product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
JNK (D-2) Antibody
catalog :
sc-7345
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, other
citations: 79
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5f
Shami Shah A, Batrouni A, Kim D, Punyala A, Cao W, Han C, et al. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Cell Rep. 2019;27:2157-2170.e8 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4b
Wu J, Liu Y, Liang J, Huang Q, Dou Y, Nie J, et al. Protective role of ?-patchoulene from Pogostemon cablin against indomethacin-induced gastric ulcer in rats: Involvement of anti-inflammation and angiogenesis. Phytomedicine. 2018;39:111-118 pubmed publisher
  • immunocytochemistry; human; fig 7e
  • western blot; human; fig 7e
Chhabra A, Mukherji B, Batra D. Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53. Expert Opin Ther Targets. 2017;21:117-129 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 9a
Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed publisher
  • western blot; mouse; fig 2a
Su F, Myers V, Knezevic T, Wang J, Gao E, Madesh M, et al. Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury. JCI Insight. 2016;1:e90931 pubmed publisher
  • western blot; mouse; loading ...; fig 6e
Kennedy T, Swiderski K, Murphy K, Gehrig S, Curl C, Chandramouli C, et al. BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle. Am J Pathol. 2016;186:3246-3260 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Zhong W, Wang X, Pan B, Li F, Kuang L, Su Z. Eupatilin induces human renal cancer cell apoptosis via ROS-mediated MAPK and PI3K/AKT signaling pathways. Oncol Lett. 2016;12:2894-2899 pubmed
  • western blot; mouse; loading ...; fig 7a
Wu Y, Ren D, Chen G. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol. 2016;197:3336-3347 pubmed
  • western blot; human; fig 3
Lee J, Jung H, Han Y, Yoon Y, Yun C, Sun H, et al. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016;14:3777-84 pubmed publisher
  • western blot; mouse; 1:200; fig 3
Wang J, Li H, Li B, Gong Q, Chen X, Wang Q. Co-culture of bone marrow stem cells and macrophages indicates intermediate mechanism between local inflammation and innate immune system in diabetic periodontitis. Exp Ther Med. 2016;12:567-572 pubmed
  • western blot; mouse; loading ...; fig 7c
Wu Y, Lan C, Ren D, Chen G. Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-?1 Production. J Biol Chem. 2016;291:12370-82 pubmed publisher
  • western blot; human; loading ...; fig 1b
Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 3
Choi J, Kim I, Kim Y, Lee M, Nam T. Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of D-galactosamine/lipopolysaccharide-induced acute liver failure. Mol Med Rep. 2016;13:3110-4 pubmed publisher
  • western blot; human; 1:1000; fig 4
Wu T, Li Y, Liu B, Zhang S, Wu L, Zhu X, et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS ONE. 2016;11:e0149361 pubmed publisher
  • western blot; human; fig 5
Fu X, Xie F, Dong P, Li Q, Yu G, Xiao R. High-Dose Fluoride Impairs the Properties of Human Embryonic Stem Cells via JNK Signaling. PLoS ONE. 2016;11:e0148819 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; 1:1000; fig 5
Xu Y, Wu D, Zheng W, Yu F, Yang F, Yao Y, et al. Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. Oncotarget. 2016;7:6146-58 pubmed publisher
  • western blot; mouse; fig 1
  • western blot; human; fig s1
Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher
  • western blot; rat; 1:500; fig 4
Wang Z, Tang B, Tang F, Li Y, Zhang G, Zhong L, et al. Protection of rat intestinal epithelial cells from ischemia/reperfusion injury by (D-Ala2, D-Leu5)-enkephalin through inhibition of the MKK7-JNK signaling pathway. Mol Med Rep. 2015;12:4079-4088 pubmed publisher
  • western blot; mouse
Bargut T, Mandarim de Lacerda C, Aguila M. A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice. J Nutr Biochem. 2015;26:960-9 pubmed publisher
  • western blot; human; fig 5
Zou H, Limpert A, Zou J, Dembo A, Lee P, Grant D, et al. Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines. ACS Chem Neurosci. 2015;6:464-75 pubmed publisher
  • western blot; rat; 1:500
Passos E, Pereira C, Gonçalves I, Rocha Rodrigues S, Silva N, Guimarães J, et al. Role of physical exercise on hepatic insulin, glucocorticoid and inflammatory signaling pathways in an animal model of non-alcoholic steatohepatitis. Life Sci. 2015;123:51-60 pubmed publisher
  • western blot; human; loading ...; fig 3a
Suzuki S, Okada M, Shibuya K, Seino M, Sato A, Takeda H, et al. JNK suppression of chemotherapeutic agents-induced ROS confers chemoresistance on pancreatic cancer stem cells. Oncotarget. 2015;6:458-70 pubmed
  • western blot; human
Tobar N, Toyos M, Urra C, Méndez N, Arancibia R, Smith P, et al. c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer. 2014;14:640 pubmed publisher
  • western blot; rat; 1:200
Wei X, Zhang F, Wang K, Zhang Q, Rong L. Assembly of the FKBP51-PHLPP2-AKT signaling complex in cerebral ischemia/reperfusion injury in rats. Brain Res. 2014;1566:60-8 pubmed publisher
  • western blot; human; fig 4a, 4b
Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, et al. JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression. Int J Oncol. 2014;44:591-9 pubmed publisher
Tsai T, Lin J, Lin Y, Chou K, Chen H, Ho C, et al. Cisplatin contributes to programmed death-ligand 1 expression in bladder cancer through ERK1/2-AP-1 signaling pathway. Biosci Rep. 2019;39: pubmed publisher
Mohan A, Dean K, Isogai T, Kasitinon S, Murali V, Roudot P, et al. Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Dev Cell. 2019;49:444-460.e9 pubmed publisher
Ibrahim D, Ko J, Iwata W, Okumichi H, Kiuchi Y. An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y-27632, a Rho kinase inhibitor. Cell Biochem Funct. 2019;37:113-124 pubmed publisher
Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, et al. Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Cancer Cell. 2019;35:177-190.e8 pubmed publisher
Wang X, Cui X, Zhu C, Li M, Zhao J, Shen Z, et al. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Mol Med Rep. 2018;18:4428-4438 pubmed publisher
Choppara S, Ganga S, Manne R, Dutta P, Singh S, Santra M. The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. J Biol Chem. 2018;293:16291-16306 pubmed publisher
Prinz E, Aviram S, Aronheim A. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis. Mol Biol Cell. 2018;29:2470-2480 pubmed publisher
Wang Q, He Q, Chen Y, Shao W, Yuan C, Wang Y. JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss. J Neuroinflammation. 2018;15:184 pubmed publisher
Taga M, Mouton Liger F, Sadoune M, Gourmaud S, Norman J, Tible M, et al. PKR modulates abnormal brain signaling in experimental obesity. PLoS ONE. 2018;13:e0196983 pubmed publisher
Chen H, Zhang Z, Zhang L, Wang J, Zhang M, Zhu B. miR-27a protects human mitral valve interstitial cell from TNF-α-induced inflammatory injury via up-regulation of NELL-1. Braz J Med Biol Res. 2018;51:e6997 pubmed publisher
Li X, Shang E, Dong Q, Li Y, Zhang J, Xu S, et al. Small molecules capable of activating DNA methylation-repressed genes targeted by the p38 mitogen-activated protein kinase pathway. J Biol Chem. 2018;293:7423-7436 pubmed publisher
Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017;292:17681-17702 pubmed publisher
Takahashi M, Li Y, Dillon T, Stork P. Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. J Biol Chem. 2017;292:1449-1461 pubmed publisher
Ryu Y, Jin L, Kee H, Piao Z, Cho J, Kim G, et al. Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. Sci Rep. 2016;6:34790 pubmed publisher
Okada M, Shibuya K, Sato A, Seino S, Suzuki S, Seino M, et al. Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation. Oncotarget. 2014;5:5100-12 pubmed
Wang L, Luo H, Chen X, Jiang Y, Huang Q. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS ONE. 2014;9:e90472 pubmed publisher
Jia G, Kong R, Ma Z, Han B, Wang Y, Pan S, et al. The activation of c-Jun NH?-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells. J Exp Clin Cancer Res. 2014;33:8 pubmed publisher
Okada M, Shibuya K, Sato A, Seino S, Watanabe E, Suzuki S, et al. Specific role of JNK in the maintenance of the tumor-initiating capacity of A549 human non-small cell lung cancer cells. Oncol Rep. 2013;30:1957-64 pubmed publisher
Zhang J, Gao Z, Ye J. Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation. Biochim Biophys Acta. 2013;1832:1980-8 pubmed publisher
Cheng T, Zhang L, Fu X, Wang W, Xu H, Song H, et al. The potential protective effects of calcitonin involved in coordinating chondrocyte response, extracellular matrix, and subchondral trabecular bone in experimental osteoarthritis. Connect Tissue Res. 2013;54:139-46 pubmed publisher
Zhang X, Wang T, Deng T, Xiong W, Lui P, Li N, et al. Damaged spermatogenic cells induce inflammatory gene expression in mouse Sertoli cells through the activation of Toll-like receptors 2 and 4. Mol Cell Endocrinol. 2013;365:162-73 pubmed publisher
Sun Y, Zou M, Hu C, Qin Y, Song X, Lu N, et al. Wogonoside induces autophagy in MDA-MB-231 cells by regulating MAPK-mTOR pathway. Food Chem Toxicol. 2013;51:53-60 pubmed publisher
Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, et al. Targeting JNK for therapeutic depletion of stem-like glioblastoma cells. Sci Rep. 2012;2:516 pubmed publisher
Xiang J, Chen D, Yang L. Effect of PANDER in ?TC6-cell lipoapoptosis and the protective role of exendin-4. Biochem Biophys Res Commun. 2012;421:701-6 pubmed publisher
Eftychi C, Karagianni N, Alexiou M, Apostolaki M, Kollias G. Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia. PLoS ONE. 2012;7:e31550 pubmed publisher
Hu C, Zou M, Zhao L, Lu N, Sun Y, Gou S, et al. E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells. Toxicol Lett. 2012;210:78-86 pubmed publisher
Kim J, Lee E, Jeon K, Choi H, Lim H, Kim S, et al. Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice. Biochim Biophys Acta. 2012;1823:876-88 pubmed publisher
Salerno D, Tront J, Hoffman B, Liebermann D. Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signaling. J Cell Physiol. 2012;227:3613-20 pubmed publisher
Liu L, Fang Y, Xue Z, He Y, Fang R, Li L. Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1. Eur J Pharmacol. 2012;680:34-40 pubmed publisher
Niemela M, Kauko O, Sihto H, Mpindi J, Nicorici D, Pernilä P, et al. CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes. Oncogene. 2012;31:4266-78 pubmed publisher
Rzeczkowski K, Beuerlein K, Müller H, Dittrich Breiholz O, Schneider H, Kettner Buhrow D, et al. c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol. 2011;194:581-96 pubmed publisher
Ju K, Lim J, Kim K, Kim H. Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-?1 in the pathophysiology of acute pancreatitis. Inflamm Res. 2011;60:791-800 pubmed publisher
Bhatt K, Sodhi A, Chakraborty R. Role of mitogen-activated protein kinases in peptidoglycan-induced expression of inducible nitric oxide synthase and nitric oxide in mouse peritoneal macrophages: extracellular signal-related kinase, a negative regulator. Clin Vaccine Immunol. 2011;18:994-1001 pubmed publisher
Banerjee N, Wang H, Broker T, Chow L. Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes. J Biol Chem. 2011;286:15473-82 pubmed publisher
Castro J, Ribo M, Navarro S, Nogués M, Vilanova M, Benito A. A human ribonuclease induces apoptosis associated with p21WAF1/CIP1 induction and JNK inactivation. BMC Cancer. 2011;11:9 pubmed publisher
Gonzalo S, Grasa L, Arruebo M, Plaza M, Murillo M. Lipopolysaccharide-induced intestinal motility disturbances are mediated by c-Jun NH2-terminal kinases. Dig Liver Dis. 2011;43:277-85 pubmed publisher
Wang Y, Kuo J, Lee S, Liu J, Hsieh Y, Shih Y, et al. Cobra CRISP functions as an inflammatory modulator via a novel Zn2+- and heparan sulfate-dependent transcriptional regulation of endothelial cell adhesion molecules. J Biol Chem. 2010;285:37872-83 pubmed publisher
Xu B, Yang L, Lye R, Hinton B. p-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in mice. Biol Reprod. 2010;83:807-17 pubmed publisher
Sharma N, Mani P, Nandwani N, Mishra R, Rana A, Sarkar D. Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion. J Virol. 2010;84:4366-82 pubmed publisher
Ginet V, Puyal J, Magnin G, Clarke P, Truttmann A. Limited role of the c-Jun N-terminal kinase pathway in a neonatal rat model of cerebral hypoxia-ischemia. J Neurochem. 2009;108:552-62 pubmed publisher
Nitta R, Chu A, Wong A. Constitutive activity of JNK2 alpha2 is dependent on a unique mechanism of MAPK activation. J Biol Chem. 2008;283:34935-45 pubmed publisher
Lee D, Yeh C, Chang S, Lee P, Chien S, Cheng C, et al. Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. J Bone Miner Res. 2008;23:1140-9 pubmed publisher
Yang J, Moulin N, van Bemmelen M, Dubuis G, Tawadros T, Haefliger J, et al. Splice variant-specific stabilization of JNKs by IB1/JIP1. Cell Signal. 2007;19:2201-7 pubmed
Tesz G, Guilherme A, Guntur K, Hubbard A, Tang X, Chawla A, et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem. 2007;282:19302-12 pubmed
Wang H, Stjernholm Y. Plasma membrane receptor mediated MAPK signaling pathways are activated in human uterine cervix at parturition. Reprod Biol Endocrinol. 2007;5:3 pubmed
Jack G, Cabrera M, Manning M, Slaughter S, Potts M, Helm R. Activated stress response pathways within multicellular aggregates utilize an autocrine component. Cell Signal. 2007;19:772-81 pubmed
Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori Adachi M, et al. Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6. Arthritis Rheum. 2006;54:2074-83 pubmed
Vega A, Chacón P, Alba G, El Bekay R, Martín Nieto J, Sobrino F. Modulation of IgE-dependent COX-2 gene expression by reactive oxygen species in human neutrophils. J Leukoc Biol. 2006;80:152-63 pubmed
Yu X, Luo A, Zhou C, Ding F, Wu M, Zhan Q, et al. Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells. Biochem Biophys Res Commun. 2006;342:286-92 pubmed
Papachristou D, Pirttiniemi P, Kantomaa T, Agnantis N, Basdra E. Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes. Eur J Orthod. 2006;28:20-6 pubmed
Papachristou D, Papachristou G, Papachristou G, Papaefthimiou O, Agnantis N, Basdra E, et al. The MAPK-AP-1/-Runx2 signalling axes are implicated in chondrosarcoma pathobiology either independently or via up-regulation of VEGF. Histopathology. 2005;47:565-74 pubmed
Griffiths J, Lovick T. GABAergic neurones in the rat periaqueductal grey matter express alpha4, beta1 and delta GABAA receptor subunits: plasticity of expression during the estrous cycle. Neuroscience. 2005;136:457-66 pubmed
Ahmed Choudhury J, Williams K, Young L, Adams D, Afford S. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal. 2006;18:456-68 pubmed
product information
Product Name :
JNK (D-2) Antibody
Gene Name :
MAPK8, MAPK9, MAPK10
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7345
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
JNK
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA