product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
SIRT1 (B-10) Antibody
catalog :
sc-74504
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-10
reactivity :
human, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1a
Liu X, Cai S, Zhang C, Liu Z, Luo J, Xing B, et al. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res. 2018;46:9601-9616 pubmed publisher
  • western blot; human; fig 4
Liu X, Ehmed E, Li B, Dou J, Qiao X, Jiang W, et al. Breast cancer metastasis suppressor 1 modulates SIRT1-dependent p53 deacetylation through interacting with DBC1. Am J Cancer Res. 2016;6:1441-9 pubmed
  • immunohistochemistry; human; 1:100; fig 1
  • western blot; human; 1:100; fig s1
Tobita T, Guzman Lepe J, Takeishi K, Nakao T, Wang Y, Meng F, et al. SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and Lipids. PLoS ONE. 2016;11:e0149344 pubmed publisher
  • western blot; human; fig s1b
Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed publisher
  • western blot; rat
Kawakami K, Nakamura A, Goto S. Dietary restriction increases site-specific histone H3 acetylation in rat liver: possible modulation by sirtuins. Biochem Biophys Res Commun. 2012;418:836-40 pubmed publisher
Hsu M, Hsiao Y, Lin Y, Chen C, Lee C, Liao W, et al. Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway. Antioxidants (Basel). 2021;10: pubmed publisher
Zhu Z, Li J, Zhang X. Salidroside protects against ox-LDL-induced endothelial injury by enhancing autophagy mediated by SIRT1-FoxO1 pathway. BMC Complement Altern Med. 2019;19:111 pubmed publisher
Martin S, Souder D, Miller K, Clark J, Sagar A, Eliceiri K, et al. GSK3? Regulates Brain Energy Metabolism. Cell Rep. 2018;23:1922-1931.e4 pubmed publisher
Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, et al. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018;37:4385-4397 pubmed publisher
Xue T, Wei L, Zha D, Qiu J, Chen F, Qiao L, et al. miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1? signaling: Implications for age-related hearing loss. Int J Mol Med. 2016;38:1387-1394 pubmed publisher
Zhu L, Qi J, Chiao C, Zhang Q, Porco J, Faller D, et al. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. Int J Oncol. 2014;45:2128-36 pubmed publisher
Lovaas J, Zhu L, Chiao C, Byles V, Faller D, Dai Y. SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. Prostate. 2013;73:522-30 pubmed publisher
Zeng R, Chen Y, Zhao S, Cui G. Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. Acta Pharmacol Sin. 2012;33:91-100 pubmed publisher
Xu Y, Nie L, Yin Y, Tang J, Zhou J, Li D, et al. Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells. Toxicol Appl Pharmacol. 2012;259:395-401 pubmed publisher
Byles V, Chmilewski L, Wang J, Zhu L, Forman L, Faller D, et al. Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci. 2010;6:599-612 pubmed
product information
Catalog Number :
sc-74504
Product Name :
SIRT1 (B-10) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
B-10
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
SIRT1
Specificity :
human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA