| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; 1:500; loading ...; fig 1c
- immunohistochemistry; mouse; loading ...; fig 4a
- western blot; human; fig 1e
| Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, et al. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017;8:2168 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig 7g
| Glal D, Sudhakar J, Lu H, Liu M, Chiang H, Liu Y, et al. ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases. Front Immunol. 2018;9:2522 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Sauer M, Herbst J, Diekmann U, Rudd C, Kardinal C. SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells. Mol Cell Biol. 2016;36:3113-3127 pubmed |
- immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig s7c
| Kikuchi I, Takahashi Kanemitsu A, Sakiyama N, Tang C, Tang P, Noda S, et al. Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nat Commun. 2016;7:12887 pubmed publisher |
- western blot; human; loading ...; fig 1Bb
| Wang S, Zheng G, Zhao L, Xu F, Qian J. Shp-2 contributes to anti-RSV activity in human pulmonary alveolar epithelial cells by interfering with the IFN-α-induced Jak/Stat1 pathway. J Cell Mol Med. 2015;19:2432-40 pubmed publisher |
| Zhao H, Agazie Y. Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment. BMC Cancer. 2015;15:109 pubmed publisher |
| Osinalde N, Sánchez Quiles V, Akimov V, Guerra B, Blagoev B, Kratchmarova I. Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics. Proteomics. 2015;15:520-31 pubmed publisher |
| Abbonante V, Gruppi C, Rubel D, Gross O, Moratti R, Balduini A. Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions. J Biol Chem. 2013;288:16738-46 pubmed publisher |
| Kramer O, Knauer S, Greiner G, Jandt E, Reichardt S, Gührs K, et al. A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev. 2009;23:223-35 pubmed publisher |
| Ahmed T, Adamopoulos C, Karoulia Z, Wu X, Sachidanandam R, Aaronson S, et al. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Cell Rep. 2019;26:65-78.e5 pubmed publisher |
| Dorenkamp M, Müller J, Shanmuganathan K, Schulten H, Müller N, Löffler I, et al. Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis. Sci Rep. 2018;8:14684 pubmed publisher |
| Zehender A, Huang J, Györfi A, Matei A, Trinh Minh T, Xu X, et al. The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat Commun. 2018;9:3259 pubmed publisher |
| Nagappan Chettiar S, Johnson Venkatesh E, Umemori H. Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation. J Biol Chem. 2018;293:12026-12042 pubmed publisher |
| Li Q, Alsaidan O, Ma Y, Kim S, Liu J, Albers T, et al. Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression. J Biol Chem. 2018;293:6434-6448 pubmed publisher |
| Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens P, Neel B. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun. 2017;8:466 pubmed publisher |
| Roccograndi L, Binder Z, Zhang L, Aceto N, Zhang Z, Bentires Alj M, et al. SHP2 regulates proliferation and tumorigenicity of glioma stem cells. J Neurooncol. 2017;135:487-496 pubmed publisher |
| Nakano M, Yahiro K, Yamasaki E, Kurazono H, Akada J, Yamaoka Y, et al. Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase ?, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521. Dis Model Mech. 2016;9:1473-1481 pubmed |
| Tien S, Lee H, Yang Y, Lin M, Chen Y, Chang Z. The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42. Nat Commun. 2016;7:10420 pubmed publisher |
| Matalkah F, Martin E, Zhao H, Agazie Y. SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal-like and triple-negative breast cancer. Breast Cancer Res. 2016;18:2 pubmed publisher |
| Craig J, Mikhailenko I, Noyes N, Migliorini M, Strickland D. The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events. PLoS ONE. 2013;8:e70432 pubmed publisher |
| Hartman Z, Schaller M, Agazie Y. The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migration. Mol Cancer Res. 2013;11:651-64 pubmed publisher |
| He Z, Zhang S, Meng Q, Li S, Zhu H, Raquil M, et al. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol. 2012;32:1867-78 pubmed publisher |
| Osinalde N, Moss H, Arrizabalaga O, Omaetxebarria M, Blagoev B, Zubiaga A, et al. Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics. J Proteomics. 2011;75:177-91 pubmed publisher |
| Pereira A, Clemente C, Cardoso A, Theizen T, Rocco S, Judice C, et al. MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice. PLoS ONE. 2009;4:e8472 pubmed publisher |
| Yashiro M, Shinto O, Nakamura K, Tendo M, Matsuoka T, Matsuzaki T, et al. Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on scirrhous gastric carcinoma. Int J Cancer. 2010;126:1004-16 pubmed publisher |
| Schuman J, Chen Y, Podd A, Yu M, Liu H, Wen R, et al. A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood. 2009;113:4566-74 pubmed publisher |
| Camilleri A, Willmann R, Sadasivam G, Lin S, Ruegg M, Gesemann M, et al. Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors. BMC Neurosci. 2007;8:46 pubmed |
| Kuchay S, Kim N, Grunz E, Fay W, Chishti A. Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets. Mol Cell Biol. 2007;27:6038-52 pubmed |
| Park T, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol. 2006;26:6272-82 pubmed |
| Monteleone G, Franchi L, Fina D, Caruso R, Vavassori P, Monteleone I, et al. Silencing of SH-PTP2 defines a crucial role in the inactivation of epidermal growth factor receptor by 5-aminosalicylic acid in colon cancer cells. Cell Death Differ. 2006;13:202-11 pubmed |
| Mortaz E, Redegeld F, van der Heijden M, Wong H, Nijkamp F, Engels F. Mast cell activation is differentially affected by heat shock. Exp Hematol. 2005;33:944-52 pubmed |
| Sun H, Shen Y, Dokainish H, Holgado Madruga M, Wong A, Ireton K. Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes. Cell Microbiol. 2005;7:443-57 pubmed |
