product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
SIRT1 (B-7) Antibody
catalog :
sc-74465
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
B-7
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 6h
  • western blot; mouse; loading ...; fig 6f
Huang S, You S, Qian J, Dai C, Shen S, Wang J, et al. Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling. Aging (Albany NY). 2021;13:4409-4427 pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 9
Merlo S, Luaces J, Spampinato S, Toro Urrego N, Caruso G, D Amico F, et al. SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence. Biomolecules. 2020;10: pubmed publisher
  • western blot; rat; loading ...; fig 4c
Wang J, Dong Z, Gui M, Yao L, Li J, Zhou X, et al. HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α deacetylation pathway. Biosci Rep. 2019;39: pubmed publisher
  • western blot; human; 1:500; fig 1
Romeo S, Conti A, Polito F, Tomasello C, Barresi V, La Torre D, et al. miRNA regulation of Sirtuin-1 expression in human astrocytoma. Oncol Lett. 2016;12:2992-2998 pubmed
  • western blot; rat; fig 5
Huang C, Wang T, Tung Y, Lin W. Effect of Exercise Training on Skeletal Muscle SIRT1 and PGC-1? Expression Levels in Rats of Different Age. Int J Med Sci. 2016;13:260-70 pubmed publisher
  • western blot; human; fig 2
Kobayashi K, Sakurai K, Hiramatsu H, Inada K, Shiogama K, Nakamura S, et al. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep. 2015;5:8428 pubmed publisher
  • western blot; human; loading ...; fig 5a
Peng L, Yuan Z, Li Y, Ling H, Izumi V, Fang B, et al. Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival. J Biol Chem. 2015;290:8904-12 pubmed publisher
Masuda M, Yoshida Shimizu R, Mori Y, Ohnishi K, Adachi Y, Sakai M, et al. Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes. J Nutr Biochem. 2022;106:109017 pubmed publisher
Guha P, Tyagi R, Chowdhury S, Reilly L, Fu C, Xu R, et al. IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration. Cell Rep. 2019;26:2692-2703.e7 pubmed publisher
Shen M, Cao Y, Jiang Y, Wei Y, Liu H. Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: Implication of an antioxidation-independent mechanism. Redox Biol. 2018;18:138-157 pubmed publisher
Piao X, Liu B, Guo L, Meng F, Gao L. Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-κB-Dependent Autophagy. Oxid Med Cell Longev. 2017;2017:7085709 pubmed publisher
Shen M, Jiang Y, Guan Z, Cao Y, Li L, Liu H, et al. Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy. Autophagy. 2017;13:1364-1385 pubmed publisher
Yan W, Fang Z, Yang Q, Dong H, Lu Y, Lei C, et al. SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. J Cereb Blood Flow Metab. 2013;33:396-406 pubmed publisher
Jang S, Min K, Paik S, Jang K. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma. J Clin Pathol. 2012;65:735-9 pubmed publisher
Huang W, Shang W, Wang H, Wu W, Hou S. Sirt1 overexpression protects murine osteoblasts against TNF-?-induced injury in vitro by suppressing the NF-?B signaling pathway. Acta Pharmacol Sin. 2012;33:668-74 pubmed publisher
Sciacca S, Pilato M, Mazzoccoli G, Pazienza V, Vinciguerra M. Anti-correlation between longevity gene SirT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease. Heart Vessels. 2013;28:268-75 pubmed publisher
Yang J, Chen D, He Y, Melendez A, Feng Z, Hong Q, et al. MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age (Dordr). 2013;35:11-22 pubmed publisher
Fatoba S, Okorokov A. Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation. Cell Cycle. 2011;10:2317-22 pubmed
Vinciguerra M, Santini M, Claycomb W, Ladurner A, Rosenthal N. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY). 2009;2:43-62 pubmed
Shang L, Zhou H, Xia Y, Wang H, Gao G, Chen B, et al. Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner. J Cell Mol Med. 2009;13:4176-84 pubmed publisher
product information
Catalog Number :
sc-74465
Product Name :
SIRT1 (B-7) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
B-7
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
SIRT1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA