product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PP1 (E-9) Antibody
catalog :
sc-7482
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E-9
reactivity :
green monkey, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, blocking or activating experiments
citations: 39
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5b
Loh J, Xu S, Huo J, Kim S, Wang Y, Lam K. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717-2729 pubmed publisher
  • western blot; human; loading ...; tbl 4
Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed publisher
  • western blot; rat; 1:1000; fig s1
Sadredini M, Danielsen T, Aronsen J, Manotheepan R, Hougen K, Sjaastad I, et al. Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure. PLoS ONE. 2016;11:e0153887 pubmed publisher
  • western blot; human; fig s3
Sansó M, Levin R, Lipp J, Wang V, Greifenberg A, Quezada E, et al. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes Dev. 2016;30:117-31 pubmed publisher
  • immunoprecipitation; human; fig 4B
  • immunocytochemistry; human; fig 4E
  • western blot; human; fig 4B
Wang Z, Ma B, Li H, Xiao X, Zhou W, Liu F, et al. Protein 4.1N acts as a potential tumor suppressor linking PP1 to JNK-c-Jun pathway regulation in NSCLC. Oncotarget. 2016;7:509-23 pubmed publisher
  • western blot; mouse; 1:3000; fig 3
Wong P, Feng Y, Wang J, Shi R, Jiang X. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 2015;6:8048 pubmed publisher
  • blocking or activating experiments; human; fig 5
Song H, Pu J, Wang L, Wu L, Xiao J, Liu Q, et al. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. Autophagy. 2015;11:1308-25 pubmed publisher
  • immunoprecipitation; human; 1:2000; fig 1c
Das I, Krzyzosiak A, Schneider K, Wrabetz L, D Antonio M, Barry N, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348:239-42 pubmed publisher
  • western blot; human; 1:1000; fig s1
Li G, Zhou J, Budhraja A, Hu X, Chen Y, Cheng Q, et al. Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis. Oncotarget. 2015;6:1834-49 pubmed
  • western blot; human
Ahmad F, Shen W, Vandeput F, Szabo Fresnais N, Krall J, Degerman E, et al. Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2. J Biol Chem. 2015;290:6763-76 pubmed publisher
  • immunoprecipitation; rat; 1:300
  • western blot; rat
Li Z, Liu Y, Liu X, Xue Y, Wang P, Liu L. Low-dose endothelial monocyte-activating polypeptide-II increases permeability of blood-tumor barrier via a PKC-ζ/PP2A-dependent signaling mechanism. Exp Cell Res. 2015;331:257-66 pubmed publisher
  • western blot; green monkey; 1:200
Jamin A, Wicklund A, Wiebe M. Cell- and virus-mediated regulation of the barrier-to-autointegration factor's phosphorylation state controls its DNA binding, dimerization, subcellular localization, and antipoxviral activity. J Virol. 2014;88:5342-55 pubmed publisher
  • western blot; human; 1:1000; fig 7
Amsailale R, Beyaert M, Smal C, Janssens V, Van Den Neste E, Bontemps F. Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation. FEBS Lett. 2014;588:727-32 pubmed publisher
  • western blot; human
Tsaytler P, Harding H, Ron D, Bertolotti A. Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis. Science. 2011;332:91-4 pubmed publisher
Pyo K, Kim C, Lee M, Kim J, Kim K, Baek S. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep. 2018;25:2878-2890.e4 pubmed publisher
He L, Ma Y, Li W, Han W, Zhao X, Wang H. Protease-activated receptor 2 signaling modulates susceptibility of colonic epithelium to injury through stabilization of YAP in vivo. Cell Death Dis. 2018;9:949 pubmed publisher
Martina J, Puertollano R. Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress. J Biol Chem. 2018;293:12525-12534 pubmed publisher
Burdyga A, Surdo N, Monterisi S, Di Benedetto G, Grisan F, Penna E, et al. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. Proc Natl Acad Sci U S A. 2018;115:E6497-E6506 pubmed publisher
Grallert A, Boke E, Hagting A, Hodgson B, Connolly Y, Griffiths J, et al. A PP1-PP2A phosphatase relay controls mitotic progression. Nature. 2015;517:94-98 pubmed publisher
Williams B, Filter J, Blake Hodek K, Wadzinski B, Fuda N, Shalloway D, et al. Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers. elife. 2014;3:e01695 pubmed publisher
Van Opdenbosch N, Van den Broeke C, De Regge N, Tabar s E, Favoreel H. The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2?. J Virol. 2012;86:7235-40 pubmed publisher
Rizzolio F, Lucchetti C, Caligiuri I, Marchesi I, Caputo M, Klein Szanto A, et al. Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1. Cell Death Differ. 2012;19:1152-61 pubmed publisher
Nohata N, Hanazawa T, Kikkawa N, Sakurai D, Fujimura L, Chiyomaru T, et al. Tumour suppressive microRNA-874 regulates novel cancer networks in maxillary sinus squamous cell carcinoma. Br J Cancer. 2011;105:833-41 pubmed publisher
Walker L, Walker J, Glazier A, Brown D, Stenmark K, Buttrick P. Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2011;301:H832-40 pubmed publisher
Wills J, Credle J, Haggerty T, Lee J, Oaks A, Sidhu A. Tauopathic changes in the striatum of A53T ?-synuclein mutant mouse model of Parkinson's disease. PLoS ONE. 2011;6:e17953 pubmed publisher
Hamdani N, Borbely A, Veenstra S, Kooij V, Vrydag W, Zaremba R, et al. More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease. J Muscle Res Cell Motil. 2010;31:289-301 pubmed publisher
Shimada M, Haruta M, Niida H, Sawamoto K, Nakanishi M. Protein phosphatase 1? is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage. EMBO Rep. 2010;11:883-9 pubmed publisher
Hirschi A, Cecchini M, Steinhardt R, Schamber M, Dick F, Rubin S. An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein. Nat Struct Mol Biol. 2010;17:1051-7 pubmed publisher
Groskreutz D, Babor E, Monick M, Varga S, Hunninghake G. Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication. J Biol Chem. 2010;285:24023-31 pubmed publisher
Wang Z, Udeshi N, Slawson C, Compton P, Sakabe K, Cheung W, et al. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal. 2010;3:ra2 pubmed publisher
Naughton R, Quiney C, Turner S, Cotter T. Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway. Leukemia. 2009;23:1432-40 pubmed publisher
Popescu M, Gurel Z, Ronni T, Song C, Hung K, Payne K, et al. Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem. 2009;284:13869-80 pubmed publisher
Slawson C, Lakshmanan T, Knapp S, Hart G. A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell. 2008;19:4130-40 pubmed publisher
Stefansson B, Ohama T, Daugherty A, Brautigan D. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry. 2008;47:1442-51 pubmed publisher
Barreyro F, Kobayashi S, Bronk S, Werneburg N, Malhi H, Gores G. Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem. 2007;282:27141-54 pubmed
Caldas H, Fangusaro J, Boue D, Holloway M, Altura R. Dissecting the role of endothelial SURVIVIN DeltaEx3 in angiogenesis. Blood. 2007;109:1479-89 pubmed
Gallego M, Kang H, Virshup D. Protein phosphatase 1 regulates the stability of the circadian protein PER2. Biochem J. 2006;399:169-75 pubmed publisher
Shmueli A, Gdalyahu A, Sapoznik S, Sapir T, Tsukada M, Reiner O. Site-specific dephosphorylation of doublecortin (DCX) by protein phosphatase 1 (PP1). Mol Cell Neurosci. 2006;32:15-26 pubmed
Greenberg C, Danos A, Brady M. Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes. Mol Cell Biol. 2006;26:334-42 pubmed
product information
Product Name :
PP1 (E-9) Antibody
Gene Name :
PPP1CA
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7482
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
PP1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA