product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Cdc25A (F-6) Antibody
catalog :
sc-7389
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
F-6
reactivity :
human, mouse, rat, chicken
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:200; loading ...; fig 5b
Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisher
  • western blot; human; loading ...; fig 1d
Shimizu K, Fukushima H, Ogura K, Lien E, Nihira N, Zhang J, et al. The SCF?-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017;10: pubmed publisher
  • western blot; human; loading ...; fig 1b
Bridges K, Chen X, Liu H, Rock C, Buchholz T, Shumway S, et al. MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells. Oncotarget. 2016;7:71660-71672 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2c
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  • western blot; mouse; 1:250; fig 3
Brosh R, Hrynyk I, Shen J, Waghray A, Zheng N, Lemischka I. A dual molecular analogue tuner for dissecting protein function in mammalian cells. Nat Commun. 2016;7:11742 pubmed publisher
  • western blot; human; 1:1000; fig 6
Soriano A, París Coderch L, Jubierre L, Martínez A, Zhou X, Piskareva O, et al. MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes. Oncotarget. 2016;7:9271-87 pubmed publisher
  • western blot; human; fig 1
Hasvold G, Lund Andersen C, Lando M, Patzke S, Hauge S, Suo Z, et al. Hypoxia-induced alterations of G2 checkpoint regulators. Mol Oncol. 2016;10:764-73 pubmed publisher
  • western blot; human; fig 3
King C, Diaz H, McNeely S, Barnard D, Dempsey J, Blosser W, et al. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Mol Cancer Ther. 2015;14:2004-13 pubmed publisher
  • western blot; human; 1:500; fig 1
Pagan J, Marzio A, Jones M, Saraf A, Jallepalli P, Florens L, et al. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol. 2015;17:31-43 pubmed publisher
  • western blot; human; 1:200
Qiu W, Kassem M. miR-141-3p inhibits human stromal (mesenchymal) stem cell proliferation and differentiation. Biochim Biophys Acta. 2014;1843:2114-21 pubmed publisher
  • western blot; chicken; fig 2
Frankenberger S, Davari K, Fischer Burkart S, Böttcher K, Tomi N, Zimber Strobl U, et al. Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res. 2014;42:3666-74 pubmed publisher
  • western blot; human
Solier S, Sordet O, Kohn K, Pommier Y. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol Cell Biol. 2009;29:68-82 pubmed publisher
Heijink A, Everts M, Honeywell M, Richards R, Kok Y, de Vries E, et al. Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Rep. 2019;28:2345-2357.e5 pubmed publisher
Bianco J, Bergoglio V, Lin Y, Pillaire M, Schmitz A, Gilhodes J, et al. Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner. Nat Commun. 2019;10:910 pubmed publisher
Rodríguez Barrueco R, Nekritz E, Bertucci F, Yu J, Sanchez Garcia F, Zeleke T, et al. miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy. Genes Dev. 2017;31:553-566 pubmed publisher
Adeyemi R, Pintel D. Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells. PLoS Pathog. 2014;10:e1003891 pubmed publisher
Neelsen K, Zanini I, Herrador R, Lopes M. Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J Cell Biol. 2013;200:699-708 pubmed publisher
Zoppoli G, Solier S, Reinhold W, Liu H, Connelly J, Monks A, et al. CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute. Oncogene. 2012;31:403-18 pubmed publisher
Roh M, Van Der Meer R, Abdulkadir S. Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment. J Cell Physiol. 2012;227:801-12 pubmed publisher
Soares D, Battistella A, Rocca C, Matuo R, Henriques J, Larsen A, et al. Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906. Biochem J. 2011;437:63-73 pubmed publisher
Vázquez Novelle M, Mailand N, Ovejero S, Bueno A, Sacristán M. Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B. J Biol Chem. 2010;285:40544-53 pubmed publisher
Larsen D, Poinsignon C, Gudjonsson T, Dinant C, Payne M, Hari F, et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol. 2010;190:731-40 pubmed publisher
Malzer E, Daly M, Moloney A, Sendall T, Thomas S, Ryder E, et al. Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. J Cell Sci. 2010;123:2892-900 pubmed publisher
Vo N, Madlener S, Bago Horvath Z, Herbacek I, Stark N, Gridling M, et al. Pro- and anticarcinogenic mechanisms of piceatannol are activated dose dependently in MCF-7 breast cancer cells. Carcinogenesis. 2010;31:2074-81 pubmed publisher
Tomko R, Azang Njaah N, Lazo J. Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition. Cell Cycle. 2009;8:299-305 pubmed
Densham R, Todd D, Balmanno K, Cook S. ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover. Cell Signal. 2008;20:1986-94 pubmed publisher
Stolfi C, Fina D, Caruso R, Caprioli F, Fantini M, Rizzo A, et al. Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase. Carcinogenesis. 2008;29:1258-66 pubmed publisher
Lehmann G, McCabe M. Arsenite slows S phase progression via inhibition of cdc25A dual specificity phosphatase gene transcription. Toxicol Sci. 2007;99:70-8 pubmed
Hong Y, Cervantes R, Stambrook P. DNA damage response and mutagenesis in mouse embryonic stem cells. Methods Mol Biol. 2006;329:313-26 pubmed
Lindqvist A, Källström H, Lundgren A, Barsoum E, Rosenthal C. Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome. J Cell Biol. 2005;171:35-45 pubmed
Takagaki K, Katsuma S, Kaminishi Y, Horio T, Tanaka T, Ohgi T, et al. Role of Chk1 and Chk2 in Ara-C-induced differentiation of human leukemia K562 cells. Genes Cells. 2005;10:97-106 pubmed
Xiao Z, Xue J, Sowin T, Rosenberg S, Zhang H. A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene. 2005;24:1403-11 pubmed
Ottey M, Han S, Druck T, Barnoski B, McCorkell K, Croce C, et al. Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant. Br J Cancer. 2004;91:1669-77 pubmed
Hu B, Han S, Wang X, Ottey M, Potoczek M, Dicker A, et al. Involvement of the Fhit gene in the ionizing radiation-activated ATR/CHK1 pathway. J Cell Physiol. 2005;202:518-23 pubmed
product information
Product Name :
Cdc25A (F-6) Antibody
Gene Name :
CDC25A
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7389
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Cdc25A
reactive species  :
m, r, h
Application :
WB, IP, IF
Epitope :
C-terminal (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA