takahama S, Zhang G, Tomarev S, Ye Y. Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells. Nat Cell Biol. 2016;18:765-76 pubmed publisher
|
- immunoprecipitation; human; fig 4d
| Chesnokova V, Zonis S, Zhou C, Recouvreux M, Ben Shlomo A, Araki T, et al. Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A. 2016;113:E3250-9 pubmed publisher
|
- western blot; human; loading ...; fig 1a
| Palazón Riquelme P, Lopez Castejon G. Method to Measure Ubiquitination of NLRs. Methods Mol Biol. 2016;1417:223-9 pubmed publisher
|
- western blot; mouse; fig 5
| Tortola L, Nitsch R, Bertrand M, Kogler M, Redouane Y, Kozieradzki I, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 2016;15:1481-1492 pubmed publisher
|
- western blot; mouse; fig 3b
| Passalacqua K, Charbonneau M, Donato N, Showalter H, Sun D, Wen B, et al. Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens. Antimicrob Agents Chemother. 2016;60:4183-96 pubmed publisher
|
- western blot; human; loading ...; fig 5b
| Francavilla C, Papetti M, Rigbolt K, Pedersen A, Sigurdsson J, Cazzamali G, et al. Multilayered proteomics reveals molecular switches dictating ligand-dependent EGFR trafficking. Nat Struct Mol Biol. 2016;23:608-18 pubmed publisher
|
- western blot; thale cress; 1:1000; fig s12
| Yang B, Han X, Yin L, Xing M, Xu Z, Xue H. Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling. Nat Commun. 2016;7:11388 pubmed publisher
|
- western blot; human; loading ...; fig 4a
| Qiu J, Sheedlo M, Yu K, Tan Y, Nakayasu E, Das C, et al. Ubiquitination independent of E1 and E2 enzymes by bacterial effectors. Nature. 2016;533:120-4 pubmed publisher
|
- western blot; human; loading ...; fig 1a
| Rorsman C, Tsioumpekou M, Heldin C, Lennartsson J. The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling. J Biol Chem. 2016;291:11608-18 pubmed publisher
|
- western blot; human; fig 2
| Richter B, Sliter D, Herhaus L, Stolz A, Wang C, Beli P, et al. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016;113:4039-44 pubmed publisher
|
- western blot; human; 1:500; fig 2
| Decorsière A, Mueller H, van Breugel P, Abdul F, Gerossier L, Beran R, et al. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016;531:386-9 pubmed publisher
|
- western blot; human; loading ...; fig 4e
| Jin H, Lee K, Kim Y, Oh H, Maeng Y, Kim T, et al. Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene. 2016;35:5106-18 pubmed publisher
|
- western blot; human; 1:500; loading ...; fig 5c
| Frum R, Love I, Damle P, Mukhopadhyay N, Palit Deb S, Deb S, et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016;14:423-36 pubmed publisher
|
- western blot; human; 1:5000; fig 3d
| Choi W, de Poot S, Lee J, Kim J, Han D, Kim Y, et al. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016;7:10963 pubmed publisher
|
- western blot; human; loading ...; fig 3a
| Llambi F, Wang Y, Victor B, Yang M, Schneider D, Gingras S, et al. BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell. 2016;165:421-33 pubmed publisher
|
- western blot; S. cerevisiae; fig s1
| Choe Y, Park S, Hassemer T, Körner R, Vincenz Donnelly L, Hayer Hartl M, et al. Failure of RQC machinery causes protein aggregation and proteotoxic stress. Nature. 2016;531:191-5 pubmed publisher
|
- western blot; rat; 1:1000; fig 6
| Wei J, Xiong Z, Lee J, Cheng J, Duffney L, Matas E, et al. Histone Modification of Nedd4 Ubiquitin Ligase Controls the Loss of AMPA Receptors and Cognitive Impairment Induced by Repeated Stress. J Neurosci. 2016;36:2119-30 pubmed publisher
|
- western blot; African green monkey; 1:1000; fig 6
| Tung H, Wei S, Lo H, Chao Y. Baculovirus IE2 Stimulates the Expression of Heat Shock Proteins in Insect and Mammalian Cells to Facilitate Its Proper Functioning. PLoS ONE. 2016;11:e0148578 pubmed publisher
|
- immunoprecipitation; rat; 1:1000; fig 5
| Kwon D, Eom G, Ko J, Shin S, Joung H, Choe N, et al. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun. 2016;7:10492 pubmed publisher
|
- western blot; human; fig 3
| DÃaz Barreiro A, Bernal Quirós M, Georg I, Marañón C, Alarcón Riquelme M, Castillejo López C. The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function. Genes Immun. 2016;17:128-38 pubmed publisher
|
- other; human; loading ...; fig st1
| Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
|
- western blot; mouse; 1:200; fig 4
| Gong G, Song M, Csordás G, Kelly D, Matkovich S, Dorn G. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015;350:aad2459 pubmed publisher
|
- western blot; human; loading ...; fig 7b
| Ying M, Zhang L, Zhou Q, Shao X, Cao J, Zhang N, et al. The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα. Oncogene. 2016;35:4358-67 pubmed publisher
|
- immunoprecipitation; human; fig s3
| Jeong J, VanHouten J, Dann P, Kim W, Sullivan C, Yu H, et al. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A. 2016;113:E282-90 pubmed publisher
|
- western blot; human; 1:500; fig 3
| Zhang H, Liu H, Chen Y, Yang X, Wang P, Liu T, et al. A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Nat Commun. 2016;7:10201 pubmed publisher
|
- western blot; human; fig 2A
| Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, et al. Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS ONE. 2015;10:e0145023 pubmed publisher
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- western blot; mouse; fig 2
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- immunoprecipitation; human; loading ...; fig 2b
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