product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
IKKbeta (H-4) Antibody
catalog :
sc-8014
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H-4
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5h
Gatla H, Zou Y, Uddin M, Singha B, Bu P, Vancura A, et al. Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells. J Biol Chem. 2017;292:5043-5054 pubmed publisher
  • western blot; human; 1:1000; fig 5a
Lin C, Lin W, Cho R, Wang C, Hsiao L, Yang C. TNF-?-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-?B Cascade on Human Pulmonary Alveolar Epithelial Cells. Front Pharmacol. 2016;7:447 pubmed
  • western blot; human; fig 6
Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed publisher
  • western blot; human
Romano S, Xiao Y, Nakaya M, D Angelillo A, Chang M, Jin J, et al. FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma. Nucleic Acids Res. 2015;43:6983-93 pubmed publisher
  • western blot; human; fig 3
Kiebala M, Singh M, Piepenbrink M, Qiu X, Kobie J, Maggirwar S. Platelet Activation in Human Immunodeficiency Virus Type-1 Patients Is Not Altered with Cocaine Abuse. PLoS ONE. 2015;10:e0130061 pubmed publisher
Wu J, Wang W, Shao Q, Xiao G, Cheng J, Yuan Y, et al. Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70. Exp Ther Med. 2014;8:893-898 pubmed
Shao H, Yang B, Hu R, Wang Y. Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-?B signaling pathway. Oncol Lett. 2013;6:517-520 pubmed
Manna S, Singha B, Phyo S, Gatla H, Chang T, Sanacora S, et al. Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKK?. J Immunol. 2013;191:2837-46 pubmed publisher
Qu Z, Dong H, Xu X, Feng W, Yi X. Combined effects of 17-DMAG and TNF on cells through a mechanism related to the NF-kappaB pathway. Diagn Pathol. 2013;8:70 pubmed publisher
Loedige I, Gaidatzis D, Sack R, Meister G, Filipowicz W. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Nucleic Acids Res. 2013;41:518-32 pubmed publisher
Tian F, Zhang C, Tian W, Jiang Y, Zhang X. Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice. Oncol Rep. 2012;28:232-40 pubmed publisher
Tian F, Fan T, Jiang Y, Zhang X, Wang X. A small interfering RNA targeting NF-?B p65 alone or combined with 5-FU inhibits growth of esophageal squamous cell carcinoma in nude mice. Pathol Res Pract. 2012;208:32-8 pubmed publisher
Wang T, Wang X, Xu J, Wu X, Qiu H, Yi H, et al. Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway. J Cell Mol Med. 2012;16:1134-45 pubmed publisher
Niida M, Tanaka M, Kamitani T. Downregulation of active IKK beta by Ro52-mediated autophagy. Mol Immunol. 2010;47:2378-87 pubmed publisher
Annunziata C, Stavnes H, Kleinberg L, Berner A, Hernandez L, Birrer M, et al. Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer. 2010;116:3276-84 pubmed publisher
Solt L, Madge L, May M. NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation. J Biol Chem. 2009;284:27596-608 pubmed publisher
Leal R, Coy C, Ayrizono M, Fagundes J, Milanski M, Saad M, et al. Differential expression of pro-inflammatory cytokines and a pro-apoptotic protein in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis. Tech Coloproctol. 2008;12:33-8 pubmed publisher
Nicholas C, Batra S, Vargo M, Voss O, Gavrilin M, Wewers M, et al. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol. 2007;179:7121-7 pubmed
Nogalski M, Podduturi J, DeMeritt I, Milford L, Yurochko A. The human cytomegalovirus virion possesses an activated casein kinase II that allows for the rapid phosphorylation of the inhibitor of NF-kappaB, IkappaBalpha. J Virol. 2007;81:5305-14 pubmed
Moore F, Buonocore S, Aksoy E, Ouled Haddou N, Goriely S, Lazarova E, et al. An alternative pathway of NF-kappaB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IkappaBalpha. J Immunol. 2007;178:1301-11 pubmed
Tian F, Zang W, Hou W, Liu H, Xue L. Nuclear factor-kB signaling pathway constitutively activated in esophageal squamous cell carcinoma cell lines and inhibition of growth of cells by small interfering RNA. Acta Biochim Biophys Sin (Shanghai). 2006;38:318-26 pubmed
Vacca A, Felli M, Palermo R, Di Mario G, Calce A, Di Giovine M, et al. Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia. EMBO J. 2006;25:1000-8 pubmed
Ear T, Cloutier A, McDonald P. Constitutive nuclear expression of the I kappa B kinase complex and its activation in human neutrophils. J Immunol. 2005;175:1834-42 pubmed
Felli M, Vacca A, Calce A, Bellavia D, Campese A, Grillo R, et al. PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene. 2005;24:992-1000 pubmed
product information
Product Name :
IKKbeta (H-4) Antibody
Gene Name :
IKBKB
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-8014
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
IKKbeta
reactive species  :
human
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
470-755 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA