product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Ribosomal Protein S6 (C-8) Antibody
catalog :
sc-74459
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 32
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2c
Chen C, Huang P, Bland K, Li M, Zhang Y, Liu Chen L. Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion. Front Pharmacol. 2022;13:835809 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3b
Terrey M, Adamson S, Gibson A, Deng T, Ishimura R, Chuang J, et al. GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis. elife. 2020;9: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4s2a
Hayes L, Duan L, Bowen K, Kalab P, Rothstein J. C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import. elife. 2020;9: pubmed publisher
  • western blot; rat; loading ...; fig 6c
  • immunohistochemistry - paraffin section; human; loading ...; fig 5a
  • immunocytochemistry; human; loading ...; fig s4a
Hartmann H, Hornburg D, Czuppa M, Bader J, Michaelsen M, Farny D, et al. Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity. Life Sci Alliance. 2018;1:e201800070 pubmed publisher
  • western blot; human; 1:250; fig 5
Kurg R, Reinsalu O, Jagur S, Ounap K, Võsa L, Kasvandik S, et al. Biochemical and proteomic characterization of retrovirus Gag based microparticles carrying melanoma antigens. Sci Rep. 2016;6:29425 pubmed publisher
  • western blot; mouse; 1:1000; fig s3
Wang J, Farris A, Xu K, Wang P, Zhang X, Duong D, et al. GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis. Nat Commun. 2016;7:11795 pubmed publisher
  • western blot; human; 1:2000; fig 1
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher
  • western blot; mouse; 1:3000; fig 1
Yan B, Zhang Z, Jin D, Cai C, Jia C, Liu W, et al. mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation. Nat Commun. 2016;7:11151 pubmed publisher
  • western blot; mouse; fig 4
da Rocha A, Pereira B, Pauli J, Cintra D, De Souza C, Ropelle E, et al. Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. PLoS ONE. 2015;10:e0140020 pubmed publisher
  • western blot; human; loading ...; fig 6a
Fonseca B, Zakaria C, Jia J, Graber T, Svitkin Y, Tahmasebi S, et al. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015;290:15996-6020 pubmed publisher
  • western blot; human
Roffé M, Lupinacci F, Soares L, Hajj G, Martins V. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015;27:1630-42 pubmed publisher
  • western blot; human; fig 5
Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
  • immunohistochemistry; rat; 1:50
Carloni S, Albertini M, Galluzzi L, Buonocore G, Proietti F, Balduini W. Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia-ischemia: role of protein synthesis and autophagic pathways. Exp Neurol. 2014;255:103-12 pubmed publisher
Challa S, Nandu T, Kim H, Gong A, Renshaw C, Li W, et al. A PARP14/TARG1-Regulated RACK1 MARylation Cycle Drives Stress Granule Dynamics in Ovarian Cancer Cells. bioRxiv. 2023;: pubmed publisher
Skinner O, Blanco Fern xe1 ndez J, Goodman R, Kawakami A, Shen H, Kem xe9 ny L, et al. Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions. Nat Metab. 2023;5:765-776 pubmed publisher
Gonthier K, Weidmann C, Berthiaume L, Jobin C, Lacouture A, Lafront C, et al. Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer. Mol Oncol. 2023;: pubmed publisher
Vittoria M, Kingston N, Kotynková K, Xia E, Hong R, Huang L, et al. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022;13:3732 pubmed publisher
Birkisdóttir M, Jaarsma D, Brandt R, Barnhoorn S, van Vliet N, Imholz S, et al. Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice. Aging Cell. 2021;20:e13302 pubmed publisher
Merrett J, Bo T, Psaltis P, Proud C. Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ and MAP kinase-interacting kinases during early adipogenesis. Adipocyte. 2020;9:427-442 pubmed publisher
Kouloulia S, Hallin E, Simbriger K, Amorim I, Lach G, Amvrosiadis T, et al. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep. 2019;29:3620-3635.e7 pubmed publisher
Charitou T, Srihari S, Lynn M, Jarboui M, Fasterius E, Moldovan M, et al. Transcriptional and metabolic rewiring of colorectal cancer cells expressing the oncogenic KRASG13D mutation. Br J Cancer. 2019;: pubmed publisher
Lin C, Liu L, Zeng C, Cui Z, Chen Y, Lai P, et al. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res. 2019;7:5 pubmed publisher
Zou W, Lai M, Zhang Y, Zheng L, Xing Z, Li T, et al. Exosome Release Is Regulated by mTORC1. Adv Sci (Weinh). 2019;6:1801313 pubmed publisher
Kalwat M, Hwang I, Macho J, Grzemska M, Yang J, McGlynn K, et al. Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. J Gen Physiol. 2018;150:1747-1757 pubmed publisher
Dionne L, Shim K, Hoshi M, Cheng T, Wang J, Marthiens V, et al. Centrosome amplification disrupts renal development and causes cystogenesis. J Cell Biol. 2018;217:2485-2501 pubmed publisher
Ding Y, Shan L, Nai W, Lin X, Zhou L, Dong X, et al. DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis. Cell Physiol Biochem. 2018;46:520-531 pubmed publisher
Mateo F, Arenas E, Aguilar H, Serra Musach J, de Garibay G, Boni J, et al. Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Oncogene. 2017;36:2737-2749 pubmed publisher
Khapre R, Patel S, Kondratova A, Chaudhary A, Velingkaar N, Antoch M, et al. Metabolic clock generates nutrient anticipation rhythms in mTOR signaling. Aging (Albany NY). 2014;6:675-89 pubmed
Khapre R, Kondratova A, Patel S, Dubrovsky Y, Wrobel M, Antoch M, et al. BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). 2014;6:48-57 pubmed
Ounap K, Käsper L, Kurg A, Kurg R. The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells. PLoS ONE. 2013;8:e75686 pubmed publisher
Meng Z, Li S, Wang L, Ko H, Lee Y, Jung D, et al. Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation. Nat Med. 2013;19:640-5 pubmed publisher
Baird N, York J, Nunberg J. Arenavirus infection induces discrete cytosolic structures for RNA replication. J Virol. 2012;86:11301-10 pubmed
product information
Catalog Number :
sc-74459
Product Name :
Ribosomal Protein S6 (C-8) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
C-8
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Ribosomal Protein S6
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA