product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Smad1 (A-4) Antibody
catalog :
sc-7965
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A-4
reactivity :
fission yeast, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 38
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 4b
Senft A, Costello I, King H, Mould A, Bikoff E, Robertson E. Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming. Cell Rep. 2018;24:1977-1985.e7 pubmed publisher
  • western blot; mouse; 1:1000; tbl 2
Muñoz Félix J, Pérez Roque L, Núñez Gómez E, Oujo B, Arevalo M, Ruiz Remolina L, et al. Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction. Biochim Biophys Acta. 2016;1862:1801-14 pubmed publisher
  • western blot; fission yeast; 1:1000; fig 6
Oujo B, Muñoz Félix J, Arévalo M, Núñez Gómez E, Pérez Roque L, Pericacho M, et al. L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction. PLoS ONE. 2014;9:e110365 pubmed publisher
  • western blot; mouse
Soofi A, Zhang P, Dressler G. Kielin/chordin-like protein attenuates both acute and chronic renal injury. J Am Soc Nephrol. 2013;24:897-905 pubmed publisher
  • chromatin immunoprecipitation; mouse
Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008;133:1106-17 pubmed publisher
Zhang B, He L, Liu Y, Zhang J, Zeng Q, Wang S, et al. Prostaglandin E2 Is Required for BMP4-Induced Mesoderm Differentiation of Human Embryonic Stem Cells. Stem Cell Reports. 2018;10:905-919 pubmed publisher
Watanabe M, Fung E, Chan F, Wong J, Coutts M, Monuki E. BMP4 acts as a dorsal telencephalic morphogen in a mouse embryonic stem cell culture system. Biol Open. 2016;5:1834-1843 pubmed publisher
Clementi C, Tripurani S, Large M, Edson M, Creighton C, Hawkins S, et al. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013;9:e1003863 pubmed publisher
Gosemann J, Friedmacher F, Fujiwara N, Alvarez L, Corcionivoschi N, Puri P. Disruption of the bone morphogenetic protein receptor 2 pathway in nitrofen-induced congenital diaphragmatic hernia. Birth Defects Res B Dev Reprod Toxicol. 2013;98:304-9 pubmed publisher
Zhou L, Ogata Y. Transcriptional regulation of the human bone sialoprotein gene by fibroblast growth factor 2. J Oral Sci. 2013;55:63-70 pubmed
Zhang X, Zhang J, Bauer A, Zhang L, Selinger D, Lu C, et al. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. EMBO J. 2013;32:996-1007 pubmed publisher
Trompeter H, Dreesen J, Hermann E, Iwaniuk K, Hafner M, Renwick N, et al. MicroRNAs miR-26a, miR-26b, and miR-29b accelerate osteogenic differentiation of unrestricted somatic stem cells from human cord blood. BMC Genomics. 2013;14:111 pubmed publisher
Zhou L, Matsumura H, Mezawa M, Takai H, Nakayama Y, Mitarai M, et al. Protamine stimulates bone sialoprotein gene expression. Gene. 2013;516:228-37 pubmed publisher
Li X, Zhou L, Takai H, Sasaki Y, Mezawa M, Li Z, et al. Aggregatibacter actinomycetemcomitans lipopolysaccharide regulates bone sialoprotein gene transcription. J Cell Biochem. 2012;113:2822-34 pubmed publisher
Wahdan Alaswad R, Bane K, Song K, Shola D, Garcia J, Danielpour D. Inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to rapamycin. Mol Cancer Res. 2012;10:821-33 pubmed publisher
Ueberham U, Hilbrich I, Ueberham E, Rohn S, Glöckner P, Dietrich K, et al. Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease. Neurobiol Aging. 2012;33:2827-40 pubmed publisher
Zhang L, Shi S, Zhang J, Zhou F, Ten Dijke P. Wnt/?-catenin signaling changes C2C12 myoblast proliferation and differentiation by inducing Id3 expression. Biochem Biophys Res Commun. 2012;419:83-8 pubmed publisher
Heining E, Bhushan R, Paarmann P, Henis Y, Knaus P. Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells. PLoS ONE. 2011;6:e25163 pubmed publisher
Zanotti S, Canalis E. Nemo-like kinase inhibits osteoblastogenesis by suppressing bone morphogenetic protein and WNT canonical signaling. J Cell Biochem. 2012;113:449-56 pubmed publisher
Honoré S, Zelarayan L, Genta S, Sánchez S. Neuronal loss and abnormal BMP/Smad signaling in the myenteric plexus of diabetic rats. Auton Neurosci. 2011;164:51-61 pubmed publisher
Xu T, Yu C, Sun J, Liu Y, Wang X, Pi L, et al. Bone morphogenetic protein-4-induced epithelial-mesenchymal transition and invasiveness through Smad1-mediated signal pathway in squamous cell carcinoma of the head and neck. Arch Med Res. 2011;42:128-37 pubmed publisher
Wang S, Sasaki Y, Ogata Y. Calcium hydroxide regulates bone sialoprotein gene transcription in human osteoblast-like Saos2 cells. J Oral Sci. 2011;53:77-86 pubmed
Zhang L, Zhou F, van Laar T, Zhang J, van Dam H, Ten Dijke P. Fas-associated factor 1 antagonizes Wnt signaling by promoting ?-catenin degradation. Mol Biol Cell. 2011;22:1617-24 pubmed publisher
Wang S, Sasaki Y, Zhou L, Matsumura H, Araki S, Mezawa M, et al. Transcriptional regulation of bone sialoprotein gene by interleukin-11. Gene. 2011;476:46-55 pubmed publisher
Haubold M, Weise A, Stephan H, Dünker N. Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. Int J Biol Sci. 2010;6:700-15 pubmed
Ho C, Zhou X, Mishina Y, Bernard D. Mechanisms of bone morphogenetic protein 2 (BMP2) stimulated inhibitor of DNA binding 3 (Id3) transcription. Mol Cell Endocrinol. 2011;332:242-52 pubmed publisher
Li Z, Sasaki Y, Mezawa M, Wang S, Li X, Yang L, et al. cAMP and fibroblast growth factor 2 regulate bone sialoprotein gene expression in human prostate cancer cells. Gene. 2011;471:1-12 pubmed publisher
Sun Y, Fei T, Yang T, Zhang F, Chen Y, Li H, et al. The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 2010;285:39039-50 pubmed publisher
Lowery J, Frump A, Anderson L, DiCarlo G, Jones M, de Caestecker M. ID family protein expression and regulation in hypoxic pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1463-77 pubmed publisher
Yang L, Takai H, Utsunomiya T, Li X, Li Z, Wang Z, et al. Kaempferol stimulates bone sialoprotein gene transcription and new bone formation. J Cell Biochem. 2010;110:1342-55 pubmed publisher
Wang Z, Li X, Li Z, Yang L, Sasaki Y, Wang S, et al. Effects of inorganic polyphosphate on bone sialoprotein gene expression. Gene. 2010;452:79-86 pubmed publisher
Costello I, Biondi C, Taylor J, Bikoff E, Robertson E. Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development. BMC Dev Biol. 2009;9:54 pubmed publisher
Shepherd T, Thériault B, Nachtigal M. Autocrine BMP4 signalling regulates ID3 proto-oncogene expression in human ovarian cancer cells. Gene. 2008;414:95-105 pubmed publisher
Velasco S, Alvarez Muñoz P, Pericacho M, Dijke P, Bernabeu C, Lopez Novoa J, et al. L- and S-endoglin differentially modulate TGFbeta1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts. J Cell Sci. 2008;121:913-9 pubmed publisher
Takai H, Araki S, Mezawa M, Kim D, Li X, Yang L, et al. AP1 binding site is another target of FGF2 regulation of bone sialoprotein gene transcription. Gene. 2008;410:97-104 pubmed publisher
Okuyama N, Kiryu Seo S, Kiyama H. Altered expression of Smad family members in injured motor neurons of rat. Brain Res. 2007;1132:36-41 pubmed
Koli K, Myllärniemi M, Vuorinen K, Salmenkivi K, Ryynänen M, Kinnula V, et al. Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am J Pathol. 2006;169:61-71 pubmed
Nakayama Y, Nakajima Y, Kato N, Takai H, Kim D, Arai M, et al. Insulin-like growth factor-I increases bone sialoprotein (BSP) expression through fibroblast growth factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene. J Cell Physiol. 2006;208:326-35 pubmed
product information
Product Name :
Smad1 (A-4) Antibody
Gene Name :
SMAD1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7965
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Smad1
reactive species  :
m, r, h, mink
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1-465 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA