product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
IKKalpha (B-8) Antibody
catalog :
sc-7606
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 4g
Abe H, Satoh J, Shirasaka Y, Kogure A, Kato H, Ito S, et al. Priming Phosphorylation of TANK-Binding Kinase 1 by IκB Kinase β Is Essential in Toll-Like Receptor 3/4 Signaling. Mol Cell Biol. 2020;40: pubmed publisher
  • western blot; human; 1:2000; fig 5A
Chen Z, Mei Y, Lei H, Tian R, Ni N, Han F, et al. LYTAK1, a TAK1 inhibitor, suppresses proliferation and epithelial?mesenchymal transition in retinal pigment epithelium cells. Mol Med Rep. 2016;14:145-50 pubmed publisher
  • western blot; human; fig 6b
Pedersen S, Chan W, Jattani R, Mackie d, Pomerantz J. Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. Mol Cell Biol. 2015;36:794-808 pubmed publisher
  • western blot; human
Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  • western blot; human
Makowski S, Wang Z, Pomerantz J. A protease-independent function for SPPL3 in NFAT activation. Mol Cell Biol. 2015;35:451-67 pubmed publisher
  • western blot; human
Chan W, Schaffer T, Pomerantz J. A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival. Mol Cell Biol. 2013;33:429-43 pubmed publisher
  • western blot; human
McCully R, Pomerantz J. The protein kinase C-responsive inhibitory domain of CARD11 functions in NF-kappaB activation to regulate the association of multiple signaling cofactors that differentially depend on Bcl10 and MALT1 for association. Mol Cell Biol. 2008;28:5668-86 pubmed publisher
Moser B, Hochreiter B, Basílio J, Gleitsmann V, Panhuber A, Pardo Garcia A, et al. The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity. Mol Cancer. 2021;20:16 pubmed publisher
Fang J, Yan Y, Teng X, Wen X, Li N, Peng S, et al. Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress. Aging (Albany NY). 2018;10:2954-2972 pubmed publisher
Shih V, Davis Turak J, Macal M, Huang J, Ponomarenko J, Kearns J, et al. Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-?B pathways. Nat Immunol. 2012;13:1162-70 pubmed publisher
Chung S, Sundar I, Hwang J, Yull F, Blackwell T, Kinnula V, et al. NF-?B inducing kinase, NIK mediates cigarette smoke/TNF?-induced histone acetylation and inflammation through differential activation of IKKs. PLoS ONE. 2011;6:e23488 pubmed publisher
Chung S, Sundar I, Yao H, Ho Y, Rahman I. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. Am J Physiol Lung Cell Mol Physiol. 2010;299:L192-203 pubmed publisher
Scotto D Abusco A, Politi L, Giordano C, Scandurra R. A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12:R18 pubmed publisher
Ear T, Cloutier A, McDonald P. Constitutive nuclear expression of the I kappa B kinase complex and its activation in human neutrophils. J Immunol. 2005;175:1834-42 pubmed
product information
Product Name :
IKKalpha (B-8) Antibody
Gene Name :
CHUK
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7606
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
IKKalpha
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
1-745 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA