product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
AMPKα1/2 (D-6) Antibody
catalog :
sc-74461
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-6
reactivity :
human, mouse, rat, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 6e
Yeh C, Liu H, Lee M, Leu Y, Chiang W, Chang H, et al. Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice. Mol Med Rep. 2022;25: pubmed publisher
  • western blot; pigs ; loading ...; fig 5c
Fan Q, Long B, Yan G, Wang Z, Shi M, Bao X, et al. Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets. Br J Nutr. 2017;117:1222-1234 pubmed publisher
  • western blot; rat; fig 2a
Zhou Y, Wu Y, Qin Y, Liu L, Wan J, Zou L, et al. Ampelopsin Improves Insulin Resistance by Activating PPAR? and Subsequently Up-Regulating FGF21-AMPK Signaling Pathway. PLoS ONE. 2016;11:e0159191 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 1
  • western blot; human; 1:200; fig 5
Mahboubi H, Barisé R, Stochaj U. 5'-AMP-activated protein kinase alpha regulates stress granule biogenesis. Biochim Biophys Acta. 2015;1853:1725-37 pubmed publisher
  • western blot; human; 1:1000
Chen M, Yi L, Jin X, Liang X, Zhou Y, Zhang T, et al. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy. 2013;9:2033-45 pubmed publisher
Murtha K, Yang Y, Ceriani F, Jeng J, Climer L, Jones F, et al. Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells. Cell Calcium. 2022;105:102613 pubmed publisher
Yang Z, Zhang L, Liu J, Lu F, Wang L, Chen Y, et al. Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1. BMC Complement Altern Med. 2019;19:136 pubmed publisher
Cordani M, Butera G, Dando I, Torrens Mas M, Butturini E, Pacchiana R, et al. Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2-· production in cancer cells. Br J Cancer. 2018;119:994-1008 pubmed publisher
Wang X, Liu W, Zhuang D, Hong S, Chen J. Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling. Oncotarget. 2017;8:90132-90143 pubmed publisher
Dong S, Baranwal S, Garcia A, Serrano Gomez S, Eastlack S, Iwakuma T, et al. Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase. J Biol Chem. 2017;292:16833-16846 pubmed publisher
Lee D, Martinez B, Crocker D, Ortiz R. Fasting increases the phosphorylation of AMPK and expression of sirtuin1 in muscle of adult male northern elephant seals (Mirounga angustirostris). Physiol Rep. 2017;5: pubmed publisher
Guo P, Pi H, Xu S, Zhang L, Li Y, Li M, et al. Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicol Sci. 2014;142:182-95 pubmed publisher
Liao C, Ou T, Huang H, Wang C. The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase. J Sci Food Agric. 2014;94:1154-62 pubmed publisher
Hutterer C, Wandinger S, Wagner S, Müller R, Stamminger T, Zeitträger I, et al. Profiling of the kinome of cytomegalovirus-infected cells reveals the functional importance of host kinases Aurora A, ABL and AMPK. Antiviral Res. 2013;99:139-48 pubmed publisher
Huang J, Lu L, Ye S, Bergman B, Sparagna G, Sarraf M, et al. Impaired contractile recovery after low-flow myocardial ischemia in a porcine model of metabolic syndrome. Am J Physiol Heart Circ Physiol. 2013;304:H861-73 pubmed publisher
Liao K, Mogridge J. Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP. Infect Immun. 2013;81:570-9 pubmed publisher
Chen M, Wu X, Gu J, Guo Q, Shen W, Lu P. Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem Biophys. 2011;60:311-22 pubmed publisher
Filomeni G, Desideri E, Cardaci S, Graziani I, Piccirillo S, Rotilio G, et al. Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment. Autophagy. 2010;6:202-16 pubmed
product information
Catalog Number :
sc-74461
Product Name :
AMPKα1/2 (D-6) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
D-6
Isotype :
IgG2a
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
AMPKalpha1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA