product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Cdk6 (B-10) Antibody
catalog :
sc-7961
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-10
reactivity :
African green monkey, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 1g
Mlcochova P, Sutherland K, Watters S, Bertoli C, de Bruin R, Rehwinkel J, et al. A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages. EMBO J. 2017;36:604-616 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5h
Liu T, Yu J, Deng M, Yin Y, Zhang H, Luo K, et al. CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nat Commun. 2017;8:13923 pubmed publisher
  • immunocytochemistry; human; fig 3
Laurenti E, Frelin C, Xie S, Ferrari R, Dunant C, Zandi S, et al. CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell. 2015;16:302-13 pubmed publisher
  • immunohistochemistry; African green monkey; 1:400
Dumitrescu A, Aberdeen G, Pepe G, Albrecht E. Placental estrogen suppresses cyclin D1 expression in the nonhuman primate fetal adrenal cortex. Endocrinology. 2014;155:4774-84 pubmed publisher
  • western blot; human; fig 3
Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed publisher
  • western blot; mouse
Ray A, James M, Larochelle S, Fisher R, Blain S. p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes. Mol Cell Biol. 2009;29:986-99 pubmed publisher
Cornell L, Wander S, Visal T, Wagle N, Shapiro G. MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Rep. 2019;26:2667-2680.e7 pubmed publisher
Brand M, Jiang B, Bauer S, Donovan K, Liang Y, Wang E, et al. Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML. Cell Chem Biol. 2019;26:300-306.e9 pubmed publisher
Chen H, Xu X, Wang G, Zhang B, Wang G, Xin G, et al. CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells. J Biol Chem. 2017;292:10131-10141 pubmed publisher
Landon A, Muniandy P, Shetty A, Lehrmann E, Volpon L, Houng S, et al. MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. Nat Commun. 2014;5:5413 pubmed publisher
Cheng J, Gao F, Chen X, Wu J, Xing C, Lv Z, et al. Prohibitin-2 promotes hepatocellular carcinoma malignancy progression in hypoxia based on a label-free quantitative proteomics strategy. Mol Carcinog. 2014;53:820-32 pubmed publisher
Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed publisher
Fang Y, Zhou X, Lin M, Jing H, Zhong L, Ying M, et al. The ubiquitin-proteasome pathway plays essential roles in ATRA-induced leukemia cells G0/G1 phase arrest and transition into granulocytic differentiation. Cancer Biol Ther. 2010;10:1157-67 pubmed
Heiferman M, Salabat M, Ujiki M, Strouch M, Cheon E, Silverman R, et al. Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle. Anticancer Res. 2010;30:73-8 pubmed
Suzuki H, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. Modulation of microRNA processing by p53. Nature. 2009;460:529-33 pubmed publisher
James M, Ray A, Leznova D, Blain S. Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol Cell Biol. 2008;28:498-510 pubmed
Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh B, et al. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem. 2007;282:11722-31 pubmed
Dumitrescu A, Aberdeen G, Pepe G, Albrecht E. Developmental expression of cell cycle regulators in the baboon fetal adrenal gland. J Endocrinol. 2007;192:237-47 pubmed
Mukhopadhyay I, Sausville E, Doroshow J, Roy K. Molecular mechanism of adaphostin-mediated G1 arrest in prostate cancer (PC-3) cells: signaling events mediated by hepatocyte growth factor receptor, c-Met, and p38 MAPK pathways. J Biol Chem. 2006;281:37330-44 pubmed
product information
Product Name :
Cdk6 (B-10) Antibody
Gene Name :
CDK6
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7961
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Cdk6
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA